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Fight Aging! Newsletter, May 23rd 2022
In conclusion, remofuscin activates the lysosome-to-nucleus pathway in C. elegans, thereby increasing the expression levels of xenobiotic detoxification genes resulted in extending their lifespan.
Naked Mole-Rat Skin Shows Fewer Signs of Aging
https://www.fightaging.org/archives/2022/05/naked-mole-rat-skin-shows-fewer-signs-of-aging/
Naked mole-rats exhibit a maximum life span that is many times longer than is the case for similarly sized mammals. Further, they are negligibly senescent, showing few age-related declines in function across much of that lengthy life span. That includes maintenance of stem c...
Source: Fight Aging! - May 22, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Science Snippet: RNA ’s Remarkable Roles
RNA, though less well known than its cousin DNA, is equally integral to our bodies. RNA molecules are long, usually single-stranded chains of nucleotides. (DNA molecules are also made up of nucleotides but are typically double-stranded.) There are three major types of RNA, which are all involved in protein synthesis:
Messenger RNA (mRNA) is complementary to one of the DNA strands of a gene and carries genetic information for protein synthesis to the ribosome—the molecular complex in which proteins are made.Transfer RNA (tRNA) works with mRNA to make sure the right amin...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 18, 2022 Category: Research Authors: Matt Mills Tags: Cells Injury and Illness Cellular Processes RNA Science Snippet Source Type: blogs
Fight Aging! Newsletter, May 9th 2022
In conclusion, although several favorable effects are obtained in our heterochronic non-myeloablative transplantation model, additional optimization is needed for better rejuvenation effects.
More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells
https://www.fightaging.org/archives/2022/05/more-on-gpnmb-as-a-target-for-senolytic-therapies-to-clear-senescent-cells/
You might recall that researchers recently demonstrated that vaccination against GPNMB is a senolytic strategy, reducing the harmful burden of senescent cells in aged tissues by directing the immune system to destroy these c...
Source: Fight Aging! - May 8, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
More on GPNMB as a Target for Senolytic Therapies to Clear Senescent Cells
In conclusion, our results taken together with the above considerations demonstrated that GPNMB was upregulated by lysosomal stress associated with cellular senescence and acted as a protective factor for senescent cells, and suggest that targeting cell/tissue-specific seno-antigens like GPNMB could be a reasonable strategy for next-generation senolytic therapy with higher selectivity and fewer off-target effects.
Link: https://doi.org/10.1038/s41598-022-10522-3
Source: Fight Aging! - May 4, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
The Top 10 Super-Creepy Medical Technologies
We are all for new technologies here, spending our days researching where the science of medicine goes. With that said, every now and then we see something so creepy that it freaks out even the seasoned team of The Medical Futurist.
So here we collected ten examples of either super creepy medical technologies or ingeniously evil uses of perfectly innocent technologies.
The blood drawing robots
First, this doesn’t really sound creepy. Drawing blood might not be our favourite thing, but nothing of a terror for most of us either. Vein scanners are around for a while, actually being a useful little tool ...
Source: The Medical Futurist - May 3, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Bioethics Cyborgization Robotics Science Fiction Security & Privacy AI dream smartwatch virtual reality blood draw sleep tracking artificial womb gene editing medical robot creepy technologies Source Type: blogs
Looking Back At Today ’s Healthcare In 2060
I receive many questions after my talks and on my online channels about the not yet visible future. People want to know what healthcare will be like in the next decades. But throwing around predictions will not help us design a better healthcare. Although showing a utopian future of healthcare might do so.
On a chilly October afternoon in 2060,
after having watched the leaves falling off the trees in our garden for too long to get bored, my beautiful and overtly curious grandchild, Nina, came to me and started asking me questions.
She pointed at one of the many CubeSensors in the living room – small,...
Source: The Medical Futurist - April 26, 2022 Category: Information Technology Authors: berci.mesko Tags: Healthcare Design Science Fiction future Medical education Medicine Personalized medicine technology gc4 Source Type: blogs
Spray Blocks SARS-CoV-2 Entry into Nasal Cells
Researchers at the University of British Columbia, and collaborators, created a nasal spray that can block the entry of SARS-CoV-2 into cells in the nasal cavity, potentially offering protection and treatment for COVID-19. Excitingly, in lab tests, t...
Source: Medgadget - April 18, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Public Health Source Type: blogs
Spherical Nucleic Acid Vaccine Uses Structural Design to Improve Efficacy
A team at Northwestern University created a new type of nanoparticle-based vaccine that employs structure-function relationships during the design phase to maximize efficacy. Called a spherical nucleic acid (SNA) vaccine, the technology consists of g...
Source: Medgadget - April 4, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine Public Health Source Type: blogs
Weekly Overseas Health IT Links – 2nd April, 2022.
Here are a few I came across last week. Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment. ----- https://ehrintelligence.com/news/epic-healthy-planet-increased-patient-adherence-to-preventive-care Epic Healthy Planet Increased Patient Adherence to Preventive Care Epic Healthy Planet used EHR data to determine care gaps for older high-risk patients, resulting in greater patient adherence to preventive care services such as cancer screening and vaccinations...
Source: Australian Health Information Technology - April 2, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
Weekly Overseas Health IT Links – 26th March, 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.-----https://mhealthintelligence.com/news/55-of-telehealth-providers-frustrated-with-overblown-patient-expectations55% of Telehealth Providers Frustrated With Overblown Patient ExpectationsProviders also cited their ability to provide quality care and technical difficulties as among their top frustrations with telehealth, a new survey shows.ByAnuja VaidyaMarch 18, 202...
Source: Australian Health Information Technology - March 26, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs
The (sort of, partial) Father mRNA Vaccines Who Now Spreads Vaccine Misinformation (Part 1)
By DAVID WARMFLASH, MD
Robert W. Malone, MD MS, is a physician-scientist who will live in infamy, thanks to the Joe Rogan Experience Podcast boosting his visibility this past December regarding his criticism of COVID-19 vaccines, particularly the mRNA vaccines (Moderna and Pfizer-BioNTech). Subsequently, Malone was banned from Twitter, which further boosted his celebrity status. Describing himself as the inventor of mRNA vaccine technology, he has been reaching a growing number of people with a narrative that makes COVID-19 vaccination sound scary. We cannot embed clips from the Rogan interview, which lasted about three...
Source: The Health Care Blog - March 17, 2022 Category: Consumer Health News Authors: matthew holt Tags: COVID-19 Health Policy antivaxxer COVID-19 vaccine David Warmflash Joe Rogan Robert Malone Source Type: blogs
How Do We Know If COVID Is Over?
Is it the end of COVID? – we hear this very question more and more often these days. This topic has been analysed over and over in the past two years, I also wrote about it more than once. Here, at the beginning, we outlined possible scenarios on how the pandemic will develop. By now we can determine that we ended up somewhere between #2 and #3.
We also discussed how widespread vaccination is the way to go, and how it will contribute to getting back our lives.
The speculation on finally getting over it is not surprising. It is in line with recent reports, and the discussion about the pandemic entering the endem...
Source: The Medical Futurist - March 15, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Covid-19 public health covid19 pandemic endemic end of covid Source Type: blogs
What the Pandemic Taught Us About Value-based Care
By RICHARD ISSACS
You’ll recall that we ran a long piece (pt 1, pt 2) about Medicare Advantage from former Kaiser Permanente CEO George Halvorson earlier this year. Here’s a somewhat related piece from the current head of the Permanente Medical Group about what actually happened there and elsewhere during the pandemic–Matthew Holt
The COVID-19 pandemic has provided important lessons regarding the structure and delivery of health care in the United States, and one of the most significant takeaways has been the need to shift to value-based models of care.
The urgency for this transformation was cle...
Source: The Health Care Blog - February 17, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Medical Practice Physicians Kaiser Permanente Medicare Advantage Pandemic Richard Isaacs value-based care Source Type: blogs
Rationing and Indication
I ' ll let y ' all in on a secret: I ' m writing a book. It ' s basically everything you need to know, as a citizen, taxpayer, consumer of medical services, friend or family member of consumers of medical services, and just plain person, about health and health care in the U.S. For some reason I haven ' t much connected the work on the book to this blog -- there is tons of materials I could have lifted from my book chapters and posted here for your delectation and delight. I ' m not sure why I haven ' t been doing that, and maybe I will.Anyway, the previous post creates an occasion to discuss a matter that seems pretty obv...
Source: Stayin' Alive - January 31, 2022 Category: American Health Source Type: blogs
Temporary Chimeric Antigen Receptor T Cells Produced in the Body via mRNA Gene Therapy
Chimeric antigen receptors applied to T cells, known as CAR-T therapies, are expensive. Isolating a patient's T cells, culturing them, engineering them, and then returning them to the body is an undertaking, particularly when it must be carried out with the very high level of reliability and quality control required by regulators. CAR-T therapies do well in attacking many types of cancer, but can have side-effects due to the lasting presence of engineered immune cells that have become too zealous. Few chimeric antigens are completely specific for cancer, and other cells will be destroyed as well. The approach noted here is...
Source: Fight Aging! - January 17, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
