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The Difference Between Adult Stem Cells and Embryonic Stem Cells
This is Ken Aldrich. I am Chairman of International Stem Cell Corporation and thought I’d talk for just a minute, or maybe a couple of minutes, about the different kinds of stem cells. People are always asking, “What’s the difference between an adult stem cell and an embryonic stem cell?” Let me try to make this as simple as possible. Adult stem cells are those that are derived from the human body any time after the first, probably, week or two of development of the fetus in the womb. So, cells that come from cord blood, or cells that come from embryonic tissue as well as cells that come from an adult hum...
Source: International Stem Cell Corporation - April 16, 2009 Category: Stem Cells Authors: internationalstemcell Tags: biotechnology health medicine parthenogenesis stem cell bank pluripotent international stem cell corporation alzheimers parkinsons leukemia vectors Source Type: podcasts
ISCO and Absorption Sytems to Commercialize Stem Cell Derived Human Corneal Tissue for Drug Test
International Stem Cell Corporation (OTCBB:ISCO (www.internationalstemcell.com), the first company to perfect a method of creating human “parthenogenetic” stem cells from unfertilized eggs, has formed a partnership with Absorption Systems to utilize ISCO’s parthenogenetic stem cell-derived human corneal tissue to measure drug disposition, drug safety and drug-drug interactions. The collaboration between the companies is focused on using Absorption Systems’ know how in creating in vitro assay systems to develop a superior method of testing drugs that will also reduce the use of laboratory animals currently nece...
Source: International Stem Cell Corporation - November 25, 2008 Category: Stem Cells Authors: internationalstemcell Tags: biotechnology science health medicine parthenogenesis stem cell Source Type: podcasts
International Stem Cell Corporation Announces a Manufacturing and Supply Agreement with Millipore Co
International Stem Cell (OTCBB:ISCO) announced today it has entered into a worldwide distribution agreement with Millipore Corporation (NYSE: MIL) to manufacture living cells and cell culture products to be sold through Millipore’s distribution network.
“To work with a company such as Millipore that has sales of over $1.5 billion and is known throughout the world is a wonderful opportunity for ISCO. This partnership will lead to a significant expansion in ISCO’s revenue generation through the manufacture of high quality cells and cell culture products. Millipore is a leader in the life science industry, with a strong...
Source: International Stem Cell Corporation - September 25, 2008 Category: Stem Cells Authors: internationalstemcell Tags: biotechnology science health medicine parthenogenesis stem cell Source Type: podcasts
Injury Activates Transient Olfactory Stem Cell States with Diverse Lineage Capacities.
Abstract
Tissue homeostasis and regeneration are mediated by programs of adult stem cell renewal and differentiation. However, the mechanisms that regulate stem cell fates under such widely varying conditions are not fully understood. Using single-cell techniques, we assessed the transcriptional changes associated with stem cell self-renewal and differentiation and followed the maturation of stem cell-derived clones using sparse lineage tracing in the regenerating mouse olfactory epithelium. Following injury, quiescent olfactory stem cells rapidly shift to activated, transient states unique to regeneration and tai...
Source: Cell Stem Cell - November 17, 2017 Category: Stem Cells Authors: Gadye L, Das D, Sanchez MA, Street K, Baudhuin A, Wagner A, Cole MB, Choi YG, Yosef N, Purdom E, Dudoit S, Risso D, Ngai J, Fletcher RB Tags: Cell Stem Cell Source Type: research
Hair Follicle Stem Cell Faith is Dependent On Chromatin Remodeling Capacity Following Low ‐Dose Radiation
This article is protected by copyright. All rights reserved.
LDR induces the accumulation of persisting, heterochromatic chromatin alterations combined with global chromatin compaction in HFSCs. Stem cells react through a combination of stem cell senescence and stem cell differentiation, independent of apoptosis. The determination of stem cell faith (senescence or migration) is dependent on ATM activity. The loss of basal stem cells, induced by differentiation, leads to increased stem cell proliferation maintaining the stem cell number at a constant level.
Source: Stem Cells - December 28, 2017 Category: Stem Cells Authors: Nadine Schuler, Sara Timm, Claudia E. R übe Tags: Tissue ‐Specific Stem Cells Source Type: research
Stem cells transplantation in the treatment of patients with liver failure.
CONCLUSION: Stem cell transplantation is a promising but challenging strategy and paves a new way for curing liver disease. But more efforts need to be made to overcome problems before this new strategy could be safely and effectively applied to humans.
PMID: 29303079 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - January 5, 2018 Category: Stem Cells Authors: Tao YC, Wang ML, Chen EQ, Tang H Tags: Curr Stem Cell Res Ther Source Type: research
Homeostatic Epidermal Stem Cell Self-Renewal Is Driven by Local Differentiation.
Abstract
Maintenance of adult tissues depends on sustained activity of resident stem cell populations, but the mechanisms that regulate stem cell self-renewal during homeostasis remain largely unknown. Using an imaging and tracking approach that captures all epidermal stem cell activity in large regions of living mice, we show that self-renewal is locally coordinated with epidermal differentiation, with a lag time of 1 to 2 days. In both homeostasis and upon experimental perturbation, we find that differentiation of a single stem cell is followed by division of a direct neighbor, but not vice versa. Finally, we s...
Source: Cell Stem Cell - September 24, 2018 Category: Stem Cells Authors: Mesa KR, Kawaguchi K, Cockburn K, Gonzalez D, Boucher J, Xin T, Klein AM, Greco V Tags: Cell Stem Cell Source Type: research
Stem cell niche: Dynamic neighbor of stem cells.
