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Taurine Supplementation Slows Aging, Extends Life in Mice
Taurine levels drop with age, and correlate with health in aged humans. Researchers here show evidence for taurine supplementation to improve health and extend life span in mice. While it isn't mentioned in this paper, if one takes a look around the literature on this topic, taurine may act on the pace of aging by increasing levels of the antioxidant enzyme glutathione, and has been shown to diminish oxidative stress. You may recall that supplementation with glutathione precursors has been shown to improve health in both old mice and old humans. Glutathione itself is harder to deliver directly, hence the more indirect stra...
Source: Fight Aging! - June 16, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Career Conversations: Q & A With Physiologist Elimelda Moige Ongeri
Credit: Courtesy of Dr. Elimelda Moige Ongeri. A career path in science is rarely clear cut and linear, which Elimelda Moige Ongeri, Ph.D., can attest adds to its excitement. She went from working in animal reproductive biology to studying proteins involved in inflammation and tissue injury. Dr. Ongeri is also currently dean of the Hairston College of Health and Human Sciences and professor of physiology at North Carolina Agricultural and Technical State University (NC A&T) in Greensboro. In this interview, she shares details of her career, including a change in research focus to human physiology; her goals for the f...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - June 14, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Profiles Proteins Source Type: blogs

Better Health Care Tests, Faster
This article looks at some specific problems and solutions. Speeding up Test Development We’ve seen with COVID-19 how quickly a virus can evolve and how hard it is to design both tests and vaccinations that accommodate different variants. Virax Biolabs uses data from the World Health Organization and others to develop tests quickly. For instance, new viral variants tend to spread in the southern hemisphere before hitting the northern hemisphere in our Winter, so Virax can check existing data to prepare better tests for the North. The company is developing a T-cell diagnostics and profiling platform called Virax Immu...
Source: EMR and HIPAA - June 13, 2023 Category: Information Technology Authors: Andy Oram Tags: Health IT Company Healthcare IT Hospital - Health System Interoperability CLIA COVID-19 Hydreight Immunexpress ixlayer Laboratories Labs Rolland Carlson Sepsis Sepsis Lab Tests Septicyte Shane Madden testing Tomasz George Source Type: blogs

Fight Aging! Newsletter, June 12th 2023
In this study, we investigated the effect of NXP032 on neurovascular stabilization through the changes of PECAM-1, PDGFR-β, ZO-1, laminin, and glial cells involved in maintaining the integrity of the blood-brain barrier (BBB) in aged mice. NXP032 was orally administered daily for 8 weeks. Compared to young mice and NXP032-treated mice, 20-month-old mice displayed cognitive impairments in Y-maze and passive avoidance tests. NXP032 treatment contributed to reducing the BBB damage by attenuating the fragmentation of microvessels and reducing PDGFR-β, ZO-1, and laminin expression, thereby mitigating astrocytes and microglia ...
Source: Fight Aging! - June 11, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Surveying Laboratory Tests From a Health IT Perspective
We read that “70% of today’s medical decisions depend on laboratory test results,” according to the CDC. This three-part series looks at modern tests from a health IT perspective. How can we make them more accurate and delivery faster results? Which ones can we move into the home? How do we eliminate wasteful, unnecessary tests? This first article offer an overview of tests and their context. Overview of Testing Gerry Miller, founder and CEO of Cloudticity, classifies the value of a test by several factors: How easy is the test to acquire? How complex is the test to administer? How much does it cost? Most im...
Source: EMR and HIPAA - June 7, 2023 Category: Information Technology Authors: Andy Oram Tags: Health IT Company Healthcare IT Interoperability CDC CLIA Cloudicity Direct to Consumer Lab Testing Dr. Yair Lewis Epstein Becker Green Gerry Miller Healthcare Interoperability IVD Laboratories Labs Navina Robert Hearn Sand Source Type: blogs

An Example of In Silico Drug Screening for Senolytic Compounds
The average small molecule drug development program starts with a mechanism, an intended outcome such as inhibition, and then screening of as many molecules as possible from the libraries. Sometimes it is possible to make educated guesses as to what types of molecule are more likely to be useful, but often screening must be very broad and with little direction. In principle, low cost computation makes it possible to dramatically reduce the cost of discovery of useful molecules given a specific target mechanism. This shift from physical to in silico screening has been underway for a while, for example at Insilico Medicine, ...
Source: Fight Aging! - June 5, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Evidence-based hope in diabetes
In this study, the people with type 2 diabetes who didn’t have any of those extra risk factors, they’re likely to have had their first heart attack was less than people who didn’t have diabetes.So again, it’s only one study. I don’t want to overstate it, but the purpose of this is to say this is what’s possible. With good care, decent care, odds are pretty good, you can do well. And again, live a long and healthy life. So, evidence-based hope. Guys, what do you think?  Scott K. Johnson: I mean, that looks wonderfu...
Source: Scott's Diabetes Blog - June 1, 2023 Category: Endocrinology Authors: Scott K. Johnson Tags: Blog Posts Source Type: blogs

Fight Aging! Newsletter, May 29th 2023
In this study, we used a Drosophila model to understand the role of the dec2P384R mutation on animal health and elucidate the mechanisms driving these physiological changes. We found that the expression of the mammalian dec2P384R transgene in fly sleep neurons was sufficient to mimic the short sleep phenotype observed in mammals. Remarkably, dec2P384Rmutants lived significantly longer with improved health despite sleeping less. In particular, dec2P384R mutants were more stress resistant and displayed improved mitochondrial fitness in flight muscles. Differential gene expression analyses went on to reveal several altered tr...
Source: Fight Aging! - May 28, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

ChatGPT In Healthcare: What Science Says
This study demonstrates that ChatGPT, a large language model, can assist in radiologic decision-making at the point of care, achieving moderate to high accuracy in determining appropriate imaging steps for breast cancer screening and breast pain evaluation, although limitations of the model, such as misalignment and “hallucinations”, must be considered when designing clinically-oriented prompts for use with large language models.Analysis of large-language model versus human performance for genetics questionsMedrxivThe use of language models like ChatGPT in clinical genetics has the potential to provide rapid an...
Source: The Medical Futurist - May 25, 2023 Category: Information Technology Authors: Pranavsingh Dhunnoo Tags: TMF Artificial Intelligence in Medicine ChatGPT digital health large language models ChatGPT in healthcare AI in healthcare AI in medicine Source Type: blogs

Fight Aging! Newsletter, May 22nd 2023
Conclusions to be Drawn A High Fat Diet Accelerates Atherosclerosis Less Directly than One Might Suspect How to Construct Measures of Biological Age A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls In Search of Distinctive Features of the Gut Microbiome in Long-Lived Individuals Greater Fitness in Humans Implies a Younger Epigenome and Transcriptome Intestinal Barrier Dysfunction as a Feature of Aging in Many Species NAFLD as an Age-Related Condition Towards Sensory Hair Cell Regeneration in the Inner Ear Raised Levels of PLG...
Source: Fight Aging! - May 21, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Major conditions strategy: call for evidence
Department of Health and Social Care -A call for evidence has been launched to invite views on how best to prevent, early diagnose, treat, and manage the six major groups of conditions which drive-ill health and contribute to the burden of disease in the population in England. The six major health conditions – cancer; cardiovascular diseases including stroke and diabetes; chronic respiratory diseases; dementia; mental ill-health and; musculoskeletal disorders – affect millions of people in England with data showing that one in four suffer from two or more of these major long-term conditions.Call for evidenceDepartment ...
Source: Health Management Specialist Library - May 17, 2023 Category: UK Health Authors: The King ' s Fund Library Tags: Consultations Source Type: blogs

A Long-Term Comparison of Metformin in Diabetics with Non-Diabetic Controls
We examined longevity in type 2 diabetes (T2D) patients treated with metformin therapy and compared them to matched controls and T2D patients treated with sulphonylurea therapy. Looking at individuals over a period of up to twenty years we showed that T2D patients had shorter survival times after first treatment than matched controls. When the study period was artificially truncated, we found a statistically significant benefit of metformin therapy for longevity over matched non-diabetic controls within the first three years. However, this benefit disappeared when we looked over longer periods of time (after five years). ...
Source: Fight Aging! - May 15, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Bonus Features – May 14, 2023 – Only 16% of organizations are using data to define clinical best practices, 84% of orgs hit with ransomware attacks lose revenue, and more
This article will be a weekly roundup of interesting stories, product announcements, new hires, partnerships, research studies, awards, sales, and more. Because there’s so much happening out there in healthcare IT we aren’t able to cover in our full articles, we still want to make sure you’re informed of all the latest news, announcements, and stories happening to help you better do your job. News In a temporary rule, the Drug Enforcement Administration (DEA) and the Substance Abuse and Mental Health Services Administration (SAMHSA) extended telemedicine flexibilities for prescribing controlled medications for six m...
Source: EMR and HIPAA - May 14, 2023 Category: Information Technology Authors: Brian Eastwood Tags: Health IT Company Healthcare IT athenahealth AVIA Marketplace Belong.life Chris Lance Controlled Substances DEA directtrust DrFirst eClinicalWorks eCW Edifecs EPIC iO AURA ePrescribing Equiva Health Forrester Health3PT Source Type: blogs

Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species. We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs