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Biological Responses of Stem Cells to Photobiomodulation Therapy.
CONCLUSION: The findings of this review suggest that PBMT -based regenerative medicine could be a useful tool for future advances in tissue engineering and cell therapy. PMID: 32013851 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - February 3, 2020 Category: Stem Cells Authors: Khorsandi K, Hosseinzadeh R, Abrahamse H, Fekrazad R Tags: Curr Stem Cell Res Ther Source Type: research

Nanofiber Scaffolds Support Bone Regeneration Associated with Pulp Stem Cells.
This study reports the bone regeneration potential using biodegradable nanofibers from poly (lactic-co-glycolic acid) (PLGA) in association with human mesenchymal stem cells from dental pulp of deciduous teeth (SCDT). Five samples of SCDT were seeded with scaffolds (test) or without scaffolds (control) for cell adhesion and viability assay. To evaluate the ability of the association in promoting bone formation, critical defects were made in the calvarium of rats (n=20), which were then divided into the following groups: I - sham group; II - implant of scaffolds; III - scaffolds/SCDT; IV - scaffolds/SCDT kept for 13 days in...
Source: Current Stem Cell Research and Therapy - February 28, 2014 Category: Stem Cells Authors: Arisoly Xavier Acasigua G, Bernardi L, Iglesias Braghirolli D, Sant'ana Filho M, Pranke P, Christina Medeiros Fossati A Tags: Curr Stem Cell Res Ther Source Type: research

Alternative Splicing Regulates Pluripotent State in Pluripotent Stem Cells.
Abstract Alternative splicing (AS) generates multiple mature mRNAs from a single pre-mRNA, so the AS is the main contributor for the diversity of the proteins, participating in most of the cellular processes. For pluripotent stem cells (PSC), great effort has been made to search for pluripotency-related genes and their regulatory mechanisms. However, the sophisticated regulation is still far to be clear. Recent studies indicate that the stem cells undergo a unique AS pattern and have a different protein expression profile from differentiated cells, giving a new clue that AS switch or AS itself may play a significa...
Source: Current Stem Cell Research and Therapy - November 11, 2014 Category: Stem Cells Authors: He L, Bai Q, Tang L Tags: Curr Stem Cell Res Ther Source Type: research

The Use of Growth Factors and Mesenchymal Stem Cells in Orthopaedics.
Conclusion Overall this review shows promising results regarding the use of MSCs and various Growth factors in the treatment of fractures and non-unions, as well as synergistic effects observed when combined together. However more research is indicated as these methods are still in the early stages of development. PMID: 27297035 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - June 12, 2016 Category: Stem Cells Authors: Khan W, Mafi R, Sinclair KL, Mafi P Tags: Curr Stem Cell Res Ther Source Type: research

Concise Review: Induced Pluripotent Stem Cell ‐Based Drug Discovery for Mitochondrial Disease
Abstract High attrition rates and loss of capital plague the drug discovery process. This is particularly evident for mitochondrial disease that typically involves neurological manifestations and is caused by nuclear or mitochondrial DNA defects. This group of heterogeneous disorders is difficult to target because of the variability of the symptoms among individual patients and the lack of viable modeling systems. The use of induced pluripotent stem cells (iPSCs) might significantly improve the search for effective therapies for mitochondrial disease. iPSCs can be used to generate patient‐specific neural cell models in w...
Source: Stem Cells - May 22, 2017 Category: Stem Cells Authors: Gizem Inak, Carmen Lorenz, Pawel Lisowski, Annika Zink, Barbara Mlody, Alessandro Prigione Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research

The Pros and Cons of Mesenchymal Stem Cell-Based Therapies.
Abstract The need to search for new, alternative treatments for various diseases has prompted scientists and physicians to focus their attention on regenerative medicine and broadly understood cell therapies. Currently, stem cells are being investigated for their potentially widespread use in therapies for many untreatable diseases. Nowadays modern treatment strategies willingly use mesenchymal stem cells (MSCs) derived from different sources. Researchers are increasingly aware of the nature of MSCs and new possibilities for their use. Due to their properties, especially their ability to self-regenerate, different...
Source: Cell Transplantation - April 23, 2019 Category: Cytology Authors: Musiał-Wysocka A, Kot M, Majka M Tags: Cell Transplant Source Type: research

The effect of inflammatory factors and their inhibitors on the hematopoietic stem cells fate.
This article is protected by copyright. All rights reserved. PMID: 33386770 [PubMed - as supplied by publisher]
Source: Cell Biology International - January 2, 2021 Category: Cytology Authors: Najafi S, Ghanavat M, Shahrabi S, Gatavizadeh Z, Saki N Tags: Cell Biol Int Source Type: research

Human mesenchymal stem cells towards non-alcoholic steatohepatitis in an immunodeficient mouse model.
Abstract Non-alcoholic steatohepatitis (NASH) is a frequent clinical picture characterised by hepatic inflammation, lipid accumulation and fibrosis. When untreated, NASH bears a high risk of developing liver cirrhosis and consecutive hepatocellular carcinoma requiring liver transplantation in its end-stage. However, donor organ scarcity has prompted the search for alternatives, of which hepatocyte or stem cell-derived hepatocyte transplantation are regarded auspicious options of treatment. Mesenchymal stem cells (MSC) are able to differentiate into hepatocyte-like cells and thus may represent an alternative cell s...
Source: Experimental Cell Research - April 28, 2014 Category: Cytology Authors: Winkler S, Borkham-Kamphorst E, Stock P, Brückner S, Dollinger M, Weiskirchen R, Christ B Tags: Exp Cell Res Source Type: research

Single-cell transcriptomics reveals gene signatures and alterations associated with aging in distinct neural stem/progenitor cell subpopulations.
Authors: Shi Z, Geng Y, Liu J, Zhang H, Zhou L, Lin Q, Yu J, Zhang K, Liu J, Gao X, Zhang C, Yao Y, Zhang C, Sun YE Abstract Aging associated cognitive decline has been linked to dampened neural stem/progenitor cells (NSC/NPCs) activities manifested by decreased proliferation, reduced propensity to produce neurons, and increased differentiation into astrocytes. While gene transcription changes objectively reveal molecular alterations of cells undergoing various biological processes, the search for molecular mechanisms underlying aging of NSC/NPCs has been confronted by the enormous heterogeneity in cellular composi...
Source: Protein and Cell - July 29, 2017 Category: Cytology Tags: Protein Cell Source Type: research

Stem cells-based and molecular-based approaches in regenerative dentistry: A topical review.
CONCLUSIONS: This topical review has been focused on the main, the most promising and the most innovative strategies for achieving the regeneration of dental pulp or dental tissues. The main and surprising "take-home message" is related to the great interest towards the dental-derived stem cells, characterized by a high angiogenic and neurogenic commitment. Future challenges will be focused on the development of biological-friendly regenerative strategies: the new approaches should overcome the current biological limitations, to promote the combined cellular and molecular-based treatments, able to ensure a predictable clin...
Source: Current Stem Cell Research and Therapy - June 25, 2019 Category: Stem Cells Authors: Tatullo M, Codispoti B, Makeeva I, Scacco S, Cocco T Tags: Curr Stem Cell Res Ther Source Type: research

Various Cell Therapy Approaches for Bone Diseases in the Controlled Clinical Trials: A Systematic Review and Meta-analysis study.
The objective of this review was to answer two critical questions in the cell-based bone defect therapies that were as follows: 1) does cell therapy associate with the increase in the occurrence of adverse events in the patients compared to control groups, 2) does the use of various cell therapy approaches, including more-than minimal manipulation (MMM) and minimal manipulation (MM), affect the occurrence of adverse events?. An electronic literature search was performed in five databases. The controlled clinical trial studies were selected according to the eligibility criteria. Then, they were categorized into MMM and MM a...
Source: Current Stem Cell Research and Therapy - November 30, 2020 Category: Stem Cells Authors: Bouhlouli M, Izadi N, Khojasteh A Tags: Curr Stem Cell Res Ther Source Type: research

Properties of Cell Sources in Tissue-Engineered Three Dimensional Oral Mucosa Model: A Review.
Abstract Oral mucosa is a mucous membrane lining the oral cavity. Its main function is to protect the deeper structures against the external factors; thermal, chemical, mechanical and biological stimuli. Apart from that, it also plays a significant role during mastication, deglutition and speech. Some oral diseases or injuries to oral mucosa lead to impairment of the oral functions and aesthetics which eventually result in permanent defect of oral mucosa. In order to overcome this defect, different approaches for the development of reconstructed oral mucosa models have been employed including skin/autologous graft...
Source: Current Stem Cell Research and Therapy - August 16, 2016 Category: Stem Cells Authors: Nor NH, Berahim Z, Ahmad A, Kannan TP Tags: Curr Stem Cell Res Ther Source Type: research

Use of adipose-derived stem cells in lymphatic tissue engineering and regeneration
Arch Plast Surg. 2021 Sep;48(5):559-567. doi: 10.5999/aps.2021.00339. Epub 2021 Sep 15.ABSTRACTThe potential to differentiate into different cell lines, added to the easy and cost-effective method of extraction, makes adipose-derived stem cells (ADSCs) an object of interest in lymphedema treatment. Our study's goal was to conduct a comprehensive systematic review of the use of ADSCs in lymphatic tissue engineering and regeneration. On July 23, 2019, using PubMed/MEDLINE, Cochrane Clinical Answers, Cochrane Central Register of Controlled Trials, and Embase databases, we conducted a systematic review of published literature ...
Source: Archives of Plastic Surgery - September 28, 2021 Category: Cosmetic Surgery Authors: Antonio Jorge Forte Daniel Boczar Rachel Sarabia-Estrada Maria T Huayllani Francisco R Avila Ricardo A Torres Gunel Guliyeva Thiha Aung Alfredo Qui ñones-Hinojosa Source Type: research