Filtered By:
Therapy: Immunotherapy

This page shows you your search results in order of date. This is page number 3.

Order by Relevance | Date

Total 418 results found since Jan 2013.

Senescent Cells as a Cancer Vaccine
Researchers here note the discovery that vaccinating mice with senescent cancer cells ensures that the immune system will more aggressively attack a later introduction of cancerous cells. Since we know that most cancer therapies induce senescence in cancerous cells to a fair degree, one has to think that the effectiveness of this approach will diminish as a cancer progresses to form a solid tumor and co-opts the immune system in various ways. Still, it sounds as though it could be a potentially useful after, for example, surgical resection of a tumor, to help reduce the odds that the cancer will reoccur. Scientis...
Source: Fight Aging! - November 9, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, November 7th 2022
In conclusion, the national prevalence of dementia and MCI in 2016 found in this cross-sectional study was similar to that of other US-based studies. Clearing Microglia Reverses Age-Related Disruption of Sleeping Patterns in Mice https://www.fightaging.org/archives/2022/11/clearing-microglia-reverses-age-related-disruption-of-sleeping-patterns-in-mice/ Microglia are innate immune cells of the central nervous system. They are analogous to macrophages in the rest of the body, but undertake additional duties relating to the function of neurons and in brain tissue. Microglia become overly active and inflamma...
Source: Fight Aging! - November 6, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Reprogramming as an Approach to Reduce T Cell Exhaustion
T cell exhaustion occurs following repeated stimulation, such as when faced with a growing cancer or persistent viral infection. It manifests as a progressive loss of function, the T cells no longer attacking pathogens or errant cells. Finding a way to minimize this phenomenon would assist in a range of conditions, such as by improving the outcome of T cell immunotherapies targeting cancer, and might help improve the aged immune system, in which T cell exhaustion is also observed. Here, the use of partial reprogramming is suggested as an approach to achieve this goal. In partial reprogramming, cells are exposed to the fact...
Source: Fight Aging! - October 31, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

3D Bioprinted Breast Tumors for Immunotherapy Testing
A team of scientists at Penn State has bioprinted breast tumor mimics with significant complexity, including a form of vascularization and the ability to precisely place cells in certain locations within the construct. The scientists used a technique...
Source: Medgadget - October 27, 2022 Category: Medical Devices Authors: Conn Hastings Tags: Materials Medicine Oncology Source Type: blogs

Fight Aging! Newsletter, October 17th 2022
This study investigated whether multimorbidity is associated with incident dementia and whether associations vary by different clusters of disease and genetic risk for dementia. The study used data from the UK Biobank cohort, with baseline data collected between 2006 and 2010 and with up to 15 years of follow-up. Participants included women and men without dementia and aged at least 60 years at baseline. The presence of at least 2 long-term conditions from a preselected list of 42 conditions was used to define multimorbidity. A total of 206,960 participants (mean age 64.1 years) were included in the final sample, of...
Source: Fight Aging! - October 16, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cancers Force T Cells into Senescence
We report that both mouse malignant tumor cells and regulatory T cells (Tregs) can induce responder T cell senescence, similar as shown in human Treg and tumor cells. Accumulated senescent T cells also exist in the TME in tumor models of lung cancer, breast cancer, and melanoma. Induction of ataxia-telangiectasia mutated protein (ATM)-associated DNA damage is the cause for T cell senescence induced by both mouse tumor cells and Treg cells, which is also regulated by mitogen-activated protein kinase (MAPK) signaling. Furthermore, blockages of ATM-associated DNA damage and/or MAPK signaling pathways in T cells can pre...
Source: Fight Aging! - October 13, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, October 10th 2022
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - October 9, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

About That Cancer Moonshot
BY KIM BELLARD Joe Biden hates cancer.  He led the Cancer Moonshot in the Obama Administration, and, as President, he reignited it, vowing to cut death rates in half over the next 25 years.  Last month, on the 60th anniversary of President Kennedy’s historic call for an actual moonshot, he vowed “to end cancer as we know it. And even cure cancers once and for all.” But, as several recent studies show, cancer is still surprising us.   ————— Our body has its own defenses against cancer, such as T-cells, and great strides have been made in cancer therapies, including ...
Source: The Health Care Blog - October 6, 2022 Category: Consumer Health News Authors: Ryan Bose-Roy Tags: Health Policy Research Cancer Cancer Progression Fungi John F. Kennedy Moonshot Source Type: blogs

