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Cancer: Brain Cancers
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Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine Reports - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts
CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research
Misdiagnosis of a Dissecting Aneurysm as a Cerebral Aneurysm: A Preoperative Case Report
CONCLUSION: Cerebral aneurysms typically involve larger arteries with rare possibilities of stenosis. Moreover, the cerebral artery is relatively small, making it challenging for Brain Computed Tomography Angiography (CTA) to distinguish true and false lumen within blood vessels. The diagnosis of dissecting aneurysms is difficult and often susceptible to clinical misdiagnosis.PMID:37678872
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xiaohong Guo Yi Wu Junkang Fang Source Type: research
IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts
CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research
Misdiagnosis of a Dissecting Aneurysm as a Cerebral Aneurysm: A Preoperative Case Report
CONCLUSION: Cerebral aneurysms typically involve larger arteries with rare possibilities of stenosis. Moreover, the cerebral artery is relatively small, making it challenging for Brain Computed Tomography Angiography (CTA) to distinguish true and false lumen within blood vessels. The diagnosis of dissecting aneurysms is difficult and often susceptible to clinical misdiagnosis.PMID:37678872
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xiaohong Guo Yi Wu Junkang Fang Source Type: research
Identifying core MRI sequences for reliable automatic brain metastasis segmentation
CONCLUSIONS: A T1-CE-only protocol suffices for the segmentation of BMs. The combination of T1-CE and T2-FLAIR is important for edema segmentation. Missing either T1-CE or T2-FLAIR decreases performance. These findings may improve imaging routines by omitting unnecessary sequences, thus allowing for faster procedures in daily clinical practice while enabling optimal neural network-based target definitions.PMID:37678623 | DOI:10.1016/j.radonc.2023.109901
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 7, 2023 Category: Radiology Authors: Josef A Buchner Jan C Peeken Lucas Etzel Ivan Ezhov Michael Mayinger Sebastian M Christ Thomas B Brunner Andrea Wittig Bj örn Menze Claus Zimmer Bernhard Meyer Matthias Guckenberger Nicolaus Andratschke Rami A El Shafie J ürgen Debus Susanne Rogers Oliv Source Type: research
IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts
CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research
Identifying core MRI sequences for reliable automatic brain metastasis segmentation
CONCLUSIONS: A T1-CE-only protocol suffices for the segmentation of BMs. The combination of T1-CE and T2-FLAIR is important for edema segmentation. Missing either T1-CE or T2-FLAIR decreases performance. These findings may improve imaging routines by omitting unnecessary sequences, thus allowing for faster procedures in daily clinical practice while enabling optimal neural network-based target definitions.PMID:37678623 | DOI:10.1016/j.radonc.2023.109901
Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - September 7, 2023 Category: Radiology Authors: Josef A Buchner Jan C Peeken Lucas Etzel Ivan Ezhov Michael Mayinger Sebastian M Christ Thomas B Brunner Andrea Wittig Bj örn Menze Claus Zimmer Bernhard Meyer Matthias Guckenberger Nicolaus Andratschke Rami A El Shafie J ürgen Debus Susanne Rogers Oliv Source Type: research
Misdiagnosis of a Dissecting Aneurysm as a Cerebral Aneurysm: A Preoperative Case Report
CONCLUSION: Cerebral aneurysms typically involve larger arteries with rare possibilities of stenosis. Moreover, the cerebral artery is relatively small, making it challenging for Brain Computed Tomography Angiography (CTA) to distinguish true and false lumen within blood vessels. The diagnosis of dissecting aneurysms is difficult and often susceptible to clinical misdiagnosis.PMID:37678872
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xiaohong Guo Yi Wu Junkang Fang Source Type: research
IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts
CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research
Misdiagnosis of a Dissecting Aneurysm as a Cerebral Aneurysm: A Preoperative Case Report
CONCLUSION: Cerebral aneurysms typically involve larger arteries with rare possibilities of stenosis. Moreover, the cerebral artery is relatively small, making it challenging for Brain Computed Tomography Angiography (CTA) to distinguish true and false lumen within blood vessels. The diagnosis of dissecting aneurysms is difficult and often susceptible to clinical misdiagnosis.PMID:37678872
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xiaohong Guo Yi Wu Junkang Fang Source Type: research
IL-27-induced, MSC-derived Exosomes Promote MMP3 Expression Through the miR-206/L3MBTL4 Axis in Synovial Fibroblasts
CONCLUSIONS: IL-27 can induce the expression of miR-206 in MSCs, and miR-206 can be transported into FLS through MSC-EVs to promote FLS migration and MMP3 expression and aggravate articular cartilage damage. Patients with RA who have a high IL-27 expression may not be suitable to receive treatment with MSCs, and clinicians can use MSCs that knock down or delete IL-27R to treat RA patients who have a high IL-27 expression.PMID:37678876
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Lihui Ma Yueli Liu Fenghuang Xu Ruiming Shen Min Wang Yunfei Zhang Chang Liu Guifu Zheng Source Type: research
Misdiagnosis of a Dissecting Aneurysm as a Cerebral Aneurysm: A Preoperative Case Report
CONCLUSION: Cerebral aneurysms typically involve larger arteries with rare possibilities of stenosis. Moreover, the cerebral artery is relatively small, making it challenging for Brain Computed Tomography Angiography (CTA) to distinguish true and false lumen within blood vessels. The diagnosis of dissecting aneurysms is difficult and often susceptible to clinical misdiagnosis.PMID:37678872
Source: Alternative Therapies in Health and Medicine - September 7, 2023 Category: Complementary Medicine Authors: Xiaohong Guo Yi Wu Junkang Fang Source Type: research
Providing End-of-Life Care in the Community: What Are the Challenges in Malaysia?
J Hosp Palliat Care. 2022 Sep 1;25(3):133-137. doi: 10.14475/jhpc.2022.25.3.133.ABSTRACTA 72-year-old woman with metastatic lung cancer to bone and brain and with left external iliac vein thrombosis was under the care of a community palliative care provider. She experienced an acute pain crisis due to acute limb ischemia of the left lower limb. Goals-of-care discussions were held with the patient and her family; she prioritized symptom control and end-of-life care at home. The family and patient were aware of her short prognosis. Her complex pain was managed by the community palliative team, and her family was empowered to...
Source: Cancer Control - September 7, 2023 Category: Cancer & Oncology Authors: Yoke Yeng Leong Ednin Hamzah Sylvia McCarthy Zee Nee Lim Source Type: research
Encephalitis in a patient with hypopharynx cancer treated with immune checkpoint inhibitors and radiotherapy: a case report and review of the literature
J Cancer Res Clin Oncol. 2023 Sep 7. doi: 10.1007/s00432-023-05328-3. Online ahead of print.ABSTRACTHypopharyngeal cancer (HPC) has one of the most unfavorable prognoses among head and neck squamous cell carcinomas. Immunotherapy in combination with chemotherapy, the same as conventional induction chemotherapy, has emerged as a vital part of the induction therapy protocol for HPC. Meanwhile, the incidence of immune-related adverse events is increasing. In this light, we present the first reported case of immune-associated encephalitis in a patient with hypopharyngeal cancer treated with Camrelizumab (a PD-1 inhibitor). Aft...
Source: Cell Research - September 7, 2023 Category: Cytology Authors: Yan Kang Hongchao Zhen Nina Ma Hong Zhao Bangwei Cao Source Type: research
