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Fight Aging! Newsletter, December 7th 2020
In this study, except for the reduction in body weight, the aging characteristics related to epidermal and muscle tissue in mice were significantly ameliorated in the CR group compared with the control group. Additional studies have indicated that not stem cells themselves but the stem cell microenvironment is the key factor mediating stem cell activation, proliferation and differentiation. Mitochondrial dysfunction is an important factor leading to age-related muscular atrophy. Considering the dependence of skeletal muscle on ATP, loss of mitochondrial function, which can lead to a decrease in strength and enduranc...
Source: Fight Aging! - December 6, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Podcast: Celebrating a COVID Christmas
We’ve made it to the end of 2020! From polarizing politics to raging fires to COVID-19, it’s been a real doozy. And now the holidays… Do we celebrate with loved ones and risk COVID or take a pass? What are the risks? In today’s show, our guest Dr. John Grohol, founder of Psych Central, explains how this isn’t going to be our regular holiday season and that’s okay: We can easily make lemonade out of lemons. SUBSCRIBE & REVIEW   Guest information for ‘Dr. John Grohol- COVID Christmas’ Podcast Episode John M. Grohol, Psy.D. is a pioneer in online mental health and psychology. Recognizing the edu...
Source: World of Psychology - December 3, 2020 Category: Psychiatry & Psychology Authors: The Psych Central Podcast Tags: General Holiday Coping Interview Podcast The Psych Central Show Source Type: blogs

Fight Aging! Newsletter, November 23rd 2020
In conclusion, the study indicates that HBOT may induce significant senolytic effects that include significantly increasing telomere length and clearance of senescent cells in the aging populations. Data on the Prevalence of Liver Fibrosis in Middle Age https://www.fightaging.org/archives/2020/11/data-on-the-prevalence-of-liver-fibrosis-in-middle-age/ Fibrosis is a consequence of age-related disarray in tissue maintenance processes, leading to the deposition of scar-like collagen that disrupts tissue structure and function. It is an ultimately fatal issue for which there are only poor treatment options a...
Source: Fight Aging! - November 22, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Hepatitis C
is a recently discovered disease. Harvey J. Alter identified the variant form of Hepatitis during the 70s, which then became known as a ‘non-A, non-B Hepatitis (NANBH)’. In the 1980s, Michael Houghton and his team isolated the genome of the new virus, and it was named ‘Hepatitis C’. Finally, in 1997 Charles M. Rice proved that the virus is a disease agent, capable of acting alone to cause Hepatitis. This year’s Nobel Prize in Medicine has been jointly awarded to Harvey J. Alter, Michael Houghton, and Charles M. Rice for the discovery of the virus. Their contributions (illustrated below) have led to improved unde...
Source: GIDEON blog - November 10, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Source Type: blogs

A Cure at Any Cost? Time to Shine a Light on Drug Pricing
By CECI CONNOLLY and BOBBY CLARK We are all are anxiously awaiting the approval and delivery of a cure to the novel coronavirus – or better yet, a vaccine. Amid the race to develop a safe and effective vaccine, some may be inclined to give drug companies a pass on their well-established bad behavior related to pricing and market competition. But that would be an awfully expensive mistake. As the COVID-19 pandemic claims more lives and families’ livelihood, policymakers and the public must press drug makers for more information on the products they are developing. The country must be protected agains...
Source: The Health Care Blog - November 2, 2020 Category: Consumer Health News Authors: Christina Liu Tags: Health Policy bobby clark Ceci Connolly COVID-19 Drug Pricing Pharma Source Type: blogs

Fight Aging! Newsletter, October 26th 2020
In conclusion, all NAFLD histological stages were associated with significantly increased overall mortality, and this risk increased progressively with worsening NAFLD histology. Most of this excess mortality was from extrahepatic cancer and cirrhosis, while in contrast, the contributions of cardiovascular disease and HCC were modest. BMP6 as a Target for Pro-Angiogenic Therapies https://www.fightaging.org/archives/2020/10/bmp6-as-a-target-for-pro-angiogenic-therapies/ Today's research materials are focused on the fine details of angiogenesis, the formation of new blood vessels, and point to BMP6 as a po...
Source: Fight Aging! - October 25, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

