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Infectious Disease: Hepatitis
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Total 32760 results found since Jan 2013.
Biological Roles of Hepatitis B Viral X Protein in the Viral Replication and Hepatocarcinogenesis
Acta Med Okayama. 2023 Aug;77(4):341-345. doi: 10.18926/AMO/65739.ABSTRACTHepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral r...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Motoyuki Otsuka Source Type: research
Design, synthesis, and structure-activity relationship of a bicyclic HBV capsid assembly modulator chemotype leading to the identification of clinical candidate AB-506
Bioorg Med Chem Lett. 2023 Aug 24:129456. doi: 10.1016/j.bmcl.2023.129456. Online ahead of print.ABSTRACTDisruption of the HBV capsid assembly process through small-molecule interaction with HBV core protein is a validated target for the suppression of hepatitis B viral replication and the development of new antivirals. Through combination of key structural features associated with two distinct series of capsid assembly modulators, a novel aminochroman-based chemotype was identified. Optimization of anti-HBV potency through generation of SAR in addition to further core modifications provided a series of related functionali...
Source: Bioorganic and Medicinal Chemistry Letters - August 26, 2023 Category: Chemistry Authors: Andrew G Cole Steven G Kultgen Nagraj Mani Jorge G Quintero Kristi Yi Fan Andrzej Ardzinski Kim Stever Bruce D Dorsey Janet R Phelps Amy C H Lee Emily P Thi Tim Chiu Sunny Tang Peter S Horanyi Stephen J Mayclin Troy O Harasym Michael J Sofia Source Type: research
Antiviral and immunoregulatory effects of curcumin on coxsackievirus B3-infected hepatitis
Virus Res. 2023 Aug 23:199203. doi: 10.1016/j.virusres.2023.199203. Online ahead of print.ABSTRACTFulminant hepatitis is a life-threatening complication of coxsackievirus B (CVB) 3 infections. The condition may deteriorate to disseminated intravascular coagulopathy with markedly increased liver enzymes, inflammatory cytokines, and chemokines, which significantly induce local and systemic inflammation. Curcumin exhibits anti-inflammatory and antiviral characteristics in inflammatory and infectious diseases. Here we determined effects of curcumin on viral replications, cytokine and chemokine expressions, and liver damage in ...
Source: Virus Research - August 25, 2023 Category: Virology Authors: Yu-Jheng Lin Li-Chiu Wang Huey-Pin Tsai Chia-Yu Chi Chih-Peng Chang Shun-Hua Chen Shih-Min Wang Source Type: research
Development and validation of a risk prediction algorithm for evaluating the efficacy of postoperative adjuvant TACE therapy for hepatocellular carcinoma
CONCLUSION: This model may be an easy-to-use tool for screening patients suitable for PA-TACE treatment and guiding the selection of clinical protocols. But further research and external validation are required.PMID:37622693 | DOI:10.2174/1386207326666230824090204
Source: Combinatorial Chemistry and High Throughput Screening - August 25, 2023 Category: Chemistry Authors: Jie Tao Xiaoli Shi Xu Feng Xinhua Wu Shiguai Qi Guoying Feng Xu Yang Yufei Zhao Hangjia Zuo Zhengrong Shi Source Type: research
Acute hepatitis of unknown etiology in an adult female: A case report
CONCLUSION: Idiopathic hepatitis makes treatment challenging. It can leave patients feeling confused and unfulfilled. Thus, educating the patient thoroughly for shared decision-making and management becomes essential.PMID:37621598 | PMC:PMC10445075 | DOI:10.12998/wjcc.v11.i22.5288
Source: Herpes - August 25, 2023 Category: Infectious Diseases Authors: Lucinda Dass Alexandra Marie Malabanan Pacia Mahgol Hamidi Source Type: research
Development and validation of a risk prediction algorithm for evaluating the efficacy of postoperative adjuvant TACE therapy for hepatocellular carcinoma
CONCLUSION: This model may be an easy-to-use tool for screening patients suitable for PA-TACE treatment and guiding the selection of clinical protocols. But further research and external validation are required.PMID:37622693 | DOI:10.2174/1386207326666230824090204
Source: Combinatorial Chemistry and High Throughput Screening - August 25, 2023 Category: Chemistry Authors: Jie Tao Xiaoli Shi Xu Feng Xinhua Wu Shiguai Qi Guoying Feng Xu Yang Yufei Zhao Hangjia Zuo Zhengrong Shi Source Type: research
Antiviral and immunoregulatory effects of curcumin on coxsackievirus B3-infected hepatitis
Virus Res. 2023 Aug 23:199203. doi: 10.1016/j.virusres.2023.199203. Online ahead of print.ABSTRACTFulminant hepatitis is a life-threatening complication of coxsackievirus B (CVB) 3 infections. The condition may deteriorate to disseminated intravascular coagulopathy with markedly increased liver enzymes, inflammatory cytokines, and chemokines, which significantly induce local and systemic inflammation. Curcumin exhibits anti-inflammatory and antiviral characteristics in inflammatory and infectious diseases. Here we determined effects of curcumin on viral replications, cytokine and chemokine expressions, and liver damage in ...
Source: Cell Research - August 25, 2023 Category: Cytology Authors: Yu-Jheng Lin Li-Chiu Wang Huey-Pin Tsai Chia-Yu Chi Chih-Peng Chang Shun-Hua Chen Shih-Min Wang Source Type: research
