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Total 20514 results found since Jan 2013.
Therapeutic antibodies in rheumatology
Z Rheumatol. 2023 Sep 1. doi: 10.1007/s00393-023-01409-3. Online ahead of print.ABSTRACTEmil von Behring's serum therapy for diphtheria was the first therapeutic use of antibodies. More than 100 years later, a new era in the treatment of rheumatic diseases began in 1998 with the approval of infliximab, an antibody directed against tumor necrosis factor alpha (TNF alpha). The special feature of antibody therapy is the ability to bind and neutralize antigens in a highly specific manner. In addition, target cells can be eliminated by activation of the immune system. These properties of the immune system are exploited in rheum...
Source: Zeitschrift fur Rheumatologie - September 1, 2023 Category: Rheumatology Authors: Fredrik N Albach Gerd-R üdiger Burmester Johanna Mucke Source Type: research
Clofazimine nanoclusters show high efficacy in experimental TB with amelioration in paradoxical lung inflammation
Biomater Adv. 2023 Aug 21;154:213594. doi: 10.1016/j.bioadv.2023.213594. Online ahead of print.ABSTRACTThe rise of tuberculosis (TB) superbugs has impeded efforts to control this infectious ailment, and new treatment options are few. Paradoxical Inflammation (PI) is another major problem associated with current anti-TB therapy, which can complicate the treatment and leads to clinical worsening of disease despite a decrease in bacterial burden in the lungs. TB infection is generally accompanied by an intense local inflammatory response which may be critical to TB pathogenesis. Clofazimine (CLF), a second-line anti-TB drug, ...
Source: Adv Data - September 1, 2023 Category: Epidemiology Authors: Krishna Jadhav Agrim Jhilta Raghuraj Singh Eupa Ray Neleesh Sharma Rahul Shukla Amit Kumar Singh Rahul Kumar Verma Source Type: research
Therapeutic antibodies in rheumatology
Z Rheumatol. 2023 Sep 1. doi: 10.1007/s00393-023-01409-3. Online ahead of print.ABSTRACTEmil von Behring's serum therapy for diphtheria was the first therapeutic use of antibodies. More than 100 years later, a new era in the treatment of rheumatic diseases began in 1998 with the approval of infliximab, an antibody directed against tumor necrosis factor alpha (TNF alpha). The special feature of antibody therapy is the ability to bind and neutralize antigens in a highly specific manner. In addition, target cells can be eliminated by activation of the immune system. These properties of the immune system are exploited in rheum...
Source: Zeitschrift fur Rheumatologie - September 1, 2023 Category: Rheumatology Authors: Fredrik N Albach Gerd-R üdiger Burmester Johanna Mucke Source Type: research
Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
CONCLUSIONS: This review identifies many of the factors that influence a person's decision to take part in a vaccine trial, and these reflect findings from reviews that examine trials more broadly. However, we also recognise some factors that become more important in connection with a vaccine trial in the context of a pandemic or epidemic. These factors include the potential stigma of taking part, the possible adverse effects of a vaccine, the added motivation for helping society, the role of community leaders in trial dissemination, and the level of trust placed in governments and companies developing vaccines. These spec...
Source: Cochrane Database of Systematic Reviews - September 1, 2023 Category: General Medicine Authors: Pauline Meskell Linda M Biesty Maura Dowling Kevin Roche Elaine Meehan Claire Glenton Declan Devane Sasha Shepperd Andrew Booth Rebecca Cox Xin Hui S Chan Catherine Houghton Source Type: research
Therapeutic antibodies in rheumatology
Z Rheumatol. 2023 Sep 1. doi: 10.1007/s00393-023-01409-3. Online ahead of print.ABSTRACTEmil von Behring's serum therapy for diphtheria was the first therapeutic use of antibodies. More than 100 years later, a new era in the treatment of rheumatic diseases began in 1998 with the approval of infliximab, an antibody directed against tumor necrosis factor alpha (TNF alpha). The special feature of antibody therapy is the ability to bind and neutralize antigens in a highly specific manner. In addition, target cells can be eliminated by activation of the immune system. These properties of the immune system are exploited in rheum...
Source: Zeitschrift fur Rheumatologie - September 1, 2023 Category: Rheumatology Authors: Fredrik N Albach Gerd-R üdiger Burmester Johanna Mucke Source Type: research
Deciphering the evolution of the temporal and geographic distribution of French Mycobacterium bovis genotypes using a high throughput SNP-targeted amplicon sequencing method
This study allowed classifying 618 different genotypic profiles (combination of a spoligotype and 8 loci-MIRU-VNTR profiles) into the nine previously identified clusters. A global analysis of the entire collection of the National Reference Laboratory has made it possible to represent the evolution of clonal complexes and clusters in time and space for better assessing epidemiological changes of bovine tuberculosis in France.PMID:37657678 | DOI:10.1016/j.meegid.2023.105497
Source: Infection, Genetics and Evolution - September 1, 2023 Category: Genetics & Stem Cells Authors: Lorraine Michelet Jennifer Tambosco Franck Biet Patrick Fach Sabine Delannoy Mar ía Laura Boschiroli Source Type: research
Factors that impact on recruitment to vaccine trials in the context of a pandemic or epidemic: a qualitative evidence synthesis
CONCLUSIONS: This review identifies many of the factors that influence a person's decision to take part in a vaccine trial, and these reflect findings from reviews that examine trials more broadly. However, we also recognise some factors that become more important in connection with a vaccine trial in the context of a pandemic or epidemic. These factors include the potential stigma of taking part, the possible adverse effects of a vaccine, the added motivation for helping society, the role of community leaders in trial dissemination, and the level of trust placed in governments and companies developing vaccines. These spec...
