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Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments
World J Gastroenterol. 2023 Aug 28;29(32):4831-4850. doi: 10.3748/wjg.v29.i32.4831.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of NAFLD is widely recognised, the precise triggers for disease progression are still to be fully elucidated. Furthermore, the propagation to cirrhosis is poorly understood. Whilst some progress in terms of treatment options have been explored, an incomplete understanding of the hepatic c...
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Lucy Petagine Mohammed Gulrez Zariwala Vinood B Patel Source Type: research
Diabetes and non-alcoholic fatty liver disease: a bittersweet symphony
Med J Aust. 2023 Sep 12. doi: 10.5694/mja2.52106. Online ahead of print.NO ABSTRACTPMID:37700569 | DOI:10.5694/mja2.52106
Source: Med J Aust - September 13, 2023 Category: General Medicine Authors: Daniel Clayton-Chubb Stuart K Roberts Source Type: research
Dysfunction of autophagy in high-fat diet-induced nonalcoholic fatty liver disease
Autophagy. 2023 Sep 12:1-21. doi: 10.1080/15548627.2023.2254191. Online ahead of print.ABSTRACTACOX1: acyl-CoA oxidase 1; ADH5: alcohol dehydrogenase 5 (class III), chi polypeptide; ADIPOQ: adiponectin, C1Q and collagen domain containing; ATG: autophagy related; BECN1: beclin 1; CRTC2: CREB regulated transcription coactivator 2; ER: endoplasmic reticulum; F2RL1: F2R like trypsin receptor 1; FA: fatty acid; FOXO1: forkhead box O1; GLP1R: glucagon like peptide 1 receptor; GRK2: G protein-coupled receptor kinase 2; GTPase: guanosine triphosphatase; HFD: high-fat diet; HSCs: hepatic stellate cells; HTRA2: HtrA serine peptidase...
Source: Autophagy - September 13, 2023 Category: Cytology Authors: Qiannan Ren Qiming Sun Junfen Fu Source Type: research
Zero alcohol, but not zero risk?
Aust N Z J Psychiatry. 2023 Sep 13:48674231200399. doi: 10.1177/00048674231200399. Online ahead of print.NO ABSTRACTPMID:37702206 | DOI:10.1177/00048674231200399
Source: The Australian and New Zealand Journal of Psychiatry - September 13, 2023 Category: Psychiatry Authors: Anthony Hew Shalini Arunogiri Source Type: research
Drug use among medical students in S ão Paulo, Brazil: a cross-sectional study during the coronavirus disease 2019 pandemic
CONCLUSION: The prevalence of substance use was high in this population and increased from the basic to the clinical cycle. The COVID-19 pandemic may have affected the frequency of drug use and prevalence estimates.PMID:37703121 | DOI:10.1590/1516-3180.2022.0493.R1.150623
Source: Sao Paulo Medical Journal - September 13, 2023 Category: General Medicine Authors: Pedro Lemos-Santos Lukas Blumrich Jordi Blanes Debia Jo ão Mauricio Castaldelli-Maia Paulo Jeng Chian Suen Andr é Malbergier Source Type: research
Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments
World J Gastroenterol. 2023 Aug 28;29(32):4831-4850. doi: 10.3748/wjg.v29.i32.4831.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of NAFLD is widely recognised, the precise triggers for disease progression are still to be fully elucidated. Furthermore, the propagation to cirrhosis is poorly understood. Whilst some progress in terms of treatment options have been explored, an incomplete understanding of the hepatic c...
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Lucy Petagine Mohammed Gulrez Zariwala Vinood B Patel Source Type: research
Relationship between nonalcoholic fatty liver disease and bone mineral density in elderly Chinese
CONCLUSION: This study suggested that NAFLD is associated with a reduced risk of reduced heel bone mass. More research needs to be done to back up the results of this study and look into possible problems.PMID:37705028 | DOI:10.1186/s13018-023-04168-8
Source: Hand Surgery - September 13, 2023 Category: Surgery Authors: Guangheng Zhang Yingsong Zhao Siyuan Wang Qing Gong Hewei Li Source Type: research
A General Strategy Toward pH-Resistant Phenolic Fluorophores for High-Fidelity Sensing and Bioimaging Applications
Angew Chem Int Ed Engl. 2023 Sep 12:e202311168. doi: 10.1002/anie.202311168. Online ahead of print.ABSTRACTAryl alcohol-type or phenolic fluorophores offer diverse opportunities for developing bioimaging agents and fluorescence probes. Due to the inherently acidic hydroxyl functionality, phenolic fluorophores provide pH-dependent emission signals. Therefore, except for developing pH probes, the pH-dependent nature of phenolic fluorophores should be considered in bioimaging applications but has been neglected. Here we show that a simple structural remedy converts conventional phenolic fluorophores into pH-resistant derivati...
