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Fight Aging! Newsletter, May 24th 2021
In conclusion, we showed that addition of resistance exercise training, but not dietary EAAs, to the myostatin inhibition further increased muscle mass through the attenuation of muscle protein breakdown with proportionate improvements in muscle strength. Interestingly, addition of dietary EAAs to the myostatin inhibition with or without resistance exercise training improved muscle quality. Thus, dissection of the underlying mechanisms behind the combined positive effect of dietary EAAs and resistance exercise training on muscle mass and quality can shed light on the discovery of effective therapeutics against muscle wasti...
Source: Fight Aging! - May 23, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

On Balance, Vegetarians Exhibit Better Biomarkers than Non-Vegetarians
There is a fair amount of epidemiological data to suggest that vegetarians have, on balance, better long-term health prospects than people who consume meat. The usual caveats apply, in that vegetarianism in many wealthier study populations is correlated with a range of other potentially relevant line items, such as education, wealth, and better lifestyle choices. Further, the average vegetarian may well be mildly calorie restricted in comparison to the average meat eater, and that may be enough in and of itself to explain health effects. Other suggested contributing factors include dietary advanced glycation end-products, ...
Source: Fight Aging! - May 18, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Epistemology VI: Epidemiology
Epidemiology originally largely meant studying how infectious diseases spread, and that ' s still a major concern of epidemiologists. However, it also includes the study of any and every environmental or behavioral factor affecting human health. For example, the finding that smoking tobacco causes lung cancer (not to mention a bazillion other diseases) is an epidemiological finding.  Epidemiology is largely an observational science, given the ethical prohibition against exposing humans to potentially hazardous conditions for experimental purposes. That ' s not to say it hasn ' t been done, with the victims being ...
Source: Stayin' Alive - May 17, 2021 Category: American Health Source Type: blogs

Fight Aging! Newsletter, May 17th 2021
This study is consistent with previous evidence showing that inflammaging, or age-related inflammation, is naturally heightened in the nervous system. Moreover, the authors disproved their hypothesis that anti-inflammatory microglia-specific genes are responsible for the elevated inflammatory response in aged brains since the expression of anti-inflammatory mediators was elevated in middle-aged brains following infection. Thus, the cause for the increase in pro-inflammatory genes remains to be elucidated. Mixed Results in Animal Studies of Gene Therapy Targeting Axonal Regrowth https://www.fightaging.org/archiv...
Source: Fight Aging! - May 16, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Towards Many Efforts to Produce Rejuvenation Therapies Based on Cellular Reprogramming
There is enthusiasm in the research community for in vivo cellular reprogramming as a path to treat aging. Reprogramming somatic cells to pluripotency recaptures some of the processes that take place in the developing embryo, and has been shown to restore youthful patterns of gene expression, leading to improved mitochondrial function. Reprogramming can't do much for DNA damage or forms of persistent molecular waste in long-lived cells, but forms of reprogramming may be able to improve tissue function to a sizable enough degree to be worth the effort. Early results in mice are promising. There is a long way to go in order ...
Source: Fight Aging! - May 13, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Tips for Managing Obsessive Stressing About Potential Disease
Many people are genetically predisposed to developing certain diseases, among them diabetes, cancer, heart disease and Alzheimer’s. It’s natural to worry if you’ve watched family members endure the illnesses. However, the cortisol released in your body by chronic stress, which can be caused by worry, could increase your susceptibility. The fix? Be proactive. Limiting stress may not completely protect you from the disease that you dread, but it can help your overall health and, for some diseases, this could help you avoid a trigger. Where do you start? Continue reading on HealthCentral to pick up some tips that might ...
Source: Minding Our Elders - May 8, 2021 Category: Geriatrics Authors: Carol Bradley Bursack Source Type: blogs

Foreword to Wheat Belly Revised & Expanded Edition
  An excerpt from the Wheat Belly Revised & Expanded Edition: Have you ever come home from the grocery store with a fresh container of milk, opened it and immediately realized that it was bad—sour-smelling, curdled, unfit to drink?  Feed it to the cat? Probably not. Lighten your coffee? I don’t think so. Pour it down the sink—yeah, that’s the ticket. Or maybe go back to the store with some of the curdled remains and ask for your money back.  That is what your reaction to conventional dietary advice should be. You should wrinkle your nose at the bad smell that emanates from advice that creates an astonish...
Source: Wheat Belly Blog - May 7, 2021 Category: Cardiology Authors: Dr. Davis Tags: Open grain-free wheat belly Source Type: blogs

Healthcare AI, Limiting Biases, and Gold Standard Data Sets: Exclusive with Vatsal Ghiya, CEO of Shaip
Shaip is an online platform that focuses on healthcare AI data solutions and offers licensed healthcare data designed to help construct AI models. It provides text-based patient medical records and claims data, audio such as physician recordings...
Source: Medgadget - May 4, 2021 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive Informatics Source Type: blogs

Fight Aging! Newsletter, May 3rd 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - May 2, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reviewing Myostatin in Muscle Growth, and Efforts to Produce Myostatin-Targeted Therapies
Myostatin is one of the better targets for enhancement therapies from the point of view of feasibility and existing data on its effects. Myostatin suppresses muscle growth via intracellular signaling. A range of possible methods exist to interfere in this process, some of which have been trialed in human patients: reducing production of myostatin, binding to circulating myostatin with antibodies to ensure clearance, preventing myostatin from binding to cell surface receptors in other ways, upregulation of follistatin, an antagonist to myostatin, and so forth. Myostatin loss of function mutants, natural and artificial, exis...
Source: Fight Aging! - April 28, 2021 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

It ’s OK to Break the Rules Now and Then
This study introduces an augmented intelligence platform for the real-time synthesis of institutional knowledge captured in EHRs.” One caveat that the researchers acknowledge in the report was that they had yet to conduct prospective validation of the augmented EHR curation approach.A second nference-based investigation reviewed the records of patients who had received more than 94,000 doses of the Pfizer COVID-19 vaccine, more than 36,000 doses of the Moderna vaccine, and 1,745 doses of the Johnson& Johnson vaccine. The study ’s goal was to determine the incidence of cerebral venous sinus thrombosis (CVST), w...
Source: Life as a Healthcare CIO - April 26, 2021 Category: Information Technology Source Type: blogs

Fight Aging! Newsletter, April 26th 2021
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 25, 2021 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Health effects of partial hydrogenation of vegetable oils
Partially hydrogenated vegetable oils contain trans fatty acids which are different from the natural fatty acids in vegetable oils and animal fat [1]. Fatty acids in partially hydrogenated vegetable oils are 14 cis and trans isomers of octadecenoic and octadecadienoic acids that are formed during hydrogenation. Trans fatty acids cause inflammation and calcification of arterial walls. They also inhibit cyclooxygenase needed for conversion of arachidonic acid to prostacyclin, a compound beneficial for the vascular tree. There are reformulations of hydrogenated fat containing the essential fatty acid linoleic acid which get...
Source: Cardiophile MD - April 25, 2021 Category: Cardiology Authors: Prof. Dr. Johnson Francis Tags: Cardiology Source Type: blogs

5 Insights About The Future Of Health Insurance In The Digital Health Age
The global health insurance market has been experiencing a declining growth rate in recent years; from 9% in 2014-2015 to 6-7% in subsequent years. The 2019 Forbes report that pointed this out also attributes this decline partly to the low adoption of digital solutions in this sector. But those very same solutions can transform the market. Already with futuristic technologies like clinical grade personal health sensors, at-home genome sequencing kits and artificial intelligence, healthcare is receiving a much-needed overhaul that democratises access to quality care. The health insurance industry could also ride on those sa...
Source: The Medical Futurist - April 22, 2021 Category: Information Technology Authors: berci.mesko Tags: 3D Printing Artificial Intelligence in Medicine Health Insurance Health Sensors & Trackers Healthcare Design Healthcare Policy Medical Education Telemedicine & Smartphones amazon bioprinting data patient gc4 Fitbit genome seque Source Type: blogs

Calorie Restriction as an Adjuvant Cancer Treatment
Calorie restriction and intermittent fasting have been extensively studied in the context of aging, and most of the age-slowing interventions so far tested in animal studies are derived in some way from a knowledge of the stress response mechanisms triggered by a lowered calorie intake. The long term effects of calorie restriction and fasting in short-lived species are quite different from those in long-lived species: only the short-lived species exhibit a meaningful extension of life span, as much as 40% in mice. Yet the short-term effects on metabolism and cellular mechanisms are very similar. The beneficial response to ...
Source: Fight Aging! - April 19, 2021 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs