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Vaccination: Vaccines
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Vaccination as a Limited Option for Removal of Senescent Cells
In today's open access paper, the authors demonstrate a form of vaccination against a surface marker that appears on a subset of senescent T cells that reside in fat tissue, thus directing the rest of the immune system to attack and destroy these cells. There is good evidence for excess fat tissue to result in an increased burden of senescent cells, which disrupt metabolism via the generation of inflammatory signals. A novel branch of medicine is under construction, based on senolytic therapies capable of selectively destroying senescent cells in aged tissues. The growing numbers of senescent cells in older people (and eve...
Source: Fight Aging! - May 26, 2020 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, May 25th 2020
In conclusion, our results suggest a previously unknown mechanism whereby the canonical NF-κB cascade and a mitochondrial fission pathway interdependently regulate endothelial inflammation.
Lin28 as a Target for Nerve Regeneration
https://www.fightaging.org/archives/2020/05/lin28-as-a-target-for-nerve-regeneration/
Researchers here show that the gene Lin28 regulates axon regrowth. In mice, raised levels of Lin28 produce greater regeneration of nerve injuries. Past research has investigated Lin28 from the standpoint of producing a more general improvement in regenerative capacity. It improves mitochondri...
Source: Fight Aging! - May 24, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The New Normal is Still Unknown, on Earth as it is in Healthcare
By HANS DUVEFELT, MD
From the vantage point of our self-quarantined shrunken universes, we cannot see even the immediate future, let alone what our personal and professional lives will look like some years from now.
Factories are closed, luxury department stores are in bankruptcy, hospitals have stopped performing elective procedures and patients are having their heart attacks at home, unattended by medical professionals. New York office workers may continue to work from home while skyscrapers stand empty and city tax revenues evaporate.
Quarantined and furloughed families are planting gardens and cooking at h...
Source: The Health Care Blog - May 22, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Hans Duvefelt Source Type: blogs
Network Medicine in the Fight Against COVID-19
COVID-19 forced stakeholders in the healthcare landscape to adopt a new perspective in this sphere. Telemedicine rose to fame as a ready-made solution; artificial intelligence’s contribution became more apparent from early outbreak predictions to resource management; and digital health technologies lent a helping hand early on.
Another promising area joining the fight is network medicine, a branch of network science. The latter field studies the interaction between actors within a network. Such analyses are applicable to virtually any sector, from the world wide web through social networks to how molecules interact wi...
Source: The Medical Futurist - May 21, 2020 Category: Information Technology Authors: Prans Tags: Network medicine Artificial Intelligence Biotechnology Telemedicine & Smartphones AI MIT coronavirus covid covid19 vaccine research pandemic network science Albert-László Barabási Source Type: blogs
Covid-19 Reuters Q & A with William Haseltine
I live-tweeted a fascinating and perhaps rather depressing meeting with William Haseltine via a Reuters Newsmaker Broadcast. His talk was upbeat but the message does not offer a positive outlook unless we can collaborate internationally to identify, trace, and isolate and go back to early antivirals to treat people urgently. A vaccine will probably never be found, we must stay on top of this virus when we get communities under control. Moreover, we must recognise that another emergent pathogen could appear any time.
These are essentially my notes from Haseltines’s talk.
Might we ever achieve herd immunity?
There is n...
Source: David Bradley Sciencebase - Songs, Snaps, Science - May 20, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Covid-19 Reuters Newsmaker Broadcast with William Haseltine
I live-tweeted a fascinating and perhaps rather depressing meeting with William Haseltine via a Reuters Newsmaker Broadcast. His talk was upbeat but the message does not offer a positive outlook unless we can collaborate internationally to identify, trace, and isolate and go back to early antivirals to treat people urgently. A vaccine will probably never be found, we must stay on top of this virus when we get communities under control. Moreover, we must recognise that another emergent pathogen could appear any time.
These are essentially my notes from Haseltines’s talk.
Might we ever achieve herd immunity?
There is n...
Source: David Bradley Sciencebase - Songs, Snaps, Science - May 20, 2020 Category: Science Authors: David Bradley Tags: Sciencebase Source Type: blogs
Some healthcare can safely wait (and some can ’t)
Among the many remarkable things that have happened since the COVID-19 pandemic began is that a lot of our usual medical care has simply stopped.
According to a recent study, routine testing for cervical cancer, cholesterol, and blood sugar is down nearly 70% across the country. Elective surgeries, routine physical examinations, and other screening tests have been canceled or rescheduled so that people can stay at home, avoid being around others who might be sick, and avoid unknowingly spreading the virus. Many clinics, hospitals, and doctors’ offices have been closed for weeks except for emergencies. Even if these facil...
