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Total 5857053 results found since Jan 2013.

Common Expression of Stemness Molecular Markers and Early Cardiac Transcription Factors In Wharton's Jelly-Derived Mesenchymal Stem Cells and hESCs.
Abstract At present, there are still significant problems that impede the clinical use of hESCs and iPS cells，including ethics, immunorejection, tumorigenesis from hESCs and teratoma formation from iPS cells. It is therefore necessary to search for alternative sources of stem cells. WJ-MSCs originate from embryonic epiblasts and possess properties intermediate between hESCs and adult stem cells. However, the stemness properties of molecules in WJ-MSCs remain unclear compared to those of hESCs. In the present study, we isolated WJ-MSCs by a non-enzymatic method. Further, using microarray analysis by Affymetrix Ge...
Source: Cell Transplantation - February 4, 2013 Category: Cytology Authors: Gao LR, Chen HY, Ding QA, Zhang NK, Wu X, Jiang S, Li TC, Chen Y, Wang ZG, Ye Y, Zhu ZM Tags: Cell Transplant Source Type: research

Understanding the application of stem cell therapy in cardiovascular diseases.
Authors: Sharma RK, Voelker DJ, Sharma R, Reddy HK Abstract Throughout their lifetime, an individual may sustain many injuries and recover spontaneously over a period of time, without even realizing the injury in the first place. Wound healing occurs due to a proliferation of stem cells capable of restoring the injured tissue. The ability of adult stem cells to repair tissue is dependent upon the intrinsic ability of tissues to proliferate. The amazing capacity of embryonic stem cells to give rise to virtually any type of tissue has intensified the search for similar cell lineage in adults to treat various diseases...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Concise Review: Fate Determination of Stem Cells by Deubiquitinating Enzymes
This article is protected by copyright. All rights reserved. Graphical Abstract Regulatory role of deubiquitinating enzymes in stem cell pluripotency and differentiation, cellular reprogramming and gametogenesis.
Source: Stem Cells - May 31, 2016 Category: Stem Cells Authors: Arun Pandian Chandrasekaran, Bharathi Suresh, Hyongbum (Henry) Kim, Kye‐Seong Kim, Suresh Ramakrishna Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

The Potential of Stem Cell Therapy for Osteoarthritis and Rheumatoid Arthritis.
This article reviews the innovative studies that have been carried out to treat arthritis using stem cells and also highlights the key challenges associated with these techniques. PMID: 24016323 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - September 9, 2013 Category: Stem Cells Authors: Keerthi N, Chimutengwende-Gordon M, Sanghani A, Khan W Tags: Curr Stem Cell Res Ther Source Type: research

Stem cell technology for tendon regeneration: current status, challenges, and future research directions.
Authors: Lui PP Abstract Tendon injuries are a common cause of physical disability. They present a clinical challenge to orthopedic surgeons because injured tendons respond poorly to current treatments without tissue regeneration and the time required for rehabilitation is long. New treatment options are required. Stem cell-based therapies offer great potential to promote tendon regeneration due to their high proliferative, synthetic, and immunomodulatory activities as well as their potential to differentiate to the target cell types and undergo genetic modification. In this review, I first recapped the challenges ...
Source: Stem Cells and Cloning: Advances and Applications - January 12, 2016 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Global Distribution of Businesses Marketing Stem Cell-Based Interventions.
Abstract A structured search reveals that online marketing of stem-cell-based interventions is skewed toward developed economies including the United States, Ireland, Australia, and Germany. Websites made broad, imprecise therapeutic claims and frequently failed to detail procedures. Widespread marketing poses challenges to regulators, bioethicists, and those seeking realistic hope from therapies. PMID: 27494673 [PubMed - in process]
Source: Cell Stem Cell - August 3, 2016 Category: Stem Cells Authors: Berger I, Ahmad A, Bansal A, Kapoor T, Sipp D, Rasko JE Tags: Cell Stem Cell Source Type: research

Current status of stem cell therapies in tissue repair and regeneration.
Abstract Tissue engineering is a multi-disciplinary field such as material science, life science, and bioengineering that are necessary to make artificial tissue or rejuvenate damaged tissue. Numerous tissue repair techniques and substitute now exist even though it has several shortcomings; these shortcomings give a good reason for the continuous research for more acceptable tissue-engineered substitutes. The search for and use of a suitable stem cell in tissue engineering is a promising concept. Stem cells have a distinctive capability to differentiate and self-renew that make more suitable for cell-based therapi...
Source: Current Stem Cell Research and Therapy - May 1, 2018 Category: Stem Cells Authors: Giri TK, Alexander A, Agrawal M, Saraf S, Saraf S, Ajazuddin Tags: Curr Stem Cell Res Ther Source Type: research

Recent Approaches for Angiogenesis in Search of Successful Tissue Engineering and Regeneration.
Abstract Angiogenesis plays a central role in human physiology from reproduction and fetal development to wound healing and tissue repair/regeneration. Clinically relevant therapies are needed for promoting angiogenesis in order to supply oxygen and nutrients after transplantation, thus relieving the symptoms of ischemia. Increase in angiogenesis can lead to restoration of damaged tissues, thereby leading the way for successful tissue regeneration. Tissue regeneration is a broad field that has shown the convergence of various interdisciplinary fields, wherein living cells in conjugation with biomaterials have been...
Source: Current Stem Cell Research and Therapy - November 3, 2019 Category: Stem Cells Authors: Reddy LVK, Murugan D, Mullick M, Begum M ET, Sen D Tags: Curr Stem Cell Res Ther Source Type: research

Clinical Applicability of Adult Human Mesenchymal Stem Cell Therapy in the Treatment of Knee Osteoarthritis.
Conclusion: The use of MSC therapy is a valid form of treatment for KOA as it targets the disease itself rather than the symptoms. We found MSC therapy in KOA patients to be safe, effective, and feasible in its execution. PMID: 33364786 [PubMed]
Source: Stem Cells and Cloning: Advances and Applications - December 30, 2020 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
Arch Plast Surg. 2021 Sep;48(5):559-567. doi: 10.5999/aps.2021.00339. Epub 2021 Sep 15.ABSTRACTThe potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study's goal was to conduct a comprehensive systematic review of the use of ADSCs in lymphatic tissue engineering and regeneration. On July 23, 2019, using PubMed/MEDLINE, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, and Embase databases, we conducted a systematic review of published literature ...
Source: Hand Surgery - September 28, 2021 Category: Surgery Authors: Antonio Jorge Forte Daniel Boczar Rachel Sarabia-Estrada Maria T Huayllani Francisco R Avila Ricardo A Torres Gunel Guliyeva Thiha Aung Alfredo Qui ñones-Hinojosa Source Type: research

An Innovative, Comprehensive Mapping and Multiscale Analysis of Registered Trials for Stem Cell-Based Regenerative Medicine
In conclusion, mapping may reveal a lack of global strategy despite the regulations and the related costs associated with good manufacturing practices. A systematic approach to preclinical data, intended to objectively and robustly reveal the most appropriate fields with the most efficient cells, is needed. Repeated exchanges between the bench and the bedside are necessary. Significance Except for a few trials concerning specific tissue stem cells used in their corresponding tissues, this global analysis revealed no real specificity of stem cell uses (including mesenchymal stromal cells). This raised the question of the p...
Source: Stem Cells Translational Medicine - May 23, 2016 Category: Stem Cells Authors: Monsarrat, P., Vergnes, J.-N., Planat-Benard, V., Ravaud, P., Kemoun, P., Sensebe, L., Casteilla, L. Tags: Tissue Engineering and Regenerative Medicine, Mesenchymal Stem Cells Source Type: research

Immune reconstitution following hematopoietic stem cell transplantation using different stem cell sources.
Authors: Elfeky R, Lazareva A, Qasim W, Veys P Abstract INTRODUCTION: Adequate immune reconstitution post-HSCT is crucial for the success of transplantation, and can be affected by both patient- and transplant-related factors. Areas covered: A systematic literature search in PubMed, Scopus, and abstracts of international congresses is performed to investigate immune recovery posttransplant. In this review, we discuss the pattern of immune recovery in the post-transplant period focusing on the impact of stem cell source (bone marrow, peripheral blood stem cells, and cord blood) on immune recovery and HSCT outcome. W...
Source: Expert Review of Clinical Immunology - May 10, 2019 Category: Allergy & Immunology Tags: Expert Rev Clin Immunol Source Type: research

Harnessing Stem Cell Potential for the Treatment of Erectile Function with Diabetes Mellitus: From Preclinical/Clinical Perspectives to Penile Tissue Engineering.
CONCLUSION: This review examines the progress and remaining challenges in diabetes-related SC research regarding ED. Moving forward, it is only with a combined effort of basic biology and translational work that the potential of SC-based therapies in diabetes can be realized. PMID: 31456525 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - August 27, 2019 Category: Stem Cells Authors: Gur S, Hellstrom WJG Tags: Curr Stem Cell Res Ther Source Type: research

Novel Therapeutics Against Breast Cancer Stem Cells by Targeting Surface Markers and Signaling Pathways.
CONCLUSION: BCSCs involved in cancer pathogenesis, therapy resistance and cancer recurrence. Thus, it is suggested that a multi-dimensional therapeutic approach by targeting surface markers and aberrantly activated signaling pathways of BCSCs alone or in combination with each other could really be worthwhile in the treatment of breast cancer. PMID: 31808385 [PubMed - in process]
Source: Current Stem Cell Research and Therapy - December 7, 2019 Category: Stem Cells Authors: Das PK, Rakib MA, Khanam JA, Pillai S, Islam F Tags: Curr Stem Cell Res Ther Source Type: research