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Infectious Disease: Tuberculosis
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Impact of Genomic Deletion RD16 on the Expression of the < em > Mycobacterium bovis < /em > BCG Moreau VapBC47 Toxin-Antitoxin System
Curr Issues Mol Biol. 2023 Aug 7;45(8):6538-6549. doi: 10.3390/cimb45080412.ABSTRACTMycobacterium bovis BCG is the only vaccine against tuberculosis. The variable forms of cultivation throughout the years, before seed-lots were developed, allowed in vitro evolution of the original strain, generating a family of vaccines with different phenotypic and genotypic characteristics. Molecular studies revealed regions of difference (RDs) in the genomes of the various BCG strains. This work aims to characterize the gene pair rv3407-rv3408 (vapB47-vapC47), coding for a toxin-antitoxin system of the VapBC family, and to evaluate poss...
Source: Current Issues in Molecular Biology - August 25, 2023 Category: Molecular Biology Authors: Talita Duarte Pagani Paloma Rezende Corr êa Cristiane Lima Leonardo Henrique Ferreira Gomes Marcos Gustavo Araujo Schwarz Teca Calcagno Galv ão Wim Maurits Degrave Napole ão Fonseca Valadares Leila Mendon ça-Lima Source Type: research
Inclusion of non-medical interventions in model-based economic evaluations for tuberculosis: A scoping review
ConclusionsThis scoping review identified a gap in literature in the evaluation of non-medical TB interventions. However, the identified articles provided useful examples of how economic modeling can be used to explore non-traditional interventions using existing economic evaluation methods.
Source: PLoS One - August 25, 2023 Category: Biomedical Science Authors: Lauren C. Ramsay Source Type: research
