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Total 20131 results found since Jan 2013.
Bone marrow mesenchymal stem cell exosomal miR-345-3p ameliorates cerebral ischemia-reperfusion injury by targeting TRAF6
CONCLUSION: This study found that BMSCs-exosomal miR-345-3p protected against CIR injury by decreasing TRAF6.PMID:37670712 | DOI:10.2174/1567202620666230905121102
Source: Current Neurovascular Research - September 6, 2023 Category: Neurology Authors: Dan Hou Lei Zhang Yujie Hu Guoshuai Yang Dan Yu Source Type: research
2022 Cannon Lecture: An ode to signal transduction - how the growth hormone pathway revealed insight into height, malignancy and obesity
Am J Physiol Endocrinol Metab. 2023 Sep 6. doi: 10.1152/ajpendo.00265.2023. Online ahead of print.ABSTRACTWalter Cannon was a highly regarded American neurologist and physiologist with extremely broad interests. In the tradition of Cannon and his broad interests, we discuss our laboratory's multi-faceted work in signal transduction over the past 40+ years. We show how our questioning of how growth hormone (GH) in the blood communicates with cells throughout the body to promote body growth and regulate body metabolism led to insight into not only body height, but also important regulators of malignancy and body weight. High...
Source: Am J Physiol Endocri... - September 6, 2023 Category: Endocrinology Authors: Christin Carter-Su Lawrence S Argetsinger Nadezhda V Svezhova Source Type: research
Bone marrow mesenchymal stem cell exosomal miR-345-3p ameliorates cerebral ischemia-reperfusion injury by targeting TRAF6
CONCLUSION: This study found that BMSCs-exosomal miR-345-3p protected against CIR injury by decreasing TRAF6.PMID:37670712 | DOI:10.2174/1567202620666230905121102
Source: Current Neurovascular Research - September 6, 2023 Category: Neurology Authors: Dan Hou Lei Zhang Yujie Hu Guoshuai Yang Dan Yu Source Type: research
2022 Cannon Lecture: An ode to signal transduction - how the growth hormone pathway revealed insight into height, malignancy and obesity
Am J Physiol Endocrinol Metab. 2023 Sep 6. doi: 10.1152/ajpendo.00265.2023. Online ahead of print.ABSTRACTWalter Cannon was a highly regarded American neurologist and physiologist with extremely broad interests. In the tradition of Cannon and his broad interests, we discuss our laboratory's multi-faceted work in signal transduction over the past 40+ years. We show how our questioning of how growth hormone (GH) in the blood communicates with cells throughout the body to promote body growth and regulate body metabolism led to insight into not only body height, but also important regulators of malignancy and body weight. High...
Source: Am J Physiol Endocri... - September 6, 2023 Category: Endocrinology Authors: Christin Carter-Su Lawrence S Argetsinger Nadezhda V Svezhova Source Type: research
Bone marrow mesenchymal stem cell exosomal miR-345-3p ameliorates cerebral ischemia-reperfusion injury by targeting TRAF6
CONCLUSION: This study found that BMSCs-exosomal miR-345-3p protected against CIR injury by decreasing TRAF6.PMID:37670712 | DOI:10.2174/1567202620666230905121102
Source: Current Neurovascular Research - September 6, 2023 Category: Neurology Authors: Dan Hou Lei Zhang Yujie Hu Guoshuai Yang Dan Yu Source Type: research
Flavonoids as promising anticancer therapeutics: Contemporary research, nanoantioxidant potential, and future scope
Phytother Res. 2023 Sep 5. doi: 10.1002/ptr.7975. Online ahead of print.ABSTRACTFlavonoids are natural polyphenolic compounds considered safe, pleiotropic, and readily available molecules. It is widely distributed in various food products such as fruits and vegetables and beverages such as green tea, wine, and coca-based products. Many studies have reported the anticancer potential of flavonoids against different types of cancers, including solid tumors. The chemopreventive effect of flavonoids is attributed to various mechanisms, including modulation of autophagy, induction of cell cycle arrest, apoptosis, and antioxidant...
