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Fight Aging! Newsletter, August 21st 2017
This study didn't measure whether receiving the cardiosphere-derived cells extended lifespans, so we have a lot more work to do. We have much to study, including whether CDCs need to come from a young donor to have the same rejuvenating effects and whether the extracellular vesicles are able to reproduce all the rejuvenating effects we detect with CDCs."
Cardiac and systemic rejuvenation after cardiosphere-derived cell therapy in senescent rats
Cardiosphere-derived cell (CDC) therapy has exhibited several favourable effects on heart structure and function in humans and in preclinical models; however, the ...
Source: Fight Aging! - August 20, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Gold Nanostars and Immunotherapy Combined for a Cancer Vaccine
Researchers at Duke University have combined an FDA approved immunotherapy and a gold nanostar/laser treatment to completely eradicate tumors and vaccinate against the cancer.
The team’s technique involves injecting gold nanoparticles into the bloo...
Source: Medgadget - August 18, 2017 Category: Medical Devices Authors: Conn Hastings Tags: Nanomedicine News Oncology Source Type: blogs
Senescent T Cells, Immunosenescence, and T Cell Exhaustion are all Distinct but to Some Degree Overlapping Phenomena
Immunosenescence is a high-level descriptive term for one collection of symptoms that manifest in the aging immune system, largely revolving around a loss of capacity: an inability to respond effectively to pathogens and to clear out damaged and dangerous cells. Cellular senescence on the other hand is a low-level descriptive term for a harmful cell state that appears in increasing numbers with advancing age, disrupting tissue function and contributing to age-related diseases. The evidence to date strongly suggests that senescence as a cellular phenomenon extends to the T cells of the adaptive immune system in later life, ...
Source: Fight Aging! - August 14, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Ultrasound to Improve Effectiveness of Cancer Drugs: Interview with Focused Ultrasound Foundation ’s Jessica Foley, PhD
Most people think of ultrasound as an imaging modality. Yet, there are many other clinical uses for the high frequency soundwaves. Focused ultrasound waves can promote the opening of the blood-brain barrier, and they can be used to ablate fibroids, a...
Source: Medgadget - August 10, 2017 Category: Medical Devices Authors: Editors Tags: Medicine News Source Type: blogs
Fight Aging! Newsletter, August 7th 2017
Discussions of radical life extension, technological acceleration, and artificial general intelligence were far more fringe concerns back then than is now the case, but this growth in awareness isn't a coincidence. Visions slowly become reality because people work to make that happen. Technological progress is not accidental: it is led by our desires.
I should say that de Magalhães is here generous in not passing judgement on the value (or lack thereof) of most of the various ventures and classes of approach he surveys. But some approaches are definitely better than others, and to my eyes one the principal challeng...
Source: Fight Aging! - August 6, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Recent Examples of Research into Protein Aggregates and their Clearance in the Context of Neurodegenerative Disease
Today the topic is protein aggregation in the aging brain, its consequences, and efforts to both understand and remove these aggregates. I'd noticed a few interesting research notices in the past few weeks, but they were pushed into the backlog by other matters. They are generally representative of the interest in aggregates in the research community, and of the incremental progress towards practical treatments. Removing solid deposits of misfolded or otherwise altered proteins from the brain has proven to be far more challenging than was first hoped when immunotherapies aimed at clearing the amyloid-β associated with Alz...
Source: Fight Aging! - August 3, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Converting Effector T Cells into Regulatory T Cells
Slow progress is being made in the development of means to adjust the operation and configuration of the immune system, especially when it comes to damping inflammation. Present approaches used in the clinic are blunt, suppressing immune activity as a whole, or at least large swathes of it, and have significant side-effects. More sophisticated ways to adjust immune cell behavior may have applications in reducing some of the consequences of the disarray of the immune system that occurs with age. In particular, if the chronic inflammation and overactivity of the aged immune system could be reduced, some benefits might be rea...