Source: Cochrane Database of Systematic Reviews - September 1, 2023 Category: General Medicine Authors: Pauline Meskell Linda M Biesty Maura Dowling Kevin Roche Elaine Meehan Claire Glenton Declan Devane Sasha Shepperd Andrew Booth Rebecca Cox Xin Hui S Chan Catherine Houghton Source Type: research
Deciphering the evolution of the temporal and geographic distribution of French Mycobacterium bovis genotypes using a high throughput SNP-targeted amplicon sequencing method
This study allowed classifying 618 different genotypic profiles (combination of a spoligotype and 8 loci-MIRU-VNTR profiles) into the nine previously identified clusters. A global analysis of the entire collection of the National Reference Laboratory has made it possible to represent the evolution of clonal complexes and clusters in time and space for better assessing epidemiological changes of bovine tuberculosis in France.PMID:37657678 | DOI:10.1016/j.meegid.2023.105497
Source: Infection, Genetics and Evolution - September 1, 2023 Category: Genetics & Stem Cells Authors: Lorraine Michelet Jennifer Tambosco Franck Biet Patrick Fach Sabine Delannoy Mar ía Laura Boschiroli Source Type: research
Post-mortem pulmonary tuberculosis: comparison of available diagnostic methods
This study was performed to look at the sensitivity and specificity of post-mortem computed tomography (PMCT) imaging when compared to culture in diagnosing pulmonary tuberculosis. This was a retrospective comparative study looking at post mortem cases where lung tissue samples sent for TB culture at Hospital Kuala Lumpur were compared against PMCT imaging. Exclusion criteria included contaminated samples, decomposed cases, immunocompromised subjects and those below 18 years of age. Subjects included 80 medico-legal autopsy cases at the National Institute of Forensic Medicine, Hospital Kuala Lumpur, Malaysia who had whole ...
Source: Tropical Biomedicine - August 31, 2023 Category: Tropical Medicine Authors: M K Chainchel Singh B Johari V R Naik P S Lai S F Siew Source Type: research
Current status of infectious diseases among migrants and non-citizens in Malaysia
Trop Biomed. 2023 Jun 1;40(2):138-151. doi: 10.47665/tb.40.2.003.ABSTRACTThe mass movement of migrants to Malaysia for employment is one of the factors contributing to the emergence and re-emergence of infectious diseases in this country. Despite mandatory health screening for migrants seeking employment, prevalence records of infectious diseases amongst migrant populations in Malaysia are still within negligible proportions. Therefore, the present review highlights the incidence, mortality and overall status of infectious diseases amongst migrants' populations in Malaysia, which maybe be useful for impeding exacerbation o...
Source: Tropical Biomedicine - August 31, 2023 Category: Tropical Medicine Authors: N W S Mohd Putera A S Azman S N Mohd Zain H Yahaya J W Lewis N Sahimin Source Type: research
Outbreak of Multidrug-Resistant Tuberculosis - Kansas, 2021-2022
MMWR Morb Mortal Wkly Rep. 2023 Sep 1;72(35):957-960. doi: 10.15585/mmwr.mm7235a4.ABSTRACTAn outbreak of multidrug-resistant (MDR) tuberculosis (TB) involved 13 persons in four households in a low-income, under-resourced urban Kansas community during November 2021-November 2022. A majority of the seven adults identified in the Kansas outbreak were born outside the United States in a country that had experienced an MDR TB outbreak with the same genotype during 2007-2009, whereas most of the six children in the Kansas outbreak were U.S.-born. Prompt identification, evaluation, and treatment of persons with MDR TB and their c...
Source: MMWR Morb Mortal Wkl... - August 31, 2023 Category: Epidemiology Authors: Elizabeth Groenweghe Lauren Swensson Kimberly D Winans Phillip Griffin Maryam B Haddad Richard J Brostrom Dawn Tuckey Chee Kin Lam Lisa Y Armitige Barbara J Seaworth Erin A Corriveau Source Type: research
Silences and Omissions in Reporting Epidemics in Russian and Soviet Prisons, 1890-2021
J Hist Med Allied Sci. 2023 Aug 31:jrad047. doi: 10.1093/jhmas/jrad047. Online ahead of print.ABSTRACTPenitentiary systems serve as breeding grounds for all kinds of diseases. Drawing upon new archival materials, this article examines the history of the management and reporting of epidemics in the Russian prison system from the late Imperial period to the present day. We use the case studies of cholera (1892-1893), typhus (1932-1933), and pulmonary tuberculosis (the 1990s) to examine how the general political and social conjuncture at different times affected the response of prison authorities to epidemics to show that, no...
Source: Medical History - August 31, 2023 Category: History of Medicine Authors: Mikhail Nakonechnyi Judith Pallot Source Type: research
Orchids of Dibru-Saikhowa: A Systematic Review on Their Traditional Use, Pharmacological Activity and Phytochemistry
CONCLUSION: Orchids found in DSNPBR hold great significance in traditional culture for their medicinal properties and have been effectively studied for their bioactivities. Nevertheless, to confirm their effectiveness as therapeutics, conducting methodical research, examining their molecular mechanisms, and performing toxicity tests are necessary.PMID:37649298 | DOI:10.2174/1568026623666230830125205
Source: Current Topics in Medicinal Chemistry - August 31, 2023 Category: Chemistry Authors: Pal Gogoi Saikat Sen Source Type: research
