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Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments
World J Gastroenterol. 2023 Aug 28;29(32):4831-4850. doi: 10.3748/wjg.v29.i32.4831.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of NAFLD is widely recognised, the precise triggers for disease progression are still to be fully elucidated. Furthermore, the propagation to cirrhosis is poorly understood. Whilst some progress in terms of treatment options have been explored, an incomplete understanding of the hepatic c...
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Lucy Petagine Mohammed Gulrez Zariwala Vinood B Patel Source Type: research
Zero alcohol, but not zero risk?
Aust N Z J Psychiatry. 2023 Sep 13:48674231200399. doi: 10.1177/00048674231200399. Online ahead of print.NO ABSTRACTPMID:37702206 | DOI:10.1177/00048674231200399
Source: The Australian and New Zealand Journal of Psychiatry - September 13, 2023 Category: Psychiatry Authors: Anthony Hew Shalini Arunogiri Source Type: research
Emerging therapeutic options for non-alcoholic fatty liver disease: A systematic review
CONCLUSION: The data analyzed in this review showed clinically significant improvement in individual histological features of NAFLD in both animal and human trials for all four classes, as well as good safety profiles (P < 0.05). We believe this compilation of information will have positive clinical implications in obtaining an FDA-approved therapy for NAFLD.PMID:37701920 | PMC:PMC10494562 | DOI:10.4254/wjh.v15.i8.1001
Source: World Journal of Hepatology - September 13, 2023 Category: Gastroenterology Authors: Jasmine Tidwell Natalie Balassiano Anjiya Shaikh Mahmoud Nassar Source Type: research
Non-alcoholic fatty liver disease: Immunological mechanisms and current treatments
World J Gastroenterol. 2023 Aug 28;29(32):4831-4850. doi: 10.3748/wjg.v29.i32.4831.ABSTRACTNon-alcoholic fatty liver disease (NAFLD) causes significant global disease burden and is a leading cause of mortality. NAFLD induces a myriad of aberrant changes in hepatocytes at both the cellular and molecular level. Although the disease spectrum of NAFLD is widely recognised, the precise triggers for disease progression are still to be fully elucidated. Furthermore, the propagation to cirrhosis is poorly understood. Whilst some progress in terms of treatment options have been explored, an incomplete understanding of the hepatic c...
Source: World Journal of Gastroenterology - September 13, 2023 Category: Gastroenterology Authors: Lucy Petagine Mohammed Gulrez Zariwala Vinood B Patel Source Type: research
Zero alcohol, but not zero risk?
Aust N Z J Psychiatry. 2023 Sep 13:48674231200399. doi: 10.1177/00048674231200399. Online ahead of print.NO ABSTRACTPMID:37702206 | DOI:10.1177/00048674231200399
Source: The Australian and New Zealand Journal of Psychiatry - September 13, 2023 Category: Psychiatry Authors: Anthony Hew Shalini Arunogiri Source Type: research
Emerging therapeutic options for non-alcoholic fatty liver disease: A systematic review
CONCLUSION: The data analyzed in this review showed clinically significant improvement in individual histological features of NAFLD in both animal and human trials for all four classes, as well as good safety profiles (P < 0.05). We believe this compilation of information will have positive clinical implications in obtaining an FDA-approved therapy for NAFLD.PMID:37701920 | PMC:PMC10494562 | DOI:10.4254/wjh.v15.i8.1001
Source: World Journal of Hepatology - September 13, 2023 Category: Gastroenterology Authors: Jasmine Tidwell Natalie Balassiano Anjiya Shaikh Mahmoud Nassar Source Type: research
Drug use among medical students in S ão Paulo, Brazil: a cross-sectional study during the coronavirus disease 2019 pandemic
CONCLUSION: The prevalence of substance use was high in this population and increased from the basic to the clinical cycle. The COVID-19 pandemic may have affected the frequency of drug use and prevalence estimates.PMID:37703121 | PMC:PMC10495101 | DOI:10.1590/1516-3180.2022.0493.R1.150623
Source: Sao Paulo Medical Journal - September 13, 2023 Category: General Medicine Authors: Pedro Lemos-Santos Lukas Blumrich Jordi Blanes Debia Jo ão Mauricio Castaldelli-Maia Paulo Jeng Chian Suen Andr é Malbergier Source Type: research
Does freezing induces self-assembly of polymers? A molecular dynamics study
Soft Matter, 2023, Accepted Manuscript DOI: 10.1039/D3SM00892D, PaperMangesh Bhendale, Aindrila Indra, Jayant K Singh This work investigates the freezing induced self-assembly (FISA) of poly vinyl alcohol (PVA) and PVA-like polymers using molecular dynamics simulations. In particular, the effect of the degree of supercooling, degree... The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Soft Matter latest articles - September 13, 2023 Category: Chemistry Authors: Mangesh Bhendale Source Type: research
Comparative paraCEST effect of amide and hydroxy groups in divalent cobalt and nickel complexes of tripyridine-based ligands
Dalton Trans., 2023, Advance Article DOI: 10.1039/D3DT01422C, PaperSuvam Kumar Panda, Julia Torres, Carlos Kremer, Akhilesh Kumar Singh Solution state studies of structurally characterized stable and inert Co(II) and Ni(II) complexes of tri-pyridine-containing ligands with alcohol and amide pendant arms show potential ParaCEST Contrast behaviour. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - Dalton Trans. latest articles - September 12, 2023 Category: Chemistry Authors: Suvam Kumar Panda Source Type: research
Aralia saponin A isolated from Achyranthes bidentata Bl. ameliorates LPS/D-GalN induced acute liver injury via SPHK1/S1P/S1PR1 pathway in vivo and in vitro
CONCLUSIONS: AsA can ameliorate LPS/D-GalN-induced ALI by inhibiting inflammation and oxidative stress via the SPHK1/S1P/S1PR1 pathway. In this way, a molecular justification is provided for AsA application in ALI treatment.PMID:37699301 | DOI:10.1016/j.intimp.2023.110912
Source: International Immunopharmacology - September 12, 2023 Category: Allergy & Immunology Authors: Mengnan Zeng Aozi Feng Li Wang Kun Li Jihong Zhou Source Type: research
Elastic and Conductive Cross-linked Anion Exchange Membranes Based on Polyphenylene Oxide and Poly(vinyl alcohol) for H2-O2 Fuel Cells
ChemSusChem. 2023 Sep 12:e202300985. doi: 10.1002/cssc.202300985. Online ahead of print.ABSTRACTA series of cross-linked AEMs (c-DQPPO/PVA) are synthesized by using rigid polyphenylene oxide and flexible poly(vinyl alcohol) as the backbones. Dual cations are grafted on the PPO backbone to improve the ion exchange capacity (IEC), while glutaraldehyde is introduced to enhance compatibility and reduce swelling ratio of AEMs. In addition to the enhanced mechanical properties resulting from the rigid-flexible cross-linked network, c-DQPPO/PVA AEMs also exhibit impressive ionic conductivity, which can be attributed to their high...
Source: ChemSusChem - September 12, 2023 Category: Chemistry Authors: Juanjuan Han Yangyang Zhang Xiumeng Zheng Yuyang Lu Wanting Li Xiaorong Zhou Zhandong Ren Yi Liu Meixue Hu Li Xiao Lin Zhuang Source Type: research
Cobaloxime-Integrated Covalent Organic Frameworks for Photocatalytic Hydrogen Evolution Coupled with Alcohol Oxidation
We report an azide-functionalized cobaloxime proton-reduction catalyst covalently tethered into the Wurster-type covalent organic frameworks (COFs). The cobaloxime-modified COF photocatalysts exhibit enhanced photocatalytic activity for hydrogen evolution reaction (HER) in alcohol-containing solution with no presence of a typical sacrificial agent. The best performing cobaloxime-modified COF hybrid catalyzes hydrogen production with an average HER rate up to 38 μmol h-1 in ethanol/phosphate buffer solution under 4 h illumination. Ultrafast transient optical spectroscopy characterizations and charge carrier analysis reveal...
Source: Angewandte Chemie - September 12, 2023 Category: Chemistry Authors: Shihuai Wang Tai Wu Shuyang Wu Jingjing Guo Ting He Yinglong Wu Wei Yuan Zhengyang Zhang Yong Hua Yanli Zhao Source Type: research
Pancreatic ductal adenocarcinoma with a high expression of alcohol dehydrogenase 1B is associated with less aggressive features and a favorable prognosis
In conclusion, PDAC with high ADH1B expression had less cell proliferation and malignant features, along with higher immune cell infiltration, and had a better prognosis.PMID:37693153 | PMC:PMC10492124
Source: Cell Research - September 11, 2023 Category: Cytology Authors: Kohei Chida Masanori Oshi Arya Mariam Roy Takumi Sato Itaru Endo Kazuaki Takabe Source Type: research