Source: Fight Aging! - August 3, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
New Way to Reprogram Macrophages Helps Immune System Kill Tumors
Macrophages, as their greek-derived name implies, are hungry white blood cells that consume all kinds of foreign and unwanted objects within the body. They are one of the primary methods that the immune system uses to fight off disease, and they work...
Source: Medgadget - July 21, 2017 Category: Medical Devices Authors: Editors Tags: Genetics Oncology Source Type: blogs
7 Things to Know About Glioblastoma
News recently shocked the nation that Sen. John McCain was diagnosed with an aggressive form of brain cancer called glioblastoma. Dr. Mark Mishra, a radiation oncologist at the University of Maryland Greenebaum Comprehensive Cancer Center and Maryland Proton Treatment Center who specializes in treating brain cancer, tells you 7 things to know about glioblastoma.
How common is glioblastoma?
Glioblastoma is the most common type of primary brain tumor that is diagnosed in adults. There are estimated to be nearly 13,000 patients who will be diagnosed with a glioblastoma annually within the United States.
Why is it so aggr...
Source: Life in a Medical Center - July 21, 2017 Category: Universities & Medical Training Authors: UMMC Tags: Cancer Source Type: blogs
Senator McCain has brain cancer. Here ’s what that means.
This article originally appeared in the American Thinker.
Image credit: Shutterstock.com
Your patients are rating you online: How to respond. Manage your online reputation: A social media guide. Find out how.
Source: Kevin, M.D. - Medical Weblog - July 20, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/brian-c-joondeph" rel="tag" > Brian C. Joondeph, MD < /a > Tags: Conditions Cancer Source Type: blogs
Engineering Macrophages to Ignore " Don ' t Eat Me " Signals from Cancer Cells
Macrophages are one of the types of immune cell responsible for destroying potentially dangerous cells, such as those that have become cancerous. Unfortunately cancerous cells tend to circumvent the immune system by displaying molecules on their outer surface that cause macrophages to leave them alone. This is an abuse of recognition mechanisms that exist to protect other cell types. Researchers here show that producing engineered macrophages that ignore this signal can be a viable approach to cancer therapy, even though past attempts have proven too harmful to normal cells to proceed towards the clinic. Their new methodol...
Source: Fight Aging! - July 20, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
PhRMA Report Shows More than 240 Immuno-Oncology Treatments in Development
In early June 2017, the Pharmaceutical Research and Manufacturers of America (PhRMA) – in partnership with the American Cancer Society Cancer Action Network (ACS CAN) – released a report that found there are over 240 immuno-oncology medicines and vaccines currently in development.
Immuno-oncology treatments are found through research into the role of the body’s immune system in fighting cancer. New immuno-oncology treatment options are allowing the patient’s own immune system to fight cancer similar to the way it fights disease-causing viruses and bacteria. The treatments can help the patient’s own immune system...
Source: Policy and Medicine - July 14, 2017 Category: American Health Authors: Thomas Sullivan - Policy & Medicine Writing Staff Source Type: blogs
Progress in the Creation of a Neoantigen Cancer Vaccine
Targeting therapies to some combination of neoantigens, distinctive markers on the surface of cancerous cells that the immune system learns to recognize, and which vary from patient to patient, represents an advance in the specificity of targeted cancer immunotherapy. It should, in principle, better rouse the immune system to attack cancerous cells, while producing fewer side-effects. Researchers here report on an early human trial of this sort of approach; the initial results look promising, certainly from the perspective of an absence of serious side-effects, though a more robust demonstration of the ability to reduce tu...
Source: Fight Aging! - July 7, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, July 3rd 2017
In conclusion, the analyses do not permit us to predict the trajectory that maximum lifespans will follow in the future, and hence provide no support for their central claim that the maximum lifespan of humans is "fixed and subject to natural constraints". This is largely a product of the limited data available for analysis, owing to the challenges inherent in collecting and verifying the lifespans of extremely long-lived individuals.
A reply from Jan Vijg's research group
The authors of the accompanying comment disagree with our finding of a limit to human lifespan. Although we thank them for alerting us...
Source: Fight Aging! - July 2, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
