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Inhibition of Nitric Oxide Synthases, But Not Inducible Nitric Oxide Synthase, Selectively Worsens Left Ventricular Function After Successful Resuscitation From Cardiac Arrest in Swine
ConclusionsGlobal inhibition of NOS after cardiac arrest and resuscitation markedly worsens hemodynamic variables. Selective inhibition of iNOS after cardiac arrest and resuscitation does not prevent postresuscitation myocardial stunning. There were no significant differences in neurological outcome or survival between treatment groups.
Source: Academic Emergency Medicine - January 29, 2015 Category: Emergency Medicine Authors: Betsy B. Dokken, Mohamed A. Gaballa, Ronald W. Hilwig, Robert A. Berg, Karl B. Kern Tags: Original Contribution Source Type: research

Development of an in vivo swine model of biliary dilatation‐based direct peroralcholangioscopy
ConclusionAn in vivo swine model of biliary dilatation‐based direct peroralcholangioscopy was established. This novel animal model may be useful for the preclinical research of new materials or devices because direct visualization of the biliary tree is feasible. This article is protected by copyright. All rights reserved.
Source: Digestive Endoscopy - February 2, 2016 Category: Gastroenterology Authors: Jin‐Seok Park, Seok Jeong, Chang‐Il Kwon, Hyun Jong Choi, Dong Hee Koh, Jae Hee Cho, Jong Jin Hyun, Jong Ho Moon, Don Haeng Lee Tags: Original Article Source Type: research

Emergence of a Multidrug-Resistant Shiga Toxin-Producing Enterotoxigenic Escherichia coli Lineage in Diseased Swine in Japan Clinical Veterinary Microbiology
Enterotoxigenic Escherichia coli (ETEC) and Shiga toxin-producing E. coli (STEC) are important causes of diarrhea and edema disease in swine. The majority of swine-pathogenic E. coli strains belong to a limited range of O serogroups, including O8, O138, O139, O141, O147, O149, and O157, which are the most frequently reported strains worldwide. However, the circumstances of ETEC and STEC infections in Japan remain unknown; there have been few reports on the prevalence or characterization of swine-pathogenic E. coli. In the present study, we determined the O serogroups of 967 E. coli isolates collected between 1991 and 2014 ...
Source: Journal of Clinical Microbiology - March 24, 2016 Category: Microbiology Authors: Kusumoto, M., Hikoda, Y., Fujii, Y., Murata, M., Miyoshi, H., Ogura, Y., Gotoh, Y., Iwata, T., Hayashi, T., Akiba, M. Tags: Clinical Veterinary Microbiology Source Type: research

Development of an in vivo swine model of biliary dilatation‐based direct peroral cholangioscopy
ConclusionAn in vivo swine model of biliary dilatation‐based direct peroral cholangioscopy was established. This novel animal model may be useful for preclinical research of new materials or devices because direct visualization of the biliary tree is feasible.
Source: Digestive Endoscopy - April 4, 2016 Category: Gastroenterology Authors: Jin‐Seok Park, Seok Jeong, Chang‐Il Kwon, Hyun Jong Choi, Dong Hee Koh, Jae Hee Cho, Jong Jin Hyun, Jong‐Ho Moon, Don Haeng Lee Tags: Original Article Source Type: research

Genetic diversity of subgenotype 2.1 isolates of classical swine fever virus.
Abstract As the causative agent of classical swine fever, the economically devastating swine disease worldwide, classical swine fever virus (CSFV) is currently classified into the 11 subgenotypes, of which subgenotype 2.1 is distributed worldwide and showing more genetic diversity than other subgenotypes. Prior to this report, subgenotype 2.1 was divided into three sub-subgenotypes (2.1a-2.1c). To further analyze the genetic diversity of CSFV isolates in China, 39 CSFV isolates collected between 2004 and 2012 in two Chinese provinces Guangxi and Guangdong were sequenced and subjected to phylogenetic analysis toget...
Source: Infection, Genetics and Evolution - April 12, 2016 Category: Genetics & Stem Cells Authors: Gong W, Wu J, Lu Z, Zhang L, Qin S, Chen F, Peng Z, Wang Q, Ma L, Bai A, Guo H, Shi J, Tu C Tags: Infect Genet Evol Source Type: research

Development of an in  vivo swine model of biliary dilatation‐based direct peroral cholangioscopy
ConclusionAn in vivo swine model of biliary dilatation‐based direct peroral cholangioscopy was established. This novel animal model may be useful for preclinical research of new materials or devices because direct visualization of the biliary tree is feasible.
Source: Digestive Endoscopy - April 4, 2016 Category: Gastroenterology Authors: Jin ‐Seok Park, Seok Jeong, Chang‐Il Kwon, Hyun Jong Choi, Dong Hee Koh, Jae Hee Cho, Jong Jin Hyun, Jong‐Ho Moon, Don Haeng Lee Tags: Original Article Source Type: research

HA1-2-fljB Vaccine Induces Immune Responses against Pandemic Swine-Origin H1N1 Influenza Virus in Mice
In 2009, a novel pandemic swine-origin influenza A (H1N1) virus caused a public emergency of international concern. Vaccination is the primary strategy for the control of influenza epidemics. However, the poor immunopotency of many vaccine antigens is a major barrier to the development of effective vaccines against influenza. Flagellin, a Toll-like receptor 5 (TLR5) ligand, has been used as an adjuvant to enhance the immunopotency of vaccines in preclinical studies. Here, we developed a recombinant candidate vaccine, HA1-2-fljB, in which the globular head of the hemagglutinin (HA) antigen (residues 62-284) from H1N1 virus ...
Source: Journal of Molecular Microbiology and Biotechnology - October 7, 2016 Category: Microbiology Source Type: research

Effects of tibial and humerus intraosseous administration of epinephrine in a cardiac arrest swine model.
CONCLUSION: The TIO and HIO provide rapid and reliable access to administer life-saving medications during cardiac arrest. PMID: 28140439 [PubMed - in process]
Source: American Journal of Disaster Medicine - February 2, 2017 Category: Global & Universal Tags: Am J Disaster Med Source Type: research

Treatment rates for injectable tiamulin and lincomycin as an estimate of morbidity in a swine herd with endemic swine dysentery.
Abstract Treatment can be used as an indirect measure of morbidity, and treatment records can be used to describe disease patterns in a population. The aim of this study was to describe the rates of treatments with tiamulin and lincomycin by the intramuscular route in cohorts of pigs affected by swine dysentery. Data from treatment records from 19 cohorts of a 1500-head grower-finisher barn were analyzed using Poisson regression to determine factors associated with rates of treatment. Serial interval and reproductive numbers were extracted. Treatment rates displayed marked seasonality. The mean serial interval was...
Source: The Canadian Veterinary Journal - May 1, 2017 Category: Veterinary Research Authors: Walczak K, Friendship R, Brockoff E, Greer A, Poljak Z Tags: Can Vet J Source Type: research

High Fat, High Fructose, High Cholesterol Feeding Causes Severe NASH and Cecal Microbiota Dysbiosis in Juvenile Ossabaw Swine.
Abstract Pediatric obesity and nonalcoholic steatohepatitis (NASH) are on the rise in industrialized countries, yet our ability to mechanistically examine this relationship is limited by the lack of a suitable higher animal model. Here, we examined the effects of high fat, high fructose corn syrup, high cholesterol Western style diet (WD)-induced obesity on NASH and cecal microbiota dysbiosis in juvenile Ossabaw swine. Juvenile female Ossabaw swine (5 weeks old) were fed WD (43.0% fat; 17.8% high fructose corn syrup; 2% cholesterol) or low-fat diet (CON/lean; 10.5% fat) for 16 wks (n=6 each) or 36 wks (n=4 each). WD...
Source: American Journal of Physiology. Endocrinology and Metabolism - September 12, 2017 Category: Physiology Authors: Panasevich MR, Meers GM, Linden MA, Booth FW, Perfield JW, Fritsche KL, Wankhade UD, Chintapalli SV, Shankar K, Ibdah JA, Rector RS Tags: Am J Physiol Endocrinol Metab Source Type: research

Detailed mapping of the linear B Cell epitopes of the hemagglutinin (HA) protein of swine influenza virus.
Abstract Using the Hemagglutinin (HA) protein peptide array of H1N1 pdm09 and a panel of swine antisera against various swine influenza H1 and H3 clusters, we identified three immunoreactive epitopes with one (peptide 15) located in HA1 (amino acids 57-71) and two (peptides 121 and 139) in HA2 (amino acids 481-495 and 553-566). Further analysis showed that all swine antisera of H1 clusters efficiently recognized two HA2 epitopes; peptides 121 and 139, with only a subset of antisera reactive to HA1-derived peptide 15. Interestingly, none of these peptides were reactive to SIV H3 antisera. Finally, intranasal inocul...
Source: Virology - July 17, 2018 Category: Virology Authors: Wang Z, Huang B, Thomas M, Sreenivasan CC, Sheng Z, Yu J, Hause BM, Wang D, Francis DH, Kaushik RS, Li F Tags: Virology Source Type: research

Swine flu symptoms: How long does Swine Flu last? Is Swine Flu contagious?
SWINE FLU has started making rounds again this year as flu season enters 2019 and claims its first victims. How long does Swine Flu last and is it contagious?
Source: Daily Express - Health - January 9, 2019 Category: Consumer Health News Source Type: news

Swine flu symptoms: What are the symptoms of swine flu? How is swine flu diagnosed?
SWINE FLU remains a prominent threat every year when flu season rolls around, despite no longer being a major pandemic. What are the symptoms of Swine Flu and how is it diagnosed?
Source: Daily Express - Health - January 9, 2019 Category: Consumer Health News Source Type: news

Cas12a-Based On-Site and Rapid Nucleic Acid Detection of African Swine Fever
The mortality rate of hemorrhagic African swine fever (ASF), which targets domestic pigs and wild boars is caused by African swine fever virus (ASFV), can reach 100%. Since the first confirmed ASF outbreak in China on 3 August 2018, 156 ASF outbreaks were detected in 32 provinces. About 1,170,000 pigs were culled in order to halt further spread. There is no effective treatment or vaccine for it and the present molecular diagnosis technologies have trade-offs in sensitivity, specificity, cost and speed, and none of them cater perfectly to ASF control. Thus, a technology that overcomes the need for laboratory facilities, is ...
Source: Frontiers in Microbiology - December 9, 2019 Category: Microbiology Source Type: research

Viruses, Vol. 13, Pages 664: Genotyping and Molecular Characterization of Classical Swine Fever Virus Isolated in China during 2016 –2018
In conclusion, the new isolates showed molecular variations and antigenic alterations, which provide evidence for the emergence of vaccine-escaping mutants and emphasize the need of updated strategies for CSF control.
Source: Viruses - April 12, 2021 Category: Virology Authors: Madiha Fatima Yuzi Luo Li Zhang Peng-Ying Wang Hao Song Yanhui Fu Yongfeng Li Yuan Sun Su Li Yun-Juan Bao Hua-Ji Qiu Tags: Article Source Type: research