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Fecal Microbiota Transplant as a Treatment for Neurodegenerative Conditions
It is thought that an appreciable fraction of the chronic inflammation of aging is caused by changes in the gut microbiome. There is a bidirectional interaction between the immune system and the microbial populations of the intestinal tract. The immune system gardens these populations, destroying problematic microbes. Microbes secrete metabolites and other molecules that can either benefit or harm the function of the immune system, the harms caused particularly by those microbes capable of provoking a sustained inflammatory response. The immune system declines with age for a range of reasons, and reduced efficacy in immune...
Source: Fight Aging! - September 3, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Metformin Remains a Poor Choice in the Treatment of Aging
Now that we find ourselves in an era in which there is growing support and funding for the treatment of aging as a medical condition, the battle ceases to be one of persuading people to take the idea seriously, and more a matter of convincing research and development concerns to focus on projects that are more likely rather than less likely to produce meaningful gains. Rejuvenation and many added years is the desired goal, not merely a gentle slowing of aging that is little better than the results of optimal exercise and diet. Unfortunately, most of the research and development community is indeed working on projects that ...
Source: Fight Aging! - September 2, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
The Top 12 Health Chatbots In 2021
Over the past years, smart algorithm-powered, text- or voice-based interfaces have multiplied, and they are also taking their place in healthcare. The Medical Futurist believes Molly, Ginger, Replika and the others will ease the burden on doctors in primary care and help patients learn to take care of their health responsibly.
Would you like to try one? Check out the following video about healthcare chatbots:
The age of talking algorithms is here
In 2018, Google stunned the world with the latest feature of the Google Assistant, Duplex, which was able to make an appointment in a hair salon in eerily hum...
Source: The Medical Futurist - August 31, 2021 Category: Information Technology Authors: berci.mesko Tags: Artificial Intelligence in Medicine Future of Medicine Healthcare Design AI chatbot digital health Innovation List medical Personalized medicine technology chatbots health chatbot Source Type: blogs
The 9 Trends Shaping the Future of Pharma
The drug sends a message to a caregiver after the patient swallowed it. The doctor prescribes virtual reality treatments for migraines. Do you think it is science fiction? You are mistaken. Just let me familiarize you with the top 10 trends shaping the future of pharma.
And if you want to have a more in-depth analysis of the topic, read our related ebook, Technologies Shaping the Future of Pharma!
Technologies Shaping the Future of Pharma
We designed this e-book to serve as a collection of relevant examples, best practices and exciting ideas that can help any pha...
Source: The Medical Futurist - August 26, 2021 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Future of Pharma 3d printing artificial intelligence augmented reality digital health Innovation nanotechnology Personalized medicine pharmacology virtual reality VR gc4 pharmacies pharmacogenetics Source Type: blogs
The 10 Trends Shaping the Future of Pharma
The drug sends a message to a caregiver after the patient swallowed it. The doctor prescribes virtual reality treatments for migraines. Do you think it is science fiction? You are mistaken.
The pharma industry has taken a big swung into digital transformation. All participants invest in digital health topics. But as with all trending issues, and there is a lot of fuss that is hard to see through. As the medical community increasingly acknowledges the importance of digital health, the cultural shift we so often talk about is still a way to go. To change that, the first step is always getting to know what’s coming.
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Source: The Medical Futurist - August 26, 2021 Category: Information Technology Authors: berci.mesko Tags: Future of Medicine Future of Pharma 3d printing artificial intelligence augmented reality digital health Innovation nanotechnology Personalized medicine pharmacology virtual reality VR gc4 pharmacies pharmacogenetics Source Type: blogs
Fight Aging! Newsletter, August 23rd 2021
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 22, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
George Halvorson HIMSS Changemaker Lifetime Achievement Award Acceptance Speech, Part 1
Former Kaiser Permanente CEO George Halvorson has written on THCB on and off over the years, most notably last year with his proposal for Medicare Advantage for All post-COVID. This month he was given a lifetime achievement award by HIMSS and we are running his acceptance speech in two parts. Here’s part one — Matthew Holt
Thank you for giving me this first ever HIMSS Changemaker In Health Care Lifetime Achievement Award.
You are honoring an extremely impressive set of other current changemakers at this particular national meeting for 2021 and I am very honored and pleased to be the first person to b...
Source: The Health Care Blog - August 18, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology George Halvorson HIMSS Changemaker Lifetime Achievement Award Source Type: blogs
The Antagonistic Pleiotropy of IGF-1 Signaling in Aging
In this study, we used the UK Biobank (n = 440,185) to resolve previous ambiguities in the relationship between serum IGF-1 levels and clinical disease. We examined prospective associations of serum IGF-1 with mortality, dementia, vascular disease, diabetes, osteoporosis, and cancer, finding two generalized patterns.
First, IGF-1 interacts with age to modify risk in a manner consistent with antagonistic pleiotropy; younger individuals with high IGF-1 are protected from disease, while older individuals with high IGF-1 are at increased risk for incident disease or death. Second, the association between IGF-1 and risk ...
Source: Fight Aging! - August 18, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
We Need to Open Up the AI Black Box
To convince physicians and nurses that deep learning algorithms are worth using in everyday practice, developers need to explain how they work in plain clinical English.Paul Cerrato, senior research analyst and communications specialist, Mayo Clinic Platform, and John Halamka, M.D., president, Mayo Clinic Platform, wrote this article.AI ’s so-called black box refers to the fact that much of the underlying technology behind machine learning-enhanced algorithms isprobability/statistics without a human readable explanation.Oftentimes that ’s the case because the advanced math or the data science behind the algorithms is t...
Source: Life as a Healthcare CIO - August 17, 2021 Category: Information Technology Source Type: blogs
Do Senescent Cells Have Sufficiently Distinct Surface Markers to be Targeted for Destruction?
Many of the approaches to selective cell destruction pioneered in the cancer research community distinguish target cells from bystander cells via cell surface markers. Do senescent cells have a sufficiently distinct set of surface markers to safely employ this strategy to reduce the burden of cellular senescence in old tissue, and thereby produce rejuvenation of tissue function? Almost certainly yes, as the immune system uses exactly this approach to identify and kill senescent cells. Identifying the surface markers involved is a plausible goal, presently underway. Several biotech companies work on forms of senolytic immun...
Source: Fight Aging! - August 17, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, August 16th 2021
In conclusion, cancer survivors, especially older individuals, demonstrate greater odds of and accelerated functional decline, suggesting that cancer and/or its treatment may alter aging trajectories.
Linking Particulate Air Pollution and Dementia in a Small Region of the US
https://www.fightaging.org/archives/2021/08/linking-particulate-air-pollution-and-dementia-in-a-small-region-of-the-us/
It is fairly settled that evident particulate air pollution, such as daily exposure to smoke from wood-fueled cooking fires, has a strongly detrimental effect on long-term health. The mechanisms involved are inflamm...
Source: Fight Aging! - August 15, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CaMKII Oxidation in Heart Function as an Example of Antagonistic Pleiotropy
CaMKII can be oxidized readily in mammals, but not in flies. This is a small change in DNA sequence, but it produces a greater physical capacity in youth, coupled to a greater vulnerability and loss of tissue function in the environment of chronic oxidative stress characteristic of old age. This is a good example of antagonistic pleiotropy, a concept at the center of the consensus on how evolution reliably leads to the production of species that undergo aging. Individuals that reproduce successfully early in life are favored, and thus mutations - such as CaMKII vulnerability to oxidation - that provide an advantage in yout...
Source: Fight Aging! - August 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Health Care You Do Not See
By KIM BELLARD
Within a mile from my home in one direction, there are two pharmacies and a primary care office. In another direction, there’s a multi-specialty physician practice, complete with lab and pharmacy. And in a third direction, an urgent care center. Widen the circle another mile, and there are more physician offices, a plethora of other health care professionals, another urgent care, a retail clinic, and an imaging center. Add a couple more miles and hospitals – plural – to start show up.
I’m not sure that’s a good thing.
Admittedly, not everyone has so many options.&nb...
Source: The Health Care Blog - August 10, 2021 Category: Consumer Health News Authors: Christina Liu Tags: Health Tech Health Technology Kim Bellard Source Type: blogs
Fight Aging! Newsletter, August 9th 2021
In conclusion, the present study supports that some age-related diseases as well as education are causally related to longevity and highlights several new targets for achieving longevity, including management of venous thromboembolism, appropriate intake of sugar, and control of body fat. Our results warrant further studies to elucidate the underlying mechanisms of these reported causal associations.
Pol III Inhibition Extends Longevity in Short-Lived Species
https://www.fightaging.org/archives/2021/08/pol-iii-inhibition-extends-longevity-in-short-lived-species/
As this paper notes, Pol III is downstream...
Source: Fight Aging! - August 8, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Future Treatment For Autoimmune Diseases
New digital health tech targeted to fight autoimmune diseases or their symptoms are diverse and creative. These often completely different illnesses, like type 1 diabetes, inflammatory bowel disease, rheumatoid arthritis, and multiple sclerosis, indicate an immune system dysfunction. Immune cells and mechanisms target the body’s own cells and structures, deconstructing it bit by bit and inducing inflammation.
An estimated 24-50 million people in the US alone are living with autoimmune conditions. It affects their day-to-day life, but scientists suggest people living with chronic conditions could also be more suscepti...
Source: The Medical Futurist - July 29, 2021 Category: Information Technology Authors: szandra Tags: Biotechnology Future of Medicine Portable Medical Diagnostics Telemedicine & Smartphones chatbot diabetes digital health sleep optimization chronic pain chronic illness skin coronavirus autoimmune disease Source Type: blogs