Source: Angewandte Chemie - September 13, 2023 Category: Chemistry Authors: Sourav Sarkar Anushree Shil Suman Maity Yun Lim Jung Mingchong Dai Atanu Acharya Kyo Han Ahn Source Type: research
Child abuse and neglect and mental health outcomes in adulthood by ethnicity: Findings from a 40-year longitudinal study in New Zealand/Aotearoa
CONCLUSIONS: Exposure to childhood maltreatment has long-term effects into middle-age. Further research employing culturally-sensitive approaches may help clarify Māori childhood maltreatment outcomes.PMID:37703676 | DOI:10.1016/j.chiabu.2023.106444
Source: Child Abuse and Neglect - September 13, 2023 Category: Child Development Authors: S Telfar G F H McLeod B Dhakal J Henderson S Tanveer H E T Broad W Woolhouse S Macfarlane J M Boden Source Type: research
Development of a joint derivatization protocol for the unequivocal identification of the monosaccharide composition in four dendrobium polysaccharides and free monosaccharide by GC-MS
In this study, sugar alcohol acetylation, saccharonitrile acetylation, silylation and a combination of sugar alcohols acetylation and saccharonitrile acetylation were compared. The optimal method was verified with the monosaccharide determination of four polysaccharides and four free monosaccharides from Dendrobium. The results showed that the novel combined derivatization method was superior to the other three methods in terms of content analysis of monosaccharides. Furthermore, it possessed good linearity (all calibration curves showed relative coefficients ≥ 0.999), sensitivity, precision (relative standard deviation ...
Source: Biomedical Chromatography : BMC - September 13, 2023 Category: Biomedical Science Authors: Wei-Han Yang Jing-Wen Hao Nai-Dong Chen Jiao Li Source Type: research
Addressing endogeneity between hazardous actions and motorcyclist injury severity by integrating generalized propensity score approach and instrumental variable model
Accid Anal Prev. 2023 Sep 11;192:107297. doi: 10.1016/j.aap.2023.107297. Online ahead of print.ABSTRACTMotorcyclist hazardous actions (e.g., particularly speed too fast or failing to stop in assured clear distance (ACD)) are commonly identified as risk factors that significantly impact the motorcyclist injury severity. However, endogenous effects resulting from motorcyclist hazardous actions have seldom been considered, which may cause the biased estimates. Specifically, two important sources of endogeneities (i.e., endogeneity arising from observed confounding factors and endogeneity caused by unobserved confounders) tend...
Source: Accident; Analysis and Prevention. - September 13, 2023 Category: Accident Prevention Authors: Qiong Yu Yue Zhou Eskindir Ayele Atumo Lin Qu Nan Zhang Xinguo Jiang Source Type: research
Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments
World J Gastroenterol. 2023 Aug 28;29(32):4831-4850. doi: 10.3748/wjg.v29.i32.4831.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of NAFLD is widely recognised, the precise triggers for disease progression are still to be fully elucidated. Furthermore, the propagation to cirrhosis is poorly understood. Whilst some progress in terms of treatment options have been explored, an incomplete understanding of the hepatic c...
Source: World Journal of Gastroenterology : WJG - September 13, 2023 Category: Gastroenterology Authors: Lucy Petagine Mohammed Gulrez Zariwala Vinood B Patel Source Type: research
Multifunctional composite films based on polyvinyl alcohol, quaternary ammonium salt modified cellulose nanofibers and tannic acid-iron ion coordination complexes for food packaging
Int J Biol Macromol. 2023 Sep 11:126857. doi: 10.1016/j.ijbiomac.2023.126857. Online ahead of print.ABSTRACTThe development of sustainable and well-performing food packaging materials takes on critical significance, whereas it is still challenging. To overcome the shortcomings of polyvinyl alcohol (PVA) as a degradable packaging material, in this work, hydrophobic quaternary ammonium salt (QAS) modified cellulose nanofibers (CNF) and tannic acid‑iron ion coordination complexes (TA-Fe) were adopted for the preparation of functional PVA films. The modified CNF (CNF-QAS) not only improved the mechanical properties and water...
Source: International Journal of Biological Macromolecules - September 13, 2023 Category: Biochemistry Authors: Zhiqiang Li Jiahui Qu Liwei Qian Yan Li Jingtao Liu Xue Yao Sufeng Zhang Nica Valentin Wenqi Song Source Type: research
Emerging therapeutic options for non-alcoholic fatty liver disease: A systematic review
CONCLUSION: The data analyzed in this review showed clinically significant improvement in individual histological features of NAFLD in both animal and human trials for all four classes, as well as good safety profiles (P < 0.05). We believe this compilation of information will have positive clinical implications in obtaining an FDA-approved therapy for NAFLD.PMID:37701920 | PMC:PMC10494562 | DOI:10.4254/wjh.v15.i8.1001
Source: World Journal of Hepatology - September 13, 2023 Category: Gastroenterology Authors: Jasmine Tidwell Natalie Balassiano Anjiya Shaikh Mahmoud Nassar Source Type: research
Unexpected rapid < em > P < /em > -stereomutation of phosphine oxides catalysed by chlorophosphonium salts
Chem Commun (Camb). 2023 Sep 13. doi: 10.1039/d3cc03719c. Online ahead of print.ABSTRACTP-Stereomutation of phosphine oxides is extremely slow. We show that it is catalysed by chlorophosphonium salts (CPS) which can directly be formed in the system in situ. The racemization of phosphine oxides at ambient conditions catalysed by 1 mol% of CPS takes 1-2 hours and can be arrested by additon of a primary alcohol. The process probably proceeds via the development of oxodiphosphonium P-O-P species.PMID:37700722 | DOI:10.1039/d3cc03719c
Source: Chemical Communications - September 13, 2023 Category: Chemistry Authors: Sulaiman Al-Sulaimi Kamalraj Rajendran Kirill Nikitin Declan G Gilheany Source Type: research
