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Pre-Transplantation Serum Parathyroid Hormone Influences the Number of Mobilized CD34+ Hematopoietic Stem Cells in Autologous Hematopoietic Stem Cell Transplantation
CONCLUSION: We suggested that serum PTH levels before transplantation could be influential in raising the number of circulating CD34+ hematopoietic stem cell after mobilization.PMID:34277871 | PMC:PMC8279713 | DOI:10.52547/rbmb.10.1.76
Source: Mol Biol Cell - July 19, 2021 Category: Molecular Biology Authors: Abdolhamed Kian Sayeh Parkhideh Haniyeh Ghaffari Nazari Maryam Nikoonezhad Arsalan Jalili Shaghayegh Shahsavan Abbas Hajifathali Source Type: research
Enteric glial cell heterogeneity regulates intestinal stem cell niches
Cell Stem Cell. 2021 Oct 25:S1934-5909(21)00416-1. doi: 10.1016/j.stem.2021.10.004. Online ahead of print.ABSTRACTThe high turnover and regenerative capacity of the adult intestine relies on resident stem cells located at the bottom of the crypt. The enteric nervous system consists of an abundant network of enteric glial cells (EGCs) and neurons. Despite the close proximity of EGCs to stem cells, their in vivo role as a stem cell niche is still unclear. By analyzing the mouse and human intestinal mucosa transcriptomes at the single-cell level, we defined the regulation of EGC heterogeneity in homeostasis and chronic inflam...
Source: Cell Stem Cell - November 2, 2021 Category: Stem Cells Authors: Meryem B Baghdadi Arshad Ayyaz Sabrina Coquenlorge Bonnie Chu Sandeep Kumar Catherine Streutker Jeffrey L Wrana Tae-Hee Kim Source Type: research
Foraging for the Optimal Dressing Scaffold to Carry Adipose-Derived Stromal/Progenitor Cells for Cell Therapy
Cell Transplant. 2022 Jan-Dec;31:9636897221113798. doi: 10.1177/09636897221113798.ABSTRACTIn our daily plastic surgery practice, we have seen many chronic wounds that need new biotechnology to help and improve wound healing. Stem cells play a crucial role in regenerative medicine. Many pre-clinical researches had reported the beneficial paracrine effects of stem cell therapy for chronic wounds. Cell-friendly scaffolds may provide the protection and three-dimensional space required for adherence of stem cells, thus allowing these stem cells to proliferate and differentiate for treatment purpose. A successful scaffold may en...
Source: Cell Transplantation - July 25, 2022 Category: Cytology Authors: Chia-Chieh Wu Ying-Che Chen Yi-Chia Wu Shu-Hung Huang Yur-Ren Kuo Su-Shin Lee Source Type: research
The miR ‐200 family is required for ectodermal organ development through the regulation of the epithelial stem cell niche
In this study, we inhibited themiR ‐200 family in developing murine embryos using new technology, resulting in an expanded epithelial stem cell niche and lack of cell differentiation. Inhibition of individual miRs within themiR ‐200 cluster resulted in differential developmental and cell morphology defects.miR ‐200 inhibition increased the expression of dental epithelial stem cell markers, expanded the stem cell niche and decreased progenitor cell differentiation. RNA ‐seq. identifiedmiR ‐200 regulatory pathways involved in cell differentiation and compartmentalization of the stem cell niche. ThemiR ‐200 family...
Source: Stem Cells - February 2, 2021 Category: Stem Cells Authors: Mason Sweat,
Yan Sweat,
Wenjie Yu,
Dan Su,
Riley J. Leonard,
Steven L. Eliason,
Brad A. Amendt Tags: Tissue ‐Specific Stem Cells Source Type: research
The interplay between extracellular matrix and progenitor/stem cells during wound healing: Opportunities and future directions
Acta Histochem. 2021 Sep 6;123(7):151785. doi: 10.1016/j.acthis.2021.151785. Online ahead of print.ABSTRACTSkin wound healing, a dynamic physiological process, progresses through coordinated overlapping phases to restore skin integrity. In some pathological conditions such as diabetes, wounds become chronic and hard-to-heal resulting in substantial morbidity and healthcare costs. Despite much advancement in understanding mechanisms of wound healing, chronic and intractable wounds are still a considerable challenge to nations' health care systems. Extracellular matrix (ECM) components play pivotal roles in all phases of wou...
Source: Acta Histochemica - September 9, 2021 Category: Biochemistry Authors: Mehdi Rasouli Azam Rahimi Masoud Soleimani Saeed Heidari Keshel Source Type: research
Foraging for the Optimal Dressing Scaffold to Carry Adipose-Derived Stromal/Progenitor Cells for Cell Therapy
Cell Transplant. 2022 Jan-Dec;31:9636897221113798. doi: 10.1177/09636897221113798.ABSTRACTIn our daily plastic surgery practice, we have seen many chronic wounds that need new biotechnology to help and improve wound healing. Stem cells play a crucial role in regenerative medicine. Many pre-clinical researches had reported the beneficial paracrine effects of stem cell therapy for chronic wounds. Cell-friendly scaffolds may provide the protection and three-dimensional space required for adherence of stem cells, thus allowing these stem cells to proliferate and differentiate for treatment purpose. A successful scaffold may en...
Source: Cell Transplantation - July 25, 2022 Category: Cytology Authors: Chia-Chieh Wu Ying-Che Chen Yi-Chia Wu Shu-Hung Huang Yur-Ren Kuo Su-Shin Lee Source Type: research
Neural stem cell-derived exosomes and regeneration: cell-free therapeutic strategies for traumatic brain injury
Stem Cell Res Ther. 2023 Aug 8;14(1):198. doi: 10.1186/s13287-023-03409-1.ABSTRACTRegenerative repair of the brain after traumatic brain injury (TBI) remains an extensive clinical challenge, inspiring intensified interest in therapeutic approaches to explore superior repair strategies. Exosome therapy is another research hotspot following stem cell alternative therapy. Prior research verified that exosomes produced by neural stem cells can participate in the physiological and pathological changes associated with TBI and have potential neuroregulatory and repair functions. In comparison with their parental stem cells, exoso...
Source: Cell Research - August 8, 2023 Category: Cytology Authors: Lin Zhong Jingjing Wang Peng Wang Xiaoyin Liu Peng Liu Xu Cheng Lujia Cao Hongwei Wu Jing Chen Liangxue Zhou Source Type: research
The Ellis Martin Report: Interview with International Stem Cell Corporation’s Founder/Co-Chairman
TEMR: Welcome to The Ellis Martin Report. I’m Bob Lange. We’re talking with Kenneth Aldrich, Executive Chairman of International Stem Cell Corporation, trading on the OTC Market with the symbol ISCO. International Stem Cell Corporation has been one of the most exciting companies trading in the biotech sector with respect to non-embryonic stem cell development. They have a proprietary process and commercial products that give them a tremendous edge in the marketplace. Ken welcome back to the show. I understand there’s a lot going on at International Stem Cell Corporation. Can you give us at least a portion...
Source: International Stem Cell Corporation - October 21, 2011 Category: Stem Cells Authors: internationalstemcell Tags: biotechnology stem cell international stem cell corporation cosmeceutical Lifeline Cell Technology Lifeline Skin Care stem cell reagent stem cell skin care Source Type: podcasts
