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Infectious Disease: Hepatitis
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Therapeutic strategies and promising vaccine for hepatitis C virus infection
AbstractHepatitis C virus (HCV) infection is still a significant global health problem despite therapeutic advancements. Ribavirin and interferon therapy have been the sole available treatments for HCV infection for a number of years with low efficacy. Thus, currently, a number of therapeutic strategies are being used, including nanoparticles (NPs), micro-RNAs such as small interfering RNA (siRNA), RNAi-based gene silencing and antisense oligonucleotide-based microRNA-122, microRNA-155, and short hairpin RNAs (shRNAs), and immunotherapeutic approaches such as anti-programmed cell death 1(PD-1), monoclonal antibodies (mAb Â...
Source: Immunity, Inflammation and Disease - August 28, 2023 Category: Allergy & Immunology Authors: Adane Adugna Tags: REVIEW ARTICLE Source Type: research
Biological Roles of Hepatitis B Viral X Protein in the Viral Replication and Hepatocarcinogenesis
Acta Med Okayama. 2023 Aug;77(4):341-345. doi: 10.18926/AMO/65739.ABSTRACTHepatitis B virus is a pathogenic virus that infects 300 million people worldwide and causes chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma. Hepatitis B virus encodes four proteins. Among them, the HBx protein plays a central role in the HBV pathogenesis. Because the HBx protein is considered to play a central role in the induction of viral replication and hepatocarcinogenesis, the regulation of its function could be a key factor in the development of new interventions against hepatitis B. In this review, HBx protein-related viral r...
Source: Acta Med Okayama - August 27, 2023 Category: Universities & Medical Training Authors: Motoyuki Otsuka Source Type: research
