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Fight Aging! Newsletter, April 3rd 2023
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter,
please visit:
https://www.fightaging.org/newsletter/
Longevity Industry Consulting Services
Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - April 2, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 27th 2023
This study has potentially significant implications in the field of OA as it provides a novel strategy for OA treatment.
A Vicious Cycle of Heart Failure and Dementia
https://www.fightaging.org/archives/2023/03/a-vicious-cycle-of-heart-failure-and-dementia/
The end of life is not pretty. The body is a failing machine of many complex essential parts, and the failures cascade and feed into one another as it breaks down. There is pain, loss of capacity, loss of the self as the brain runs down. There is a tendency to paper over the ugly reality in public discussion, to not talk about the facts of the matter,...
Source: Fight Aging! - March 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Levels Is Making Metabolism and Blood Glucose Tracking Accessible To Everyone
Levels has done something truly transformative: the company made continuous glucose monitors (CGMs) accessible to the general population and every day consumer.
In many circles, it seems the trend of bringing healthcare to the home and directly to...
Source: Medgadget - March 23, 2023 Category: Medical Devices Authors: Alice Ferng Tags: Exclusive Medicine Sports Medicine CGM glucose Levels Source Type: blogs
Empowering Stroke Survivors: Interview with Kirsten Carroll, General Manager at Kandu Health
Kandu Health, a digital health company based in California, has developed a platform to assist stroke survivors with aftercare. Healthcare for stroke patients is primarily focused on acute care to limit the damage caused by the stroke. However, the c...
Source: Medgadget - March 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Rehab kanduhealth stroke rehab Source Type: blogs
Empowering Stroke Survivors: Interview with Kirsten Carroll, CEO at Kandu Health
Kandu Health, a digital health company based in California, has developed a platform to assist stroke survivors with aftercare. Healthcare for stroke patients is primarily focused on acute care to limit the damage caused by the stroke. However, the c...
Source: Medgadget - March 20, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Exclusive Neurology Rehab kanduhealth stroke rehab Source Type: blogs
On Adipose Tissue Inflammation in Aging
One of the more important reasons not to carry excess fat tissue is that it becomes ever more inflammatory with age, particularly visceral fat. Chronic, unresolved inflammation is a feature of aging that accelerates the onset and progress of all of the common fatal age-related conditions. To the degree that excess fat tissue contributes to this inflammation, one might argue that it is accelerating aging. The contribution of fat to this form of immune system dysfunction is a two-way street, as noted here. In part, the contribution of fat to inflammation becomes worse with age because of harmful changes in the immune system ...
Source: Fight Aging! - March 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Cellular Senescence in Type 2 Diabetes
It has been a few years since researchers suggested a role for senescent cells in mediating the damage done by excess fat tissue in the context of type 2 diabetes. Senescent cells accumulate with age, but accumulate significantly faster in people who are meaningfully overweight or obese. The inflammatory signaling produced by lingering senescent cells is disruptive of tissue structure and function throughout the body, and that includes problems in the insulin-generating regions of the pancreas that take place in diabetes patients. Interestingly, senescent cells may also be important in type 1 diabetes, a completely differe...
Source: Fight Aging! - March 20, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo.
T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions
https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/
Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, March 13th 2023
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 12, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Misfolded Proteins Accumulate with Age in Nematodes and Mice
In this study, we report the extensive and progressive accumulation of misfolded proteins during natural aging/senescence in different models, in the absence of disease. We coined the term age-ggregates to refer to this subset of proteins. Our findings demonstrate that age-ggregates exhibit the main characteristics of misfolded protein aggregates implicated in PMDs, including insolubility in detergents, protease-resistance, and staining with dyes specific for misfolded aggregates. Misfolded protein aggregates with these characteristics are thought to be implicated in some of today most prevalent diseases, including Alzheim...
Source: Fight Aging! - March 10, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Comparing Protein Restriction and Isoleucine Restriction in Aged Mice
Proteins are made up of amino acids. It is known that reducing only protein in the diet, while maintaining the same calorie intake, produces a modest slowing of aging. Some of the beneficial effects of reduced calorie intake, such as upregulation of autophagy and improved cell maintenance, are triggered by sensing protein levels rather than other components of diet. The sensor mechanisms are more specific than simply protein as a whole, however, and can be triggered by reducing levels of individual essential amino acids, meaning amino acids that are required for protein synthesis in cells, but must be consumed because they...
Source: Fight Aging! - March 9, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, March 6th 2023
In this study, we develop a rFOXN1 fusion protein that contains the N-terminal of CCR9, FOXN1, and TAT. We show here that, when injected intravenously (i.v.) into aged mice, the rFOXN1 fusion protein can migrate into the thymus and enhance T cell generation in the thymus, resulting in increased number of peripheral T cells. Our results suggest that the rFOXN1 fusion protein has the potential to be used in preventing and treating T cell immunodeficiency in the older adult.
Increased miR-181a-5p Expression Improves Neural Stem Cell Activity, Learning, and Memory in Old Mice
https://www.fightaging.org/archives/202...
Source: Fight Aging! - March 5, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Economics 101 continued
While the fictitious Free Market ™ fails to produce the purported paradise in general, the concept is glaringly absurd in the case of health care.* In the first place, asymmetrical information is part of the definition of the service -- the produce is expertise. If I knew everything my doctor knows, I wouldn ' t need one. In the second place, it has positive externalities that produce public goods. Infectious disease control is maybe the most obvious, but a healthier workforce, not having to watch people suffering and dying in the streets, † and fewer families psychologically burdened by premature loss are among the ma...
Source: Stayin' Alive - March 4, 2023 Category: American Health Source Type: blogs
Connecting NANOG Expression with the Response to Methionine Restriction
Calorie restriction is known to slow aging, albeit to a much greater degree in short-lived species than in long-lived species. Finding important mechanisms involved in the beneficial response to calorie restriction continues to be a major focus on the research community, even though it is questionable as to whether this is a good approach to the treatment of aging. A sizable fraction of the response to calorie restriction appears to be mediated by methionine sensing, at least judging by the degree to which reducing methioninine intake can reproduce the benefits of full calorie restriction.
In today's open access pap...
Source: Fight Aging! - February 27, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Fight Aging! Newsletter, February 27th 2023
This study tested the hypothesis that ischemic vascular repair in aging by Ang-(1-7) involves attenuation of myelopoietic potential in the bone marrow and decreased mobilization of inflammatory cells.
Young or Old male mice of age 3-4 and 22-24 months, respectively, received Ang-(1-7) for four weeks. Myelopoiesis was evaluated in the bone marrow (BM) cells by carrying out the colony forming unit (CFU-GM) assay followed by flow cytometry of monocyte-macrophages. Expression of pro-myelopoietic factors and alarmins in the hematopoietic progenitor-enriched BM cells was evaluated. Hindlimb ischemia (HLI) was induced by ...
Source: Fight Aging! - February 26, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
