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Total 69618 results found since Jan 2013.
Travel Medicine
Ann Intern Med. 2023 Sep 12. doi: 10.7326/AITC202309190. Online ahead of print.ABSTRACTInternational travel can cause new illness or exacerbate existing conditions. Because primary care providers are frequent sources of health advice to travelers, they should be familiar with destination-specific disease risks, be knowledgeable about travel and routine vaccines, be prepared to prescribe chemoprophylaxis and self-treatment regimens, and be aware of travel medicine resources. Primary care providers should recognize travelers who would benefit from referral to a specialized travel clinic for evaluation. Those requiring yellow...
Source: Annals of Internal Medicine - September 11, 2023 Category: Internal Medicine Authors: Robert J Rolfe Edward T Ryan Regina C LaRocque Source Type: research
Isolation and Characterization of a Novel Alpha-Hemolytic Streptococcus spp. from the Oral Cavity and Blood of Septicemic Periparturient Immunodeficient Mice
Comp Med. 2023 Sep 11. doi: 10.30802/AALAS-CM-23-000020. Online ahead of print.ABSTRACTMISTRG is an immunodeficient mouse strain that expresses multiple human cytokines that support hematopoietic stem cell maintenance and myelopoiesis. While establishing a breeding colony of MISTRG mice in a dedicated barrier room, 6 cases of death or disease occurred in pregnant or postpartum mice. Clinically, this manifested as hunched posture, dyspnea, and 1 case of emaciation with ataxia. Pathologic analysis of 7 mice revealed multisystemic necrosuppurative inflammation variably affecting the uterus and placenta, joints, meninges, inne...
Source: Comparative Medicine - September 11, 2023 Category: Zoology Authors: Amy Funk Qidong Jia Laura Janke Ashley Crawford Amy Iverson Jason Rosch Joseph Emmons Chandra Savage Heather Glasgow Randall Hayden Elisa Margolis Harshan Pisharath Source Type: research
Impact of pumpkin seeds supplementation on anemia in antenatal mothers at Andhra Pradesh, India
Bioinformation. 2022 Nov 30;18(11):1092-1097. doi: 10.6026/973206300181092. eCollection 2022.ABSTRACTAnemia during pregnancy causes 40% of maternal fatalities in underdeveloped nations, according to statistics from the WHO. Pregnant women should meet the requirements for various nutrients, notably micronutrients, to ensure a better pregnancy outcome in the future. Cucurbita moschata (Pumpkin) seeds contain a variety of compounds, such as m-carboxyphenylalanine, amino butyrate, and citrulline, as well as a number of other amino acids. It has a wide variety of biological activity such as antioxidant, anticancer, anti-inflamm...
Source: Bioinformation - September 11, 2023 Category: Bioinformatics Authors: Swapna Kumari Andugula Veerraju Andugula Mani Vadivel Rajapandian Rajapandian Chaitra Jinka Shyamaladevi Babu Babu A Gouri Shankar Source Type: research
Characteristics of Premature Myocardial Infarction Among Women With Prior Adverse Pregnancy Outcomes
CONCLUSIONS: Among women with premature MIs, 39% had a history of an APO. Women with APO history presented sooner after pregnancy but had similar MI characteristics vs those without APOs. Pregnancy history may identify women who warrant early, aggressive cardiovascular disease prevention.PMID:37694271 | PMC:PMC10487279 | DOI:10.1016/j.jacadv.2023.100411
Source: Adv Data - September 11, 2023 Category: Epidemiology Authors: Malamo E Countouris Agnes Koczo Harmony R Reynolds Anais Hausvater Harnoor Mann Yisi Wang Danielle Sharbaugh Floyd W Thoma Suresh R Mulukutla Janet M Catov Source Type: research
Genome-wide identification of transcriptional enhancers During human placental development and association with function, differentiation, and disease
Biol Reprod. 2023 Sep 11:ioad119. doi: 10.1093/biolre/ioad119. Online ahead of print.ABSTRACTThe placenta is a dynamic organ which must perform a remarkable variety of functions during its relatively short existence in order to support a developing fetus. These functions include nutrient delivery, gas exchange, waste removal, hormone production, and immune barrier functions. Proper placenta development and function is critical for healthy pregnancy outcomes, but the underlying genomic regulatory events that control this process remain largely unknown. We hypothesized that mapping sites of transcriptional enhancer activity ...
Source: Biology of Reproduction - September 11, 2023 Category: Reproduction Medicine Authors: David M Owen Minjung Kwon Xuan Huang Anusha Nagari Tulip Nandu W Lee Kraus Source Type: research
Adverse birth outcomes related to concentrations of per- and polyfluoroalkyl substances (PFAS) in maternal blood collected from pregnant women in 1960-1966
CONCLUSIONS: Using data from this US-based cohort study, we found that 1) maternal PFAS levels from the 1960s exceeded values in contemporaneous populations and 2) that gestational concentrations of certain PFAS were associated with lower birth weight and infant ponderal index. Additional studies with larger sample size are needed to further examine the associations of gestational exposure to individual PFAS and their mixtures with adverse birth outcomes.PMID:37696323 | DOI:10.1016/j.envres.2023.117010
Source: Environmental Research - September 11, 2023 Category: Environmental Health Authors: T Zheng K Kelsey C Zhu K D Pennell Q Yao K E Manz Y F Zheng J M Braun Y Liu G Papandonatos Q Liu K Shi S Brochman S L Buka Source Type: research
Development of a xylose-inducible promoter and riboswitch combination system for manipulating gene expression in < em > Fusobacterium nucleatum < /em >
In this study, we engineered a leakage-free hybrid system for precise gene expression controls in Fusobacterium nucleatum by integrating the xylose-inducible expression system with the theophylline-responsive riboswitch. This innovative method enables concurrent control of target gene expression at both transcription and translation initiation levels. Using luciferase and the indole-producing enzyme tryptophanase (TnaA) as reporters, we demonstrated that the hybrid system displays virtually no observable signal in the absence of inducers. We employed this system to express FtsX, a protein related to fusobacterial cytokines...
Source: Applied and Environmental Microbiology - September 11, 2023 Category: Microbiology Authors: Bibek G C Peng Zhou Arindam Naha Jianhua Gu Chenggang Wu Source Type: research
Ambient temperature and preeclampsia: A historical cohort study
Environ Res. 2023 Sep 9:117107. doi: 10.1016/j.envres.2023.117107. Online ahead of print.ABSTRACTPrevious studies found inconsistent associations between ambient temperature during pregnancy and the risk of preeclampsia. If such associations are causal, they may impact the future burden of preeclampsia in the context of climate change. We used a historical cohort of 129,009 pregnancies (5074 preeclampsia cases) from southern Israel that was merged with temperature assessments from a hybrid satellite-based exposure model. Distributed-lag and cause-specific hazard models were employed to study time to all preeclampsia cases,...
Source: Environmental Research - September 11, 2023 Category: Environmental Health Authors: Iaroslav Youssim Offer Erez Lena Novack Daniel Nevo Itai Kloog Raanan Raz Source Type: research
Double-edged sword: γδ T cells in mucosal homeostasis and disease
Exp Mol Med. 2023 Sep 11. doi: 10.1038/s12276-023-00985-3. Online ahead of print.ABSTRACTThe mucosa is a tissue that covers numerous body surfaces, including the respiratory tract, digestive tract, eye, and urogenital tract. Mucosa is in direct contact with pathogens, and γδ T cells perform various roles in the tissue. γδ T cells efficiently defend the mucosa from various pathogens, such as viruses, bacteria, and fungi. In addition, γδ T cells are necessary for the maintenance of homeostasis because they select specific organisms in the microbiota and perform immunoregulatory functions. Furthermore, γδ T cells dire...
Source: Molecular Medicine - September 11, 2023 Category: Molecular Biology Authors: In Kang Yumin Kim Heung Kyu Lee Source Type: research
Timing of umbilical cord occlusion, delayed vs early, in preterm babies: A randomized controlled trial (CODE-P Trial)
CONCLUSION: The primary and secondary outcomes of our study were not achieved. Therefore, more meta-analysis and trials are needed to evaluate the appropriate timing of cord clamping in preterm birth.PMID:37696147 | DOI:10.1016/j.ejogrb.2023.08.376
Source: Reproductive Biology - September 11, 2023 Category: Reproduction Medicine Authors: A Gregoraci M Carbonell A Linde M Goya N Maiz P Gabriel Y Villena S B érgamo D Beneitez I Montserrat M C C éspedes M Vargas F Castillo E Carreras Source Type: research
Genome-wide identification of transcriptional enhancers During human placental development and association with function, differentiation, and disease
Biol Reprod. 2023 Sep 11:ioad119. doi: 10.1093/biolre/ioad119. Online ahead of print.ABSTRACTThe placenta is a dynamic organ which must perform a remarkable variety of functions during its relatively short existence in order to support a developing fetus. These functions include nutrient delivery, gas exchange, waste removal, hormone production, and immune barrier functions. Proper placenta development and function is critical for healthy pregnancy outcomes, but the underlying genomic regulatory events that control this process remain largely unknown. We hypothesized that mapping sites of transcriptional enhancer activity ...
Source: Reproductive Biology - September 11, 2023 Category: Reproduction Medicine Authors: David M Owen Minjung Kwon Xuan Huang Anusha Nagari Tulip Nandu W Lee Kraus Source Type: research
Transcriptomics integrated with metabolomics reveals perfluorobutane sulfonate (PFBS) exposure effect during pregnancy and lactation on lipid metabolism in rat offspring
Chemosphere. 2023 Sep 9:140120. doi: 10.1016/j.chemosphere.2023.140120. Online ahead of print.ABSTRACTEmerging epidemiological evidence indicates potential associations between gestational perfluorobutane sulfonate (PFBS) exposure and adverse metabolic outcomes in offspring. However, the underlying mechanisms remain unclear. Our study aimed to investigate PFBS exposure effects during pregnancy and lactation on rat offspring lipid profiles and the possible underlying mechanisms. Although the biochemical index difference including total cholesterol (TC), triglyceride (TG), high-density lipoprotein (HDL), low-density lipoprot...
Source: Chemosphere - September 11, 2023 Category: Chemistry Authors: Xi Meng Guoqi Yu Tingyu Luo Ruiyuan Zhang Jun Zhang Yongjie Liu Source Type: research
Long exposure to a mixture of endocrine disruptors prediposes the ventral prostate of rats to preneoplastic lesions
Environ Sci Pollut Res Int. 2023 Sep 11. doi: 10.1007/s11356-023-29768-z. Online ahead of print.ABSTRACTEndocrine disruptors (ED) are compounds dispersed in the environment that modify hormone biosynthesis, affecting hormone-dependent organs such as the prostate. Studies have only focused on evaluating the effects of ED alone or in small groups and short intervals and have not adequately portrayed human exposure. Therefore, we characterized the prostate histoarchitecture of rats exposed to an ED mixture (ED Mix) mimicking human exposure. Pregnant females of the Sprague-Dawley strain were randomly distributed into two exper...
Source: Environmental Science and Pollution Research International - September 11, 2023 Category: Environmental Health Authors: Thaina Cavalleri Sousa Let ícia Pereira de Souza Maria Luiza Silva Ricardo Andreia Yuri Yoshigae Karianne Delalibera Hinokuma Ana Beatriz Ratto Gorzoni Ariana Musa de Aquino Wellerson Rodrigo Scarano Anthony C ésar de Sousa Castillho Maria Eduarda Almei Source Type: research
Effects of exposure to PM < sub > 2.5 < /sub > during pregnancy on the multigenerational reproductive outcomes of male mouse offspring and the role of Sertoli cells
This study explored the effects of PM2.5 exposure during pregnancy on the spermatogenesis of three consecutive generations of male mouse offspring. We randomized pregnant C57BL/6 mice into the control group, the Quartz Fiber Membrane control group, and two experimental groups exposed to different concentrations of PM2.5 (4.8 and 43.2 mg/kg B.Wt.). Pregnant mice from experimental groups received intratracheal instillation of PM2.5 of different doses on a three-day basis until birth. F1 mature male offspring from PM2.5-exposed pregnant mice were mated with normal female C57BL/6 mice. Likewise, their F2 mature male followed t...
Source: Environmental Science and Pollution Research International - September 11, 2023 Category: Environmental Health Authors: Jing Huang Hong Lu Jiwei Du Lianshuang Zhang Jialiu Wei Qifang Huang Shaowei Wu Xianqing Zhou Lihua Ren Source Type: research
