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Condition: Alcoholism
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Total 52199 results found since Jan 2013.
Macrophage-expressed SRA ameliorates alcohol-induced liver injury by suppressing S-glutathionylation of Notch1 via recruiting Thioredoxin
J Leukoc Biol. 2023 Sep 19:qiad110. doi: 10.1093/jleuko/qiad110. Online ahead of print.ABSTRACTScavenger receptor A (SRA) is preferentially expressed in macrophages and implicated as a multifunctional pattern recognition receptor for innate immunity. Hepatic macrophages play a primary role in the pathogenesis of alcoholic liver disease (ALD). Herein, we observed that SRA expression was significantly increased in the liver tissues of mice with alcohol-related liver injury. SRA-deficient (SRA-/-) mice developed more severe alcohol-induced liver disease than wild-type (WT) mice. Enhanced liver inflammation existed in alcohol-...
Source: Journal of Leukocyte Biology - September 19, 2023 Category: Hematology Authors: Lei Li Jialiang Luo Zhengyumeng Zhu Ping Wang Qishan Xu Bo Chang Di Wang Lu Yu Xiao Lu Jia Zhou Qingyun Chen Daming Zuo Source Type: research
Akkermansia muciniphila - a Potential Next-generation Probiotic for Non-alcoholic Fatty Liver Disease
Curr Pharm Biotechnol. 2023 Sep 15. doi: 10.2174/1389201025666230915103052. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions, and its growing prevalence is a serious concern worldwide, especially in Western countries. Researchers have pointed out several genetic mutations associated with NAFLD; however, the imbalance of the gut microbial community also plays a critical role in the progression of NAFLD. Due to the lack of approved medicine, probiotics gain special attention in controlling metabolic disorders like NAFLD. Among these probiotics, Akkermansia muciniphila (...
Source: Current Pharmaceutical Biotechnology - September 19, 2023 Category: Biotechnology Authors: Goutam Banerjee Suraya Rahman Papri Sanjaya K Satapathy Pratik Banerjee Source Type: research
Sequencing and analysis of micro RNAs in camel milk exosomes
Acta Vet Hung. 2023 Sep 19. doi: 10.1556/004.2023.00869. Online ahead of print.ABSTRACTIn order to study the species and functions of micro (mi)RNAs in the exosomes of camel milk, non-coding small (s)RNAs were sequenced and identified by Illumina sequencing technology, and the miRNA fraction was analysed by bioinformatics. After quality control, the average length of sRNA of camel milk exosomes was 18-24 nucleotides. A total of 2,659 miRNAs were identified, including 2,458 known, and 201 new miRNAs. Among the known miRNAs, miR-148a and let-7i had the highest expression levels. The results of gene ontology enrichment analys...
Source: Acta Veterinaria Hungarica - September 19, 2023 Category: Veterinary Research Authors: Rinile Wu Caifeng Yue Yina Xie Yuerong Fu Xin Yu Zhuoyuan Li Bin Yang Source Type: research
Implementation of substance use screening in rural federally-qualified health center clinics identified high rates of unhealthy alcohol and cannabis use among adult primary care patients
CONCLUSIONS: Self-administered EHR-integrated screening was feasible to implement, and detected substantial alcohol, cannabis, and tobacco use in rural FQHC clinics. Counseling was documented for a minority of patients with moderate-high risk use, possibly indicating a need for better support of primary care providers in addressing substance use. There is potential to broaden the reach of screening by offering it at routine medical visits rather than restricting to annual preventive care visits, within these and other rural primary care clinics.PMID:37726839 | PMC:PMC10510292 | DOI:10.1186/s13722-023-00404-y
