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A Novel Mutation of < em > MSH2 < /em > Gene in a Patient with Lynch Syndrome Presenting with Thirteen Metachronous Malignancies
J Clin Med. 2023 Aug 24;12(17):5502. doi: 10.3390/jcm12175502.ABSTRACTLynch syndrome (LS), also known as hereditary nonpolyposis colorectal cancer (HNPCC), accounts for 2-3% of all colorectal cancers. This autosomal dominant disorder is associated with a predisposition to endometrial, stomach, small bowel, pancreatic, biliary tract, ovary, urinary tract, brain, and skin tumors. Lynch syndrome is caused by the mutation of the MLH1, MSH2 (EPCAM), MSH6, and PMS2 genes. In this article, a case study of a 70-year-old female patient with Lynch syndrome is presented. Over a span of 30 years, the patient underwent multiple surgica...
Source: Clinical Colorectal Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Ugne Silinskaite Edita Gavelien ė Rokas Stulpinas Ramunas Janavicius Tomas Poskus Source Type: research
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
Brain Behav Immun. 2023 Sep 7;114:299-310. doi: 10.1016/j.bbi.2023.09.004. Online ahead of print.ABSTRACTPatients characterized by stress-related disorders such as depression display elevated circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis. Psychedelics are demonstrating promising results in treatment of such disorders, however the mechanisms of their therapeutic effects are still unknown. To date the evidence of acute and persisting effects of psychedelics on immune functioning, HPA axis activity in response to stress, and associated psychological outcomes is preliminary. To address thi...
Source: Brain, Behavior, and Immunity - September 9, 2023 Category: Neurology Authors: N L Mason A Szabo K P C Kuypers P A Mallaroni R de la Torre Fornell J T Reckweg D H Y Tse N R P W Hutten A Feilding J G Ramaekers Source Type: research
Two Sides of The Same Coin: Normal and Tumoral Stem Cells, The Relevance of In Vitro Models and Therapeutic Approaches: The Experience with Zika Virus in Nervous System Development and Glioblastoma Treatment
Int J Mol Sci. 2023 Aug 31;24(17):13550. doi: 10.3390/ijms241713550.ABSTRACTNeural stem cells (NSCs) were described for the first time more than two decades ago for their ability to differentiate into all neural cell lineages. The isolation of NSCs from adults and embryos was carried out by various laboratories and in different species, from mice to humans. Similarly, no more than two decades ago, cancer stem cells were described. Cancer stem cells, previously identified in hematological malignancies, have now been isolated from several solid tumors (breast, brain, and gastrointestinal compartment). Though the origin of th...
Source: Molecular Medicine - September 9, 2023 Category: Molecular Biology Authors: Rosaria Tinnirello Cinzia Maria Chinnici Vitale Miceli Rosalia Bus à Matteo Bulati Alessia Gallo Giovanni Zito Pier Giulio Conaldi Gioacchin Iannolo Source Type: research
Differentiation of lung and breast cancer brain metastases: Comparison of texture analysis and deep convolutional neural networks
CONCLUSION: CNNs achieved superior diagnostic performance in differentiating brain metastases from lung and breast malignancies than texture-based image features. Differentiation using 3D volumes as input exhibited a higher success rate than 2D sagittal images.PMID:37688435 | DOI:10.1002/jcu.23558
Source: Clinical Genitourinary Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Mehmet Ali Gultekin Abdusselim Adil Peker Ayse Betul Oktay Haci Mehmet Turk Dilek Hacer Cesme Abdallah T M Shbair Temel Fatih Yilmaz Ahmet Kaya Ayse Irem Yasin Mesut Seker Alpaslan Mayadagli Alpay Alkan Source Type: research
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
Brain Behav Immun. 2023 Sep 7:S0889-1591(23)00268-4. doi: 10.1016/j.bbi.2023.09.004. Online ahead of print.ABSTRACTPatients characterized by stress-related disorders such as depression display elevated circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis. Psychedelics are demonstrating promising results in treatment of such disorders, however the mechanisms of their therapeutic effects are still unknown. To date the evidence of acute and persisting effects of psychedelics on immune functioning, HPA axis activity in response to stress, and associated psychological outcomes is preliminary. To a...