About that Cancer Moonshot
By KIM BELLARD Joe Biden hates cancer.  He led the Cancer Moonshot in the Obama Administration, and, as President, he reignited it, vowing to cut death rates in half over the next 25 years.  Last month, on the 60th anniversary of President Kennedy’s historic call for an actual moonshot, he vowed “to end cancer as we know it. And even cure cancers once and for all.” But, as several recent studies show, cancer is still surprising us.  ————— Our body has its own defenses against cancer, such as T-cells, and great strides have been made in cancer therapies, includi...
Source: The Health Care Blog - October 6, 2022 Category: Consumer Health News Authors: matthew holt Tags: Health Policy Public Health Biden Cancer Cancer Moonshot Source Type: blogs

Fight Aging! Newsletter, October 3rd 2022
In conclusion, based on the analysis of proteomics and transcriptome, we identified four SRMs that may affect aging and speculated their possible mechanisms, which provides a new target for preventing aging, especially skin aging. A Popular Science Article on the State of Epigenetic Clocks https://www.fightaging.org/archives/2022/09/a-popular-science-article-on-the-state-of-epigenetic-clocks/ This popular science article is a good view of the present state of development and use of epigenetic clocks, covering the issues as well as the promise. Epigenetic age can be measured, with many different clocks ...
Source: Fight Aging! - October 2, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Cytotoxic T Cells Become More Effective at Killing Cancer Cells With Age
Researchers here note that cytotoxic T cells undergo age-related changes in protein expression that make them more effective in the task of destroying cancer cells, an unusual example of a component of the immune system improving with age. Overall, an aged immune system is impaired in numerous ways, and is worse at protecting the individual against the onset of cancer. Identifying specific populations of immune cells that can effectively destroy cancer cells, if given direction and greater numbers, is relevant to the production of better immunotherapies, however. The older someone is, the more likely they are to g...
Source: Fight Aging! - September 28, 2022 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, September 26th 2022
This study examined the dose-response association between daily step count and intensity and incidence of all-cause dementia among adults in the UK. This was a UK Biobank prospective population-based cohort study (February 2013 to December 2015) with 6.9 years of follow-up (data analysis conducted May 2022). A total of 78,430 of 103,684 eligible adults aged 40 to 79 years with valid wrist accelerometer data were included. Registry-based dementia was ascertained through October 2021. We found no minimal threshold for the beneficial association of step counts with incident dementia. Our findings suggest that approxima...
Source: Fight Aging! - September 25, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

A Powerful Partnership: AI and Humans Take on Healthcare Challenges
The following is a guest article by Christopher Larkin, Chief Product and Technology Officer at Concord Technologies. Artificial intelligence (AI) is pervasive in our daily decisions. We are assisted by AI-powered solutions that map optimal travel routes, deliver targeted online search results, manage vital banking functions, and even guide our driving.  Healthcare is another area that has become increasingly influenced using data and algorithms that make human-like conclusions. While much of medicine was once bogged down by legacy systems and paper files, the widespread digitization of records has streamlined processes a...
Source: EMR and HIPAA - September 22, 2022 Category: Information Technology Authors: Guest Author Tags: AI/Machine Learning Analytics/Big Data C-Suite Leadership Healthcare IT Hospital - Health System AI Solutions Artificial Intelligence Charles Graeber Christopher Larkin Concord Technologies The Breakthrough Source Type: blogs

Fight Aging! Newsletter, September 19th 2022
Conclusion Use of the Khavinson peptides and melatonin in combination in this way, at this dose, negatively impacts the thymus, producing a reduction in active tissue and increase in atrophy to fatty tissue. The degree to which this atrophy occurred is greater than one would expect to take place over nine months of aging at this stage of life. Why did this outcome occur, given the animal studies showing thymic regrowth, and the studies showing reduced later life mortality following use of thymogen? We can only speculate. Firstly, the dose makes the poison, and the dosing here may have been too high, too frequ...
Source: Fight Aging! - September 18, 2022 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

SENS Research Foundation Annual Reports for 2022
The SENS Research Foundation has published its annual reports for 2022, for those interested. SENS, the Strategies for Engineered Negligible Senescence, is both (a) a laundry list of forms of cell and tissue damage that cause aging, with supporting evidence from the past century of scientific research into aging, and (b) a laundry list methods of intervention that should produce rejuvenation. Aging is damage accumulation, and rejuvenation is repair of that damage. Funding for SENS programs, and initiatives to produce therapies based on the SENS view of damage repair, remain as relevant as ever. In fact, even more re...
Source: Fight Aging! - September 14, 2022 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs