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Fight Aging! Newsletter, December 27th 2021
We report that whereas microglia are characterized by marked gene-level alterations related to negative regulation of protein phosphorylation and phagocytic vesicles, astrocytes show activation of enzyme- or peptidase-inhibitor signaling after detectable changes in BBB permeability. We also identify several genes enriched in these pathways that are notably altered after BBB breakdown. Our data reveal that microglia and astrocytes play an active role in maintaining BBB stabilization and corralling infiltrating cells, and thus might potentially function in ameliorating the lesions and neurologic disabilities in CNS diseases....
Source: Fight Aging! - December 26, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Join Dr. Davis ’ Infinite Health Boot Camp January 5th to the 14th
Undoctored is now Dr. Davis Infinite Health (www.DrDavisInfiniteHealth that goes live in early January) as its name suggests, puts personal control over health back in your hands. We continue many of the strategies of the Wheat Belly lifestyle but expand them with lessons learned through this worldwide experience, while adding new dimensions and practices. While we make the transition to Dr. Davis Infinite Health and away from Undoctored, the concepts and practices remain the same.
The Dr. Davis’ Wild, Naked, and Unwashed program causes you to revert back to the way humans were supposed to be eating and living all ...
Source: Wheat Belly Blog - December 22, 2021 Category: Cardiology Authors: April Duval Tags: Open Undoctored Source Type: blogs
Join the Undoctored Boot Camp January 5th to the 14th
Undoctored, as its name suggests, puts personal control over health back in your hands. We continue many of the strategies of the Wheat Belly lifestyle but expand them with lessons learned through this worldwide experience, while adding new dimensions and practices.
The Undoctored Wild, Naked, and Unwashed program causes you to revert back to the way humans were supposed to be eating and living all along to mimic the behavior and health of primitive people who have virtually no modern diseases such as diabetes, colon cancer, and obesity (still lived to old age if they did not succumb to injury or infection). Learn:
How...
Source: Wheat Belly Blog - December 22, 2021 Category: Cardiology Authors: April Duval Tags: Open Undoctored Source Type: blogs
Fight Aging! Newsletter, December 20th 2021
In conclusion, the low dose, prolonged angiotensin II exposure is associated with the induction of senescence in kidneys and the promotion of an inflammatory microenvironment through both secreted factors and immune cells. Endothelial cells appear to be a major cell type impacted. The elimination of senescent cells in the INK-ATTAC transgenic model prevents these effects of angiotensin II and reveals a novel pathophysiologic mechanism amenable to targeting by senolytic drugs in development.
CYTOR Upregulation as a Path to Improved Muscle Function in Later Life
https://www.fightaging.org/archives/2021/12/cytor-u...
Source: Fight Aging! - December 19, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
ANGPTL2 as a Marker of Cellular Senescence
The accumulation of senescent cells is an important contributing cause of degenerative aging. Since these cells can be specifically targeted via a range of mechanisms, and selective destruction of senescent cells produces significant and rapid rejuvenation in animal studies, there is considerable interest in the research community in finding novel ways to measure the burden of cellular senescence. Senescent cells secrete a mix of pro-growth, inflammatory molecules into circulation, and so it is possible that some of those molecules can form the basis for low-cost assays conducted on blood samples.
Cellular senesce...
Source: Fight Aging! - December 16, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Top 10 Digital Health News Of 2021
From the approval of a new prescription VR treatment to renewed privacy concerns, 2021 has been full of digital health developments. Indeed, some news might have gone under the radar or might require a quick refresher; so we’re wrapping up 2021 with a round-up of 10 of the most important digital health news of this year.
1. FDA-approved prescription VR treatment for chronic back pain
In mid-November, the FDA authorised a virtual reality (VR) system as a prescription treatment for chronic back pain. Called EaseVRx, it combines cognitive behaviour therapy techniques and breathing exercises to help relax, distract...
Source: The Medical Futurist - December 16, 2021 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Covid-19 3D Printing Health Sensors & Trackers Portable Medical Diagnostics Security & Privacy Telemedicine & Smartphones apple telehealth blood pressure A.I. 23andme news remote care 2021 Source Type: blogs
Fight Aging! Newsletter, December 13th 2021
In conclusion, there is a good amount of pre-clinical and clinical data showing a strong positive correlation between reduction of senescent cells frequencies and functional improvement of skin. Whether senescence of skin cells makes a significant causal contribution to skin ageing can still not be conclusively decided, however. Nonetheless, there is strong evidence existing today to assume that better understanding of cell senescence in skin may lead to a breakthrough in interventions into skin ageing.
Isomerization of Tau May be Involved in Alzheimer's Disease
https://www.fightaging.org/archives/2021/12/isome...
Source: Fight Aging! - December 12, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Exercise Slows Retinal Aging, but Which of the Many Mechanisms Involved are Important?
As researchers note here, there is evidence for exercise to slow retinal aging and the progression of conditions involving retinal degeneration. Exercise affects many aspects of aging, not to the same degree as the practice of calorie restriction, but likely through an overlapping set of mechanisms related to cellular stress response upregulation, including increased autophagy and mitochondrial quality control. There is is a vast forest of interacting metabolic changes to explore, however, and the research community has yet to come to a solid grasp of which of the effects of exercise are the most relevant in any given tiss...
Source: Fight Aging! - December 10, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
A Sign Of Vitamin D Deficiency In The Back Or Knees
Diseases linked to vitamin D deficiency include cardiovascular disease, diabetes and cancer.
Source: PsyBlog | Psychology Blog - December 7, 2021 Category: Psychiatry & Psychology Authors: Jeremy Dean Tags: Nutrition Source Type: blogs
Fight Aging! Newsletter, December 6th 2021
In this study, they found these drugs can kill senescent cells from cultures of human fat tissue. The tissue was donated by individuals with obesity who were known to have metabolic troubles. Without treatment, the human fat tissues induced metabolic problems in immune-deficient mice. After treatment with dasatinib and quercetin, the harmful effects of the fat tissue were almost eliminated.
Targeting p21Cip1 highly expressing cells in adipose tissue alleviates insulin resistance in obesity
Insulin resistance is a pathological state often associated with obesity, representing a major risk factor for type 2...
Source: Fight Aging! - December 5, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Adult Disruption of Growth Hormone Receptor in Mice Produces Improved Health and Longevity
Genetic engineering of mouse lineages to produce life-long disruption of growth hormone metabolism, either growth hormone itself or growth hormone receptor, extends life. Animals are smaller, more challenged in maintaining body temperature, have more fat tissue, yet enhanced insulin sensitivity, and exhibit as much as a 70% longer life span. The present record for engineered mouse longevity has been held since 2003 by growth hormone receptor knockout (GHRKO) mice. That this record still stands in 2021 might be taken as a sign that the research and development community are not yet trying hard enough to produce therapies ca...
Source: Fight Aging! - December 2, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Making first contact: What to do with all that information! part 2
Last week I described some of the reasons for using a case formulation approach when working through initial assessment information, and today I’m going to describe one approach for organising a formulation. This is the “4 P” formulation, and it’s one that’s often used in mental health (Bolton, 2014).
In the 4 P model, there are four questions to ask yourself:
Preconditions – Why is this person vulnerable to this problem?Precipitating factors – Why now? This can mean “why is this person having symptoms now?” or “why is this person presenting to this person ...
Source: HealthSkills Weblog - November 28, 2021 Category: Anesthesiology Authors: BronnieLennoxThompson Tags: Assessment Chronic pain Clinical reasoning Pain conditions Professional topics Research Science in practice biopsychosocial case formulation Occupational therapy pain management Therapeutic approaches Source Type: blogs
Fight Aging! Newsletter, November 29th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - November 28, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
How advanced analytics can help social determinants of health
Health care costs in the U.S. have increased dramatically over the past five decades, from $74 billion in 1970 to $3.8 trillion in 2019. This trend has been fueled in large part by an increase in the number of people who struggle with chronic conditions such as cancer, diabetes, hypertension, and lung disease. Stanford UniversityRead more …How advanced analytics can help social determinants of health originally appeared inKevinMD.com.
Source: Kevin, M.D. - Medical Weblog - November 25, 2021 Category: General Medicine Authors: < span itemprop="author" > < a href="https://www.kevinmd.com/blog/post-author/mike-dulin" rel="tag" > Mike Dulin, MD, PhD < /a > < /span > Tags: Policy Public Health & Source Type: blogs
Fight Aging! Newsletter, November 22nd 2021
This study nicely illustrates the importance of the cellular metabolic state of myeloid cells: it highlights that not only the availability of glucose, but also its channeling into different pathways (glycolysis versus glycogen synthesis) contributes to maintaining proper myeloid function.
On the Ability of Redundant Blood Vessels to Lower Cardiovascular Mortality
https://www.fightaging.org/archives/2021/11/on-the-ability-of-redundant-blood-vessels-to-lower-cardiovascular-mortality/
A few strategies offer the possibility of growing additional redundant blood vessels, though this is far from rigorously pr...
Source: Fight Aging! - November 21, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
