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Condition: Depression
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Total 96277 results found since Jan 2013.
Open-label study of consecutive ibogaine and 5-MeO-DMT assisted-therapy for trauma-exposed male Special Operations Forces Veterans: prospective data from a clinical program in Mexico
Conclusions: Data suggest combined ibogaine and 5-MeO-DMT assisted therapy has potential to provide rapid and robust changes in mental health functioning with a signal of durable therapeutic effects up to 6-months. Future research in controlled settings is warranted.PMID:37734158 | DOI:10.1080/00952990.2023.2220874
Source: The American Journal of Drug and Alcohol Abuse - September 21, 2023 Category: Addiction Authors: Alan Kooi Davis Yitong Xin Nathan Sepeda Lynnette A Averill Source Type: research
Novel antidepressant mechanism of hypericin: Role of connexin 43-based gap junctions
Biomed Pharmacother. 2023 Sep 19;167:115545. doi: 10.1016/j.biopha.2023.115545. Online ahead of print.ABSTRACTHypericin is widely utilized for its precise antidepressant properties, but its exact antidepressant mechanism remains unclear. Gap junctions, which were predominantly expressed in astrocytes in the central nervous system, are concerned with the pathogenesis of depression. However, the role of hypericin in gap junctional dysfunction in depression has rarely been investigated. Here, we found that gap junctions were ultra-structurally broadened in the chronic unpredictable stress (CUS) rat model of depression, while ...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - September 21, 2023 Category: Drugs & Pharmacology Authors: Huiqin Wang Xueying Yang Huaqing Lai Yang Sun Xu Yan Qidi Ai Meiyu Lin Songwei Yang Yantao Yang Shifeng Chu Zhenzhen Wang Naihong Chen Source Type: research
Development and evaluation of a predictive algorithm and telehealth intervention to reduce suicidal behavior among university students
CONCLUSIONS: Predictive risk algorithms embedded into universal screening, coupled with telehealth intervention, offer significant potential as a suicide prevention approach for students.PMID:37732419 | DOI:10.1017/S0033291723002714
Source: Psychological Medicine - September 21, 2023 Category: Psychiatry Authors: Penelope A Hasking Kealagh Robinson Peter McEvoy Glenn Melvin Ronny Bruffaerts Mark E Boyes Randy P Auerbach Delia Hendrie Matthew K Nock David A Preece Clare Rees Ronald C Kessler Source Type: research
Systemic Administration of < em > Porphyromonas Gingivalis < /em > Lipopolysaccharide Induces Glial Activation and Depressive-Like Behavior in Rats
CONCLUSIONS: The major result of this study is that a repeated systemic administration of Pg-LPS caused depressive-like behavior and both microglial and astrocytic activation in rats. This finding may comprise biological evidence of a causal relationship between periodontitis and MD.PMID:37735127 | DOI:10.31083/j.jin2205120
Source: Journal of Integrative Neuroscience - September 21, 2023 Category: Neuroscience Authors: Rahman Mamunur Sadayuki Hashioka Ilhamuddin A Azis Muhammad A Jaya Sultana J F Jerin Kaori Kimura-Kataoka Junko Fujihara Ken Inoue Masatoshi Inagaki Haruo Takeshita Source Type: research
The global prevalence of suicidal ideation and suicide attempts among men who have sex with men: a systematic review and meta-analysis
ConclusionConsidering that the prevalence of suicidal ideation and attempts among these people is many times higher than that among men in the general population, developing programs for the prevention of mental disorders with special attention to suicide is necessary for these people. Screening programs are also recommended for early diagnosis and prevention of suicide among these people.
Source: European Journal of Medical Research - September 21, 2023 Category: Research Source Type: research
Research hotspots and trend analysis of abdominal pain in inflammatory bowel disease: A bibliometric and visualized analysis
This study provides the first bibliometric analysis of papers in this research area using visualization software and data information mining. It provides insights into this field's current status, hot spots, and trends. However, many outstanding issues in this research area still need further exploration to provide a theoretical basis for its clinical application.
