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Cancer: Brain Cancers
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Total 20131 results found since Jan 2013.
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia ‑induced invasion and therapeutic resistance
Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1.ABSTRACTGlioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Jan C Lumibao Payton L Haak Vladimir L Kolossov Jee-Wei Emily Chen Jeremy Stutchman Alejandra Ruiz Mayandi Sivaguru Jann N Sarkaria Brendan A C Harley Andrew J Steelman H Rex Gaskins Source Type: research
Sodium fluorescein uptake by the tumor microenvironment in human gliomas and brain metastases
CONCLUSIONS: SF is not just a marker of BBB damage, but its intracellular detection suggests that it selectively accumulates intracellularly. Future efforts should target the mechanisms of its differential uptake by the different TME cell types in depth.PMID:37657099 | DOI:10.3171/2023.7.JNS23873
Source: Journal of Neurosurgery - September 1, 2023 Category: Neurosurgery Authors: Beatrice Musca Camilla Bonaudo Ada Tushe Greta Battaggia Maria G Russo Micol Silic-Benussi Agnese Pedone Alessandro Della Puppa Susanna Mandruzzato Source Type: research
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia ‑induced invasion and therapeutic resistance
Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1.ABSTRACTGlioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Jan C Lumibao Payton L Haak Vladimir L Kolossov Jee-Wei Emily Chen Jeremy Stutchman Alejandra Ruiz Mayandi Sivaguru Jann N Sarkaria Brendan A C Harley Andrew J Steelman H Rex Gaskins Source Type: research
Sodium fluorescein uptake by the tumor microenvironment in human gliomas and brain metastases
CONCLUSIONS: SF is not just a marker of BBB damage, but its intracellular detection suggests that it selectively accumulates intracellularly. Future efforts should target the mechanisms of its differential uptake by the different TME cell types in depth.PMID:37657099 | DOI:10.3171/2023.7.JNS23873
Source: Journal of Neurosurgery - September 1, 2023 Category: Neurosurgery Authors: Beatrice Musca Camilla Bonaudo Ada Tushe Greta Battaggia Maria G Russo Micol Silic-Benussi Agnese Pedone Alessandro Della Puppa Susanna Mandruzzato Source Type: research
CHCHD2 mediates glioblastoma cell proliferation, mitochondrial metabolism, hypoxia ‑induced invasion and therapeutic resistance
Int J Oncol. 2023 Nov;63(5):117. doi: 10.3892/ijo.2023.5565. Epub 2023 Sep 1.ABSTRACTGlioblastoma (GBM) is the most common and malignant primary brain tumor affecting adults and remains incurable. The mitochondrial coiled‑coil‑helix‑coiled‑coil‑helix domain‑containing protein 2 (CHCHD2) has been demonstrated to mediate mitochondrial respiration, nuclear gene expression and cell migration; however, evidence of this in GBM is lacking. In the present study, it was hypothesized that CHCHD2 may play a functional role in U87 GBM cells expressing the constitutively active epidermal growth factor receptor variant III (...
Source: International Journal of Oncology - September 1, 2023 Category: Cancer & Oncology Authors: Jan C Lumibao Payton L Haak Vladimir L Kolossov Jee-Wei Emily Chen Jeremy Stutchman Alejandra Ruiz Mayandi Sivaguru Jann N Sarkaria Brendan A C Harley Andrew J Steelman H Rex Gaskins Source Type: research
Sodium fluorescein uptake by the tumor microenvironment in human gliomas and brain metastases
CONCLUSIONS: SF is not just a marker of BBB damage, but its intracellular detection suggests that it selectively accumulates intracellularly. Future efforts should target the mechanisms of its differential uptake by the different TME cell types in depth.PMID:37657099 | DOI:10.3171/2023.7.JNS23873
Source: Journal of Neurosurgery - September 1, 2023 Category: Neurosurgery Authors: Beatrice Musca Camilla Bonaudo Ada Tushe Greta Battaggia Maria G Russo Micol Silic-Benussi Agnese Pedone Alessandro Della Puppa Susanna Mandruzzato Source Type: research
AI rivals the human nose when it comes to naming smells
When Jonathan Deutsch agreed to sniff 400 vials of unlabeled liquid for science, he didn’t know he would be competing with a computer. A research chef who helps with food product development at Drexel University, he simply welcomed the chance to hone his sense of smell. But odor profiles generated by Deutsch and 13 other volunteers served as a test for a computer program that had been trained to produce these same types of descriptions—such as fruity, cooling, fishy, piny—using chemical structure alone.
The results, reported today in
Science
, show that the program, a so-called graph neural network, is
...
Source: ScienceNOW - August 31, 2023 Category: Science Source Type: news
Mechanisms Involved in the Therapeutic Effect of Cannabinoid Compounds on Gliomas: A Review with Experimental Approach
CONCLUSION: The evaluated compounds exhibited favorable interactions with the analyzed enzy-matic targets, thus representing potential candidates for further in vitro and in vivo studies.PMID:37649287 | DOI:10.2174/1389203724666230830125423
Source: Current Protein and Peptide Science - August 31, 2023 Category: Biochemistry Authors: Hugo Fernandes Oliveira Pires Pablo Rayff da Silva Arthur Lins Dias Cleyton de Sousa Gomes Nat ália Ferreira de Sousa Aline Matilde Ferreira Dos Santos L ívia Roberta Pimenta Souza Jaisl ânia Lucena de Figueiredo Lima Mayara Cecile Nascimento Oliveira Source Type: research
Massive Hemorrhage and Mortality Following Thyroid Radiofrequency Ablation
In conclusion, massive hemorrhages caused by RFA require immediate diagnosis and hemostasis.PMID:37649333 | DOI:10.1177/01455613231182234
Source: Ear, Nose and Throat Journal - August 31, 2023 Category: ENT & OMF Authors: Seulki Song Jin Pyeong Kim Source Type: research
The importance of escalating molecular diagnostics in patients with low-grade pediatric brain cancer
We report two cases of pilocytic astrocytoma with atypical tumor progression. Case 1 involves a 12-year-old boy with an unresectable suprasellar tumor, negative for BRAF rearrangement but harboring a BRAF p.V600E mutation. He experienced tumor size reduction and stable disease following dabrafenib treatment. Case 2 describes a 6-year-old boy with a thalamic tumor that underwent multiple resections, with no actionable driver detected using targeted next-generation sequencing (NGS). Whole-genome and RNAseq analysis identified an internal tandem duplication in FGFR1 and RAS pathway activation. Future management options includ...
Source: Molecular Medicine - August 31, 2023 Category: Molecular Biology Authors: Majd Al Assaad Gunes Gundem Benjamin Liechty Andrea Sboner Juan Medina Elli Papaemmanuil Cora N Sternberg Asher Marks Mark M Souweidane Jeffrey P Greenfield Ivy Tran Matija Snuderl Oliver Elemento Marcin Imielinski David J Pisapia Juan Miguel Mosquera Source Type: research
