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Condition: Depression
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The heterogeneity of metabolic syndrome presentation and challenges this causes in its pharmacological management. A narrative review focusing on principal risk modifiers
Expert Rev Clin Pharmacol. 2023 Sep 18. doi: 10.1080/17512433.2023.2259306. Online ahead of print.ABSTRACTINTRODUCTION: Metabolic syndrome (MetS), i.e. the cluster of cardiometabolic risk factors comprising visceral obesity, impaired glucose metabolism, arterial hypertension and atherogenic dyslipidemia, is prevalent globally and exacts a heavy toll on health care expenditures.AREAS COVERED: The pathophenotypes of individual traits of the MetS in adults are discussed first, with strong emphasis on nonalcoholic fatty liver disease (NAFLD) and sex differences. Next, I discuss recent studies on phenotypic and outcome heteroge...
Source: Pharmacological Reviews - September 18, 2023 Category: Drugs & Pharmacology Authors: Amedeo Lonardo Source Type: research
Persian version of the Chalder Fatigue Questionnaire and Multidimensional Fatigue Symptom Inventory-Short Form: psychometric properties in Iranian chronic stroke survivors
CONCLUSIONS: The results of this study showed that the CFQ and MFSI-SF have high reliability and validity for chronic stroke survivors.PMID:37723098 | DOI:10.1080/10749357.2023.2175421
Source: Topics in Stroke Rehabilitation - September 18, 2023 Category: Neurology Authors: Soheila Fallah Ghorban Taghizadeh Zahra Parnain Moslem Cheraghifard Parvaneh Taghavi Azar Sharabiani Mahin Yousefi Mohammad Taghi Joghataei Ali Gholizade Source Type: research
Impact of rehabilitation adherence and depressive symptoms on post-stroke self-care ability and quality of life: a longitudinal study
CONCLUSION: Both depressive symptoms and rehabilitation adherence behavior impacted the rehabilitation effect among patients who are recovering from a stroke.PMID:37722691 | DOI:10.1080/10749357.2023.2259652
Source: Topics in Stroke Rehabilitation - September 18, 2023 Category: Neurology Authors: Jeng Wang Wen-Yu Kuo Min-Chi Chen Chen-Yin Chen Source Type: research
Relationship between seminal vesicle displacement and distribution of hydrogel spacer within the perirectal space in prostate radiotherapy
In conclusion, SV cranial displacement was influenced by HS lateral distribution of ≥1.00 cm in the upper two slices. Therefore, when the sigmoid colon or small bowel is depressed in rectovesical excavation and SV needs to be included in the target volume, HS insertion should be performed carefully.PMID:37719041 | PMC:PMC10502802 | DOI:10.3892/mco.2023.2674
Source: Clinical Prostate Cancer - September 18, 2023 Category: Cancer & Oncology Authors: Kenji Makita Yasushi Hamamoto Hiromitsu Kanzaki Kei Nagasaki Katsuyoshi Hashine Source Type: research
Programmed Cell Death in Unicellular Versus Multicellular Organisms
Annu Rev Genet. 2023 Sep 18. doi: 10.1146/annurev-genet-033123-095833. Online ahead of print.ABSTRACTProgrammed cell death (self-induced) is intrinsic to all cellular life forms, including unicellular organisms. However, cell death research has focused on animal models to understand cancer, degenerative disorders, and developmental processes. Recently delineated suicidal death mechanisms in bacteria and fungi have revealed ancient origins of animal cell death that are intertwined with immune mechanisms, allaying earlier doubts that self-inflicted cell death pathways exist in microorganisms. Approximately 20 mammalian death...
Source: Annual Review of Genetics - September 18, 2023 Category: Genetics & Stem Cells Authors: Madhura Kulkarni J Marie Hardwick Source Type: research
Uncovering associations between gender nonconformity, psychosocial factors, and mental health in adolescents: a birth cohort study
CONCLUSIONS: Persistent gender nonconformity during adolescence is associated with subsequent mental health. Psychosocial factors play a vital mediating role in this association, highlighting the essential need for social intervention and change to reduce stigmatization and ameliorate mental health challenges.PMID:37721216 | DOI:10.1017/S0033291723002623
Source: Psychological Medicine - September 18, 2023 Category: Psychiatry Authors: Zui Narita Jordan DeVylder Syudo Yamasaki Shuntaro Ando Kaori Endo Mitsuhiro Miyashita Satoshi Yamaguchi Satoshi Usami Daniel Stanyon Gemma Knowles Mariko Hiraiwa-Hasegawa Toshiaki A Furukawa Kiyoto Kasai Atsushi Nishida Source Type: research
Mitochondrial health index correlates with plasma circulating cell-free mitochondrial DNA in bipolar disorder
This study aimed to evaluate the composite mitochondrial health index (MHI) in BD subjects and non-psychiatry controls. We will also explore whether lower MIH will be related to higher cell-free mtDNA (ccf-mtDNA) levels and poor clinical outcomes. In this study, 14 BD-I patients and 16 age- and sex-matched non-psychiatry controls were enrolled. Peripheral blood mononuclear cells (PBMCs) were used to measure the enzymatic activities of citrate synthase and complexes I, II, and IV and mtDNA copy number. Ccf-mtDNA was evaluated by qPCR in plasma. Mitochondrial quality control (MQC) proteins were evaluated by western blotting....
Source: Cancer Control - September 18, 2023 Category: Cancer & Oncology Authors: Rafaela C Cordeiro Camila N C Lima Gabriel R Fries Giovana Zunta-Soares Jair C Soares Jo ão Quevedo Giselli Scaini Source Type: research
Assessing the association between probable posttraumatic stress disorder symptoms and quality of life among emergency service workers using path analysis
CONCLUSION: Active coping in response to stressful situations is important for maintaining good mental health among emergency service workers. Active coping and social support may strengthen resilience, and resilience may improve QOL. Screening for mental health and QOL should include simultaneous assessment of stress-coping, social support, and resilience. Although the findings of this cross-sectional study are important, it could not confirm a causal relationship between PTSD and QOL.PMID:37718827 | DOI:10.3233/WOR-220551
Source: Work - September 18, 2023 Category: Occupational Health Authors: Yoshikazu Noda Kenichi Asano Eiji Shimizu Yoshiyuki Hirano Source Type: research
The role of thwarted belongingness and perceived burdensomeness in passive suicide ideation among Latinx and Black youth
CONCLUSION: These findings confirm the importance of examining the IPTS constructs and their relationship to passive SI in diverse populations. The relationship between TB and SI in Latinx and Black youth suggests it may be an important target for suicide prevention.PMID:37720934 | DOI:10.1111/sltb.13003
Source: Suicide and Life-Threatening Behavior - September 18, 2023 Category: Psychiatry & Psychology Authors: Carolina V élez-Grau Melissa McTernan Laura Mufson Michael A Lindsey Source Type: research
Specificity, frequency, and intent: Multiple characteristics of adolescents' suicide plan correlate with their history of suicidal behavior
CONCLUSIONS: It may not only be whether, but how, adolescents plan for suicide that relates to their tendency to engage in SB.PMID:37720928 | DOI:10.1111/sltb.13002
Source: Suicide and Life-Threatening Behavior - September 18, 2023 Category: Psychiatry & Psychology Authors: Maura A Beaton Ilana Gratch Christine B Cha Source Type: research
Paved with good intentions: How our systems intersect to create health disparities for multiply marginalized youth
CONCLUSIONS: This piece highlights the inaccessibility of dialectical behavior therapy for multiply marginalized youth, and outlines suggestions for improving access to high-quality care for minoritized youth engaging in suicidal behavior.PMID:37718961 | DOI:10.1111/sltb.13001
Source: Suicide and Life-Threatening Behavior - September 18, 2023 Category: Psychiatry & Psychology Authors: Anna Maria Ros Claire A Coyne Stephanie Clarke Source Type: research
Endocrine disruptors in Adansonia digitata (Linn) extract induce alteration of female Wistar rats' oestrous cycle, hormone and lipid profiles
CONCLUSION: AAMF fraction of A. digitata (L) root bark disrupts the endocrine activity in female Wistar rats. The oleic acid component of the AAMF fraction may be responsible for modulating the activities of reproductive hormones. The authors recommend further studies to ascertain the significance of Adansonia digitata extract's oleic acid in regulating the female reproductive cycle.PMID:37722461 | DOI:10.1016/j.ygcen.2023.114385
Source: General and Comparative Endocrinology - September 18, 2023 Category: Endocrinology Authors: Chibuogwu Ijeoma Chika Nwannenna Agnes Ifeyinwa Ogwu David Garba Magaji Ubah Simon Azubuike Ajayi Itopa Etudaye Source Type: research
Emergency department visits and hospital admissions for suicidal ideation, self-poisoning and self-harm among adolescents in Canada during the COVID-19 pandemic
CMAJ. 2023 Sep 18;195(36):E1221-E1230. doi: 10.1503/cmaj.220507.ABSTRACTBACKGROUND: The COVID-19 pandemic had profound effects on the mental wellbeing of adolescents. We sought to evaluate pandemic-related changes in health care use for suicidal ideation, self-poisoning and self-harm.METHODS: We obtained data from the Canadian Institute for Health Information on emergency department visits and hospital admissions from April 2015 to March 2022 among adolescents aged 10-18 years in Canada. We calculated the quarterly percentage of emergency department visits and hospital admissions for a composite outcome comprising suicidal...
Source: cmaj - September 18, 2023 Category: General Medicine Authors: Naveen Poonai Stephen B Freedman Amanda S Newton Scott Sawyer Nathalie Gaucher Samina Ali Bruce Wright Michael R Miller Ahmed Mater Eleanor Fitzpatrick Mona Jabbour Roger Zemek Mohamed Eltorki Quynh Doan Pediatric Emergency Research Canada (PERC) Network Source Type: research
Osteoporosis and fracture as risk factors for self-harm and suicide: a systematic review and meta-analysis
CONCLUSION: Patients with vertebral fractures, a risk potential factor for suicide, may benefit from clinical case finding for mood disorders with personalised primary care management. However, because of the limited number and quality of studies and mixed findings, further examination of these associations is warranted.PMID:37722857 | DOI:10.3399/BJGP.2023.0035
Source: The British Journal of General Practice - September 18, 2023 Category: Primary Care Authors: Fay M Manning Faraz Mughal Hazem Ahmed Saad Mohamed Ismail Libby M Baines Carolyn A Chew-Graham Zoe Paskins James A Prior Source Type: research
Interventions to help patients withdraw from depression drugs: A systematic review
CONCLUSION: The true proportion of patients on depression drugs who can stop safely without relapse is likely considerably higher than the 50% we found.PMID:37718853 | DOI:10.3233/JRS-230011
Source: International Journal of Risk and Safety in Medicine - September 18, 2023 Category: Drugs & Pharmacology Authors: Peter C G øtzsche Maryanne Demasi Source Type: research
