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Evaluation of machine learning classifiers for predicting essential genes in < em > Mycobacterium tuberculosis < /em > strains
Bioinformation. 2022 Dec 31;18(12):1126-1130. doi: 10.6026/973206300181126. eCollection 2022.ABSTRACTAccurate investigation and prediction of essential genes from bacterial genome is very important as it might be explored in effective targets for antimicrobial drugs and understanding biological mechanism of a cell. A subset of key features data obtained from 14 genome sequence-based features of 20 strains of Mycobacterium tuberculosis bacteria whose essential gene information was downloaded from ePath and NCBI database for mapping and matching essential genes by using a genome extraction program. The selection of key featu...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Monish Mukul Das Keka Sarkar Source Type: research
Miliary tuberculosis mimicking COVID-19 multisystemic inflammatory syndrome in children
We present the case of a 6-year-old girl with no remarkable history who had recurrent fever for 3 months. She was initially diagnosed with, and treated for, refractory multisystem inflammatory syndrome in children (MIS-C). When the study was extended to other differential diagnoses, thoraco-abdominopelvic computed tomography revealed miliary pulmonary nodules in addition to lymph nodes and spleen lesions. Magnetic resonance imaging of the brain revealed multiple tuberculomas. The tuberculin test results were positive. The course of the disease was favorable under quadruple therapy.PMID:37704522 | DOI:10.1016/j.arcped.2023.08.003
Source: Archives de Pediatrie - September 13, 2023 Category: Pediatrics Authors: Roeya Kolsi Mariem Ammar Lamia Sfaihi Fatma Charfi Ines Maaloul Thouraya Kammoun Source Type: research
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Cell Mol Life Sci. 2023 Sep 14;80(10):291. doi: 10.1007/s00018-023-04914-5.ABSTRACTLipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy macrophages accumulate lipids in granulomas, providing metabolic adaptation and survival strategies for Mtb against multiple stresses. Host-derived lipid species, including triacylglycerol and cholesterol, can also contribute to the development of drug-tolerant Mtb, leading to reduced efficacy of antibiotics targeting the bacterial cell wall or transcription. Tran...
Source: Cellular and Molecular Life Sciences : CMLS - September 13, 2023 Category: Cytology Authors: Hagyu Kim Sung Jae Shin Source Type: research
Evaluation of machine learning classifiers for predicting essential genes in < em > Mycobacterium tuberculosis < /em > strains
Bioinformation. 2022 Dec 31;18(12):1126-1130. doi: 10.6026/973206300181126. eCollection 2022.ABSTRACTAccurate investigation and prediction of essential genes from bacterial genome is very important as it might be explored in effective targets for antimicrobial drugs and understanding biological mechanism of a cell. A subset of key features data obtained from 14 genome sequence-based features of 20 strains of Mycobacterium tuberculosis bacteria whose essential gene information was downloaded from ePath and NCBI database for mapping and matching essential genes by using a genome extraction program. The selection of key featu...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Monish Mukul Das Keka Sarkar Source Type: research
CROI 2023: Tuberculosis and Infectious Complications in Persons With HIV
Top Antivir Med. 2023 Jun 30;31(4):529-537.ABSTRACTNovel implementation strategies to increase uptake and adherence to tuberculosis (TB) preventive therapy hold promise for reducing TB incidence in persons with HIV in high-burden settings. In persons who develop drug-susceptible TB, progress to shorten TB treatment continues to be made with the introduction of new drugs and novel treatment strategies that could allow for treatment shortening to 2 months for most people. A global case series provided powerful evidence that mpox should be considered an HIV-related opportunistic infection given its severe manifestations and p...
Source: Topics in HIV Medicine - September 13, 2023 Category: Infectious Diseases Authors: Andrew D Kerkhoff Diane V Havlir Source Type: research
Miliary tuberculosis mimicking COVID-19 multisystemic inflammatory syndrome in children
We present the case of a 6-year-old girl with no remarkable history who had recurrent fever for 3 months. She was initially diagnosed with, and treated for, refractory multisystem inflammatory syndrome in children (MIS-C). When the study was extended to other differential diagnoses, thoraco-abdominopelvic computed tomography revealed miliary pulmonary nodules in addition to lymph nodes and spleen lesions. Magnetic resonance imaging of the brain revealed multiple tuberculomas. The tuberculin test results were positive. The course of the disease was favorable under quadruple therapy.PMID:37704522 | DOI:10.1016/j.arcped.2023.08.003
Source: Archives de Pediatrie - September 13, 2023 Category: Pediatrics Authors: Roeya Kolsi Mariem Ammar Lamia Sfaihi Fatma Charfi Ines Maaloul Thouraya Kammoun Source Type: research
Revolutionizing control strategies against Mycobacterium tuberculosis infection through selected targeting of lipid metabolism
Cell Mol Life Sci. 2023 Sep 14;80(10):291. doi: 10.1007/s00018-023-04914-5.ABSTRACTLipid species play a critical role in the growth and virulence expression of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB). During Mtb infection, foamy macrophages accumulate lipids in granulomas, providing metabolic adaptation and survival strategies for Mtb against multiple stresses. Host-derived lipid species, including triacylglycerol and cholesterol, can also contribute to the development of drug-tolerant Mtb, leading to reduced efficacy of antibiotics targeting the bacterial cell wall or transcription. Tran...
Source: Cellular and Molecular Life Sciences : CMLS - September 13, 2023 Category: Cytology Authors: Hagyu Kim Sung Jae Shin Source Type: research
CROI 2023: Tuberculosis and Infectious Complications in Persons With HIV
Top Antivir Med. 2023 Jun 30;31(4):529-537.ABSTRACTNovel implementation strategies to increase uptake and adherence to tuberculosis (TB) preventive therapy hold promise for reducing TB incidence in persons with HIV in high-burden settings. In persons who develop drug-susceptible TB, progress to shorten TB treatment continues to be made with the introduction of new drugs and novel treatment strategies that could allow for treatment shortening to 2 months for most people. A global case series provided powerful evidence that mpox should be considered an HIV-related opportunistic infection given its severe manifestations and p...
Source: Topics in HIV Medicine - September 13, 2023 Category: Infectious Diseases Authors: Andrew D Kerkhoff Diane V Havlir Source Type: research
Evaluation of machine learning classifiers for predicting essential genes in < em > Mycobacterium tuberculosis < /em > strains
Bioinformation. 2022 Dec 31;18(12):1126-1130. doi: 10.6026/973206300181126. eCollection 2022.ABSTRACTAccurate investigation and prediction of essential genes from bacterial genome is very important as it might be explored in effective targets for antimicrobial drugs and understanding biological mechanism of a cell. A subset of key features data obtained from 14 genome sequence-based features of 20 strains of Mycobacterium tuberculosis bacteria whose essential gene information was downloaded from ePath and NCBI database for mapping and matching essential genes by using a genome extraction program. The selection of key featu...
Source: Bioinformation - September 13, 2023 Category: Bioinformatics Authors: Monish Mukul Das Keka Sarkar Source Type: research
Best practice guidelines for professional nurses to provide self-management support to adults with tuberculosis-human immunodeficiency virus coinfection: A scoping review
ConclusionThere is a dearth of updated and relevant high-quality guidelines that guide healthcare professionals to provide self-management support to adults with tuberculosis-human immunodeficiency virus coinfection in primary healthcare settings. Systematic reviews of effectiveness, economic and contextual evidence related to self-management support interventions are required for guideline production.
Source: PLoS One - September 12, 2023 Category: Biomedical Science Authors: Eric Tornu Source Type: research
Clove Buds Volatile Compounds: Inhibitory Activity on Mycobacterium Growth and Molecular Docking on Mmr Efflux Pump Drug Resistance
Chem Biodivers. 2023 Sep 11:e202300895. doi: 10.1002/cbdv.202300895. Online ahead of print.ABSTRACTSyzygium aromaticum is used in traditional and modern medicine for its various and outstanding pharmacological properties. Here, we studied the chemical composition of n-hexane extract and non-polar fractions (NPF) obtained from the maceration and fractionation of clove buds, in order to evaluate their in vitro antimycobacterial activity, as well as their contribution against efflux pump (EP) resistance through molecular docking experiments. The gas chromatography-mass spectrometry (GC-MS) analysis of the volatile profiles re...
Source: Chemistry and Biodiversity - September 11, 2023 Category: Biochemistry Authors: Yassine El Ghallab Jamal Jamal Eddine Achraf Aainouss My Driss El Messaoudi Mohamed Dakir Sanae Derfoufi Source Type: research