Source: Brain, Behavior, and Immunity - September 9, 2023 Category: Neurology Authors: N L Mason A Szabo K P C Kuypers P A Mallaroni R de la Torre Fornell J T Reckweg D H Y Tse N R P W Hutten A Feilding J G Ramaekers Source Type: research
Machine-Learning-Aided Prediction of Brain Metastases Development in Non-Small-Cell Lung Cancers
CONCLUSION: Analysis of the importance of input features suggests that the models are learning the relevant relationships between clinical features/development of BM. A higher number of samples is to be prioritized to improve performance. Employed prospectively at initial diagnosis, such models can help select high-risk subgroups for surveillance brain MRI.PMID:37689579 | DOI:10.1016/j.cllc.2023.08.002
Source: Clinical Lung Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Giovanni Vison à Lisa M Spiller Sophia Hahn Elke Hattingen Thomas J Vogl Gabriele Schweikert Katrin Bankov Melanie Demes Henning Reis Peter Wild Pia S Zeiner Fabian Acker Martin Sebastian Katharina J Wenger Source Type: research
Differentiation of lung and breast cancer brain metastases: Comparison of texture analysis and deep convolutional neural networks
CONCLUSION: CNNs achieved superior diagnostic performance in differentiating brain metastases from lung and breast malignancies than texture-based image features. Differentiation using 3D volumes as input exhibited a higher success rate than 2D sagittal images.PMID:37688435 | DOI:10.1002/jcu.23558
Source: Clinical Lung Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Mehmet Ali Gultekin Abdusselim Adil Peker Ayse Betul Oktay Haci Mehmet Turk Dilek Hacer Cesme Abdallah T M Shbair Temel Fatih Yilmaz Ahmet Kaya Ayse Irem Yasin Mesut Seker Alpaslan Mayadagli Alpay Alkan Source Type: research
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
Brain Behav Immun. 2023 Sep 7;114:299-310. doi: 10.1016/j.bbi.2023.09.004. Online ahead of print.ABSTRACTPatients characterized by stress-related disorders such as depression display elevated circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis. Psychedelics are demonstrating promising results in treatment of such disorders, however the mechanisms of their therapeutic effects are still unknown. To date the evidence of acute and persisting effects of psychedelics on immune functioning, HPA axis activity in response to stress, and associated psychological outcomes is preliminary. To address thi...
Source: Brain, Behavior, and Immunity - September 9, 2023 Category: Neurology Authors: N L Mason A Szabo K P C Kuypers P A Mallaroni R de la Torre Fornell J T Reckweg D H Y Tse N R P W Hutten A Feilding J G Ramaekers Source Type: research
The origin of brain malignancies at the blood-brain barrier
Cell Mol Life Sci. 2023 Sep 9;80(10):282. doi: 10.1007/s00018-023-04934-1.ABSTRACTDespite improvements in extracranial therapy, survival rate for patients suffering from brain metastases remains very poor. This is coupled with the incidence of brain metastases continuing to rise. In this review, we focus on core contributions of the blood-brain barrier to the origin of brain metastases. We first provide an overview of the structure and function of the blood-brain barrier under physiological conditions. Next, we discuss the emerging idea of a pre-metastatic niche, namely that secreted factors and extracellular vesicles from...
Source: Cellular and Molecular Life Sciences : CMLS - September 9, 2023 Category: Cytology Authors: Brennan McDonald Kathrin Barth Mirko H H Schmidt Source Type: research
The Complexity of Treatments and the Multidisciplinary Team-A Rare Case of Long-Term Progression-Free Survival in Prostate Cancer until Development of Liver and Brain Metastases
CONCLUSIONS: Brain metastases are an unfavorable prognostic factor in prostate cancer. The therapeutic options developed in recent years allow the improvement of survival.PMID:37685646 | PMC:PMC10488423 | DOI:10.3390/jcm12175579
Source: Clinical Prostate Cancer - September 9, 2023 Category: Cancer & Oncology Authors: Roxana-Andreea Rahnea-Nita Laura-Florentina Rebegea Alexandru Nechifor Cristian Mare ș Radu-Valeriu Toma Alexandru-Rares Stoian Anda-Natalia Ciuhu Liliana-Florina Andronache Georgiana Bianca Constantin Gabriela Rahnea-Nita Source Type: research
Psilocybin induces acute and persisting alterations in immune status in healthy volunteers: An experimental, placebo-controlled study
Brain Behav Immun. 2023 Sep 7;114:299-310. doi: 10.1016/j.bbi.2023.09.004. Online ahead of print.ABSTRACTPatients characterized by stress-related disorders such as depression display elevated circulating concentrations of pro-inflammatory cytokines and a hyperactive HPA axis. Psychedelics are demonstrating promising results in treatment of such disorders, however the mechanisms of their therapeutic effects are still unknown. To date the evidence of acute and persisting effects of psychedelics on immune functioning, HPA axis activity in response to stress, and associated psychological outcomes is preliminary. To address thi...
Source: Brain, Behavior, and Immunity - September 9, 2023 Category: Neurology Authors: N L Mason A Szabo K P C Kuypers P A Mallaroni R de la Torre Fornell J T Reckweg D H Y Tse N R P W Hutten A Feilding J G Ramaekers Source Type: research
Radiation dose to sleep-relevant brain structures linked to impaired sleep quality in primary brain tumor patients
Acta Oncol. 2023 Sep 9:1-6. doi: 10.1080/0284186X.2023.2249219. Online ahead of print.NO ABSTRACTPMID:37688522 | DOI:10.1080/0284186X.2023.2249219
Source: Acta Oncologica - September 9, 2023 Category: Cancer & Oncology Authors: Ali Amidi Lene Haldbo-Classen Jesper F Kallehauge Lisa M Wu Robert Zachariae Yasmin Lassen-Ramshad Slavka Lukacova Morten H øyer Source Type: research
Advancements and emerging trends in brain tumor classification using MRI: a systematic review
AbstractBrain tumor (BT) classification plays a crucial role in the diagnosis and treatment of BTs using Magnetic Resonance Imaging (MRI) scans. This systematic review aims to analyze and summarize the existing literature on BT classification using MRI, focusing on the advancements, techniques, and trends in this field. A comprehensive search strategy was employed to identify relevant articles published between 2020 and 2023. The selected articles were analyzed based on their pre-processing techniques, feature extraction methods, segmentation approaches, and classification algorithms. The review highlights the strengths an...
Source: Network Modeling Analysis in Health Informatics and Bioinformatics - September 9, 2023 Category: Bioinformatics Source Type: research
Iron oxide nanoparticles induce ferroptosis via the autophagic pathway by synergistic bundling with paclitaxel
Mol Med Rep. 2023 Oct;28(4):198. doi: 10.3892/mmr.2023.13085. Epub 2023 Sep 8.ABSTRACTIn recent years, inhibiting tumor cell activity by triggering cell ferroptosis has become a research hotspot. The development of generic targeted nanotherapeutics might bring new ideas for non‑invasive applications. Currently, the potential mechanism underlying the universal application of paclitaxel (PTX)‑loaded iron oxide nanoparticles (IONP@PTX) to different types of tumors is unclear. The present study aimed to prepare IONP@PTX for targeted cancer therapy and further explore the potential mechanisms underlying the inhibitory effec...
Source: Molecular Medicine Reports - September 8, 2023 Category: Molecular Biology Authors: Qi Nie Wenqing Chen Tianmei Zhang Shangrong Ye Zhongyu Ren Peng Zhang Jian Wen Source Type: research
