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Towards an Artificial Lymph Node
Artificial structures capable of replicating at least some of the functions of natural organs and tissues may turn out to be quite different in shape, structure, and content when compared to their natural counterparts. This is particularly true for chemical factory tissues, such as the liver, or tissues in which cells migrate and collaborate, such as lymph nodes. In today's research, scientists demonstrate that a comparatively simple structure can perform some of the same useful functions of a lymph node, at least those related to training and replicating T cells to attack a particular pathogen or cancer cell population.
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Source: Fight Aging! - April 23, 2019 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Advances in cancer treatment
Parliamentary Office of Science and Technology (POST) - The pace of innovation in cancer treatment is rapid, with promising developments for patients in terms of survival and quality of life. Research in the fields of immunotherapy and radiotherapy has shown positive results in treating some cancers where established treatments are not effective. This POSTnote gives an overview of recent advances, the potential benefits and risks, and considers the opportunities and challenges of using new technologies in the NHS.POSTnoteMore detail
Source: Health Management Specialist Library - April 14, 2019 Category: UK Health Authors: The King ' s Fund Information & Knowledge Service Source Type: blogs
Fight Aging! Newsletter, April 15th 2019
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - April 14, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Aubrey de Grey on the Dawn of the Era of Human Rejuvenation
In this interview, Aubrey de Grey of the SENS Research Foundation discusses the present state of rejuvenation biotechnology. The first rejuvenation therapies now exist, these being the various methods of selectively removing senescent cells that de Grey and others called for back in 2002. The world is finally catching up to the vision of rejuvenation therapies that our community has advocated for more than fifteen years. Now that we are finally here, there is, if anything, even more work to be accomplished than was the case in past years. The funding for clinical development exists, but it is still true that many lines of ...
Source: Fight Aging! - April 9, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Our Visit to WIRED Health 2019 at London ’s Francis Crick Institute
WIRED Health, now in its sixth year, returned to London’s Francis Crick Institute. The event was opened by Crick Institute director Paul Nurse who introduced the institute and its mission to understand the fundamental biology of human health and d...
Source: Medgadget - April 2, 2019 Category: Medical Devices Authors: Tom Peach Tags: Exclusive Medicine Public Health Society Source Type: blogs
Fight Aging! Newsletter, April 1st 2019
In conclusion, long-term aerobic exercise appears to attenuate the decline in endothelial vascular function, a benefit which is maintained during chronological aging. However, currently there is not enough evidence to suggest that exercise interventions improve vascular function in previously sedentary healthy older adults.
Hijacking the Proteasome to Dispose of Unwanted Molecules in Age-Related Disease
https://www.fightaging.org/archives/2019/03/hijacking-the-proteasome-to-dispose-of-unwanted-molecules-in-age-related-disease/
Cells are equipped with a protein disposal system in the form of the proteaso...
Source: Fight Aging! - March 31, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Last Couple of Months in Oncology with Dr. Bishal Gyawali: March 2019
By BISHAL GYAWALI MD, PhD
Hey, I’m back!
Well, you might not have noticed that my blogs were missing for the last three months but anyways, its good to be back. I was having a little time off blogs and social media as I was transitioning in my career but now I am back. Sometimes, it is very difficult to manage time for things that you must do versus things you enjoy doing, especially when these two don’t intersect. For me, these last few months the things I had to do were all bureaucratic while I couldn’t find the time for things I enjoy doing like writing these blogs. But now that we are back, let’s rec...
Source: The Health Care Blog - March 26, 2019 Category: Consumer Health News Authors: Matthew Holt Tags: Medical Practice Physicians Bishal Gyawali Cancer drugs Clinical Trials Oncology Prostate Cancer RCTs Source Type: blogs
Cancer treatment: Is a clinical trial right for you?
Clinical trials are research studies that test a new drug or therapy in patients who have a disease. These studies are classified as phase I, II, or III depending on their purpose.
Phase I: These initial, small studies test promising new drugs that effectively kill cancer cells in laboratory experiments. The goal is to understand the safe dose and capture early evidence of benefit. Phase I trials may be open to patients with any type of cancer, or only certain types of cancers more likely to respond to specific drugs. Generally, fewer than 50 patients are enrolled.
Phase II: Once a phase I trial identifies a safe dose, ...
Source: Harvard Health Blog - March 22, 2019 Category: Consumer Health News Authors: Guru P. Sonpavde, MD Tags: Breast Cancer Health Treatments Source Type: blogs
Fight Aging! Newsletter, March 11th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - March 10, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Video of Investor Jim Mellon Presenting at Abundance 360 Summit 2019
Jim Mellon's Juvenescence venture is at present one of the few major venture organizations focused on approaches to treat aging as a medical condition. Mellon and his colleagues outlined their take on the field in a 2017 book, also called Juvenescence. We are fortunate in that he is among the first few high net worth individuals to both agree with the SENS philosophy of damage repair, and then, much more importantly, follow through in action as well as word. He is not just seeing a massive market opportunity in treating aging, though that is certainly there, but is doing this because he wishes to achieve the goal of radica...
Source: Fight Aging! - March 4, 2019 Category: Research Authors: Reason Tags: Healthy Life Extension Community Source Type: blogs
Fight Aging! Newsletter, March 4th 2019
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - March 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
“ Oncology is a very dynamic specialty and is of the utmost importance ”
Can you tell us a little bit about your work and current research?
To tell you about my work as a specialist in Medical Oncology, I must first briefly present the situation in Romania. Unfortunately, in Romania, a medical oncologist must overcome many difficulties. As a resident, you become a specialist in medical oncology following 5 years of specialization in the field and an examination. Then, after another 5 years, you will specialize in medical oncology and receive the title of “Primary Doctor” (this is the highest professional degree in medical care, in other words: Senior Medical Oncologist).
Unfortunately, rese...
Source: Naturally Selected - February 28, 2019 Category: Biomedical Science Authors: Hannah Towfiq Tags: F1000 Institutions Source Type: blogs
A Guide to Logical Fallacies for Rejuvenation Research Advocates
The world has not yet rallied to the cause of defeating aging. Aging remains by far the greatest cause of suffering, pain, and death in this world, and yet it is accepted as set in stone by the vast majority of people. Few think of doing something about it. Little funding goes towards the research and development programs that could plausibly bring aging under medical control, indefinitely extending healthy life spans. Humanity spends more on sports stadiums than it does on addressing the impending death and drawn out, painful decline of everyone presently alive.
All of this is why, even as our community grows and w...
Source: Fight Aging! - February 27, 2019 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Request for Startups in the Rejuvenation Biotechnology Space, 2019 Edition
I am a little late with the 2019 list of projects in rejuvenation biotechnology that I'd like to see startups tackling sometime soon. In my defense, this year I have a startup of my own to keep up with, and the first part of 2019 was a wall to wall series of conferences alternating between the US and Europe. It continues to be the case that this is a new industry of near endless potential, yet little of that potential is under active development. This is the state of affairs despite the arrival of hundreds of millions of dollars in venture funds managed by the like of Juvenescence, Life Biosciences, and so on. The research...
Source: Fight Aging! - February 25, 2019 Category: Research Authors: Reason Tags: Investment Source Type: blogs
Fight Aging! Newsletter, February 4th 2019
In this study, we examined the benefits of early-onset, lifelong AET on predictors of health, inflammation, and cancer incidence in a naturally aging mouse model.
Lifelong, voluntary wheel-running (O-AET; 26-month-old) prevented age-related declines in aerobic fitness and motor coordination vs. age-matched, sedentary controls (O-SED). AET also provided partial protection against sarcopenia, dynapenia, testicular atrophy, and overall organ pathology, hence augmenting the 'physiologic reserve' of lifelong runners. Systemic inflammation, as evidenced by a chronic elevation in 17 of 18 pro- and anti-inflammatory cytokin...
Source: Fight Aging! - February 3, 2019 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
