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Why “ Precision Health ” May Not Be the Precise Word
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: OP-ED Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
A New Gimish Model of Complex Disease?
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
A More Precise Definition of Precision Medicine?
By DAVID SHAYWITZ, MD
The appeal of precision medicine is the promise that we can understand disease with greater specificity and fashion treatments that are more individualized and more effective.
A core tenet (or “central dogma,” as I wrote in 2015) of precision medicine is the idea that large disease categories – like type 2 diabetes – actually consist of multiple discernable subtypes, each with its own distinct characteristics and genetic drivers. As genetic and phenotypic research advances, the argument goes, diseases like “type 2 diabetes” will go the way of quaint descriptive diagnoses like “dropsy”...
Source: The Health Care Blog - November 28, 2017 Category: Consumer Health News Authors: John Irvine Tags: Uncategorized Broad Institute CAD Circulation Disease Categories Gimish Model of Disease Kathiresan Khera Massachussetts General Hospital Source Type: blogs
Expanding the " Don ' t Eat Me " Signal Blockade Approach to Killing Cancer Cells
Cancers evolve to abuse mechanisms that suppress or control the immune system, as any cancer that fails to do so tends to be destroyed early-on by immune cells. One of these mechanisms is the presentation of "don't eat me" signals on the cell surface that prevent macrophage cells of the innate immune system from engulfing and destroying a cancer cell. CD47 was identified some years ago as one of these signals, and bypassing it or suppressing it has the potential to be a broad basis for the treatment of many types of cancer. As a bonus, it also appears to be a potentially viable strategy for treating age-related fibrosis, a...
Source: Fight Aging! - November 28, 2017 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Genome Editing Primes T-Cells to Attack Cancer
Scientists at Cardiff University in the UK have found a way to enhance the cancer-destroying ability of T-cells through DNA editing. The research team used CRISPR genome editing technique to remove the receptors naturally present on T-cells, and inst...
Source: Medgadget - November 20, 2017 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Oncology Source Type: blogs
MSK-IMPACT: New Tumor Profiling Genetic Test Approved by the FDA
Memorial Sloan Kettering Cancer Center has developed the first tumor-profiling laboratory developed test (LDT) approved by the FDA. It's called MSK-IMPACT. Below are some details about the test from a recent article (see:FDA Authorizes MSK-IMPACT Test for Analyzing Patient Tumor):The FDA ’s authorization of MSK-IMPACT sets a precedent for future authorization of tests developed by both academic and commercial labs....The test was developed by Memorial Sloan Kettering’s Department of Pathology to look for genetic mutations and other alterations in patients’ tumors.....MSK-IMPACT, which stands for integrated ...
Source: Lab Soft News - November 18, 2017 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Clinical Lab Industry News Clinical Lab Testing Food and Drug Administration Lab Industry Trends Lab Processes and Procedures Medical Research Source Type: blogs
Fight Aging! Newsletter, November 13th 2017
In conclusion, we have developed an effective PILs strategy to deliver the AUF1 plasmid to a specific target, and this system may be useful for the development of new anti-aging drugs.
Considering the Evidence for Vascular Amyloidosis as a Cause of Aging
https://www.fightaging.org/archives/2017/11/considering-the-evidence-for-vascular-amyloidosis-as-a-cause-of-aging/
The balance of evidence for the aging of the cardiovascular system suggests the following view. It starts off in the blood vessels, with the accumulation of senescent cells and cross-links. Cross-links directly stiffen these tissues, while ...
Source: Fight Aging! - November 12, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Targeted Radiotherapy Combined with Immunotherapy Kills 100% of Colorectal Cancer
Researchers from Memorial Sloan Kettering Cancer Center and from MIT are reporting the development of a new combination therapy that completely eliminates colon cancer, at least in laboratory mice. The technique is a type of radioimmunotherapy, whic...
Source: Medgadget - November 7, 2017 Category: Medical Devices Authors: Editors Tags: Nuclear Medicine Radiation Oncology Source Type: blogs
“ Gut bacteria ‘ boost ’ cancer therapy ”
That’s the title of a very interesting BBC News article I read this morning, thanks to my friend Paul: goo.gl/pkXS1J It’s about two recent studies that examined patients with cancer (1. lung or kidney; 2. melanoma), discovering that those who had a lot of “friendly” gut bacteria responded better to immunotherapy.