Source: Addiction Science and Clinical Practice - September 19, 2023 Category: Addiction Authors: Jennifer McNeely Bethany McLeman Trip Gardner Noah Nesin Vijay Amarendran Sarah Farkas Aimee Wahle Seth Pitts Margaret Kline Jacquie King Carmen Rosa Lisa Marsch John Rotrosen Leah Hamilton Source Type: research
Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
CONCLUSIONS: Project ENHANCE is expected to generate novel findings to inform future hospital-based efforts to promote AUD treatment engagement among diverse patient populations, including those most impacted by AUD.CLINICAL TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT05338151.PMID:37726823 | PMC:PMC10510167 | DOI:10.1186/s13722-023-00407-9
Source: Addiction Science and Clinical Practice - September 19, 2023 Category: Addiction Authors: E Jennifer Edelman Oscar F Rojas-Perez Charla Nich Joanne Corvino Tami Frankforter Derrick Gordon Ayana Jordan Manuel Paris Melissa B Weimer Brian T Yates Emily C Williams Brian D Kiluk Source Type: research
Implementation of substance use screening in rural federally-qualified health center clinics identified high rates of unhealthy alcohol and cannabis use among adult primary care patients
CONCLUSIONS: Self-administered EHR-integrated screening was feasible to implement, and detected substantial alcohol, cannabis, and tobacco use in rural FQHC clinics. Counseling was documented for a minority of patients with moderate-high risk use, possibly indicating a need for better support of primary care providers in addressing substance use. There is potential to broaden the reach of screening by offering it at routine medical visits rather than restricting to annual preventive care visits, within these and other rural primary care clinics.PMID:37726839 | PMC:PMC10510292 | DOI:10.1186/s13722-023-00404-y
Source: Addiction Science and Clinical Practice - September 19, 2023 Category: Addiction Authors: Jennifer McNeely Bethany McLeman Trip Gardner Noah Nesin Vijay Amarendran Sarah Farkas Aimee Wahle Seth Pitts Margaret Kline Jacquie King Carmen Rosa Lisa Marsch John Rotrosen Leah Hamilton Source Type: research
Promoting alcohol treatment engagement post-hospitalization with brief intervention, medications and CBT4CBT: protocol for a randomized clinical trial in a diverse patient population
CONCLUSIONS: Project ENHANCE is expected to generate novel findings to inform future hospital-based efforts to promote AUD treatment engagement among diverse patient populations, including those most impacted by AUD.CLINICAL TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT05338151.PMID:37726823 | PMC:PMC10510167 | DOI:10.1186/s13722-023-00407-9
Source: Addiction Science and Clinical Practice - September 19, 2023 Category: Addiction Authors: E Jennifer Edelman Oscar F Rojas-Perez Charla Nich Joanne Corvino Tami Frankforter Derrick Gordon Ayana Jordan Manuel Paris Melissa B Weimer Brian T Yates Emily C Williams Brian D Kiluk Source Type: research
Akkermansia muciniphila - a Potential Next-generation Probiotic for Non-alcoholic Fatty Liver Disease
Curr Pharm Biotechnol. 2023 Sep 15. doi: 10.2174/1389201025666230915103052. Online ahead of print.ABSTRACTNonalcoholic fatty liver disease (NAFLD) is a spectrum of liver conditions, and its growing prevalence is a serious concern worldwide, especially in Western countries. Researchers have pointed out several genetic mutations associated with NAFLD; however, the imbalance of the gut microbial community also plays a critical role in the progression of NAFLD. Due to the lack of approved medicine, probiotics gain special attention in controlling metabolic disorders like NAFLD. Among these probiotics, Akkermansia muciniphila (...
Source: Current Pharmaceutical Biotechnology - September 19, 2023 Category: Biotechnology Authors: Goutam Banerjee Suraya Rahman Papri Sanjaya K Satapathy Pratik Banerjee Source Type: research
Patterns and predictors of mental health service use among older veterans with alcohol use disorder who received a video-enabled tablet
Conclusion: Video-enabled tablets may help older adults with AUD overcome access barriers to mental health services, although targeted support for certain groups may be necessary.PMID:37723897 | DOI:10.1080/13607863.2023.2253448
Source: Aging and Mental Health - September 19, 2023 Category: Geriatrics Authors: Ana J Alfaro Liberty Greene James Van Campen Donna M Zulman Christine E Gould Daniel M Blonigen Source Type: research
Smell and Taste Disorders in Primary Care
Am Fam Physician. 2023 Sep;108(3):240-248.ABSTRACTDisorders of smell and taste are reported by approximately one-fifth of people 40 years and older, and one-third of people 80 years and older. These disorders affect quality of life and the ability to identify smoke and toxins. Smell and taste disorders can be early signs of dementia or Parkinson disease and are associated with increased mortality. Dysfunction may be apparent or may develop insidiously. Screening questionnaires are available, but many patients are unaware of their disorder. Most smell and taste disorders are due to sinonasal disease but also could be caused...
Source: American Family Physician - September 19, 2023 Category: Primary Care Authors: Dillon J Savard Francesca G Ursua Heidi L Gaddey Source Type: research
Sequencing and analysis of micro RNAs in camel milk exosomes
Acta Vet Hung. 2023 Sep 19. doi: 10.1556/004.2023.00869. Online ahead of print.ABSTRACTIn order to study the species and functions of micro (mi)RNAs in the exosomes of camel milk, non-coding small (s)RNAs were sequenced and identified by Illumina sequencing technology, and the miRNA fraction was analysed by bioinformatics. After quality control, the average length of sRNA of camel milk exosomes was 18-24 nucleotides. A total of 2,659 miRNAs were identified, including 2,458 known, and 201 new miRNAs. Among the known miRNAs, miR-148a and let-7i had the highest expression levels. The results of gene ontology enrichment analys...
Source: Acta Veterinaria Hungarica - September 19, 2023 Category: Veterinary Research Authors: Rinile Wu Caifeng Yue Yina Xie Yuerong Fu Xin Yu Zhuoyuan Li Bin Yang Source Type: research
An Fe ·MOF–Mo·POM hybrid material: a novel and efficient catalyst for selective benzyl alcohol oxidation to benzaldehyde
CrystEngComm, 2023, Advance Article DOI: 10.1039/D3CE00778B, PaperMaryam Mohammadikish, Mahsa Panahi Designing and synthesis of an efficient catalyst for the selective oxidation of benzyl alcohol (BzOH) to benzaldehyde (BzCHO) is a significant method in green chemistry and catalysis. To cite this article before page numbers are assigned, use the DOI form of citation above. The content of this RSS Feed (c) The Royal Society of Chemistry
Source: RSC - CrystEngComm latest articles - September 18, 2023 Category: Chemistry Authors: Maryam Mohammadikish Source Type: research
CRISPR/Cas9-mediated deletion of adipocyte genes associated with NAFLD alters adipocyte lipid handling and reduces steatosis in hepatocytes < em > in vitro < /em >
Am J Physiol Cell Physiol. 2023 Sep 18. doi: 10.1152/ajpcell.00291.2023. Online ahead of print.ABSTRACTObesity is a major risk factor for the development of non-alcoholic fatty liver disease (NAFLD) and the subcutaneous white adipose tissue (scWAT) is the primary lipid storage depot and regulates lipid fluxes to other organs. Our previous work identified genes up-regulated in scWAT of patients with NAFLD: SOCS3, DUSP1, and SIK1. Herein, we knocked down (KD) their expression in human adipose-derived mesenchymal stem cells (hADMSCs) using CRISPR/Cas9 technology and characterized their phenotype. We found that SOCS3, DUSP1, a...
Source: American Journal of Physiology. Cell Physiology - September 18, 2023 Category: Cytology Authors: Marta Lopez-Yus Scott Frendo-Cumbo Raquel Del Moral-Bergos Maria Pilar Garcia-Sobreviela Vanesa Bernal-Monterde Mikael Ryd én Silvia Lorente-Cebrian Jose M Arbones-Mainar Source Type: research
