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Infectious Disease: Tuberculosis

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Total 20514 results found since Jan 2013.

Multilayer precision-based screening of potential inhibitors targeting Mycobacterium tuberculosis acetate kinase using in silico approaches
Comput Biol Chem. 2023 Aug 23;107:107942. doi: 10.1016/j.compbiolchem.2023.107942. Online ahead of print.ABSTRACTTuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major threat to global health, with the emergence of multi-drug and extensively drug-resistant strains posing a serious challenge. Thereby, understanding the molecular basis of MTB virulence and disease pathogenesis is critical for developing effective therapeutic strategies. Targeting proteins involved in central metabolism has been recognized as a promising therapeutic approach to combat MTB. In this regard, the enzyme AckA of the acetate...
Source: Computational Biology and Chemistry - September 6, 2023 Category: Bioinformatics Authors: Sneha Subramaniyan Hemavathy Nagarajan Umashankar Vetrivel Jeyakanthan Jeyaraman Source Type: research

Glycated Haemoglobin Trajectories and their Association with Treatment Outcomes among Pulmonary Tuberculosis Cases in India - A Prospective Cohort Study
Chest. 2023 Sep 4:S0012-3692(23)05377-1. doi: 10.1016/j.chest.2023.08.026. Online ahead of print.ABSTRACTBACKGROUND: Transient hyperglycemia is commonly seen during tuberculosis treatment, yet its association with unfavorable treatment outcomes is unclear.RESEARCH QUESTION: Is there an association between glycated Haemoglobin (HbA1c) trajectories and tuberculosis treatment outcomes?STUDY DESIGN AND METHODS: Adults with pulmonary tuberculosis were prospectively evaluated for 18 months after their second HbA1c measurement. HbA1c trajectories during the initial three months of treatment were defined as follows - Persistent eu...
Source: Chest - September 6, 2023 Category: Respiratory Medicine Authors: Geeta Pardeshi Vidya Mave Sanjay Gaikwad Dileep Kadam Madhusudan Barthwal Nikhil Gupte Sachin Atre Sona Deshmukh Jonathan E Golub Akshay Gupte Source Type: research

Multilayer precision-based screening of potential inhibitors targeting Mycobacterium tuberculosis acetate kinase using in silico approaches
Comput Biol Chem. 2023 Aug 23;107:107942. doi: 10.1016/j.compbiolchem.2023.107942. Online ahead of print.ABSTRACTTuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), remains a major threat to global health, with the emergence of multi-drug and extensively drug-resistant strains posing a serious challenge. Thereby, understanding the molecular basis of MTB virulence and disease pathogenesis is critical for developing effective therapeutic strategies. Targeting proteins involved in central metabolism has been recognized as a promising therapeutic approach to combat MTB. In this regard, the enzyme AckA of the acetate...
Source: Computational Biology and Chemistry - September 6, 2023 Category: Bioinformatics Authors: Sneha Subramaniyan Hemavathy Nagarajan Umashankar Vetrivel Jeyakanthan Jeyaraman Source Type: research

Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection
CMAJ. 2023 Sep 5;195(34):E1151-E1153. doi: 10.1503/cmaj.230317.NO ABSTRACTPMID:37669793 | DOI:10.1503/cmaj.230317
Source: cmaj - September 5, 2023 Category: General Medicine Authors: Gousia Dhhar Jeanine McColl Ian Kitai Deborah M Levy Ruud H J Verstegen Source Type: research

TREATMENT OF TUBERCULOSIS IN THE 17th CENTURY BASED ON THE ORIGINAL WORK DE PHTHISI (ON TUBERCULOSIS) FROM 1679
This article endeavors to elucidate the history of TB and its therapy in the 17th century on the basis of the Latin inau- gural academic disputation De phthisi (On Tuberculosis) from 1679, which was first transla- ted into Slovak in 2021. It was written by Matthaeus Palumbini, a Hungarian physician of Slovak origin born in Turiec County (Comitatus Thurociensis) in the Kingdom of Hungary. Although this dissertation is due to the anatomical, physiological, and clinical views of the Early Modern period, the ideas about the disease inhalation route as well as the fact that the disease transmission happens indirectly through th...
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Nora Malinovsk á M ária Bujalková Renata P éčová Source Type: research

Rifampin-induced flu-like syndrome with shock in a patient with tuberculosis infection
CMAJ. 2023 Sep 5;195(34):E1151-E1153. doi: 10.1503/cmaj.230317.NO ABSTRACTPMID:37669793 | PMC:PMC10480000 | DOI:10.1503/cmaj.230317
Source: cmaj - September 5, 2023 Category: General Medicine Authors: Gousia Dhhar Jeanine McColl Ian Kitai Deborah M Levy Ruud H J Verstegen Source Type: research

TREATMENT OF TUBERCULOSIS IN THE 17th CENTURY BASED ON THE ORIGINAL WORK DE PHTHISI (ON TUBERCULOSIS) FROM 1679
This article endeavors to elucidate the history of TB and its therapy in the 17th century on the basis of the Latin inau- gural academic disputation De phthisi (On Tuberculosis) from 1679, which was first transla- ted into Slovak in 2021. It was written by Matthaeus Palumbini, a Hungarian physician of Slovak origin born in Turiec County (Comitatus Thurociensis) in the Kingdom of Hungary. Although this dissertation is due to the anatomical, physiological, and clinical views of the Early Modern period, the ideas about the disease inhalation route as well as the fact that the disease transmission happens indirectly through th...
Source: Medical History - September 5, 2023 Category: History of Medicine Authors: Nora Malinovsk á M ária Bujalková Renata P éčová Source Type: research