Source: Harvard Health Blog - May 20, 2020 Category: Consumer Health News Authors: Robert H. Shmerling, MD Tags: Health Health care Healthy Aging Men's Health Women's Health Source Type: blogs
Fight Aging! Newsletter, May 18th 2020
This study provides direct evidence for the contribution of gut microbiota to the cognitive decline during normal aging and suggests that restoring microbiota homeostasis in the elderly may improve cognitive function.
On Nutraceutical Senolytics
https://www.fightaging.org/archives/2020/05/on-nutraceutical-senolytics/
Nutraceuticals are compounds derived from foods, usually plants. In principle one can find useful therapies in the natural world, taking the approach of identifying interesting molecules and refining them to a greater potency than naturally occurs in order to produce a usefully large therape...
Source: Fight Aging! - May 17, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Problem With “Herd Immunity” as a COVID-19 Strategy
This article originally appeared on his blog here.
The post The Problem With “Herd Immunity” as a COVID-19 Strategy appeared first on The Health Care Blog.
Source: The Health Care Blog - May 5, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy Dave deBronkart e-Patient Dave e-Patient Dave DeBronkart Pandemic Source Type: blogs
Predicting the Future by Listening to the Experts
Stephanie Kuku
Hugh Harvey
By STEPHANIE KUKU, MD and HUGH HARVEY, MBBS
The ability to predict in healthcare is the utopia promised by every artificial intelligence for healthcare built, funded and tested in the last decade. Yet very few doctors, technologists, or investors would have imagined they would live to witness a pandemic of the scale we are currently experiencing. We are still getting our heads round the lives lost, the lives of the frontline workers at risk, the disruption and self-isolation, the less fortunate who will suffer the most, the companies in survival mode, and a battered global economy. ...
Source: The Health Care Blog - May 4, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology Hardian Health Hugh Harvey Stephanie Kuku Source Type: blogs
Fight Aging! Newsletter, May 4th 2020
The objective is to start treating chronic diseases from the root and not the symptoms of the disease. As we are starting to enroll patients in "senolytics-clinical trials," it will be imperative to assess if senolysis efficiently targets the primary cause of disease or if it works best in combination with other drugs. Additional basic science research is required to address the fundamental role of senescent cells, especially in the established contexts of disease.
Notes on Self-Experimentation with Sex Steroid Ablation for Regrowth of the Thymus
https://www.fightaging.org/archives/2020/04/notes-on-self-experim...
Source: Fight Aging! - May 3, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
COVID-19: Physicians in Shackles
By ANISH KOKA, MD
A number of politically tinged narratives have
divided physicians during the pandemic. It would be unfortunate if politics
obscured the major problem brought into stark relief by the pandemic: a system
that marginalizes physicians and strips them of agency.
In practices big and small, hospital-employed
or private practice, nursing homes or hospitals, there are serious issues
raising their heads for doctors and their patients.
No masks for you
When I walked into my office Thursday, March 12th, I assembled the office staff for the first time to talk about COVID. The prior weekend had been awa...
Source: The Health Care Blog - May 2, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Physicians Anish Koka medical autonomy Pandemic Source Type: blogs
The False Choice Between Science And Economics
This article originally appeared on The Bulwark here.
The post The False Choice Between Science And Economics appeared first on The Health Care Blog.
Source: The Health Care Blog - May 1, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Health Policy David Shaywitz Source Type: blogs
Weight loss can help head off lasting damage caused by fatty liver
Non-alcoholic fatty liver disease is the most common cause of liver disease in the United States, and is estimated to affect up to a quarter of adults in the world. It is defined by excess fat accumulating in the liver and usually occurs in people with obesity, high blood sugars (diabetes), abnormal cholesterol or triglyceride levels, or high blood pressure. These disorders often run together and as a group are called metabolic syndrome. The “non-alcoholic” part of “non-alcoholic fatty liver disease” is important to distinguish it from alcohol-related liver disease, which can also cause excess liver fat.
How fat ca...
Source: Harvard Health Blog - April 30, 2020 Category: Consumer Health News Authors: Irun Bhan, MD Tags: Diet and Weight Loss Digestive Disorders Source Type: blogs
Nursing Students and Educators Must Be Part of a National Public Health Surveillance Strategy
By KAREN JOHNSON PhD, RN
Shortly before our
world was turned upside down by COVID-19, I visited Space Center Houston with
my family. We marveled at the collective ambition and investment it took to
move from space travel being an aspirational dream to setting foot on the moon.
I thought about my favorite scene from the movie Apollo 13, when Gene Kranz
overhears the NASA Director saying “This could be the worst disaster NASA has
ever experienced,” and candidly replies, “With all due respect, sir, I believe
this is going to be our finest hour.”
Just months later, our entire planet is on a mission to turn trag...
Source: The Health Care Blog - April 20, 2020 Category: Consumer Health News Authors: Christina Liu Tags: COVID-19 Medical Practice Karen Johnson Nursing Source Type: blogs
