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Infectious Disease: HIV AIDS
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Who's your data? Primary immune deficiency differential diagnosis prediction via machine learning and data mining of the USIDNET registry
DISCUSSION: Clinicians should remember to consider the negative predictive features together with the positives. We are calling this a proof-of-concept study to continue with our explorations. A good performance is encouraging, and feature importance might aid feature selection for future endeavors. In the meantime, we can learn from the rules derived by the model and build a user-friendly decision tree to generate differential diagnoses.PMID:37678719 | DOI:10.1016/j.clim.2023.109759
Source: Clinical Immunology - September 7, 2023 Category: Allergy & Immunology Authors: Jose Alfredo M éndez Barrera Samuel Rocha Guzm án Elisa Hierro Cascajares Elizabeth K Garabedian Ramsay L Fuleihan Kathleen E Sullivan Saul O Lugo Reyes Source Type: research
Italian Orthopaedic and Traumatology Society (SIOT) position statement on the non-surgical management of knee osteoarthritis
ConclusionsFor non-surgical management of knee OA, the recommended first step is to bring about lifestyle changes, particularly management of body weight combined with physical exercise and/or hydrotherapy. For acute symptoms, non-steroidal anti-inflammatory drugs (NSAIDs), topic or oral, can be used. Opioids can only be used as third-line pharmacological treatment. Glucosamine and chondroitin are also suggested as chronic pharmacological treatment. Regarding intra-articular infiltrative therapy, the use of hyaluronic acid is recommended in cases of chronic knee OA [platelet-rich plasma (PRP) as second line), in the absenc...
Source: Journal of Orthopaedics and Traumatology - September 7, 2023 Category: Orthopaedics Source Type: research
Featured Health IT Jobs – Epic Application Analyst/Coordinator
We like to regularly feature a healthcare IT job that might be of interest to readers. Today, we’re featuring the Epic Application Analyst/Coordinator position that was recently posted on Healthcare IT Central. This position was posted by Yakima Valley Farm Workers Clinic and is remote.
Here’s a description of the position:
In this role, you’ll drive the design, implementation, and maintenance of electronic systems, collaborating closely with clinical, operational, and administrative stakeholders to enhance workflows. Your expertise in Epic EMR systems configuration and troubleshooting will be invaluable as...
Source: EMR and HIPAA - September 6, 2023 Category: Information Technology Authors: John Lynn Tags: Career and Jobs Healthcare IT Analyst Jobs Coordinator Jobs Epic Application Analyst Epic Application Coordinator Featured Opportunities Health IT Careers Health IT Jobs Healthcare IT Jobs Job Seekers Yakima Valley Farm Workers Clini Source Type: blogs
Trimethylsilyl Chloride Aids in Solubilization of Oxidative Addition Intermediates from Zinc Metal
Angew Chem Int Ed Engl. 2023 Sep 6:e202307787. doi: 10.1002/anie.202307787. Online ahead of print.ABSTRACTTrimethylsilyl chloride (TMSCl) is commonly used to "activate" metal(0) powders toward oxidative addition of organohalides, but knowledge of its mechanism remains limited by the inability to characterize chemical intermediates under reaction conditions. Here, fluorescence lifetime imaging microscopy (FLIM) overcomes these prior limitations and shows that TMSCl aids in solubilization of the organozinc intermediate from zinc(0) metal after oxidative addition, a previously unknown mechanistic role. This mechanistic role i...
Source: Angewandte Chemie - September 6, 2023 Category: Chemistry Authors: Erin M Hanada Patrick J McShea Suzanne A Blum Source Type: research
Speech With Pauses Sounds Deceptive to Listeners With and Without Hearing Impairment
CONCLUSIONS: Listeners may have only partial awareness of the cues that influence their impression of dishonesty. Listeners with hearing impairment may place greater weight on acoustical cues according to the differing degrees of access provided by hearing aids.SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.24052446.PMID:37672786 | DOI:10.1044/2023_JSLHR-22-00618
Source: Journal of speech, language, and hearing research : JSLHR - September 6, 2023 Category: Speech-Language Pathology Authors: Bindiya Patel Ziyun Zhang Carolyn McGettigan Michel Belyk Source Type: research
Factors Associated With Hearing Aid Outcomes Including Social Networks, Self-Reported Mental Health, and Service Delivery Models
CONCLUSIONS: Novel factors including social network of persons with hearing loss who use hearing aids, self-reported mental health, service delivery model, and work situation are significant contributors to hearing aid outcomes. These newly identified factors can inform public hearing health promotion and individualized audiological care to optimize hearing aid outcomes.SUPPLEMENTAL MATERIAL: https://doi.org/10.23641/asha.24060486.PMID:37669616 | DOI:10.1044/2023_AJA-22-00206
Source: American Journal of Audiology - September 5, 2023 Category: Audiology Authors: Bopane Mothemela Vinaya Manchaiah Faheema Mahomed-Asmail Marien Graham De Wet Swanepoel Source Type: research
pH-Triggered polymeric Nanoparticles-in-Gel for Preventing Vaginal Transmission of HIV and Unintended Pregnancy
Eur J Pharm Biopharm. 2023 Sep 3:S0939-6411(23)00234-5. doi: 10.1016/j.ejpb.2023.09.001. Online ahead of print.ABSTRACTHuman Immunodeficiency Virus/Acquired Immunodeficiency Syndrome (HIV/ AIDS) and unplanned pregnancy affect female reproductive health globally. A single product providing a dual purpose of contraception and HIV prophylaxis may improve adherence to the therapy. Thus, we formulated a female-centric multipurpose prevention technology (MPT) comprising of nanoparticle loaded vaginal gel formulation acting as a contraceptive and microbicide. Eudragit® S100 nanoparticles of Atazanavir sulphate (ATZ; antiviral) a...
Source: European Journal of Pharmaceutics and Biopharmaceutics - September 5, 2023 Category: Drugs & Pharmacology Authors: Trinette Fernandes Vainav Patel Clara Aranha Shilpa Velhal Munira Momin Madhura Mulkutkar Sujata Sawarkar Source Type: research
HIV/AIDS patients' knowledge, attitude, and practice toward anti-retroviral therapy medications' adverse effects and associated factors in Tikur Anbessa Specialized Hospital
CONCLUSION: Overall, the study participants had poor knowledge, lack of positive attitudes, and non-adherence to the actual recommended practice toward AEs of ART medications. Lack of comorbidity, having prior AEs experience, and lack of counseling regarding ART medication AEs were associated with poor knowledge. Female gender and a lack of counseling on the AEs of ART medications were associated with a negative attitude.PMID:37667777 | PMC:PMC10475229 | DOI:10.1177/20420986231194752
Source: Adv Data - September 5, 2023 Category: Epidemiology Authors: Zenebe Negash Yohannes Yibeltal Akeberegn Gorems Ayele Source Type: research
Usefulness of one-arm motorized gait device for chronic hemiplegic stroke survivors
CONCLUSION: The results of this study suggest that one-arm motorized gait devices developed for hemiplegic stroke survivors may be more effective potentially than parallel bars and hemi-walkers in gait assistance of chronic hemiplegic stroke survivors.PMID:37661897 | DOI:10.3233/THC-230197
Source: Technology and Health Care - September 4, 2023 Category: Medical Devices Authors: Ki-Hun Cho Dong-Geon Lee Won-Kyung Song Gyu-Chang Lee Source Type: research
GMP manufacture of Shigella flexneri 2a Artificial Invaplex (Invaplex < sub > AR < /sub > ) and evaluation in a Phase 1 Open-label, dose escalating study administered intranasally to healthy, adult volunteers
Vaccine. 2023 Sep 2:S0264-410X(23)00995-7. doi: 10.1016/j.vaccine.2023.08.051. Online ahead of print.ABSTRACTShigella species cause severe disease among travelers to, and children living in, endemic countries. Although significant efforts have been made to improve sanitation, increased antibiotic resistance and other factors suggest an effective vaccine is a critical need. Artificial Invaplex (InvaplexAR) is a subunit vaccine approach complexing Shigella LPS with invasion plasmid antigens. In pre-clinical studies, the InvaplexAR vaccine demonstrated increased immunogenicity as compared to the first generation product and w...
Source: Vaccine - September 4, 2023 Category: Allergy & Immunology Authors: Christopher Duplessis Kristen A Clarkson K Ross Turbyfill Ashley N Alcala Ramiro Gutierrez Mark S Riddle Tida Lee Kristopher Paolino Hailey P Weerts Amanda Lynen Edwin V Oaks Chad K Porter Robert Kaminski Source Type: research
Usefulness of one-arm motorized gait device for chronic hemiplegic stroke survivors
CONCLUSION: The results of this study suggest that one-arm motorized gait devices developed for hemiplegic stroke survivors may be more effective potentially than parallel bars and hemi-walkers in gait assistance of chronic hemiplegic stroke survivors.PMID:37661897 | DOI:10.3233/THC-230197
Source: Technology and Health Care - September 4, 2023 Category: Medical Devices Authors: Ki-Hun Cho Dong-Geon Lee Won-Kyung Song Gyu-Chang Lee Source Type: research
GMP manufacture of Shigella flexneri 2a Artificial Invaplex (Invaplex < sub > AR < /sub > ) and evaluation in a Phase 1 Open-label, dose escalating study administered intranasally to healthy, adult volunteers
Vaccine. 2023 Sep 2:S0264-410X(23)00995-7. doi: 10.1016/j.vaccine.2023.08.051. Online ahead of print.ABSTRACTShigella species cause severe disease among travelers to, and children living in, endemic countries. Although significant efforts have been made to improve sanitation, increased antibiotic resistance and other factors suggest an effective vaccine is a critical need. Artificial Invaplex (InvaplexAR) is a subunit vaccine approach complexing Shigella LPS with invasion plasmid antigens. In pre-clinical studies, the InvaplexAR vaccine demonstrated increased immunogenicity as compared to the first generation product and w...
Source: Vaccine - September 4, 2023 Category: Allergy & Immunology Authors: Christopher Duplessis Kristen A Clarkson K Ross Turbyfill Ashley N Alcala Ramiro Gutierrez Mark S Riddle Tida Lee Kristopher Paolino Hailey P Weerts Amanda Lynen Edwin V Oaks Chad K Porter Robert Kaminski Source Type: research
Usefulness of one-arm motorized gait device for chronic hemiplegic stroke survivors
CONCLUSION: The results of this study suggest that one-arm motorized gait devices developed for hemiplegic stroke survivors may be more effective potentially than parallel bars and hemi-walkers in gait assistance of chronic hemiplegic stroke survivors.PMID:37661897 | DOI:10.3233/THC-230197
Source: Technology and Health Care - September 4, 2023 Category: Medical Devices Authors: Ki-Hun Cho Dong-Geon Lee Won-Kyung Song Gyu-Chang Lee Source Type: research
