Filtered By:
Infectious Disease: Tuberculosis
This page shows you your search results in order of date. This is page number 4.
Order by Relevance | Date
Total 20514 results found since Jan 2013.
Case Report: Nocardia amamiensis Infection Leading to Worsening of Chronic Obstructive Pulmonary Disease Symptoms in an Elderly Man
Am J Trop Med Hyg. 2023 Sep 11:tpmd230284. doi: 10.4269/ajtmh.23-0284. Online ahead of print.ABSTRACTNocardiosis is a rare opportunistic infection mostly affecting the lungs, brain, or skin of immunocompromised individuals. Most pulmonary nocardiosis patients present with nonspecific clinical features such as productive cough, exertional dyspnea, and fever. The disease is uncommonly suspected, especially in tuberculosis-endemic regions, and clinical diagnosis is often delayed, resulting in high mortality. Pulmonary nocardiosis in apparently immunocompetent individuals is uncommon. Here, we present the case of an elderly ge...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Ahalya Kanakan Amit Kumar Upinder Kaur Prity Narwade Zinnu Rain Nidhi Yadav Ishan Kumar Deepak Kumar Sankha Shubhra Chakrabarti Source Type: research
Novel modeling approach integrating population pharmacokinetics and interspecies scaling to predict human pharmacokinetics of the new anti-tuberculosis agent telacebec (Q203)
This study aimed to characterize the pharmacokinetics of telacebec via interspecies scaling and population pharmacokinetic modeling for the prediction of human pharmacokinetics. Preclinical pharmacokinetic data were obtained from mice, rats, and dogs following intravenous and oral doses of telacebec. A population pharmacokinetic model was developed to describe the pharmacokinetic data from all three species. The disposition parameters were well correlated with the body weight for all species using an allometric equation. Thus, the allometric scaling was incorporated into the population pharmacokinetic model, which could si...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 11, 2023 Category: Drugs & Pharmacology Authors: Jeongjun Kim Tae Hwan Kim Jinho Choi Kiyean Nam Beom Soo Shin Soyoung Shin Source Type: research
Case Report: Nocardia amamiensis Infection Leading to Worsening of Chronic Obstructive Pulmonary Disease Symptoms in an Elderly Man
Am J Trop Med Hyg. 2023 Sep 11:tpmd230284. doi: 10.4269/ajtmh.23-0284. Online ahead of print.ABSTRACTNocardiosis is a rare opportunistic infection mostly affecting the lungs, brain, or skin of immunocompromised individuals. Most pulmonary nocardiosis patients present with nonspecific clinical features such as productive cough, exertional dyspnea, and fever. The disease is uncommonly suspected, especially in tuberculosis-endemic regions, and clinical diagnosis is often delayed, resulting in high mortality. Pulmonary nocardiosis in apparently immunocompetent individuals is uncommon. Here, we present the case of an elderly ge...
Source: Am J Trop Med Hyg - September 11, 2023 Category: Infectious Diseases Authors: Ahalya Kanakan Amit Kumar Upinder Kaur Prity Narwade Zinnu Rain Nidhi Yadav Ishan Kumar Deepak Kumar Sankha Shubhra Chakrabarti Source Type: research
Impact of Mycobacterium tuberculosis Glycolipids on the CD4+ T Cell-Macrophage Immunological Synapse
This study extended these findings to the interaction between primary human CD4+ T cells and macrophages infected by mycobacteria. Exposure of human CD4+ T cells to ManLAM before activation resulted in loss of polyfunctionality, as measured by IL-2, IFN-γ, and TNF-α expression, and reduced CD25 expression. This was not associated with upregulation of inhibitory receptors CTLA-4, PD-1, TIM-3, and Lag-3. By confocal microscopy and imaging flow cytometry, ManLAM exposure reduced conjugate formation between macrophages and CD4+ T cells. ManLAM colocalized to the immunological synapse (IS) and reduced translocation of lymphoc...
Source: Journal of Immunology - September 11, 2023 Category: Allergy & Immunology Authors: Ivan Mwebaza Rachel Shaw Qing Li Shane Fletcher Jacqueline M Achkar Clifford V Harding Stephen M Carpenter W Henry Boom Source Type: research
