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Therapy: Immunotherapy
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Total 418 results found since Jan 2013.
Adjusting Macrophage Polarization as a Basis for Cancer Immunotherapy
Macrophage polarization is a hot topic of late. The innate immune cells known as macrophages are responsible for a wide range of duties that include destroying errant cells, attacking pathogens, cleaning up waste and debris, and participation in tissue regrowth and regeneration. The polarization of a macrophage describes its state and inclination as to which of those duties it undertakes: M1 macrophages are aggressive and inflammatory, while M2 macrophages tend towards participation in the gentler processes of rebuilding and regeneration. Many of the common inflammatory age-related conditions appear to be characterized by ...
Source: Fight Aging! - July 4, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 25th 2018
In this study, we investigate mitochondrial energetics and mtDNA methylation in senescent cells, and evaluate the potential of humanin and MOTS-c as novel senolytics or SASP modulators that can alleviate symptoms of frailty and extend health span by targeting mitochondrial bioenergetics.
Exercise versus the Hallmarks of Aging
https://www.fightaging.org/archives/2018/06/exercise-versus-the-hallmarks-of-aging/
The paper I'll point out today walks through the ways in which exercise is known to beneficially affect the Hallmarks of Aging. The Hallmarks are a list of the significant causes of aging that I dis...
Source: Fight Aging! - June 24, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
The Lie of Precision Medicine
My next blog post will be entitled " The Lie of Precision Medicine "— sarcastic_f (@sarcastic_f)June 23, 2018This post will be my own personalized rant about the false promises of personalized medicine. It will not be about neurological or psychiatric diseases, the typical topics for this blog. It will be about oncology, for very personal reasons: misery, frustration, and grief. After seven months of research on immunotherapy clinical trials, I couldn ' t find a single [acceptable] one1 in either Canada or the US that would enroll my partner with stage 4 cancer. For arbitrary reasons, for financial reasons, because ...
Source: The Neurocritic - June 24, 2018 Category: Neuroscience Authors: The Neurocritic Source Type: blogs
CD36 as a Potentially Important Marker and Mechanism in Cellular Senescence
In this study, we conducted comparative RNAseq experiments to detect genes associated with replicative senescence in two different human fibroblast cell lines and at different time points. We identified 841 and 900 genes (core senescence-associated genes) that are significantly up- and downregulated in senescent cells, respectively, in both cell lines.
Our functional enrichment analysis showed that downregulated core genes are primarily involved in cell cycle processes while upregulated core gene enrichment indicated various lipid-related processes. We further demonstrated that downregulated genes are significantly ...
Source: Fight Aging! - June 22, 2018 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs
Sugar Nanoparticles Reprogram Immune Cells to Help Destroy Tumors
This report is in line with a number of recent papers from the Weissleder Lab and labs around the world to reprogram the immune system to fight cancer. Cancer immunotherapy was ranked the biggest breakthrough in 2012 by the magazine Science, and team...
Source: Medgadget - June 11, 2018 Category: Medical Devices Authors: Ben Ouyang Tags: Nanomedicine Oncology Source Type: blogs
Fight Aging! Newsletter, June 11th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 10, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
An Interview with Jim Mellon, and Update on Juvenescence
This interview with Jim Mellon opens with an update on some of the recent investment activities of Juvenescence, founded last year in order to participate in the enormous market opportunity afforded by the development of the first working rejuvenation therapies. It is in Mellon's self-interest to help educate the world about the size of this market, and draw in other, larger entities that will help to carry his portfolio companies to the finish line. So he is doing just that, and in doing so benefits us all. His advocacy will help all fronts in fundraising for research and development in this field.
That advocacy co...
Source: Fight Aging! - June 4, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Fight Aging! Newsletter, June 4th 2018
Fight Aging! provides a weekly digest of news and commentary for thousands of subscribers interested in the latest longevity science: progress towards the medical control of aging in order to prevent age-related frailty, suffering, and disease, as well as improvements in the present understanding of what works and what doesn't work when it comes to extending healthy life. Expect to see summaries of recent advances in medical research, news from the scientific community, advocacy and fundraising initiatives to help speed work on the repair and reversal of aging, links to online resources, and much more.
This content is...
Source: Fight Aging! - June 3, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
Rapid Autopsies: Reformulating the Classic Autopy Toward a Focus on Cancer Research
The non-forensic autopsy is on life support in most hospitals with only about 10% of patients undergoing the procedure nationally (see:The Vanishing Nonforensic Autopsy). However, the rapid autopsy has moved front-and-center for selected cancer patients with the need for rapid tumor tissue harvesting. This specialized type of autopsy was described in a recent article (see: Rapid autopsies could speed cancer research. They ’re also fraught for families),. Below is an excerpt from it:Medical teams have long rushed to save the living. Now, increasingly, they ’re rushing to attend to the dead.A small but fast-g...
Source: Lab Soft News - June 2, 2018 Category: Laboratory Medicine Authors: Bruce Friedman Tags: Genomic Testing Healthcare Delivery Healthcare Innovations Medical Consumerism Medical Education Medical Research Source Type: blogs
When I am Eighty-Five
I will be 85 somewhere in the mid 2050s. It seems like a mirage, an impossible thing, but the future eventually arrives regardless of whatever you or I might think about it. We all have a vision of what it is to be 85 today, informed by our interactions with elder family members, if nothing else. People at that age are greatly impacted by aging. They falter, their minds are often slowed. They are physically weak, in need of aid. Perhaps that is why we find it hard to put ourselves into that position; it isn't a pleasant topic to think about. Four decades out into the future may as well be a science fiction novel, a far awa...
Source: Fight Aging! - May 29, 2018 Category: Research Authors: Reason Tags: Of Interest Source Type: blogs
Mice don ’ t vomit
The fact that mice don’t vomit is one of the many things that I learned while reading an extraordinary May 16 Boston Globe article about an experimental cancer treatment that cured, yes, cured a dog, a golden retriever, from soft tissue sarcoma. This cancer treatment, immunotherapy, might possibly (someday) help human patients, too.
Anyway, have a look here: goo.gl/DyBnJZ
Really quite amazing. Incidentally, many thanks to Cynthia for posting the link to this article on Facebook…
Quick update: our 8.5 month old kittens, Pandora and Pixie, were sterilized on Monday and are doing well, phew… Tomorrow I̵...
Source: Margaret's Corner - May 23, 2018 Category: Cancer & Oncology Authors: Margaret Tags: Blogroll golden retriever immunotherapy sarcoma Source Type: blogs
Fight Aging! Newsletter, May 14th 2018
This study found that professional chess players had shorter lifespans than those players who had careers outside of chess and argued that this might be due to the mental strain of international chess competition.
In the present study, we focused on survival of International Chess Grandmasters (GMs) which represent players, of whom most are professional, at the highest level. In 2010, the overall life expectancy of GMs at the age of 30 years was 53.6 years, which is significantly greater than the overall weighted mean life expectancy of 45.9 years for the general population. In all three regions examined, mean life...
Source: Fight Aging! - May 13, 2018 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs
CAR-T Therapy Eliminates Metastatic Colorectal Cancer in Mice
In this study, the researchers tested a human-ready version of the therapy in mice. They showed that mice with human colorectal tumors treated with CAR-T therapy successfully fought the tumor cells. All of the mice studied survived without side effects for the duration of the observation period - or 75 days, compared to a 30-day average survival of mice with control treatment. In order to more closely replicate late-stage disease in humans, researchers also looked at a mouse model of colorectal cancer that developed lung metastases, a common site for metastasis in colorectal cancer patients. Mice that were treated with the...
Source: Fight Aging! - May 8, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
Significant Improvements to Chimeric Antigen Receptor T Cell Therapies Lie Ahead
Chimeric antigen receptor T cell (CAR-T) therapies have proven to be a promising advance in the state of the art when it comes to cancer immunotherapy, though there are certainly challenges remaining to be overcome. The real promise is not only the improved effectiveness, however, but rather that this technology platform offers the ability to treat many different cancers with only an incremental cost in adaptation to each new target.
Over the long term, economics is the driver of success in cancer research. Given that there are hundreds of types of cancer and only so many scientists and only so much funding, the mos...
Source: Fight Aging! - April 27, 2018 Category: Research Authors: Reason Tags: Daily News Source Type: blogs
