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Total 418 results found since Jan 2013.

Microneedle Skin Patch Measures Cancer Biomarkers
Researchers at the Harvard Wyss Institute have developed a technique that lets clinicians to characterize and monitor melanoma. The system involves using a microneedle patch that can draw deep interstitial fluid into itself through a series of penetr...
Source: Medgadget - September 14, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Dermatology Diagnostics Medicine Oncology harvard wyssinstitute Source Type: blogs

mRNA Immunotherapy Targets Cancer
Researchers at the Mount Sinai Hospital have developed an mRNA-based treatment for cancer. The approach combines the delivery of mRNA therapy in lipid nanoparticles and also involves co-delivering dendritic cells that have also been primed through tr...
Source: Medgadget - August 25, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Genetics Medicine Oncology immunotherapy MountSinaiNYC mRNA Immunotherapy Source Type: blogs

Fight Aging! Newsletter, July 31st 2023
In conclusion, an SBP level below 130 mmHg was found to be associated with longevity among older women. The longer SBP was controlled at a level between 110 and 130 mmHg, the higher the survival probability to age 90. Preventing age-related rises in SBP and increasing the time with controlled BP levels constitute important measures for achieving longevity. « Back to Top
Source: Fight Aging! - July 30, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Why oncology is ripe for digital innovation
In every aspect of our lives, whether it is online banking or shopping, we rely on technology to make things better, more convenient, and more efficient. Yet in health care, and particularly cancer care, that is not the case. Oncology has been revolutionized in recent decades by therapies targeted to specific biomarkers and immunotherapy. Despite Read more… Why oncology is ripe for digital innovation originally appeared in KevinMD.com.
Source: Kevin, M.D. - Medical Weblog - July 18, 2023 Category: General Medicine Authors: Tags: Tech Health IT Oncology/Hematology Source Type: blogs

Fight Aging! Newsletter, June 26th 2023
This study explored the association between different cooking fuel types and the risk of cancer and all-cause mortality among seniors constructing Cox regression models. Data were obtained by linking waves of 6, 7, and 8 of the Chinese Longitudinal Healthy Longevity Survey, which included a total of 7,269 participants who were 65 years old and over. Cooking fuels were categorized as either biomass, fossil, or clean fuels. And the effects of switching cooking fuels on death risk were also investigated using Cox regression models. The results indicate that, compared with the users of clean fuels, individuals using bio...
Source: Fight Aging! - June 25, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, June 19th 2023
In conclusion, among Swedish middle-aged subjects, nearly two-thirds showed complete fatty degeneration of thymus on CT. Age-Related Dysfunction of Water Homeostasis https://www.fightaging.org/archives/2023/06/age-related-dysfunction-of-water-homeostasis/ Dehydration can be an issue in older people. As in every complex system in the body, the mechanisms by which hydration is regulated become dysfunctional with advancing age. Researchers here look at the brain region responsible for regulating some of the response to dehydration, cataloging altered gene expression in search of the more important mechani...
Source: Fight Aging! - June 18, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Fight Aging! Newsletter, May 15th 2023
In this study, we examined the average telomere length and telomerase activity, as well as the formation of telomere associated foci (TAFs) and the mRNA expression levels of the shelterin components in cultured primary cells of Spalax, a long-lived, hypoxia-tolerant, and cancer-resistant blind mole-rat species. We showed that with cell passages, Spalax fibroblasts demonstrated significant shortening in telomere length, similar to rat cells, and in line with the processes observed earlier in tissues. We also demonstrated that the average telomere length in Spalax fibroblasts was significantly higher than the average ...
Source: Fight Aging! - May 14, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

The New Alzheimer ' s Therapies are Not What One Would Call Successful
The first batch of immunotherapies demonstrated to be capable of clearing extracellular amyloid-β from the brain have performed poorly in late stage Alzheimer's patients. Data is beginning to emerge for their ability to modestly slow down the progression of the condition at earlier stages, however. This somewhat fits with the amyloid cascade hypothesis, in that it is evidence to support the idea that amyloid-β is no longer important to disease progression once the condition has reached the stage of becoming a feedback loop involving tau aggregation, chronic inflammation, and cell death. Unfortunately, it isn't str...
Source: Fight Aging! - May 11, 2023 Category: Research Authors: Reason Tags: Medicine, Biotech, Research Source Type: blogs

Career Conversations: Q & A With Biochemist Prabodhika Mallikaratchy
Credit: CUNY School of Medicine. “One of the biggest things I hope for in my career is that in 20 years, I still feel the same joy and enthusiasm for research and training that I feel now,” says Prabodhika Mallikaratchy, Ph.D., a professor in the department of molecular, cellular, and biomedical sciences at the City University of New York (CUNY) School of Medicine. Dr. Mallikaratchy talks with us about her career path, research on developing new immunotherapies and molecular tools using nucleic acids, and her belief in the importance of being passionate about your career. Q: How did you first become interested in ...
Source: Biomedical Beat Blog - National Institute of General Medical Sciences - May 10, 2023 Category: Research Authors: Chrissa Chverchko Tags: Being a Scientist Chemistry, Biochemistry and Pharmacology Tools and Techniques DNA Medicines Profiles Proteins Source Type: blogs

Reviewing T Cell Immunotherapies to Treat Cancer
The use of immunotherapies will most likely replace chemotherapy and radiation therapy for the treatment near all cancers over the next twenty years, and has already done so for many types of cancer. We should expect immunotherapies to in turn be replaced by approaches that target the telomere lengthening essential to all cancers. The wheel turns slowly, but this progress will lead steadily to an end to the suffering and loss of life accompanying cancer. Cancer will become a mild, annoying but controllable condition within a matter of decades, within the lifetimes of most of those reading this now. The review paper noted h...
Source: Fight Aging! - May 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Immunotherapy Implant to Treat Pancreatic Cancer
Researchers at Houston Methodist have developed an implant that can provide localized and sustained release of immunotherapies to treat pancreatic cancer. Their device is tiny, at approximately the size of a grain of rice, and they have termed it a &...
Source: Medgadget - May 8, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Oncology Urology HoustonMethodist prostate CA prostate cancer Source Type: blogs

Bottlebrush Nanoparticles Deliver Immunostimulatory Drugs
Researchers at MIT have developed a nanoparticle system that is designed to deliver immunostimulatory drugs to tumors. These drugs are intended to stimulate immune cells in the vicinity of tumors to begin destroying tumor cells, but when delivered sy...
Source: Medgadget - May 3, 2023 Category: Medical Devices Authors: Conn Hastings Tags: Medicine Nanomedicine mit Source Type: blogs

Fight Aging! Newsletter, April 17th 2023
In conclusion, oral NR altered the gut microbiota in rats and mice, but not in humans. In addition, NR attenuated body fat mass gain in rats, and increased fat and energy absorption in the HFD context. Glycine Supplementation as a Methionine Restriction Mimetic https://www.fightaging.org/archives/2023/04/glycine-supplementation-as-a-methionine-restriction-mimetic/ Supplementation with the non-essential amino acid glycine has been shown to modestly slow aging in short-lived laboratory species. In today's open access review paper, researchers note glycine supplementation as essentially a calorie restrictio...
Source: Fight Aging! - April 16, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs

Immunotherapies Targeting Amyloid- β May Produce Brain Shrinkage
Immunotherapies offer great potential, but are not without side-effects as presently implemented. This is well demonstrated in the cancer field, where a chance of severe short-term, or even lasting immune-related issues is a risk that patients are willing to take given the alternatives on the table. Here, researchers suggest that the immunotherapies tested against Alzheimer's disease in clinical trials are producing an accelerated shrinkage of brain tissue, perhaps because of raised inflammation. In recent years, these immunotherapies have succeeded in clearing extracellular amyloid-β, but have not improved patient outcom...
Source: Fight Aging! - April 10, 2023 Category: Research Authors: Reason Tags: Daily News Source Type: blogs

Fight Aging! Newsletter, March 20th 2023
This study also provides the potential for de novo generation of complex organs in vivo. T Cells May Play a Role in the Brain Inflammation Characteristic of Neurodegenerative Conditions https://www.fightaging.org/archives/2023/03/t-cells-may-play-a-role-in-the-brain-inflammation-characteristic-of-neurodegenerative-conditions/ Alzheimer's disease, and other forms of neurodegenerative condition, are characterized by chronic inflammation in brain tissue. Unresolved inflammatory signaling is disruptive of tissue structure and function. Here, researchers provide evidence for T cells to become involved in this...
Source: Fight Aging! - March 19, 2023 Category: Research Authors: Reason Tags: Newsletters Source Type: blogs