Excerpt: Dr Jennifer Wargo, from Texas, told the BBC: “If you disrupt a patient’s microbiome you may impair their ability to respond to cancer treatment.”
Okay, so the patients in the two studies didn’t have myeloma. But I would bet anything that those three types o...
Source: Margaret's Corner - November 4, 2017 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll BBC News Clostridium difficile gut bacteria microbiome probiotics SCT Source Type: blogs
Fight Aging! Newsletter, October 30th 2017
In this study, the researchers showed a causal link between dynamic changes in the shapes of mitochondrial networks and longevity.
The scientists used C. elegans (nematode worms), which live just two weeks and thus enable the study of aging in real time in the lab. Mitochondrial networks inside cells typically toggle between fused and fragmented states. The researchers found that restricting the worms' diet, or mimicking dietary restriction through genetic manipulation of an energy-sensing protein called AMP-activated protein kinase (AMPK), maintained the mitochondrial networks in a fused or "youthful" state. In add...
Source: Fight Aging! - October 29, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Fight Aging! Newsletter, October 16th 2017
In this study, we have shown that the lipid chaperones FABP4/FABP5 are critical intermediate factors in the deterioration of metabolic systems during aging. Consistent with their roles in chronic inflammation and insulin resistance in young prediabetic mice, we found that FABPs promote the deterioration of glucose homeostasis; metabolic tissue pathologies, particularly in white and brown adipose tissue and liver; and local and systemic inflammation associated with aging. A systematic approach, including lipidomics and pathway-focused transcript analysis, revealed that calorie restriction (CR) and Fabp4/5 deficiency result ...
Source: Fight Aging! - October 15, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Immune Cell Telomeres and Senescence in the Context of Viral Infection and Aging
In this study, we sought to measure the in vivo changes of telomere length, inflammation-related cytokine and anti-CMV antibody titer with age and to determine the trajectory of these age-associated immune changes and their inter-relationship using longitudinal analysis over an average of 13 years. Specifically, we assessed the individual longitudinal trajectories of peripheral blood mononuclear cell (PBMC) telomere length, eight pro-inflammatory cytokines, and anti-CMV IgG titer in 456 subjects. Strikingly, aging-associated changes in these variables occur with a distinct trajectory in each individual. Thus, immune aging ...
Source: Fight Aging! - October 13, 2017 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Technique to Produce Multi-Target Antibody Therapies
Researchers in The Netherlands and Switzerland have devised a new technique to reliably produce antibodies that can bind to two different target molecules at the same time, which could be very useful for cancer immunotherapy.
Antibodies are Y-shaped ...
Source: Medgadget - August 30, 2017 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Oncology Source Type: blogs
Fight Aging! Newsletter, August 28th 2017
In conclusion, CAVD is highly prevalent. Long understood as a passive process, it is now known to be complex and one which involves pathophysiological mechanisms similar to those of atherosclerosis. Understanding these mechanisms could help to establish new therapeutic targets that might allow us to halt or at least slow down the progression of the disease.
Early Steps in the Tissue Engineering of Intervertebral Discs
https://www.fightaging.org/archives/2017/08/early-steps-in-the-tissue-engineering-of-intervertebral-discs/
In this paper, researchers report on progress towards the manufacture of interver...
Source: Fight Aging! - August 27, 2017 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Health care at the N of 1
In the past few weeks, there has been a question regarding my use of the hashtag #Nof1 along with how I end the majority of my posts and tweets: Health care is delivered at the N of 1.
One person even believed there might be a trademark infringement with the company N-of-1 who provides molecular testing for patients and then delivers evidenced-based medical recommendations for oncology patients. The reality is that, while the company N-of-1 provides services, the topic I speak about is how the evolution of health care is occurring.
This seed was planted in me during my clinical rotations in 1998–1999 while at the Univers...
Source: Kevin, M.D. - Medical Weblog - August 24, 2017 Category: General Medicine Authors: < a href="http://www.kevinmd.com/blog/post-author/andy-delao" rel="tag" > Andy DeLao < /a > Tags: Patient Hospital-Based Medicine Oncology/Hematology Primary Care Source Type: blogs