Source: Frontiers in Pharmacology - September 21, 2023 Category: Drugs & Pharmacology Source Type: research
The Effect of Deep Repetitive Transcranial Magnetic Stimulation with an H1 Coil on Hopelessness in Patients with Major Depressive Disorder: A Randomized Controlled Trial
CONCLUSIONS: rTMS with an H1 coil improved the symptoms of hopelessness in patients with MDD.PMID:37727902 | DOI:10.1080/15622975.2023.2251055
Source: The World Journal of Biological Psychiatry - September 20, 2023 Category: Psychiatry Authors: Tomislav Gaj šak Željko Milovac Natko Gere š Strahimir Su čić Zoran Zori čić Igor Filip čić Source Type: research
Healthy lifestyle promotion via digital self-help for mental health patients in primary care: a pilot study including an embedded randomized recruitment trial
CONCLUSIONS: Recruitment routines seemed to be decisive for reaching as many patients as possible. The relatively low rate of unhealthy lifestyle behaviors and small effect sizes suggests that the intervention may only suit patients at risk.TRIAL REGISTRATION: ClinicalTrials.gov NCT03691116 (01/10/2018), focusing on the embedded trial. Retrospectively registered for the first clinic and prospectively for the second clinic.PMID:37728142 | DOI:10.1017/S146342362300049X
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Karoline Kolaas Erland Axelsson Erik Hedman-Lagerl öf Anne H Berman Source Type: research
The Association Between Depression and Substance Use Among Primary Care Patients With Comorbid Medical and Behavioral Health Conditions
CONCLUSIONS: The findings suggest that substance use disorder is associated with depression severity cross-sectionally and over time. Primary care clinics and health systems might consider implementing substance use screening in addition to the more common screening strategies for depression. Especially for patients with severe depression or those who do not respond to frontline depression treatments, the undermining presence of a substance use disorder should be explored.PMID:37728047 | DOI:10.1177/21501319231200302
Source: Primary Care - September 20, 2023 Category: Primary Care Authors: Mark P McGovern Julia Dunn Levi N Bonnell George Leibowitz Elizabeth Waddell Gail Rose Benjamin Littenberg Source Type: research
Association between frailty and depression: A bidirectional Mendelian randomization study
Sci Adv. 2023 Sep 22;9(38):eadi3902. doi: 10.1126/sciadv.adi3902. Epub 2023 Sep 20.ABSTRACTFrailty and depression were linked in observational studies, but the causality remains ambiguous. We intended to explore it using Mendelian randomization (MR). We obtained frailty genome-wide association study (GWAS) data from UK Biobank and TwinGen meta-analysis, and depression GWAS data from Psychiatric Genomics Consortium (PGC) and FinnGen (respectively recorded as PD and FD). We performed univariable and multivariable-adjusted MR with adjustments for body mass index (BMI) and physical activity (PA). Frailty was significantly asso...
Source: Adv Data - September 20, 2023 Category: Epidemiology Authors: Ming-Gang Deng Fang Liu Yuehui Liang Kai Wang Jia-Qi Nie Jiewei Liu Source Type: research
Health of people with selected citizenships in Germany: prevalence of non-communicable diseases and associated social as well as migration-related factors
DISCUSSION: Given the importance of subjective sense of belonging to the society in Germany and self-reported experience of discrimination for the health outcomes studied, the results point to health inequalities among people with selected citizenships that may indicate mechanisms of social exclusion.PMID:37728772 | DOI:10.1007/s00103-023-03767-4
Source: Bundesgesundheitsblatt, Gesundheitsforschung, Gesundheitsschutz - September 20, 2023 Category: International Medicine & Public Health Authors: Susanne Bartig Marleen Bug Carmen Koschollek Katja Kajikhina Miriam Blume Manuel Siegert Christin Heidemann Lena Walther Hannelore Neuhauser Claudia H övener Source Type: research
Effects of Transcutaneous Trigeminal Electrical Stimulation and Sound Therapy in Patients with Tinnitus
CONCLUSION: Based on the results of our study, we could confirm that TTES combined with NST can significantly improve tinnitus, catastrophic symptoms, and the overall quality of life of patients.PMID:37727921 | DOI:10.3349/ymj.2022.0611
Source: Yonsei Medical Journal - September 20, 2023 Category: Universities & Medical Training Authors: Young Sang Cho Sungwon Park Ga-Young Kim Mini Jo Sung Hwa Hong Il Joon Moon Source Type: research
Submandibular suction lipectomy and single-hole inflator-free endoscopic thyroidectomy with a submental approach: a new surgical technique
Gland Surg. 2023 Jul 31;12(7):974-981. doi: 10.21037/gs-22-624. Epub 2023 Jun 30.ABSTRACTWe have successfully carried out single-hole inflator-free endoscopic thyroidectomy through a submental approach, which has the advantages of less trauma, fewer complications, and hidden incisions. However, for patients with submandibular fat accumulation, submental incisions are not easy to hide, which directly affects the cosmetic effect. We developed a new surgical strategy "submandibular suction lipectomy and single-hole inflator-free endoscopic thyroidectomy with a submental approach" for these patients. We initially used submandi...
Source: Hand Surgery - September 20, 2023 Category: Surgery Authors: Zhongliang Lang Jing Lv Deling Wu Chunlei Sun Zhiwei Xing Gaoyuan Yu Gongshuai Tao Liping Zhao Xiaopeng Ma Source Type: research
Exploring the Access and Use of Social Technologies by Older Adults in Support of Their Mental Health During the COVID-19 Pandemic: A Rapid Review
This study aimed to explore the accessibility, outcomes, and challenges of social technology use among community-dwelling older adults, older adults in long-term care, older adults with neurocognitive disorder, and older adults with pre-frailty and frailty, to help guide future research in this area. A rapid review was conducted, and articles were retrieved from four online databases, including Medline, AgeLine, EconLit and CINAHL, and grey literature from Google Scholar. Of the 131 articles retrieved, 24 were included in this review. The positive outcomes of social technology use include improved mental and physical healt...
Source: Canadian Journal on Aging - September 20, 2023 Category: Geriatrics Authors: Joelle R DesCh âtelets Asif R Khowaja Kristin Mechelse Henriette Koning Dominic Ventresca Source Type: research
