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Infectious Disease: Hepatitis
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Total 32760 results found since Jan 2013.
Transcription Factor JunB Suppresses Hepatitis C Virus Replication
Kobe J Med Sci. 2023 Aug 31;69(3):E86-E95.ABSTRACTWe previously reported that hepatitis C virus (HCV) infection activates the reactive oxygen species (ROS)/c-Jun N-terminal kinase (JNK) signaling pathway. Activation of JNK contributes to the development of liver diseases, including metabolic disorders, steatosis, liver cirrhosis and hepatocellular carcinoma. JNK is known to have numerous target genes, including JunB, a member of activator protein-1 transcription factor family. However, the roles of JunB in the HCV life cycle and HCV-associated pathogenesis remain unclear. To clarify a physiological role of JunB in HCV infe...
Source: Kobe J Med Sci - September 4, 2023 Category: General Medicine Authors: Adi Ariffianto Lin Deng Saki Harada Yujiao Liang Chieko Matsui Takayuki Abe Ikuo Shoji Source Type: research
Acute liver failure following immune checkpoint inhibitors
We report the case of a 64-year-old man admitted to intensive care unit for liver failure secondary to immune-mediated hepatitis. This patient suffered from a progressing laryngeal squamous cell carcinoma. A treatment was started with immune checkpoint inhibitors combining anti PD-L1 plus novel anti-TIGIT or placebo (ATEZOLIZUMAB plus TIRAGOLUMAB or placebo), as part of a clinical trial. The patient then developed immune-mediated hepatitis, proven by liver biopsy. Despite 14 days of corticosteroids at 2 mg/kg the condition of the patient worsened, with the development of liver failure. The patient was admitted to intensive...
Source: Cell Research - September 3, 2023 Category: Cytology Authors: Thomas Renault Lucy Meunier Cl ément Monet Source Type: research
Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders
Biochem Pharmacol. 2023 Aug 31:115776. doi: 10.1016/j.bcp.2023.115776. Online ahead of print.ABSTRACTThe farnesoid-x-receptor (FXR) and the G protein bile acid activated receptor (GPBAR)1 are two bile acid activated receptors highly expressed in entero-hepatic, immune, adipose and cardiovascular tissues. FXR and GPBAR1 are clinically validated targets in the treatment of metabolic disorders and FXR agonists are currently trialled in patients with non-alcoholic steato-hepatitis (NASH). Results of these trials, however, have raised concerns over safety and efficacy of selective FXR ligands suggesting that the development of ...
Source: Biochemical Pharmacology - September 2, 2023 Category: Drugs & Pharmacology Authors: Stefano Fiorucci Valentina Sepe Michele Biagioli Bianca Fiorillo Pasquale Rapacciuolo Eleonora Distrutti Angela Zampella Source Type: research
Avian anti-HBV immunoglobulin: New tool to improve hepatitis B diagnosis methods
In conclusion, it was possible producing anti-HBs IgY by immunizing chickens with HBV vaccine; this molecule could be used as capture antibody to help detecting HBsAg in-house ELISA.PMID:37659497 | DOI:10.1016/j.ijbiomac.2023.126644
Source: International Journal of Biological Macromolecules - September 2, 2023 Category: Biochemistry Authors: Raissa Martins Deodato Debora Regina Lopes Dos Santos Mayara Torquato Lima da Silva Helena Medina Cruz Vanessa Salete de Paula Livia Melo Villar Source Type: research
Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
In conclusion, our study provides compelling evidence suggesting that telbivudine-induced myopathy is associated with mitochondrial toxicity and impaired energy metabolism. The observed muscle pathology, depletion of mtDNA, elevation of oxidative stress and altered mitochondrial function support the hypothesis that telbivudine disrupts mitochondrial homeostasis, ultimately leading to muscle damage. This may be also a common mechanism for NAs to cause neuromyopathy.PMID:37659625 | DOI:10.1016/j.cbi.2023.110692
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Wenfei Yu Zhuxvn Li Wenjing Wu Dandan Zhao Chuanzhu Yan Pengfei Lin Source Type: research
Avian anti-HBV immunoglobulin: New tool to improve hepatitis B diagnosis methods
In conclusion, it was possible producing anti-HBs IgY by immunizing chickens with HBV vaccine; this molecule could be used as capture antibody to help detecting HBsAg in-house ELISA.PMID:37659497 | DOI:10.1016/j.ijbiomac.2023.126644
Source: International Journal of Biological Macromolecules - September 2, 2023 Category: Biochemistry Authors: Raissa Martins Deodato Debora Regina Lopes Dos Santos Mayara Torquato Lima da Silva Helena Medina Cruz Vanessa Salete de Paula Livia Melo Villar Source Type: research
Development of bile acid activated receptors hybrid molecules for the treatment of inflammatory and metabolic disorders
Biochem Pharmacol. 2023 Aug 31:115776. doi: 10.1016/j.bcp.2023.115776. Online ahead of print.ABSTRACTThe farnesoid-x-receptor (FXR) and the G protein bile acid activated receptor (GPBAR)1 are two bile acid activated receptors highly expressed in entero-hepatic, immune, adipose and cardiovascular tissues. FXR and GPBAR1 are clinically validated targets in the treatment of metabolic disorders and FXR agonists are currently trialled in patients with non-alcoholic steato-hepatitis (NASH). Results of these trials, however, have raised concerns over safety and efficacy of selective FXR ligands suggesting that the development of ...
Source: Biochemical Pharmacology - September 2, 2023 Category: Drugs & Pharmacology Authors: Stefano Fiorucci Valentina Sepe Michele Biagioli Bianca Fiorillo Pasquale Rapacciuolo Eleonora Distrutti Angela Zampella Source Type: research
Insights into the mechanisms of telbivudine-induced myopathy associated with mitochondrial dysfunction
In conclusion, our study provides compelling evidence suggesting that telbivudine-induced myopathy is associated with mitochondrial toxicity and impaired energy metabolism. The observed muscle pathology, depletion of mtDNA, elevation of oxidative stress and altered mitochondrial function support the hypothesis that telbivudine disrupts mitochondrial homeostasis, ultimately leading to muscle damage. This may be also a common mechanism for NAs to cause neuromyopathy.PMID:37659625 | DOI:10.1016/j.cbi.2023.110692
Source: Chemico-Biological Interactions - September 2, 2023 Category: Molecular Biology Authors: Wenfei Yu Zhuxun Li Wenjing Wu Dandan Zhao Chuanzhu Yan Pengfei Lin Source Type: research
Ligand-mediated Targeted Drug Delivery Approaches against Hepatocellular Carcinoma
Curr Cancer Drug Targets. 2023;23(11):879-888. doi: 10.2174/1568009623666230503094346.ABSTRACTOne of the most important health problems in the world today is cancer. The World Health Organization (WHO) reported that it results in 8.9 million deaths annually. Malignant tumours and unregulated cell proliferation are features of malignant neoplasms, which can also invade nearby body regions. Hepatocellular carcinoma is the third most prevalent cause of cancer-related death worldwide and the fifth most common kind of cancer, according to a recent analysis. Patients with liver disease as well as chronic hepatitis B and C are mo...
Source: Current Cancer Drug Targets - September 1, 2023 Category: Cancer & Oncology Authors: Amrita Singh Sudhanshu Mishra Saurabh Sharma Smriti Ojha Sunil Yagnik Sudhi Pandey Source Type: research
Duck Hepatitis A virus: full-length genome-based phylogenetic and phylogeographic view during 1986-2020
Virus Res. 2023 Aug 30:199216. doi: 10.1016/j.virusres.2023.199216. Online ahead of print.ABSTRACTDuck hepatitis A virus (DHAV) is one of key pathogens for duck viral hepatitis, especially in Asian duck industry. Currently, two main genotypes (DHAV-1 and -3) exist. To explore insightfully the evolutionary character, we assessed the available 141 full-length genome sequences of DHAV isolated in 1986-2020 globally and divided DHAV-1 and DHAV-3 into further seven (DHAV-1 a-g) and five (DHAV-3 a-e) sub-clades, respectively. Phylogenetic and phylogeographic network analyses indicated great genetic diversity of DHAV identified i...
Source: Virus Research - September 1, 2023 Category: Virology Authors: Caiting Yang Pir Tariq Shah Amina Nawal Bahoussi Changxin Wu Li Wang Li Xing Source Type: research
