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Condition: Depression
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Total 96277 results found since Jan 2013.
Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats
Behav Brain Res. 2023 Sep 14;455:114664. doi: 10.1016/j.bbr.2023.114664. Online ahead of print.ABSTRACTDepressive illness has been associated with impaired cognitive processes accompanied by reduced neurotrophin levels, especially brain-derived neurotrophic factor (BDNF), and dysfunctions in the hypothalamic-pituitary-adrenal (HPA) axis. In addition, depression is characterized by a decreased functioning of the serotonergic system due to changes in the activity or expression of its receptors including, most significantly, 5-HT1A, 5-HT2A, and 5-HT3 in brain regions that regulate mood, emotions, and memory, such as the prefr...
Source: Brain Research - September 15, 2023 Category: Neurology Authors: Ofelia Lim ón-Morales Kenia Morales-Quintero Marcela Arteaga-Silva Tania Molina-Jim énez Marco Cerb ón Herlinda Bonilla-Jaime Source Type: research
Cognitive Behaviour Therapy (CBT) for Depersonalization Derealization Disorder (DDD): a self-controlled cross-over study of waiting list vs. active treatment
We report on a clinical audit of 36 participants with a diagnosis of chronic DDD who were sequentially recruited from a specialist DDD National Health Service clinic in London, United Kingdom, and who completed Cognitive Behavioural Therapy specifically adapted for DDD. The sample population had a mean age of 38.7 years (s.d. = 13.4), 61% were male and 69% were of White ethnicity. Three outcomes were assessed (Cambridge Depersonalisation Scale [CDS], Beck Depression Inventory [BDI], and the Beck Anxiety Inventory [BAI]) at three time points in a naturalistic, self-controlled, cross-over design. Hierarchical longitudinal an...
Source: Cognitive Behaviour Therapy - September 15, 2023 Category: Psychiatry & Psychology Authors: Elaine C M Hunter Cheuk Lon Malcolm Wong Rafael Gafoor Glyn Lewis Anthony S David Source Type: research
Efficacy of Low-dose Olanzapine in Combination with Sertraline on Negative Symptoms and Psychosocial Functioning in Schizophrenia: A Randomized Controlled Trial
CONCLUSION: This study demonstrates that low-dose OLA in combination with sertraline had clinically meaningful improvements not only in the negative and depressive symptoms but also in psychosocial functioning in patients with FE-SCH, while not affecting positive symptoms.PMID:37711125 | DOI:10.2174/1570159X21666230913152344
Source: Current Neuropharmacology - September 15, 2023 Category: Drugs & Pharmacology Authors: Meihong Xiu Lei Zhao Qianqian Sun Xiaoe Lang Source Type: research
Emotion dynamics of clients with test anxiety before and after an imagery-based treatment
CONCLUSION: These results provide first evidence for the idea that emotion dynamics may be associated with response to treatment for TA. Furthermore, effective imagery-based treatments may be tied to changes within these dynamics.PMID:37714799 | DOI:10.1016/j.jbtep.2023.101909
Source: Behavior Therapy - September 15, 2023 Category: Psychiatry & Psychology Authors: Jessica Uhl Steffen Eberhardt Brian Schwartz Eshkol Rafaeli Wolfgang Lutz Source Type: research
Negative mood and optimism bias: An experimental investigation of sadness and belief updating
CONCLUSIONS: These findings suggest that momentary fluctuations in mood affect how individuals integrate information to form beliefs.PMID:37714798 | DOI:10.1016/j.jbtep.2023.101910
Source: Behavior Therapy - September 15, 2023 Category: Psychiatry & Psychology Authors: Aleksandr T Karnick Brian W Bauer Daniel W Capron Source Type: research
The Combination of Depression and Obesity was Associated with Increased Incidence of Subsequent Total Knee Arthroplasty
CONCLUSION: The incidence of subsequent TKA was greatest for those with the combination of obesity and depression when compared to the Control group and those with individual diagnosis of obesity or depression.PMID:37714551 | DOI:10.3899/jrheum.2023-0367
Source: J Rheumatol - September 15, 2023 Category: Rheumatology Authors: Caitlin E W Conley David C Landy Christian Lattermann Joanne Borg-Stein Jamie E Collins Ana-Maria Vranceanu Cale A Jacobs Source Type: research
Role of Minocycline as an Adjunct Neuroinflammatory Modulator in Treatment-Resistant Depression: A Systematic Review of Randomized Controlled Trials
Conclusions: The results were inconsistent regarding the clinical and neuroprotective role of minocycline in TRD. More study is needed to clarify the pathophysiologic and clinical role of minocycline as an immunomodulator in TRD.Prim Care Companion CNS Disord 2023;25(5):22r03467.Author affiliations are listed at the end of this article.PMID:37713730 | DOI:10.4088/PCC.22r03467
Source: The Primary Care Companion for CNS Disorders - September 15, 2023 Category: Primary Care Authors: Wisam Al Jumaili Darshini Vora Chintan Trivedi Shailesh Jain Source Type: research
Alterations of learning and memory are accompanied by alterations in the expression of 5-HT receptors, glucocorticoid receptor and brain-derived neurotrophic factor in different brain regions of an animal model of depression generated by neonatally male treatment with clomipramine in male rats
Behav Brain Res. 2023 Sep 14;455:114664. doi: 10.1016/j.bbr.2023.114664. Online ahead of print.ABSTRACTDepressive illness has been associated with impaired cognitive processes accompanied by reduced neurotrophin levels, especially brain-derived neurotrophic factor (BDNF), and dysfunctions in the hypothalamic-pituitary-adrenal (HPA) axis. In addition, depression is characterized by a decreased functioning of the serotonergic system due to changes in the activity or expression of its receptors including, most significantly, 5-HT1A, 5-HT2A, and 5-HT3 in brain regions that regulate mood, emotions, and memory, such as the prefr...
Source: Behavioural Brain Research - September 15, 2023 Category: Neurology Authors: Ofelia Lim ón-Morales Kenia Morales-Quintero Marcela Arteaga-Silva Tania Molina-Jim énez Marco Cerb ón Herlinda Bonilla-Jaime Source Type: research
VPS13A knockdown impairs corticostriatal synaptic plasticity and locomotor behavior in a new mouse model of chorea-acanthocytosis
Neurobiol Dis. 2023 Sep 13:106292. doi: 10.1016/j.nbd.2023.106292. Online ahead of print.ABSTRACTChorea-acanthocytosis (ChAc) is an inherited neurodegenerative movement disorder caused by VPS13A gene mutations leading to the absence of protein expression. The striatum is the most affected brain region in ChAc patients. However, the study of the VPS13A function in the brain has been poorly addressed. Here we generated a VPS13A knockdown (KD) model and aimed to elucidate the contribution of VPS13A to synaptic plasticity and neuronal communication in the corticostriatal circuit. First, we infected primary cortical neurons wit...
Source: Neurobiology of Disease - September 15, 2023 Category: Neurology Authors: Esther Garc ía-García Alba Ram ón-Lainez Sara Conde-Berriozabal Daniel Del Toro Georgia Escaramis Albert Giralt Merc è Masana Jordi Alberch Manuel J Rodr íguez Source Type: research
The relationship of food addiction with binge eating disorder and obesity: A network analysis study
Appetite. 2023 Sep 13:107037. doi: 10.1016/j.appet.2023.107037. Online ahead of print.ABSTRACTFood addiction (FA) has been associated with binge eating disorder (BED) and obesity at varying levels of severity and treatment outcomes. Despite much debate and scientific interest in FA, the mechanisms that underlie its co-occurrence with both conditions are not yet well understood. In order to understand this relationship, this study explores FA in a clinical sample of individuals with BED and obesity using network analysis (NA). A total of 303 patients (151 with BED and 152 with obesity) completed a battery of tests that inve...
Source: Appetite - September 15, 2023 Category: Nutrition Authors: Elvira Anna Carbone Matteo Aloi Marianna Rania Renato de Filippis Daria Quirino Teresa Vanessa Fiorentino Cristina Segura-Garcia Source Type: research
The SOFIA pilot study: assessing feasibility and fidelity of coordinated care to reduce excess mortality and increase quality of life in patients with severe mental illness in a general practice setting; a cluster-randomised pilot trial
CONCLUSION: Our findings suggest that delivering the coordinated care program in a fully powered trial in primary care is likely feasible. However, the recruitment methodology requires improvement to ensure sufficient recruitment and minimize selective inclusion.TRIAL REGISTRATION: The date of pilot trial protocol registration was 05/11/2020, and the registration number is NCT04618250.PMID:37715123 | PMC:PMC10504748 | DOI:10.1186/s12875-023-02141-2
Source: Primary Care - September 15, 2023 Category: Primary Care Authors: Katrine Tranberg Alexandra J ønsson Tina Due Volkert Siersma John Brandt Brodersen Kristine Bissenbakker Frederik Martiny Annette Davidsen Pia K ürstein Kjellberg Kevin Doherty Stewart W Mercer Maria Haahr Nielsen Susanne Reventlow Anne M øller Maarten Source Type: research
Mental Health Screening Differences in Non-English Speaking Patients: Results From a Retrospective Cohort Study
CONCLUSIONS: Results highlight the inequities between the language groups that are probably the result of the challenges to access multilingual depression and anxiety screening instruments. Furthermore, providers may be prone to bias about who they think "needs" a mental health screening. We suggest that measures are implemented to ensure consistency in mental health screening regardless of a patients' preferred language.PMID:37714820 | PMC:PMC10504842 | DOI:10.1177/21501319231200304
Source: Primary Care - September 15, 2023 Category: Primary Care Authors: Frank M üller Alyssa M Abdelnour Diana N Rutaremara Judith E Arnetz Eric D Achtyes Omayma Alshaarawy Harland T Holman Source Type: research
Understanding depression beyond the "mind-body" dichotomy
World Psychiatry. 2023 Oct;22(3):349-350. doi: 10.1002/wps.21142.NO ABSTRACTPMID:37713548 | DOI:10.1002/wps.21142
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Mario Maj Source Type: research
Role of Minocycline as an Adjunct Neuroinflammatory Modulator in Treatment-Resistant Depression: A Systematic Review of Randomized Controlled Trials
Conclusions: The results were inconsistent regarding the clinical and neuroprotective role of minocycline in TRD. More study is needed to clarify the pathophysiologic and clinical role of minocycline as an immunomodulator in TRD.Prim Care Companion CNS Disord 2023;25(5):22r03467.Author affiliations are listed at the end of this article.PMID:37713730 | DOI:10.4088/PCC.22r03467
Source: Primary Care - September 15, 2023 Category: Primary Care Authors: Wisam Al Jumaili Darshini Vora Chintan Trivedi Shailesh Jain Source Type: research
The psychedelic experience and treatment-resistant depression
World Psychiatry. 2023 Oct;22(3):420-422. doi: 10.1002/wps.21140.NO ABSTRACTPMID:37713542 | DOI:10.1002/wps.21140
Source: World Psychiatry - September 15, 2023 Category: Psychiatry Authors: Guy M Goodwin Source Type: research
