Filtered By:
Therapy: Immunotherapy

This page shows you your search results in order of date. This is page number 11.

Order by Relevance | Date

Total 418 results found since Jan 2013.

RSNA 2019 AI Round-Up
Shah Islam Hugh Harvey By HUGH HARVEY, MBBS and SHAH ISLAM, MBBS AI in medical imaging entered the consciousness of radiologists just a few years ago, notably peaking in 2016 when Geoffrey Hinton declared radiologists’ time was up, swiftly followed by the first AI startups booking exhibiting booths at RSNA. Three years on, the sheer number and scale of AI-focussed offerings has gathered significant pace, so much so that this year a decision was made by the RSNA organising committee to move the ever-growing AI showcase to a new space located in the lower level of the North Hall. In some ways it made sense to offe...
Source: The Health Care Blog - December 10, 2019 Category: Consumer Health News Authors: Christina Liu Tags: Artificial Intelligence Health Tech Start-Ups AI Hugh Harvey Radiology RSNA RSNA 2019 RSNA19 Shah Islam Source Type: blogs

AI Tool to Predict Checkpoint Therapy ’s Effectiveness
Researchers from Case Western Reserve University have developed a new computational tool to predict, based on CT imaging, whether lung cancer patients will benefit from immune-checkpoint inhibitor cancer therapy. This is an exciting development for p...
Source: Medgadget - December 2, 2019 Category: Medical Devices Authors: Siavash Parkhideh Tags: Informatics Medicine Source Type: blogs

Gene Delivery Device to Make Engineered Cell Therapies Much Cheaper
Engineered cell treatments, such as CAR-T cell cancer immunotherapies and hematopoietic stem cell gene therapies, are extremely expensive. In large part that is because it’s not easy to grow myriads of precisely engineered cells that are origin...
Source: Medgadget - November 27, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Genetics Source Type: blogs

Fight Aging! Newsletter, November 25th 2019
This study demonstrates for the first time that senescent cells secrete functional LTs, significantly contributing to the LTs pool known to cause or exacerbate idiopathic pulmonary fibrosis. Against Senolytics https://www.fightaging.org/archives/2019/11/against-senolytics/ There is no consensus in science that is so strong as to have no heretics. So here we have an interview with a naysayer on the matter of senolytic treatments, who argues that the loss of senescent cells in aged tissues will cause more harm to long-term health than the damage they will do by remaining. To be clear, I think this to be a ...
Source: Fight Aging! - November 24, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, October 14th 2019
In conclusion, a polypharmacology approach of combining established, prolongevity drug inhibitors of specific nodes may be the most effective way to target the nutrient-sensing network to improve late-life health. Deletion of p38α in Neurons Slows Neural Stem Cell Decline and Loss of Cognitive Function in Mice https://www.fightaging.org/archives/2019/10/deletion-of-p38%ce%b1-in-neurons-slows-neural-stem-cell-decline-and-loss-of-cognitive-function-in-mice/ Researchers here provide evidence for p38α to be involved in the regulation of diminished neural stem cell activity with age. It is thought that the ...
Source: Fight Aging! - October 13, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, October 7th 2019
In conclusion, our findings link the calcification of the vascular tissue with the expression of FGF23 in the vessels and with the elevation of circulating levels this hormone. Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance https://www.fightaging.org/archives/2019/09/permanently-boosting-levels-of-natural-killer-cells-in-mice-to-increase-cancer-resistance/ Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the ...
Source: Fight Aging! - October 6, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

New Imaging Technique Reveals Deep Tumors, Helps Attack Them
Tumors deep inside the body can be very difficult to spot, track, and study. The brain, being surrounded by a thick skull, is particularly challenging to image using light, so MRI and CT are currently the go-to imaging modalities when looking at deep...
Source: Medgadget - October 3, 2019 Category: Medical Devices Authors: Medgadget Editors Tags: Diagnostics Neurology Neurosurgery Oncology Radiology Source Type: blogs

Permanently Boosting Levels of Natural Killer Cells in Mice to Increase Cancer Resistance
Researchers here demonstrate a very interesting approach to immunotherapy: they introduce engineered stem cells in mice that will give rise to additional natural killer T cells, boosting the capability of the immune system for the entire life span of the mouse. Even if this class of treatment is not actually permanent in the same way in humans, and merely long-lasting, it still seems a promising step towards enhancing the immune system at any age, not just trying to repair it when it fails in later life. They've been called the "special forces" of the immune system: invariant natural killer T cells. Although there...
Source: Fight Aging! - September 30, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Chimeric Antigen Receptor T Cells as a Treatment for Fibrosis
Chimeric antigen receptor (CAR) T cell therapies are used to treat cancer, engineering T cells to be more aggressive towards cancer cells. The approach has proven quite effective in comparison to past treatments for a number of cancer types. In principle this CAR-T immunotherapy can be used to target any cell population that has distinct surface markers, not just cancer cells. Here, researchers demonstrate the ability to destroy the fibroblasts responsible for generating fibrosis in the aging heart. Fibrosis is a form of dysregulated tissue maintenance, in which cells build up scar-like deposits of collagen that degrade ti...
Source: Fight Aging! - September 18, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 9th 2019
We examined human lung tissue from COPD patients and normal control subjects, and found a substantial increase in p16-expressing alveolar cells in COPD patients. Using a transgenic mouse deficient for p16, we demonstrated that lungs of mice lacking p16 were structurally and functionally resistant to CS-induced emphysema due to activation of IGF1/Akt regenerative and protective signaling. Fat Tissue Surrounds Skeletal Muscle to Accelerate Atrophy in Aging and Obesity https://www.fightaging.org/archives/2019/09/fat-tissue-surrounds-skeletal-muscle-to-accelerate-atrophy-in-aging-and-obesity/ Researchers her...
Source: Fight Aging! - September 8, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Destroying CD163 Tumor Associated Macrophages Allows the Immune System to Better Attack a Cancer
Cancers tend to subvert portions of the immune system into aiding and protecting growth of tumors. The innate immune cells known as macrophages are involved in growth and regeneration, and populations of macrophages resident in tumors become a part of the cancer process. Some of these macrophages have clear surface markers, and can thus be targeted for destruction. Researchers here demonstrate that doing this allows the rest of the immune system to more aggressively attack a tumor. This class of approach may turn out to be quite effective when combined with other forms of immunotherapy that are focused on making T cells mo...
Source: Fight Aging! - September 4, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, August 19th 2019
In conclusion, our data show how oncogenic and tumor-suppressive drivers of cellular senescence act to regulate surveillance processes that can be circumvented to enable SnCs to elude immune recognition but can be reversed by cell surface-targeted interventions to purge the SnCs that persist in vitro and in patients. Since eliminating SnCs can prevent tumor progression, delay the onset of degenerative diseases, and restore fitness; since NKG2D-Ls are not widely expressed in healthy human tissues and NKG2D-L shedding is an evasion mechanism also employed by tumor cells; and since increasing numbers of B cells express NKG2D ...
Source: Fight Aging! - August 18, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Support for LIfT Biosciences to Develop the LIFT Approach to a Universal Cancer Therapy
It is good to see that more of the promising technical approaches to aspects of aging, originally put forward by people in the SENS rejuvenation research network some years ago, are now making solid progress towards commercial implementation. The LIFT, or GIFT, approach to cancer therapy involves the transplantation of suitably aggressive leukocyte or granulocyte immune cells from a donor. At the time it was first demonstrated to be highly effective in mice, more than a decade ago, the underlying mechanisms were not well explored, and that always makes it hard to obtain further support from scientific funding institutions....
Source: Fight Aging! - August 15, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Improved Quality of Care as the Major Goal for the Merger of Pathology and Radiology
I recently returned to the topic of merging pathology and radiology after a thirteen year hiatus (see:Increasing Interest in Merging the Specialties of Pathology and Radiology). This caused me to reflect on the question of why this idea has remained dormant despite the fact that (I believe) it's worthy of serious consideration. This question, in turn, caused me to think about the factors that serve as incentives for major changes in hospitals and healthcare. I came up with the following four drivers for change emanating from either the C-suite or hospital physician leadership. These factors may operate singly or ...
Source: Lab Soft News - August 13, 2019 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Testing Diagnostics Electronic Health Record (EHR) Healthcare Business Healthcare Innovations Hospital Financial Lab Industry Trends Quality of Care Source Type: blogs

Jim Mellon Interviewed by Adam Ford at Undoing Aging 2019
Adam Ford of Science, Technology, and the Future carried out a number of interviews while at Undoing Aging in Berlin earlier this year. The interview materials are steadily being processed and uploaded, and that just recently included this interview with Jim Mellon, billionaire investor and philanthropist, cofounder of Juvenescence, and a very down to earth fellow who is interested in improving the human condition by targeting aging with new biotechnologies. Accordingly, he has used his resources to put himself into a position to talk up the longevity industry, move research forward, and attract a great deal more funding f...
Source: Fight Aging! - August 12, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs