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Updated Austrian treatment algorithm for metastatic triple-negative breast cancer
Wien Klin Wochenschr. 2023 Sep 8. doi: 10.1007/s00508-023-02254-9. Online ahead of print.ABSTRACTApproximately 15% of newly diagnosed breast cancer patients have neither hormone receptors expression nor HER2 overexpression and/or HER2/neu gene amplification. This subtype of breast cancer is known as Triple Negative Breast Cancer (TNBC), and carries a significantly elevated risk of local and distant recurrence. In comparison with other breast cancer subtypes, there is a higher rate of visceral and brain metastases. The majority of metastases of TNBC are diagnosed within three years after initial breast cancer diagnosis. Whi...
Source: Wiener Klinische Wochenschrift - September 8, 2023 Category: General Medicine Authors: Rupert Bartsch Gabriel Rinnerthaler Edgar Petru Daniel Egle Michael Gnant Marija Balic Thamer Sliwa Christian Singer Source Type: research
A meta-analysis for the efficacy and safety of icotinib combined with radiotherapy in treating brain metastases of non-small cell lung cancer
CONCLUSION: Icotinib combined with radiotherapy can significantly short-term and long-term efficacy of NSCLC patients with brain metastases but not increase adverse reactions.PMID:37682155 | DOI:10.1097/MD.0000000000034572
Source: Cancer Control - September 8, 2023 Category: Cancer & Oncology Authors: Bo Zhang Source Type: research
Clinicopathologic study of stage I adenosquamous carcinoma of the lung
CONCLUSIONS: Early-stage adenosquamous carcinoma of the lung is a histological type associated with severe prognosis and postoperative recurrence, often in distant sites, in approximately one-third of cases. High serum carcinoembryonic antigen levels and vascular invasion might be risk factors of recurrence.PMID:37681230 | DOI:10.1093/jjco/hyad122
Source: Clinical Lung Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Yoshinori Handa Takuhiro Ikeda Hideaki Hanaki Yoshihiro Miyata Hidenori Mukaida Morihito Okada Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Therapeutic potential of targeting prokineticin receptors in diseases
This article reviews and summarizes our current knowledge of PK family functions from development of heart and brain to regulation of homeostasis in health and diseases. Finally, the review summarizes the established roles of the endogenous peptides, synthetic peptides and the selective ligands of PKR1 and PKR2, and nonpeptide orthostatic and allosteric modulator of the receptors in preclinical disease models. The present review emphasizes the ambiguous aspects and gaps in our knowledge of functions of PKR ligands and elucidates future perspectives for PK research. Significance Statement This review provides an in-depth vi...
Source: Pharmacological Reviews - September 8, 2023 Category: Drugs & Pharmacology Authors: Martina Vincenzi Amin Kremic Appoline Jouve Roberta Lattanzi Rossella Miele Mohamed Benharouga Nadia Alfaidy-Benharouga Stephanie Migrenne-Li Anumantha G Kanthasamy Marimelia Porcionatto Napoleone Ferrara Igor V Tetko Laurent D ésaubry Canan G Nebigil Source Type: research
Updated Austrian treatment algorithm for metastatic triple-negative breast cancer
Wien Klin Wochenschr. 2023 Sep 8. doi: 10.1007/s00508-023-02254-9. Online ahead of print.ABSTRACTApproximately 15% of newly diagnosed breast cancer patients have neither hormone receptors expression nor HER2 overexpression and/or HER2/neu gene amplification. This subtype of breast cancer is known as Triple Negative Breast Cancer (TNBC), and carries a significantly elevated risk of local and distant recurrence. In comparison with other breast cancer subtypes, there is a higher rate of visceral and brain metastases. The majority of metastases of TNBC are diagnosed within three years after initial breast cancer diagnosis. Whi...
Source: Wiener Klinische Wochenschrift - September 8, 2023 Category: General Medicine Authors: Rupert Bartsch Gabriel Rinnerthaler Edgar Petru Daniel Egle Michael Gnant Marija Balic Thamer Sliwa Christian Singer Source Type: research
Therapeutic potential of targeting prokineticin receptors in diseases
This article reviews and summarizes our current knowledge of PK family functions from development of heart and brain to regulation of homeostasis in health and diseases. Finally, the review summarizes the established roles of the endogenous peptides, synthetic peptides and the selective ligands of PKR1 and PKR2, and nonpeptide orthostatic and allosteric modulator of the receptors in preclinical disease models. The present review emphasizes the ambiguous aspects and gaps in our knowledge of functions of PKR ligands and elucidates future perspectives for PK research. Significance Statement This review provides an in-depth vi...
Source: Pharmacological Reviews - September 8, 2023 Category: Drugs & Pharmacology Authors: Martina Vincenzi Amin Kremic Appoline Jouve Roberta Lattanzi Rossella Miele Mohamed Benharouga Nadia Alfaidy-Benharouga Stephanie Migrenne-Li Anumantha G Kanthasamy Marimelia Porcionatto Napoleone Ferrara Igor V Tetko Laurent D ésaubry Canan G Nebigil Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine Reports - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Clinicopathologic study of stage I adenosquamous carcinoma of the lung
CONCLUSIONS: Early-stage adenosquamous carcinoma of the lung is a histological type associated with severe prognosis and postoperative recurrence, often in distant sites, in approximately one-third of cases. High serum carcinoembryonic antigen levels and vascular invasion might be risk factors of recurrence.PMID:37681230 | DOI:10.1093/jjco/hyad122
Source: Clinical Lung Cancer - September 8, 2023 Category: Cancer & Oncology Authors: Yoshinori Handa Takuhiro Ikeda Hideaki Hanaki Yoshihiro Miyata Hidenori Mukaida Morihito Okada Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine Reports - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
Updated Austrian treatment algorithm for metastatic triple-negative breast cancer
Wien Klin Wochenschr. 2023 Sep 8. doi: 10.1007/s00508-023-02254-9. Online ahead of print.ABSTRACTApproximately 15% of newly diagnosed breast cancer patients have neither hormone receptors expression nor HER2 overexpression and/or HER2/neu gene amplification. This subtype of breast cancer is known as Triple Negative Breast Cancer (TNBC), and carries a significantly elevated risk of local and distant recurrence. In comparison with other breast cancer subtypes, there is a higher rate of visceral and brain metastases. The majority of metastases of TNBC are diagnosed within three years after initial breast cancer diagnosis. Whi...
Source: Wiener Klinische Wochenschrift - September 8, 2023 Category: General Medicine Authors: Rupert Bartsch Gabriel Rinnerthaler Edgar Petru Daniel Egle Michael Gnant Marija Balic Thamer Sliwa Christian Singer Source Type: research
Therapeutic potential of targeting prokineticin receptors in diseases
This article reviews and summarizes our current knowledge of PK family functions from development of heart and brain to regulation of homeostasis in health and diseases. Finally, the review summarizes the established roles of the endogenous peptides, synthetic peptides and the selective ligands of PKR1 and PKR2, and nonpeptide orthostatic and allosteric modulator of the receptors in preclinical disease models. The present review emphasizes the ambiguous aspects and gaps in our knowledge of functions of PKR ligands and elucidates future perspectives for PK research. Significance Statement This review provides an in-depth vi...
Source: Pharmacological Reviews - September 8, 2023 Category: Drugs & Pharmacology Authors: Martina Vincenzi Amin Kremic Appoline Jouve Roberta Lattanzi Rossella Miele Mohamed Benharouga Nadia Alfaidy-Benharouga Stephanie Migrenne-Li Anumantha G Kanthasamy Marimelia Porcionatto Napoleone Ferrara Igor V Tetko Laurent D ésaubry Canan G Nebigil Source Type: research
Updated Austrian treatment algorithm for metastatic triple-negative breast cancer
Wien Klin Wochenschr. 2023 Sep 8. doi: 10.1007/s00508-023-02254-9. Online ahead of print.ABSTRACTApproximately 15% of newly diagnosed breast cancer patients have neither hormone receptors expression nor HER2 overexpression and/or HER2/neu gene amplification. This subtype of breast cancer is known as Triple Negative Breast Cancer (TNBC), and carries a significantly elevated risk of local and distant recurrence. In comparison with other breast cancer subtypes, there is a higher rate of visceral and brain metastases. The majority of metastases of TNBC are diagnosed within three years after initial breast cancer diagnosis. Whi...
Source: Wiener Klinische Wochenschrift - September 8, 2023 Category: General Medicine Authors: Rupert Bartsch Gabriel Rinnerthaler Edgar Petru Daniel Egle Michael Gnant Marija Balic Thamer Sliwa Christian Singer Source Type: research
