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Infectious Disease: HIV AIDS

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Total 15008 results found since Jan 2013.

Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report
CONCLUSIONS: This report highlights the safety and effectiveness of BTK inhibitors, as well as lenalidomide and PD-1 inhibitor in HIV-related PCNSL patients. Both the new therapeutic approaches and a multidisciplinary team authentically contributed to improved survival outcome among HIV-positive PCNSL patients.PMID:37644480 | PMC:PMC10466696 | DOI:10.1186/s12981-023-00554-8
Source: AIDS Research and Therapy - August 29, 2023 Category: Infectious Diseases Authors: Ying Zhou Xiaoxue Wang Xuyong Lin Jun Wang Xiaojing Yan Ying Wen Source Type: research

< em > "We're just winging it < /em > ". Identifying targets for intervention to improve the provision of hearing support for residents living with dementia in long-term care: an interview study with care staff
CONCLUSIONS: Future interventions should include staff Training (on hearing support), Education (on the consequences of unsupported hearing loss), Enablement (dementia-friendly hearing devices), Incentivisation and Modelling (of Hearing Champions) and Environmental Restructuring (flexible audiology appointments to take place within the LTCH). Interventions should be multi-faceted to boost the capabilities, opportunities and motivations of LTCH staff.PMID:37641847 | DOI:10.1080/09638288.2023.2245746
Source: Disability and Rehabilitation - August 29, 2023 Category: Rehabilitation Authors: Hannah Cross Christopher J Armitage Piers Dawes Iracema Leroi Rebecca E Millman Source Type: research

Sustained response following BTK inhibitors based treatment in HIV-related primary central nervous system lymphoma: case report
CONCLUSIONS: This report highlights the safety and effectiveness of BTK inhibitors, as well as lenalidomide and PD-1 inhibitor in HIV-related PCNSL patients. Both the new therapeutic approaches and a multidisciplinary team authentically contributed to improved survival outcome among HIV-positive PCNSL patients.PMID:37644480 | PMC:PMC10466696 | DOI:10.1186/s12981-023-00554-8
Source: AIDS Research and Therapy - August 29, 2023 Category: Infectious Diseases Authors: Ying Zhou Xiaoxue Wang Xuyong Lin Jun Wang Xiaojing Yan Ying Wen Source Type: research

Kinect-based objective assessment for early frailty identification in patients with Parkinson's disease
CONCLUSIONS: Our findings demonstrated the promise of utilizing Kinect-based kinematic data from MDS-UPDRS III tasks as early indicators of frailty in PD patients.PMID:37639172 | DOI:10.1007/s40520-023-02525-5
Source: Aging Clinical and Experimental Research - August 28, 2023 Category: Geriatrics Authors: Ludi Xie Ronghua Hong Zhuang Wu Lei Yue Kangwen Peng Shuangfang Li Jingxing Zhang Xijin Wang Lingjing Jin Qiang Guan Source Type: research

The AIDS and Cancer Specimen Resource (ACSR): HIV malignancy specimens and data available at no cost
AIDS Res Ther. 2023 Aug 28;20(1):61. doi: 10.1186/s12981-023-00558-4.ABSTRACTThe goal of the AIDS and Cancer Specimen Resource (ACSR) is to play a major role in the advancement of HIV/AIDS cancer-related research/treatment by providing richly annotated biospecimens and data to researchers at no cost. The ACSR acquires, stores, and equitably distributes these samples and associated clinical data to investigators conducting HIV/AIDS-related research, at no costs. Currently, it is the only biorepository of human biospecimens from people with HIV and cancer available to eligible researchers globally who are studying HIV associ...
Source: AIDS Research and Therapy - August 28, 2023 Category: Infectious Diseases Authors: Sylvia Silver Monika Schmelz Source Type: research

Rescue therapy with an albuvirtide-based antiretroviral regimen in an HIV-infected child with multidrug resistance and multiple opportunistic infections: a case report
CONCLUSIONS: The case reported here could suggest that an ABT-based antiretroviral therapy might be beneficial and without relevant toxicity in children with MDR HIV. Infectiologists specializing in managing HIV should be prepared to manage an increasing number of children with MDR HIV. ABT might be a new treatment option for MDR HIV infection in children.PMID:37641133 | PMC:PMC10463494 | DOI:10.1186/s12981-023-00560-w
Source: AIDS Research and Therapy - August 28, 2023 Category: Infectious Diseases Authors: Wei Tang Xiao-Yun Song Jing Cao Chun Liu Fang Zheng Source Type: research

Assessment of satisfaction with antiretroviral drugs and the need for long-acting injectable medicines among people living with HIV in Japan and its associated factors: a prospective multicenter cross-sectional observational study
CONCLUSIONS: Patients currently receiving anti-HIV drugs who express dissatisfaction with tablet size and daily oral therapy may prefer a long-acting injectable formulation, taking into consideration patient age, employment status, ART history, frequency of daily dosage and concomitant medications other than ART.PMID:37641099 | PMC:PMC10463659 | DOI:10.1186/s12981-023-00557-5
Source: AIDS Research and Therapy - August 28, 2023 Category: Infectious Diseases Authors: Masashi Ishihara Shinichi Hikasa Mariko Tsukiji Yusuke Kunimoto Kazuko Nobori Takeshi Kimura Kenta Onishi Yuki Yamamoto Kyohei Haruta Yohei Kashiwabara Kenji Fujii Shota Shimabukuro Daichi Watanabe Hisashi Tsurumi Akio Suzuki Source Type: research

The AIDS and Cancer Specimen Resource (ACSR): HIV malignancy specimens and data available at no cost
AIDS Res Ther. 2023 Aug 28;20(1):61. doi: 10.1186/s12981-023-00558-4.ABSTRACTThe goal of the AIDS and Cancer Specimen Resource (ACSR) is to play a major role in the advancement of HIV/AIDS cancer-related research/treatment by providing richly annotated biospecimens and data to researchers at no cost. The ACSR acquires, stores, and equitably distributes these samples and associated clinical data to investigators conducting HIV/AIDS-related research, at no costs. Currently, it is the only biorepository of human biospecimens from people with HIV and cancer available to eligible researchers globally who are studying HIV associ...
Source: AIDS Research and Therapy - August 28, 2023 Category: Infectious Diseases Authors: Sylvia Silver Monika Schmelz Source Type: research

Rescue therapy with an albuvirtide-based antiretroviral regimen in an HIV-infected child with multidrug resistance and multiple opportunistic infections: a case report
CONCLUSIONS: The case reported here could suggest that an ABT-based antiretroviral therapy might be beneficial and without relevant toxicity in children with MDR HIV. Infectiologists specializing in managing HIV should be prepared to manage an increasing number of children with MDR HIV. ABT might be a new treatment option for MDR HIV infection in children.PMID:37641133 | DOI:10.1186/s12981-023-00560-w
Source: AIDS Research and Therapy - August 28, 2023 Category: Infectious Diseases Authors: Wei Tang Xiao-Yun Song Jing Cao Chun Liu Fang Zheng Source Type: research

Assessment of satisfaction with antiretroviral drugs and the need for long-acting injectable medicines among people living with HIV in Japan and its associated factors: a prospective multicenter cross-sectional observational study
CONCLUSIONS: Patients currently receiving anti-HIV drugs who express dissatisfaction with tablet size and daily oral therapy may prefer a long-acting injectable formulation, taking into consideration patient age, employment status, ART history, frequency of daily dosage and concomitant medications other than ART.PMID:37641099 | DOI:10.1186/s12981-023-00557-5
Source: AIDS Research and Therapy - August 28, 2023 Category: Infectious Diseases Authors: Masashi Ishihara Shinichi Hikasa Mariko Tsukiji Yusuke Kunimoto Kazuko Nobori Takeshi Kimura Kenta Onishi Yuki Yamamoto Kyohei Haruta Yohei Kashiwabara Kenji Fujii Shota Shimabukuro Daichi Watanabe Hisashi Tsurumi Akio Suzuki Source Type: research

Chemical Synthesis of Human Milk Oligosaccharides: para-Lacto-N-hexaose and para-Lacto-N-neohexaose
Chemistry. 2023 Aug 28:e202302288. doi: 10.1002/chem.202302288. Online ahead of print.ABSTRACTHuman milk oligosaccharides (HMO) have emerged as a very active area of research in glycoscience and nutrition. HMO are involved in the early development of infants and may help to prevent certain diseases. The development of chemical methods for obtaining individual HMO aids the global effort dedicated to understanding the roles of these biomolecules. Reported herein is the chemical synthesis of two common core hexasaccharides found in human milk, i. e.para-lacto-N-hexaose (pLNH) and para-lacto-N-neohexaose (pLNnH). After screeni...
Source: Chemistry - August 28, 2023 Category: Chemistry Authors: Yashapal Singh Samira Escopy Melanie Shadrick Mithila Bandara Keith Stine Alexei V Demchenko Source Type: research

Rheumatoid arthritis ‐associated interstitial lung disease hotspots and future directions: A Web‐of‐Science based scientometric and visualization study
ConclusionPathogenesis, treatment, and predictive and prognostic factors were among the RA-ILD research directions and hotspots. Antirheumatoid drugs, especially biologics and small molecule inhibitors, were among the most actively researched treatment options. The results of this study provides an in-depth understanding of the development of RA-ILD publications, aids researchers in understanding hotspots and trends and provides a new perspective for future RA-ILD research.
Source: Immunity, Inflammation and Disease - August 28, 2023 Category: Allergy & Immunology Authors: Yue Yang, Zixuan Zhang, Xieyu Zhang, Xinwen Zhang, Kai Zhi, Xin Zhao, Jiahe Zhao, Wei Cao Tags: REVIEW ARTICLE Source Type: research

A decision support tool has similar high PrEP uptake and increases early PrEP persistence in adolescent girls and young women in South Africa: results from a randomized controlled trial
CONCLUSIONS: Among AGYW attending a South African PHC clinic, PrEP uptake was >90% with two-fold higher PrEP persistence at 1 month in those randomized to use the MyPrEP DST. Given the need for strategies to support PrEP implementation and improve low PrEP persistence among African AGYW, a PrEP DST warrants further evaluation.PMID:37634942 | DOI:10.1002/jia2.26154
Source: Cancer Control - August 27, 2023 Category: Cancer & Oncology Authors: Connie Celum Dominika Seidman Danielle Travill Christine Dehlendorf Sanele Gumede Kidist Zewdie Whitney Wilson Jennifer F Morton Jared M Baeten Deborah Donnell Sinead Delany-Moretlwe Source Type: research