Source: Cell Research - September 5, 2023 Category: Cytology Authors: Mukta Gupta Javed Ahmad Javed Ahamad Snehashis Kundu Archit Goel Awanish Mishra Source Type: research
Transcranial Direct Current Stimulation in Nicotine Use: Nursing Implications for Patient Outcomes
J Addict Nurs. 2023 Jul-Sep 01;34(3):E74-E78. doi: 10.1097/JAN.0000000000000542.ABSTRACTTobacco use is a leading cause of cancer, cardiovascular and respiratory disease, and preventable death in the United States. The brains of individuals with nicotine dependence are characterized by damaged mesolimbic pathways in the medial portion of the limbic and frontal lobes, creating positive reinforcing mechanisms. Transcranial direct current stimulation (tDCS) targets this neuroadaptation to improve smokers' nicotine-related outcomes, such as craving and smoking behavior, by depolarizing or hyperpolarizing the neurons of the brai...
Source: Cancer Control - September 5, 2023 Category: Cancer & Oncology Authors: Seok Hyun Gwon Han-Joo Lee Hyochol Brian Ahn Source Type: research
Toward Precision Oncology in Glioblastoma with a Personalized Cancer Genome Reporting Tool and Genetic Changes Identified by Whole Exome Sequencing
This study demonstrates the prospects of precision/personalized medicine in GBM specifically, and neurosurgical oncology more generally, including the potential for genomic profiling coupled with personalized cancer genome reporting. Further research and larger studies are warranted to validate these findings and advance the treatment options and outcomes for patients with GBM.PMID:37669106 | DOI:10.1089/omi.2023.0117
Source: Cancer Control - September 5, 2023 Category: Cancer & Oncology Authors: Onur Erdogan Şeyma Çolakoğlu Özkaya Can Erzik Kaya Bilguvar Kaz ım Yalçın Arga Fatih Bayrakl ı Source Type: research
Synthesis and in Vitro Cytotoxicity Evaluation of Jadomycins
In this study, we achieved the total synthesis of jadomycin T and jadomycin aglycons using L-threonine and 1-amino-2-propanol as nitrogen sources. Additionally, we evaluated the cytotoxic activity of eight compounds, including glycosides, jadomycin T, and their corresponding aglycons, in eight types of tumor cells. The evaluated jadomycins tended to exhibit stronger cytotoxic activity as aglycons than as glycosides. Although the presence of a 1,3-oxazolidine ring derived from an amino acid was not essential, the presence of the 1,3-oxazolidine ring showed strong activity when the ring had a carboxyl group. Furthermore, com...
Source: Chemical and Pharmaceutical Bulletin - September 4, 2023 Category: Drugs & Pharmacology Authors: Erika Iwasaki Yoshimi Shimizu Yusuke Akagi Toshiya Komatsu Source Type: research
Management Paradigm of Central Nervous System Metastases in NSCLC: An Australian Perspective
JTO Clin Res Rep. 2023 Jul 26;4(9):100553. doi: 10.1016/j.jtocrr.2023.100553. eCollection 2023 Sep.ABSTRACTLife-prolonging central nervous system active systemic therapies for metastatic NSCLC have increased the complexity of managing brain metastases (BMs). Australian medical oncologists, radiation oncologists, and neurosurgeons discussed the evidence guiding the diverse clinical approaches to the management of BM in NSCLC. The Australian context is broadly applicable to other jurisdictions; therefore, we have documented these discussions as principles with broader applications. Patient management was stratified according...
Source: Clinical Lung Cancer - September 4, 2023 Category: Cancer & Oncology Authors: Chee Khoon Lee Yu Yang Soon Rosalind L Jeffree Rohit Joshi Eng-Siew Koh Wei-Sen Lam Hien Le Zarnie Lwin Mark B Pinkham Shankar Siva Evan Ng Thomas John Source Type: research
