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Increased mobilization and yield of stem cells using plerixafor in combination with granulocyte-colony stimulating factor for the treatment of non-Hodgkin's lymphoma and multiple myeloma.
Authors: Pelus LM, Farag SS Abstract Multiple myeloma and non-Hodgkin's lymphoma remain the most common indications for high-dose chemotherapy and autologous peripheral blood stem cell rescue. While a CD34+ cell dose of 1 × 10(6)/kg is considered the minimum required for engraftment, higher CD34+ doses correlate with improved outcome. Numerous studies, however, support targeting a minimum CD34+ cell dose of 2.0 × 10(6)/kg, and an "optimal" dose of 4 to 6 × 10(6)/kg for a single transplant. Unfortunately, up to 40% of patients fail to mobilize an optimal CD34+ cell dose using myeloid growth factors alone. Plerixa...
Source: Stem Cells and Cloning: Advances and Applications - December 1, 2015 Category: Stem Cells Tags: Stem Cells Cloning Source Type: research

Concise Review: Review and Perspective of Cell Dosage and Routes of Administration From Preclinical and Clinical Studies of Stem Cell Therapy for Heart Disease
An important stage in the development of any new therapeutic agent is establishment of the optimal dosage and route of administration. This can be particularly challenging when the treatment is a biologic agent that might exert its therapeutic effects via complex or poorly understood mechanisms. Multiple preclinical and clinical studies have shown paradoxical results, with inconsistent findings regarding the relationship between the cell dose and clinical benefit. Such phenomena can, at least in part, be attributed to variations in cell dosing or concentration and the route of administration (ROA). Although clinical trials...
Source: Stem Cells Translational Medicine - January 27, 2016 Category: Stem Cells Authors: Golpanian, S., Schulman, I. H., Ebert, R. F., Heldman, A. W., DiFede, D. L., Yang, P. C., Wu, J. C., Bolli, R., Perin, E. C., Moye, L., Simari, R. D., Wolf, A., Hare, J. M., for the Cardiovascular Cell Therapy Research Network Tags: Standards, Policies, Protocols, and Regulations for Cell-Based Therapies, Mesenchymal Stem Cells Source Type: research

Postnatal periodontal ligament as a novel adult stem cell source for regenerative corneal cell therapy.
Abstract Corneal opacities are a leading cause of global blindness. They are conventionally treated by the transplantation of donor corneal tissue, which is, restricted by a worldwide donor material shortage and allograft rejection. Autologous adult stem cells with a potential to differentiate into corneal stromal keratocytes (CSKs) could offer a suitable choice of cells for regenerative cell therapy. Postnatal periodontal ligament (PDL) contains a population of adult stem cells, which has a similar embryological origin as CSK, that is cranial neural crest. We harvested PDL cells from young adult teeth extracted b...
Source: J Cell Mol Med - March 13, 2018 Category: Molecular Biology Authors: Yam GH, Teo EP, Setiawan M, Lovatt MJ, Yusoff NZBM, Fuest M, Goh BT, Mehta JS Tags: J Cell Mol Med Source Type: research

Comparative Efficacy and Clinical Outcomes of Haploidentical Stem Cell Transplantation to Other Stem Sources for Treatment in Acute Myeloid Leukemia and Myelodysplastic Syndrome Patients: A Systematic Review and Meta-Analysis.
Abstract The use of allogeneic hematopoietic stem cell transplantation (HSCT) is recommended during the first complete remission of acute myeloid leukemia (AML) and high-risk myelodysplastic syndrome (MDS). However, only 30% of these cases have fully matched sibling donors (MSDs). Alternatively, matched unrelated donors (MUDs) and haploidentical (haplo) donors from first-degree relatives increase the access to transplantation, with some reported differences in outcomes. The current systematic review and meta-analysis was conducted with the aim of summarizing the results of those studies to compare the efficacy and...
Source: Cell Transplantation - December 31, 2019 Category: Cytology Authors: Kunacheewa C, Ungprasert P, Phikulsod P, Issaragrisil S, Owattanapanich W Tags: Cell Transplant Source Type: research

A Frank Discussion About Stem Cell Research with International Stem Cell CEO
Ken Aldrich, CEO of International Stem Cell Corporation, addresses some timely issues regarding stem cell research. To learn more about ISCO or to contact them regarding further questions, please visit their website here
Source: International Stem Cell Corporation - July 13, 2008 Category: Stem Cells Authors: internationalstemcell Tags: biotechnology science health medicine Source Type: podcasts

iPSC-derived human mesenchymal stem cells improve myocardial strain of infarcted myocardium.
Abstract We investigated global and regional effects of myocardial transplantation of human induced pluripotent stem cell (iPSC)-derived mesenchymal stem cells (iMSCs) in infarcted myocardium. Acute myocardial infarction (MI) was induced by ligation of left coronary artery of severe combined immunodeficient mice before 2 × 10(5) iMSCs or cell-free saline were injected into peri-infarcted anterior free wall. Sham-operated animals received no injection. Global and regional myocardial function was assessed serially at 1-week and 8-week by segmental strain analysis by using two dimensional (2D) speckle tracking ech...
Source: J Cell Mol Med - June 28, 2014 Category: Molecular Biology Authors: Miao Q, Shim W, Tee N, Lim SY, Chung YY, Ja KP, Ooi TH, Tan G, Kong G, Wei H, Lim CH, Sin YK, Wong P Tags: J Cell Mol Med Source Type: research

Reaching out: junctions between cardiac telocytes and cardiac stem cells in culture.
Abstract Telocytes (TCs) were previously shown by our group to form a tandem with stem/progenitor cells in cardiac stem cell (CSC) niches, fulfilling various roles in cardiac renewal. Among these, the ability to 'nurse' CSCs in situ, both through direct physical contact (junctions) as well as at a distance, by paracrine signalling or through extracellular vesicles containing mRNA. We employed electron microscopy to identify junctions (such as gap or adherens junctions) in a co-culture of cardiac TCs and CSCs. Gap junctions were observed between TCs, which formed networks, however, not between TCs and CSCs. Instea...
Source: J Cell Mol Med - November 5, 2015 Category: Molecular Biology Authors: Popescu LM, Fertig ET, Gherghiceanu M Tags: J Cell Mol Med Source Type: research

Hair Follicle Bulge Stem Cells Appear Dispensable for the Acute Phase of Wound Re‐epithelialization
Abstract The cutaneous healing response has evolved to occur rapidly, in order to minimize infection and to re‐establish epithelial homeostasis. Rapid healing is achieved through complex coordination of multiple cell types, which importantly includes specific cell populations within the hair follicle (HF). Under physiological conditions, the epithelial compartments of HF and interfollicular epidermis remain discrete, with K15+ve bulge stem cells contributing progeny for HF reconstruction during the hair cycle and as a basis for hair shaft production during anagen. Only upon wounding do HF cells migrate from the follicle ...
Source: Stem Cells - February 2, 2016 Category: Stem Cells Authors: Clare L. Garcin, David M. Ansell, Denis J. Headon, Ralf Paus, Matthew J. Hardman Tags: Tissue ‐Specific Stem Cells Source Type: research

Nestin regulates neural stem cell migration via controlling the cell contractility.
Abstract Neural stem cells (NSCs) migration is essential for neurogenesis and neuroregeneration after brain injury. Nestin, a widely used marker of NSCs, is expressed abundantly in several cancers, where it may correlate with tumor migration and invasion. However, it is not yet known whether nestin participates in NSC migration. Here, we show that nestin down-regulation significantly inhibits the migration and contraction of murine neural stem cells, but does not obviously influence the proliferation, filamentous actin (F-actin) content, distribution or focal adhesion assembly of these cells. Mechanistically, nest...
Source: The International Journal of Biochemistry and Cell Biology - July 27, 2016 Category: Biochemistry Authors: Yan S, Li P, Wang Y, Yu W, Qin A, Liu M, Xiang AP, Zhang W, Li W Tags: Int J Biochem Cell Biol Source Type: research

A Frank Discussion About Stem Cell Research with International Stem Cell CEO
Ken Aldrich, CEO of International Stem Cell Corporation, addresses some timely issues regarding stem cell research. To learn more about ISCO or to contact them regarding further questions, please visit their website here
Source: International Stem Cell Corporation - July 13, 2008 Category: Stem Cells Authors: internationalstemcell Tags: biotechnology science health medicine Source Type: podcasts

Metabolism in Pluripotent Stem Cells and Early Mammalian Development.
Abstract Emerging and seminal studies have shown that cell metabolism influences gene expression by modifying the epigenome, which can regulate stem cell pluripotency, differentiation, and somatic cell reprogramming. Core pluripotency factors and developmental regulators reciprocally control the expression of key metabolism genes and their encoded pathways. Recent technological advances enabling sensitive detection methods during early mammalian development revealed the state-specific and context-dependent coordination of signal transduction, histone modifications, and gene expression in developing, resting, and m...
Source: Cell Metabolism - February 6, 2018 Category: Cytology Authors: Zhang J, Zhao J, Dahan P, Lu V, Zhang C, Li H, Teitell MA Tags: Cell Metab Source Type: research

Xist Intron 1 Repression by Transcriptional ‐Activator‐Like Effectors Designer Transcriptional Factor Improves Somatic Cell Reprogramming in Mice
We report that the selected dTF repressor 6 (R6) binding the intron 1 ofXist, which caused higher H3K9me3 followed by X chromosome opening and repression of X ‐linked genes in mouse embryonic fibroblasts, rather than affectingXist expression, substantially improved the iPSC generation and the SCNT preimplantation embryo development. Conversely, the dTF activator targeting the same genomic region of R6 decreased iPSC formation and blocked SCNT ‐embryo development. These results thus uncover the critical requirement for theXist locus in epigenetic resetting, which is not directly related toXist transcription. This may pr...
Source: Stem Cells - February 21, 2019 Category: Stem Cells Authors: Jindun Zhang, Xuefei Gao, Jian Yang, Xiaoying Fan, Wei Wang, Yanfeng Liang, Lihong Fan, Hongmei Han, Xiaorong Xu, Fuchou Tang, Siqin Bao, Pentao Liu, Xihe Li Tags: Embryonic Stem Cells/Induced Pluripotent Stem Cells Source Type: research