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Xist Intron 1 Repression by Transcriptional ‐Activator‐Like Effectors Designer Transcriptional Factor Improves Somatic Cell Reprogramming in Mice
We report that the selected dTF repressor 6 (R6) binding the intron 1 ofXist, which caused higher H3K9me3 followed by X chromosome opening and repression of X ‐linked genes in mouse embryonic fibroblasts, rather than affectingXist expression, substantially improved the iPSC generation and the SCNT preimplantation embryo development. Conversely, the dTF activator targeting the same genomic region of R6 decreased iPSC formation and blocked SCNT ‐embryo development. These results thus uncover the critical requirement for theXist locus in epigenetic resetting, which is not directly related toXist transcription. This may pr...
Source: Stem Cells - February 21, 2019 Category: Stem Cells Authors: Jindun Zhang, Xuefei Gao, Jian Yang, Xiaoying Fan, Wei Wang, Yanfeng Liang, Lihong Fan, Hongmei Han, Xiaorong Xu, Fuchou Tang, Siqin Bao, Pentao Liu, Xihe Li Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer
Cell Death & Disease, Published online: 28 May 2019; doi:10.1038/s41419-019-1656-4A juxtacrine/paracrine loop between C-Kit and stem cell factor promotes cancer stem cell survival in epithelial ovarian cancer
Source: Cell death and disease - May 27, 2019 Category: Internal Medicine Authors: Elena Laura Mazzoldi Simona Pavan Giorgia Pilotto Kevin Leone Anna Pagotto Simona Frezzini Maria Ornella Nicoletto Alberto Amadori Anna Past ò Source Type: research

Alteration of fatty acid oxidation by increased CPT1A on replicative senescence of placenta-derived mesenchymal stem cells.
CONCLUSIONS: These findings suggest that alteration of FAO by increased CPT1A plays an important role in mitochondrial dysfunction and senescence of PD-MSCs during long-term cultivation. PMID: 31900237 [PubMed - in process]
Source: Cell Research - January 2, 2020 Category: Cytology Authors: Seok J, Jung HS, Park S, Lee JO, Kim CJ, Kim GJ Tags: Stem Cell Res Ther Source Type: research

Stem Cell Research Lab Resource: Stem Cell LineInduced pluripotent stem cell (iPSC) line MLi-003A derived from an individual with the maximum number of filaggrin (FLG) tandem repeats
Publication date: Available online 24 April 2020Source: Stem Cell ResearchAuthor(s): Preeti Khurana, Nikola Kolundzic, Marija Rogar, Carl Hobbs, X.F. Colin C. Wong, John E.A. Common, Dusko Ilic, Mirjana Liovic
Source: Stem Cell Research - April 25, 2020 Category: Stem Cells Source Type: research

Undifferentiated Wharton?s Jelly Mesenchymal Stem Cell Transplantation Induces Insulin-Producing Cell Differentiation and Suppression of T Cell-Mediated Autoimmunity in Non-Obese Diabetic Mice.
In conclusion, undifferentiated WJ-MSCs candifferentiate into insulin-producing cells in vivo with immunomodulatory effects and repair the destroyed islets in NOD mice. PMID: 25198179 [PubMed - as supplied by publisher]
Source: Cell Transplantation - July 15, 2014 Category: Cytology Authors: Tsai PJ, Wang HS, Lin GJ, Chou SC, Chu TH, Chuan WT, Lu YJ, Weng ZC, Su CH, Hsieh PS, Sytwu HK, Lin CH, Chen TH, Shyu JF Tags: Cell Transplant Source Type: research

Cell Transplantation and Neuroengineering Approach for Spinal Cord Injury Treatment: A Summary of Current Laboratory Findings and Review of Literature.
Abstract Spinal cord injury (SCI) can cause a severe traumatic injury to the central nervous system (CNS). Current therapeutic effects achieved for SCI in clinical medicine show that there is still a long way to go to reach the desirable goal of full or meaningful functional recovery. In basic medical research, however, cell transplantation, gene therapy, application of cytokines and biomaterial scaffolds have been widely used and investigated in treatments for SCI. All these strategies when used separately would help rebuild to some extent the neural circuits in the lesion area of spinal cord. In light of this, i...
Source: Cell Transplantation - February 2, 2016 Category: Cytology Authors: Lin XY, Lai BQ, Zeng X, Che MT, Ling EA, Wu W, Zeng YS Tags: Cell Transplant Source Type: research

Planarian Epidermal Stem Cells Respond to Positional Cues to Promote Cell-Type Diversity.
Abstract Successful regeneration requires that progenitors of different lineages form the appropriate missing cell types. However, simply generating lineages is not enough. Cells produced by a particular lineage often have distinct functions depending on their position within the organism. How this occurs in regeneration is largely unexplored. In planarian regeneration, new cells arise from a proliferative cell population (neoblasts). We used the planarian epidermal lineage to study how the location of adult progenitor cells results in their acquisition of distinct functional identities. Single-cell RNA sequencing...
Source: Developmental Cell - March 12, 2017 Category: Cytology Authors: Wurtzel O, Oderberg IM, Reddien PW Tags: Dev Cell Source Type: research

What ’ s scarier than dubious stem cell clinics? A naturopathic stem cell clinic!
After nearly 13 years of blogging, I thought I'd seen it all. Then former naturopath Britt Hermes let me know that there is a naturopath in Utah offering stem cell treatments. My face is raw from the double facepalming.
Source: Respectful Insolence - September 1, 2017 Category: Surgery Authors: Orac Tags: Medicine Docere Clinics Harry Adelson naturopathy quackery stem cell clinic Utah Source Type: blogs

Down-regulation of ATAD2 restrains cancer stem cell properties in esophageal squamous cell carcinoma via blockade of the Hedgehog signaling pathway.
Abstract Esophageal squamous cell carcinoma (ESCC) ranks among the five most common cancers in China, and has a five-year survival rate of less than 15%. The transcription factor ATAD2 has potential as a therapeutic target in various tumors, and microarray-based gene expression profiling reveals dysregulation of ATAD2 specifically in ESCC. Here we investigated whether ATAD2 could mediate a regulation of cancer stem cell (CSC) biological functions in ESCC. Immunohistochemical staining, reverse transcription quantitative polymerase chain reaction, and Western blot assays all revealed up-regulation of ATAD2 in ESCC t...
Source: Am J Physiol Cell Ph... - November 19, 2019 Category: Cytology Authors: Li N, Yu Y, Wang B Tags: Am J Physiol Cell Physiol Source Type: research

Dopamine D1 receptor-mediated activation of the ERK signaling pathway is involved in the osteogenic differentiation of bone mesenchymal stem cells.
CONCLUSIONS: Taken together, these results suggest that ERK signaling may play an essential role in coordinating the DA-induced osteogenic differentiation of BMSCs by D1 receptor activation. PMID: 31900224 [PubMed - in process]
Source: Cell Research - January 2, 2020 Category: Cytology Authors: Wang CX, Ge XY, Wang MY, Ma T, Zhang Y, Lin Y Tags: Stem Cell Res Ther Source Type: research

Corrigendum to “p57Kip2 is a master regulator of human adipose derived stem cell quiescence and senescence” Stem Cell Res. 44 (2020) 101759
Publication date: March 2021Source: Stem Cell Research, Volume 51Author(s): Lian Wang, Shengkai Jin, Peibin Dai, Tianran Zhang, Yanghua Shi, Guihai Ai, Xiaowen Shao, Yutong Xie, Jun Xu, Zhongping Cheng, Zhengliang Gao
Source: Stem Cell Research - January 11, 2021 Category: Stem Cells Source Type: research

Nonredundant and locus-specific gene repression functions of PRC1 paralog family members in human hematopoietic stem/progenitor cells
The Polycomb group (PcG) protein BMI1 is a key factor in regulating hematopoietic stem cell (HSC) and leukemic stem cell self-renewal and functions in the context of the Polycomb repressive complex 1 (PRC1). In humans, each of the 5 subunits of PRC1 has paralog family members of which many reside in PRC1 complexes, likely in a mutually exclusive manner, pointing toward a previously unanticipated complexity of Polycomb-mediated silencing. We used an RNA interference screening approach to test the functionality of these paralogs in human hematopoiesis. Our data demonstrate a lack of redundancy between various paralog family ...
Source: Blood - March 28, 2013 Category: Hematology Authors: van den Boom, V., Rozenveld-Geugien, M., Bonardi, F., Malanga, D., van Gosliga, D., Heijink, A. M., Viglietto, G., Morrone, G., Fusetti, F., Vellenga, E., Schuringa, J. J. Tags: Hematopoiesis and Stem Cells Source Type: research

Clonal Growth of Human Melanocytes using Cell-free Extracellular Matrix.
This article is protected by copyright. All rights reserved. PMID: 24034857 [PubMed - as supplied by publisher]
Source: Pigment Cell and Melanoma Research - August 29, 2013 Category: Cytology Authors: Zhang R, Premi S, Kilic SS, Bacchiocchi A, Halaban R, Brash DE Tags: Pigment Cell Melanoma Res Source Type: research

Epigenetic modifications of embryonic stem cells: current trends and relevance in developing regenerative medicine.
Authors: Chung H, Sidhu KS Abstract Epigenetics is a growing field not only in the area of cancer research but recently in stem cells including human embryonic stem cell (hESC) research. The hallmark of profiling epigenetic changes in stem cells lies in maintaining pluripotency or multipotency and in attaining lineage specifications that are relevant for regenerative medicine. Epigenetic modifications including DNA methylation, histone acetylation and methylation, play important roles in regulating gene expressions. Other epigenetic modifications include X chromosome silencing, genomic stability and imprinting and ...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Live-Cell Imaging of the Adult Drosophila Ovary Using Confocal Microscopy.
Abstract The Drosophila ovary represents a key in vivo model used to study germline stem cell (GSC) maintenance and stem cell daughter differentiation because these cells and their somatic cell neighbors can be identified at single-cell resolution within their native environment. Here we describe a fluorescent-based technique for the acquisition of 4D datasets of the Drosophila ovariole for periods that can exceed 12 consecutive hours. Live-cell imaging facilitates the investigation of molecular and cellular dynamics that were not previously possible using still images. PMID: 27734349 [PubMed - in process]
Source: Mol Biol Cell - October 15, 2016 Category: Molecular Biology Authors: Shalaby NA, Buszczak M Tags: Methods Mol Biol Source Type: research