COVID-19 Is Only One of the Compelling Arguments for Developing the Means of Immune System Rejuvenation
Infectious disease is a far greater risk for the old than for the young. But then so is cancer. Both are conditions driven by the age-related failure of immune system competence, a growing inability to respond to vaccines and to destroy pathogens and errant cells, a state known as immunosenescence. Further, the failing immune system becomes inappropriately overactive at the same time as losing its efficacy, generating chronic inflammation that disrupts normal tissue function and spurs the development of numerous age-related diseases. Restoring a youthful immune function would be enormously beneficial and greatly reduce mor...
Source: Fight Aging! - October 22, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Hepatitis A in the United States
  Few Americans are aware of a major epidemic that has taken hold of large areas of their country in recent years – by a disease that is easily diagnosed and prevented. Sadly, public – and even professional interest in these events have been overshadowed by COVID-19.    AN UPTICK IN CASES Hepatitis A had been largely under control until three years ago and can be easily prevented through the use of a safe and effective vaccine.  From January 2017 to January 2019, at least 26 separate outbreaks were reported, to a total of 11,628 cases and 99 deaths, nationwide. Homeless individuals and users of illicit dru...
Source: GIDEON blog - October 21, 2020 Category: Databases & Libraries Authors: Kristina Symes Tags: Epidemiology News Outbreaks Source Type: blogs

Fight Aging! Newsletter, October 12th 2020
We report that FMT from aged donors led to impaired spatial learning and memory in young adult recipients, whereas anxiety, explorative behaviour, and locomotor activity remained unaffected. This was paralleled by altered expression of proteins involved in synaptic plasticity and neurotransmission in the hippocampus. Also, a strong reduction of bacteria associated with short-chain fatty acids (SCFAs) production (Lachnospiraceae, Faecalibaculum, and Ruminococcaceae) and disorders of the CNS (Prevotellaceae and Ruminococcaceae) was observed. Finally, the detrimental effect of FMT from aged donors on the CNS was confir...
Source: Fight Aging! - October 11, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, October 5th 2020
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 4, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

America needs to invest in proactive patient outreach now
The COVID-19 pandemic has introduced multiple new threats for physical and mental health. The novel coronavirus itself continues to infect more than 30,000 Americans as we enter the influenza season. The pandemic, economic devastation, and racial reckoning have led to a tripling of emotional distress. Essential preventive services such as cancer screenings,  childhood vaccination, maintenance visits for […]Find jobs at  Careers by KevinMD.com.  Search thousands of physician, PA, NP, and CRNA jobs now.  Learn more.
Source: Kevin, M.D. - Medical Weblog - October 3, 2020 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/jason-bae-and-alan-glaseroff" rel="tag" > Jason Bae, MD and Alan Glaseroff, MD < /a > < /span > Tags: Policy COVID-19 coronavirus Infectious Disease Public Health & Source Type: blogs

Cellular Senescence as a Mediator of Age-Related COVID-19 Severity
Wherever we find the intersection of inflammation and aging, important in many age-related conditions, it has become the case that attention is drawn to the role of senescent cells. Senescent cells cease replication, grow in size, and secrete a potent mix of inflammatory signals. Usually they self-destruct or are destroyed by the immune system shortly after entering a senescent state. Cells become senescent constantly throughout life, and for a variety of reasons, but only with advancing age do these cells linger and build up in number. Senescent cells serve a number of useful purposes when present in the short term, assis...
Source: Fight Aging! - September 30, 2020 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 28th 2020
In conclusion, it remains unclear if brain-specific regional and temporal changes occur in the expression of the different APP variants during AD progression. Since APP is also found in blood cells, assessing the changes in APP mRNA expression in peripheral blood cells from AD patients has been considering an alternative. However, again the quantification of APP mRNA in peripheral blood cells has generated controversial results. Brain APP protein has been analyzed in only a few studies, probably as it is difficult to interpret the complex pattern of APP variants and fragments. We previously characterized the soluabl...
Source: Fight Aging! - September 27, 2020 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Veterinary Vaccines
Laurel J. Gershwin and Amelia R. Woolums present a new book on Veterinary Vaccines: Current Innovations and Future Trends This concise book captures the essence of current and future shifts in vaccine development research that will likely transform our understanding of methods to stimulate specific and protective immune responses to infectious diseases, and to offer improved therapeutic applications for oncology patients. The book opens with a chapter on reverse vaccinology and systems vaccinology approaches that should lead to more effective vaccines with fewer side effects. This is followed by a chapter describing rece...
Source: Microbiology Blog: The weblog for microbiologists. - September 23, 2020 Category: Microbiology Source Type: blogs

Discrimination, high blood pressure, and health disparities in African Americans
Over the past few months, we have all seen the results of significant disruption to daily life due to the COVID-19 pandemic, high levels of unemployment, and civil unrest driven by chronic racial injustice. These overlapping waves of societal insult have begun to bring necessary attention to the importance of health care disparities in the United States. Direct links between stress, discrimination, racial injustice, and health outcomes occurring over one’s lifespan have not been well studied. But a recently published article in the journal Hypertension has looked at the connection between discrimination and increased ris...
Source: Harvard Health Blog - September 21, 2020 Category: Consumer Health News Authors: Chester Hedgepeth, III, MD, PhD Tags: Health care disparities Hypertension and Stroke Source Type: blogs