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Fight Aging! Newsletter, July 4th 2022
This study showed that centenarians had very specific changes in CD4+ T cell populations, which were manifested by an elevated Th17/Treg ratio in vivo, as well as a changed secretory phenotype. Although the T cells of centenarians cannot resist the aging-related expression of proinflammatory genes, their secretory phenotype was altered, explaining the relatively low level of inflammation in centenarians. These results suggested the presence of a mechanism to ameliorate inflammaging in centenarians. This may be achieved by reversing the imbalance of Th17/Treg cells and reducing pro-inflammatory cytokines. Longevit...
Source: Fight Aging! - July 3, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Lifestyle Medicine Could Be The Key To Digital Health Adoption
I’ve been wearing several generations and types of smartwatches for a couple of years and I only remove my watch when I shower. I use it to track my sleep and its smart alarm wakes me up at the optimal time every morning. With the pocketable Kardia, I regularly check my ECG at home to detect any anomalies. For an in-depth analysis of what my genetic makeup predisposes me to, I had my whole genome sequenced. And I bring relevant data to my general practitioner during my checkups so that we can decide on preventive measures. In short, I’m trying to live like the patient of the future, using lifestyle medicine to prev...
Source: The Medical Futurist - June 29, 2022 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: Lifestyle medicine E-Patients Health Sensors & Trackers Healthcare Design Medical Education Personalized Medicine sleep stress food scanner sleep apnea Apple Watch Dr. Vernes Baylor ACLM Source Type: blogs

Aging is Complex and Shifts Dramatically Over Late Life as it Accelerates
My attention was drawn recently to an open access paper from earlier in the year that illustrates the magnitude of the difference between aging in early old age versus later old age. The causes of aging are comparatively simple forms of damage and disarray that emerge from the normal operation of metabolism, but because a living being is an immensely complicated system, even simple damage quickly spirals into complex consequences. Simple changes in a complex system produce complex outcomes. Aging greatly changes pace and character in its early stages versus its late stages, as chains of cause and consequence pile up, and d...
Source: Fight Aging! - June 27, 2022 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

How IoT Medical Devices Save and Improve Lives
The following is a guest article by Erik Kling, Interim Head of IoT Americas at Vodafone Business. IoT, or the Internet of Things, has transformed our homes with connected lights and smart appliances. It’s also revolutionized all areas of business, including manufacturing. Sensors connected to the internet can track goods throughout the supply chain — from sourcing materials to delivering completed products to consumers. IoT technology has improved the way we live, but its most profound impact may be in healthcare, where it’s saving lives and improving health. Before IoT revolutionized healthcare, doctors and care pr...
Source: EMR and HIPAA - June 23, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Clinical Health IT Company Healthcare IT IT Infrastructure and Dev Ops AED American College of Cardiology Connected Defibrillators Continuous Glucose Monitors CPAP Dr. Ami Bhatt Elliot Erik Kling Healthcare AI Source Type: blogs

The New Buzz: These Are The Top Examples Of Digital Therapeutics
Digital Therapeutics or DTx in short is one of the latest buzzwords in the digital health ecosystem. Unlike others (NFT, Metaverse just to name a few) however, we see DTx as a meaningful trend that has the capacity to bring short-term, substantial improvements in personalised healthcare.  What is Digital Therapeutics? The definition by the Digital Therapeutics Alliance, the main professional hub is:  “Digital therapeutics (DTx) deliver evidence-based therapeutic interventions that are driven by high-quality software programs to prevent, manage, or treat a medical disorder or disease. They are used inde...
Source: The Medical Futurist - June 21, 2022 Category: Information Technology Authors: Andrea Koncz Tags: TMF Digital Health Research Future of Medicine Health Sensors & Trackers Telemedicine & Smartphones software chronic pain apps cancer care mental health DTx digital therapeutics eczema Atopic dermatitis sleep disorders Source Type: blogs

How time flies!
 It's been a couple years since I last posted. Much has happened! My hubby has been gone almost 4 years now. The pandemic is "over". I did manage to get the delta variety and survived, but I was pretty sick. I dosed myself with ivermectin and a z-pack that I had obtained from Mexico. 10 days sick. 2 months later my hair fell out. Well - that was special! It's growing back nicely. No other side effects.Bought a little r-pod travel trailer and have spent the past 2 winters in Yuma next to my sis and her hubby. Been quite the adventure. Went out camping with 4 o...
Source: Wife of a Diabetic - June 21, 2022 Category: Endocrinology Source Type: blogs

Fight Aging! Newsletter, June 20th 2022
This study showed a negative relationship between the gaps and the number of senescence cells. Moreover, we found a similar reduction in 30-month-old naturally and 7-month-old D-gal-induced aging rats. Given these consistent data from different eukaryotic organisms, it suggests that the Youth-DNA-GAP is a marker of phenotype-related aging degree Towards Scaffold-Based Regeneration of Dental Pulp https://www.fightaging.org/archives/2022/06/towards-scaffold-based-regeneration-of-dental-pulp/ Researchers are working towards the ability to regenerate the dental pulp inside teeth. Full regeneration of teeth h...
Source: Fight Aging! - June 19, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 13th 2022
In conclusion, long-term cumulative BP was associated with subsequent cognitive decline, dementia risk, and all-cause mortality in cognitively healthy adults aged ≥50 years. Efforts are required to control long-term systolic BP and pulse pressure and to maintain adequate diastolic BP. Longer-Lived Mammals Tend to Have Lower Expression of Inflammation-Related Genes https://www.fightaging.org/archives/2022/06/longer-lived-mammals-tend-to-have-lower-expression-of-inflammation-related-genes/ Researchers here make a few interesting observations on gene expression data from a range of mammalian species with ...
Source: Fight Aging! - June 12, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Is this Myo-pericarditis? Or OMI with subsequent pericarditis? Does the angiogram always explain the ECG findings?
Conclusion: Although at 1st glance, it looked like the ECG picture in Figure-1 might be suggestive of acute pericarditis — on further inspection, there are significant ECG features against the diagnosis of acute uncomplicated pericarditis.As per the superb discussion above by Dr. Smith — evolution of this case (including the ECG picture on serial tracings) — are consistent with what probably occurred in today ' s case, namely the combination of acute OMI from LCx occlusion, followed by development of post-infarction regional pericarditis.
Source: Dr. Smith's ECG Blog - June 11, 2022 Category: Cardiology Authors: Steve Smith Source Type: blogs

Cancer Correlates with Increased Risk of Later Onset of Type 2 Diabetes
Researchers here note a correlation between cancer diagnosis and greater risk of later onset of type 2 diabetes. A reasonable guess is that this is mediated by the increased burden of cellular senescence produced by chemotherapy and radiotherapy, though, as the researchers point out, the widely different risks by cancer type may indicate that tumors are metabolically active in ways that specifically promote the metabolic dysfunction that leads to type 2 diabetes. For patients with cancer, prevalent type 2 diabetes at the date of cancer diagnosis is associated with increased cancer-specific and all-cause mortality....
Source: Fight Aging! - June 9, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Commentators and Journalists Weigh In On Digital Health And Related Privacy, Safety, Social Media And Security Matters. Lots Of Interesting Perspectives - June 07, 2022.
-----This weekly blog is to explore the news around the larger issues around Digital Health, data security, data privacy, AI / ML. technology, social media and related matters.I will also try to highlightADHA Propagandawhen I come upon it.Just so we keep count, the latest Notes from the ADHA Board were dated 6 December, 2018 and we have seen none since! It ’s pretty sad!Note: Appearance here is not to suggest I see any credibility or value in what follows. I will leave it to the reader to decide what is worthwhile and what is not! The point is to let people know what is being said / published that I have come upon.-----h...
Source: Australian Health Information Technology - June 7, 2022 Category: Information Technology Authors: Dr David G More MB PhD Source Type: blogs

Fight Aging! Newsletter, June 6th 2022
This study examines evidence suggesting that mitochondrial dysfunction plays a significant early impact on AD pathology. Although mitochondrial dysfunction is a typical indication of Alzheimer's disease, it is unclear whether the cellular systems that maintain mitochondrial integrity malfunction, aggravating mitochondrial pathology. Different levels of vigilance and preventive methods are used to reduce mitochondrial damage and efficiently destroy faulty mitochondria to maintain the mitochondrial equilibrium. The form and function of mitochondria are regulated by mitochondrial fusion and fission. In contrast, mitoch...
Source: Fight Aging! - June 5, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Glucose Fuel Cell to Power Medical Implants
Scientists at MIT created a glucose fuel cell that is small and powerful enough to conceivably power medical implants using the sugar present in our blood. The ultrathin device relies on a ceramic material as an electrolyte and platinum anodes/cathod...
Source: Medgadget - May 18, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Surgery fuel cell mit Source Type: blogs

Fight Aging! Newsletter, May 16th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 15, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing Mitochondria-Derived Peptides in Aging
Researchers have explored a number of mitochondria-derived peptides as a basis for treatments in the context of aging. These peptides are created from fragments of genes in the mitochondrial DNA, released from the cell, and appear to be involved in a range of mechanisms relevant to declining function in aging. Is it possible to supply such peptides as a therapy in order to produce benefits in an aged metabolism? A number of groups working towards that goal, on the basis of data in animal studies and humans patients. The mechanisms that explain mitochondrial dysfunction in aging and healthspan continue to be studie...
Source: Fight Aging! - May 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs