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Effective Job Search Strategies to Consider
Before you begin a job search, you need to think through the question, “What’s your strategy as an executive job seeker?” There’s no right or wrong answer to the question, and sometimes it takes trial and error to truly figure out what the most effective strategy is for you. Even then, adjustments must be made […]
Source: EMR and HIPAA - September 5, 2019 Category: Information Technology Authors: Erin Kennedy Tags: Career and Jobs Healthcare IT employment Erin Kennedy Executive Resume Writer executive resumes job search LinkedIn LinkedIn Profile Development Professional Resume Services resume writing Source Type: blogs

Finding the best-fit background function for whole-powder-pattern fitting using LASSO combined with tree search
A new linear function for modelling the background in whole-powder-pattern fitting has been derived by applying LASSO (least absolute shrinkage and selection operator) and the technique of tree search. The background function (BGF) consists of terms bnL(2 θ /180) − n/2   and bnH(1   −   2 θ /180) − n/2 for the low- and high-angle sides, respectively. Some variable parameters of the BGF should be fixed at zero while others should be varied in order to find the best fit for a given data set without inducing overfitting. The LASSO algorithm can automatically select the variables in linear regression analysis. Ho...
Source: Journal of Applied Crystallography - February 14, 2021 Category: Physics Authors: Toraya, H. Tags: background functions LASSO tree search least absolute shrinkage and selection operator whole-powder-pattern fitting X-ray powder diffraction research papers Source Type: research

What is the current best RSS reader?
After it was announced that Google Reader will be shut down in July, some of my Twitter buddies asked me what I plan to use in the future as a RSS reader. I have already switched to RSS Owl. Pros: - faster and more powerful than Google Reader - portable program that does not require installation (choose the version labeled "rssowl-2.1.6.windows.zip"). You can take it on a USB drive if you wish. - keyboard shortcuts - you can either customize the existing shortcuts or create new ones - social media sharing integration (Buffer, Twitter, Facebook, etc.) - Easy export and import of your RSS subscriptions as an OPML file - o...
Source: Clinical Cases and Images - Blog - March 24, 2013 Category: Professors and Educators Tags: RSS Source Type: blogs

Phylogenetic relationship and genomic characterization of Salmonella Typhimurium strains isolated from swine in Brazil
In conclusion, molecular typing based in the wgMLST and cgMLST suggested that the S. Typhimurium isolates from swine studied were genetically related. The pathogenic potential of the strains studied was corroborated by the presence of important SPIs and virulence genes. The high number of antimicrobial resistance genes detected is worrying and reinforced their potential risk in swine in Brazil. The comparison by BLAST Atlas suggested differences in mobile genetic elements among S. Typhimurium LT2 and S. Typhimurium isolates from swine in Brazil. The orthologous proteins analysis revealed unique genes related to important c...
Source: Infection, Genetics and Evolution - June 26, 2021 Category: Genetics & Stem Cells Authors: Amanda Aparecida Seribelli Patrick da Silva Miliane Rodrigues Fraz ão Jalusa Deon Kich Marc W Allard Juliana Pfrimer Falc ão Source Type: research

SPDB: a specialized database and web-based analysis platform for swine pathogens
AbstractThe rapid and accurate diagnosis of swine diseases is indispensable for reducing their negative impacts on the pork industry. Next-generation sequencing (NGS) is a promising diagnostic tool for swine diseases. To support the application of NGS in the diagnosis of swine disease, we established the Swine Pathogen Database (SPDB). The SPDB represents the first comprehensive and highly specialized database and analysis platform for swine pathogens. The current version features an online genome search tool, which now contains 26  148 genomes of swine, swine pathogens and phylogenetically related species. This database...
Source: Database : The Journal of Biological Databases and Curation - August 6, 2020 Category: Databases & Libraries Source Type: research

Comparison of MS2, synchronous precursor selection MS3, and real-time search MS3 methodologies for lung proteomes of hydrogen sulfide treated swine.
Abstract Tandem mass tags (TMTs) have increasingly become an attractive technique for global proteomics. However, its effectiveness for multiplexed quantitation by traditional tandem mass spectrometry (MS2) suffers from ratio distortion. Synchronous precursor selection (SPS) MS3 has been widely accepted for improved quantitation accuracy, but concurrently decreased proteome coverage. Recently, a Real-Time Search algorithm has been integrated with the SPS MS3 pipeline (RTS MS3) to provide accurate quantitation and improved depth of coverage. In this mechanistic study of the impact of exposure to hydrogen sulfide (H...
Source: Analytical and Bioanalytical Chemistry - October 25, 2020 Category: Chemistry Authors: Fu Q, Liu Z, Bhawal R, Anderson ET, Sherwood RW, Yang Y, Thannhauser T, Schroyen M, Tang X, Zhang H, Zhang S Tags: Anal Bioanal Chem Source Type: research

The use of ErpY-like recombinant protein from Leptospira interrogans in the development of an immunodiagnostic test for swine leptospirosis.
Abstract Swine leptospirosis poses a major problem in the agricultural sector. The gold standard for serodiagnosis of leptospirosis is Microscopic Agglutination Test (MAT). However, the limitations of this technique make the search for alternative diagnostic methods inevitable. In the present study, ErpY-like recombinant protein (rErpY-like), produced in Escherichia coli and used as antigen in indirect enzyme-linked immunosorbent assay (ELISA), was evaluated for its efficacy as a novel diagnostic tool for swine leptospirosis. For the study, 72 samples of swine sera characterized by microscopic agglutination test (...
Source: Acta Tropica - February 15, 2019 Category: Infectious Diseases Authors: Padilha BCR, Simão HQ, Oliveira TL, Hartwig DD Tags: Acta Trop Source Type: research

Adjuvants for swine vaccines: Mechanisms of actions and adjuvant effects.
Abstract This review deals with mechanisms of actions (MOA) and adjuvant effects of various types of adjuvants for swine vaccines. A number of different types of adjuvants have been tested with swine vaccines, including oil emulsion, particulate antigen (Ag) carrier, cytokines, pathogen-associated molecular patterns and immune ligands, saponins, and bacterial cells and toxins. In addition, there are a number of chemicals and natural products that possess adjuvant activities when tested with swine vaccines, and are grouped as miscellaneous in this review. The MOA of adjuvants can be generally divided into two categ...
Source: Vaccine - August 31, 2020 Category: Allergy & Immunology Authors: Charerntantanakul W Tags: Vaccine Source Type: research

Swine virome on rural backyard farms in Mexico: communities with different abundances of animal viruses and phages
AbstractDomestic swine have been introduced by humans into a wide diversity of environments and have been bred in different production systems. This has resulted in an increased risk for the occurrence and spread of diseases. Although viromes of swine in intensive farms have been described, little is known about the virus communities in backyard production systems around the world. The aim of this study was to describe the viral diversity of 23 healthy domestic swine maintained in rural backyards in Morelos, Mexico, through collection and analysis of nasal and rectal samples. Next-generation sequencing was used to identify...
Source: Archives of Virology - January 4, 2021 Category: Virology Source Type: research

The role of rodents in the transmission of Leptospira spp. in swine farms.
Authors: Ospina-Pinto C, Rincón-Pardo M, Soler-Tovar D, Hernández-Rodríguez P Abstract Different species of rodents are potential transmitters of multiple zoonotic agents such as Leptospira spp., a spirochete that causes leptospirosis. This is an infectious disease that has a negative impact on pig production because it generates large productive, reproductive and economic losses. In swine farms, the most common rodent species are house mice (Mus musculus), brown rats (Rattus norvegicus) and black rats (Rattus rattus), which act as maintenance hosts for different serovars of Leptospira, contaminating the environ...
Source: Revista de Salud Publica - September 8, 2018 Category: International Medicine & Public Health Tags: Rev Salud Publica (Bogota) Source Type: research

Lack of evidence for long term carriers of African swine fever virus - a systematic review.
Abstract African swine fever (ASF) was first described in 1921 as a highly fatal and contagious disease which caused severe outbreaks among settlers' pigs in British East Africa. Since then the disease has expanded its geographical distribution and is currently present in large parts of Africa, Europe and Asia and considered a global threat. Although ASF is typically associated with very high case fatality rates, a certain proportion of infected animals will recover from the infection and survive. Early on it was speculated that such survivors may act as carriers of the virus, and the importance of such carries fo...
Source: Virus Research - August 16, 2019 Category: Virology Authors: Ståhl K, Sternberg-Lewerin S, Blome S, Viltrop A, Penrith ML, Chenais E Tags: Virus Res Source Type: research

Generic physiologically based kinetic modelling for farm animals: Part I. Data collection of physiological parameters in swine, cattle and sheep.
Abstract Physiologically based kinetic (PBK) models for farm animals are of growing interest in food and feed safety with key applications for regulated compounds including quantification of tissue concentrations, kinetic parameters and the setting of safe exposure levels on an internal dose basis. The development and application of these models requires data for physiological, anatomical and chemical specific parameters. Here, we present the results of a structured data collection of anatomical and physiological parameters in three key farm animal species (swine, cattle and sheep). We performed an extensive liter...
Source: Toxicology Letters - October 30, 2019 Category: Toxicology Authors: Lautz LS, Dorne JLCM, Oldenkamp R, Hendriks AJ, Ragas AMJ Tags: Toxicol Lett Source Type: research

Viruses, Vol. 13, Pages 2522: The Valproic Acid Derivative Valpromide Inhibits Pseudorabies Virus Infection in Swine Epithelial and Mouse Neuroblastoma Cell Lines
Morales Pseudorabies virus (PRV) infection of swine can produce Aujeszky’s disease, which causes neurological, respiratory, and reproductive symptoms, leading to significant economic losses in the swine industry. Although humans are not the natural hosts of PRV, cases of human encephalitis and endophthalmitis caused by PRV infection have been reported between animals and workers. Currently, a lack of specific treatments and the emergence of new PRV strains against which existing vaccines do not protect makes the search for effective antiviral drugs essential. As an alternative to traditional nucleoside an...
Source: Viruses - December 15, 2021 Category: Virology Authors: Sabina Andreu In és Ripa Beatriz Praena Jos é Antonio López-Guerrero Raquel Bello-Morales Tags: Article Source Type: research

Ultrasound‐Targeted Microbubble Destruction Enhances Gene Expression of microRNA‐21 in Swine Heart via Intracoronary Delivery
ConclusionUnder suitable conditions, UTMD can efficiently enhance gene expression in swine heart regardless of the delivery routes. The intravenous injection might be superior to intracoronary injection with less invasiveness and lower requirement of the technique. And for those undergoing percutanesous coronary intervention, intracoronary injection seems to be another alternative.
Source: Echocardiography - January 1, 2015 Category: Cardiology Authors: Yangchun Liu, Lang Li, Qiang Su, Tao Liu, Zhiying Ma, Huafeng Yang Tags: Original Investigation Source Type: research