Abstract
Stem cell niche is a specialized and dynamic microenvironment around the stem cells which plays a critical role in maintaining the stemness properties of stem cells. Over the years, advancement in the research activity has revealed the various important aspects of stem cell niche including cell-cell interaction, cell-extracellular matrix interaction, a large number of soluble signaling factors and various biochemical and biophysical cues (such as oxygen tension, flow, and shear and pore size). Stem cells have the potential to be a powerful tool in regenerative medicine due to their self-renewal property a...
Source: European Journal of Cell Biology - December 12, 2018 Category: Cytology Authors: Singh A, Yadav CB, Tabassum N, Bajpeyee AK, Verma V Tags: Eur J Cell Biol Source Type: research
Competition for Mitogens Regulates Spermatogenic Stem Cell Homeostasis in an Open Niche.
S
Abstract
In many tissues, homeostasis is maintained by physical contact between stem cells and an anatomically defined niche. However, how stem cell homeostasis is achieved in environments where cells are motile and dispersed among their progeny remains unknown. Using murine spermatogenesis as a model, we find that spermatogenic stem cell density is tightly regulated by the supply of fibroblast growth factors (FGFs) from lymphatic endothelial cells. We propose that stem cell homeostasis is achieved through competition for a limited supply of FGFs. We show that the quantitative dependence of stem cell density on...
Source: Cell Stem Cell - December 11, 2018 Category: Stem Cells Authors: Kitadate Y, Jörg DJ, Tokue M, Maruyama A, Ichikawa R, Tsuchiya S, Segi-Nishida E, Nakagawa T, Uchida A, Kimura-Yoshida C, Mizuno S, Sugiyama F, Azami T, Ema M, Noda C, Kobayashi S, Matsuo I, Kanai Y, Nagasawa T, Sugimoto Y, Takahashi S, Simons BD, Yoshid Tags: Cell Stem Cell Source Type: research
Importance of stem cell migration and angiogenesis study for regenerative cell-based therapy: A review.
Abstract
Stem cells play an essential role in maintaining homeostasis, as well as participating in new tissue regeneration. Over the past 20 years, a great deal of effort has been made to investigate the behaviour of stem cells to enable their potential use in regenerative medicine. However, a variety of biological characteristics is known to exist among the different type of stem cells due to variations in methodological approach, formulation of cell culture medium, isolation protocol and cellular niches, as well as species variation. In recent years, cell-based therapy emerges as one of the advanced techniques a...
Source: Current Stem Cell Research and Therapy - January 26, 2020 Category: Stem Cells Authors: Aziz NS, Yusop N, Ahmad A Tags: Curr Stem Cell Res Ther Source Type: research
Impact of Ultrasound Therapy on Stem Cell Differentiation, A systemic review.
CONCLUSIONS: LIPUS significantly increases the level of stem cell differentiation in cells mainly derived from BM MSCs. Clearly, there is a need for further studies to analyze the effect of LIPUS on cells derived from other sources, particularly ADS for treating hard diseases such as osteoporosis and DFU. Due to lack of reporting on standard LIPUS parameters in the field, there is a need more experiments for comparing the protocols for standardization of LIPUS parameters, in order to establish the best protocol. This would allow us for best results.
PMID: 32096749 [PubMed - as supplied by publisher]
Source: Current Stem Cell Research and Therapy - February 24, 2020 Category: Stem Cells Authors: Amini A, Chien S, Bayat M Tags: Curr Stem Cell Res Ther Source Type: research
Metabolic regulation and its molecular mechanisms in various stem cell functions.
Abstract
Recent studies on the mechanisms that link metabolic changes with stem cell fate have deepened our understanding of how specific metabolic pathways can regulate various stem cell functions during the development of an organism. Although it was originally thought to be merely a consequence of the specific cell state, metabolism is currently known to play a critical role in regulating the self-renewal capacity, differentiation potential, and quiescence of stem cells. Many studies in recent years have revealed that metabolic pathways regulate various stem cell behaviors (e.g., selfrenewal, migration, and dif...
Source: Current Stem Cell Research and Therapy - May 10, 2020 Category: Stem Cells Authors: Lee HY, Hong IS Tags: Curr Stem Cell Res Ther Source Type: research
The landscape of GPCR signaling in the regulation of epidermal stem cell fate and skin homeostasis
Skin stem cells express a variety of G ‐protein coupled receptors (GPCRs). GPCRs in the skin control multiple intracellular signaling cascades that ultimately regulate the balance of proliferation and differentiation in the stem cell compartment and the interactions of stem cells with their niche. AbstractContinuous integration of signals from the micro and macro ‐environment is necessary for somatic stem cells to adapt to changing conditions, maintain tissue homeostasis and activate repair mechanisms. G‐protein coupled receptors (GPCRs) facilitate this integration by binding to numerous hormones, metabolites and inf...
Source: Stem Cells - September 6, 2020 Category: Stem Cells Authors: M. Pila Pedro,
Katherine Lund,
Ramiro Iglesias ‐Bartolome Tags: Tissue ‐Specific Stem Cells Source Type: research
On the road again – establishment and maintenance of stemness in the neural crest from embryo to adulthood
Neural crest stem cells possess exceptionally high stem cell potential post ‐gastrulation. These cells give rise to a diverse range of derivatives of ectodermal, mesodermal‐like and endodermal‐like origin, either directly from the initial embryonic neural crest cells or later in development through an intermediate stem cell stage such as the Schwann Cell Precursors an d post‐natal neural crest‐derived stem cell reservoirs. AbstractUnique to vertebrates, the neural crest (NC) is an embryonic stem cell population that contributes to a greatly expanding list of derivatives ranging from neurons and glia of the periph...
Source: Stem Cells - October 4, 2020 Category: Stem Cells Authors: Surangi N. Perera,
Laura Kerosuo Tags: Tissue ‐Specific Stem Cells Source Type: research
