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Arguing for an Expansion of the Hallmarks of Aging
The hallmarks of aging form a catalog of largely better studied changes in cells and tissues considered relevant, and possibly more important, in the onset and development of age-related degeneration and disease. This is not the same thing as a list of causes of aging. A few of the hallmarks mostly likely are or include deeper causes of aging, or close to causes of aging. The hallmarks do overlap with the SENS description of aging as a set of root causes, forms of molecular damage that result from the normal operation of a youthful metabolism. Since the hallmarks of aging are not, and are not intended to be a list of cause...
Source: Fight Aging! - September 5, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Fight Aging! Newsletter, September 5th 2022
Conclusion Coupled with the animal data, and the existing human trial data for safety, the results here suggests that someone should run a formal, controlled trial of flagellin immunization in older people, 65 and over. The goal would be to see whether (a) this sort of outcome holds up in a larger group of people, and (b) there is a meaningful impact on chronic inflammation and other parameters of health that are known to be affected by the aging of the gut microbiome. The most interesting part of the data is perhaps the decline in microbial diversity, when considered against the gains elsewhere. Microbial dive...
Source: Fight Aging! - September 4, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Senolytics, a Promising New Field of Medicine in the Treatment of Aging
It is becoming harder for the world at large to ignore the field of senolytics, the large number of research groups and companies working towards therapies that clear a fraction of senescent cells from aged tissues. Senescent cells accumulate in later life, likely because the immune system becomes less able to remove them promptly. Lingering senescent cells actively disrupt normal tissue function and provoke chronic inflammation, thus contributing to age-related degeneration. Scores of mouse studies conducted over the last decade demonstrate that senolytic treatments produce rapid, reliable reversal of many age-related con...
Source: Fight Aging! - September 1, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Improving Hematopoietic Stem Cell Transplants
One of the causes of immune system aging is the growing dysfunction of hematopoietic stem cell populations, responsible for the production of immune cells. While some of this degeneration comes from the aging of the bone marrow niche, some it appears to be intrinsic to the cells themselves, and thus there may be benefits to be found in transplantation of functional hematopoietic stem cells derived from a patient's own cells. This would be the case if these cells could be made to reliably survive and engraft in any reasonable number, however. That is a challenging prospect, but it is worth keeping an eye on the cancer field...
Source: Fight Aging! - September 1, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Top 10 Research Topics To Pursue In Digital Health
The question we most frequently get at The Medical Futurist Institute is easily the one asking for guidance on potential research topics. In fact, we face it so often that we decided to write a summary of our thoughts to provide an overview and some insights to anyone who is willing to dive deep into digital health but is unsure about the best direction to take. Whatever you choose, take a look at these four criteria first Find a nicheAim for uncharted territoriesLook for ease of entrySeek answers to important questions We compiled a list of ten research topics we believe are in line with the above principles and ...
Source: The Medical Futurist - September 1, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Forecast Artificial Intelligence in Medicine Digital Health Research E-Patients Future of Medicine Health Sensors & Trackers Healthcare Design Healthcare Policy Portable Medical Diagnostics Telemedicine & Smartphones AI EMR v Source Type: blogs

Mining Ultrasound Data to Improve Liver Diagnostics: Interview with Beth Rogozinski, CEO at Oncoustics
Oncoustics, a medtech company based in Ontario, Canada, developed the OnX Liver Assessment Solution, an AI-powered ultrasound-based diagnostic system for liver disease. At present, detecting liver disease is a challenge, potentially involving high-en...
Source: Medgadget - August 23, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Oncology Radiology liver disease oncoustics Source Type: blogs

Weekly Australian Health IT Links – 22 August, 2022.
Here are a few I have come across the last week or so. Note: Each link is followed by a title and a few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment.General Comment-----This week we seem to have more in the way of State-Based initiatives as well as the usual rubbish info sessions from the ADHA.Also the usual from of NBN news and news of #myHR Rule 42 – which I had never heard of!-----https://www.australianageingagenda.com.au/contributors/opinion/critical-staff-shortages-affect-more-than-frontli...
Source: Australian Health Information Technology - August 22, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, August 22nd 2022
In conclusion, application of a multi-species bat epigenetic clock provides strong evidence that hibernation is associated with slower epigenetic ageing. The multi-species clock explains 94% of the variation in the chronological ages of both hibernating and non-hibernating big brown bats; however, the clock estimates are equal to or greater than the chronological age, suggesting big brown bats age slightly faster than a 'typical' bat, especially during the active period.
Source: Fight Aging! - August 21, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Weekly Overseas Health IT Links –20th August 2022.
Here are a few I came across last week.Note: Each link is followed by a title and few paragraphs. For the full article click on the link above title of the article. Note also that full access to some links may require site registration or subscription payment-----https://www.digitalhealth.net/2022/08/ai-predictive-trial-staffordshire-hn-reduce-ae-admissions/AI predictive trial in Staffordshire reduces A&E admissions by 35%A trial which looked at how existing patient data could be used to predict those most likely to need hospital care has led to a 35% reduction on average in A&E attendances across Staffordshire.Jor...
Source: Australian Health Information Technology - August 20, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Rural America is a Fertile Field for Digital Health
BY ERIC LARSEN and TOMMY IBRAHIM Eric Larsen Tommy Ibrahim Our rural health care system has suffered badly during the COVID-19 pandemic. It entered the pandemic with severe structural weaknesses, including magnified health disparities and inequities, lower rates of vaccination in the general population, and high risk of rural hospital closures. Beginning with these challenges, rural providers have been harder hit by the pandemic than just about any other health care sector.  Juxtaposed against this struggle is the optimism for digital health – one of the few bright spots of the pandemic. We have witnessed ...
Source: The Health Care Blog - August 19, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Public Health Basset Healthcare COVID-19 digital health Rural America Source Type: blogs

The Path to the Clinic for First Generation Senolytic Therapies
Senolytic therapies selectively destroy lingering senescent cells in old tissues, improving health as a result. Senescent cells, while never very large in absolute numbers, even in late life, actively maintain a degraded state of tissue and organ function via secretions that provoke chronic inflammation, detrimental alterations to the behavior of normal cells, and harmful remodeling of tissue structure, such as the development of fibrosis. A large number of animal studies have demonstrated rapid rejuvenation and reversal of aspects of specific age-related conditions to result from clearance of senescent cells. The best of ...
Source: Fight Aging! - August 18, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Discussing the State of the TAME Clinical Trial, Metformin to Slow Aging
The TAME clinical trial, still not started, intends to assess the ability of metformin to marginally slow aging in humans. Back at the start of this initiative, it required a long process of negotiation on the part of the trial organizers with the FDA to produce an endpoint that was agreed upon to sufficiently represent aging. To my mind, the TAME trial initiative has already achieved what needs to be achieved: to get the FDA to agree that there is a way to run trials to treat aging. One doesn't actually need to run the trial, and there is in fact little point in running the trial. Metformin is almost certainly a marginal ...
Source: Fight Aging! - August 16, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 15th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - August 14, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cellular Senesence, a Key Target in the Treatment of Aging
Scores of animal studies provide compelling evidence for cellular senescence to contribute meaningfully to many age-related conditions, and yet more such studies demonstrate rapid and sizable rejuvenation via targeted removal of senescent cells in old animals using varieties of senolytic therapy. Senescent cells are created constantly in the body, the result of cells reaching the Hayflick limit on replication, tissue injury, or encountering cellular damage or toxicity. When an individual is young, these newly senescent cells are near all removed by a combination of programmed cell death and the actions of the immune system...
Source: Fight Aging! - August 10, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Klotho in the Pathology of Aging
Klotho is a longevity-associated protein; more of it slows aging, less of it accelerates aging, at least in animal studies. While researchers have spent considerable effort investigating the effects of klotho on the brain, as it improves cognitive function, it seems likely that its effects arise via improved kidney function in old age. Loss of kidney function, and thus clearance of metabolic toxins and waste from the bloodstream, is harmful to tissues throughout the body. Manipulation of klotho may be a good way to assess just how much harm is generated by the age-related decline of the kidneys. The subject of thi...
Source: Fight Aging! - August 10, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs