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Infectious Disease: Epidemics
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Total 25019 results found since Jan 2013.
Circulation of Respiratory Viruses in the City: Towards an Agent-Based Ecosystem model
Bull Math Biol. 2023 Sep 10;85(10):100. doi: 10.1007/s11538-023-01203-x.ABSTRACTMathematical models play an important role in management of outbreaks of acute respiratory infections (ARI). While such models are generally used to study the spread of a solitary virus, in reality multiple viruses co-circulate in the population. These viruses have been studied in detail, including the course of infection and immune defense mechanisms. We developed an agent-based model, called ABM-ARI, assimilating heterogeneous data and theoretical knowledge into a biologically motivated system, that allows to reproduce the seasonal patterns o...
Source: Bulletin of Mathematical Biology - September 10, 2023 Category: Bioinformatics Authors: A I Vlad A A Romanyukha T E Sannikova Source Type: research
HIV-1-related factors interact with p53 to influence cellular processes
AIDS Res Ther. 2023 Sep 10;20(1):66. doi: 10.1186/s12981-023-00563-7.ABSTRACTHuman immunodeficiency virus type 1 (HIV-1) is the primary epidemic strain in China. Its genome contains two regulatory genes (tat and rev), three structural genes (gag, pol, and env), and four accessory genes (nef, vpr, vpu, and vif). Long terminal repeats (LTRs) in thegenome regulate integration, duplication, and expression of viral gene. The permissibility of HIV-1 infection hinges on the host cell cycle status. HIV-1 replicates by exploiting various cellular processes via upregulation or downregulation of specific cellular proteins that also c...
Source: AIDS Research and Therapy - September 10, 2023 Category: Infectious Diseases Authors: Shanling Liu Ting Guo Jinwei Hu Weiliang Huang Pengfei She Yong Wu Source Type: research
The different cell-specific mechanisms of voluntary exercise and forced exercise in the nucleus accumbens
Neuropharmacology. 2023 Sep 8:109714. doi: 10.1016/j.neuropharm.2023.109714. Online ahead of print.ABSTRACTPhysical inactivity is a global epidemic. People who take the initiative to exercise will feel pleasure during the exercise process and stick with it for a long time, while people who passively ask for exercise will feel pain and cannot stick with it. However, the neural mechanisms underlying voluntary and forced exercise remain unclear. Here, we report that voluntary running increased the frequency and amplitude of miniature excitatory postsynaptic currents (mEPSC) but decreased membrane excitability in D1R-MSNs, whe...
Source: Neuropharmacology - September 10, 2023 Category: Drugs & Pharmacology Authors: Yixia Gan Yigang Dong Shanghua Dai Haifeng Shi Xinyi Li Fanglin Wang Yingmei Fu Yi Dong Source Type: research
TWiV 1043: Marion Koopmans on COVID-19, Mpox, H5N1, polio and One Health
From the European Society for Clinical Virology meeting in Milan, Vincent speaks with Marion Koopmans about COVID-19, Mpox, H5N1 and polio, and the promise of a One Health approach to prevent outbreaks, epidemics, and pandemics. Host: Vincent Racaniello Guest: Marion Koopmans Click arrow to play Download TWiV 1043 (45 MB .mp3, 62 min) Subscribe (free): Apple Podcasts, Google Podcasts, RSS, email Become a patron of TWiV! Links for this episode MicrobeTV Discord Server MicrobeTV store at Cafepress Research assistant position in Rosenfeld Lab CBER/FDA (pdf) SARS-CoV-2 variants in Rotterdam wastewater (Sci Tot Envi...
Source: This Week in Virology - MP3 Edition - September 10, 2023 Category: Virology Authors: Vincent Racaniello Source Type: podcasts
Emerging threat of antimicrobial resistance in Neisseria gonorrhoeae: pathogenesis, treatment challenges, and potential for vaccine development
Arch Microbiol. 2023 Sep 9;205(10):330. doi: 10.1007/s00203-023-03663-0.ABSTRACTThe continuous rise of antimicrobial resistance (AMR) is a serious concern as it endangers the effectiveness of healthcare interventions that rely on antibiotics in the long run. The increasing resistance of Neisseria gonorrhoeae, the bacteria responsible for causing gonorrhea, to commonly used antimicrobial drugs, is a major concern. This has now become a critical global health crisis. In the coming years, there is a risk of a hidden epidemic caused by the emergence of gonococcal AMR. This will worsen the global situation. Infections caused by...
Source: Archives of Microbiology - September 9, 2023 Category: Microbiology Authors: Umairah Natasya Mohd Omeershffudin Suresh Kumar Source Type: research
Evaluating anti-viral effect of Ivermectin on porcine epidemic diarrhea virus and analyzing the related genes and signaling pathway by RNA-seq in vitro
In this study, we reported the broad-spectrum antiviral activity of Ivermectin in vitro. Ivermectin can inhibit PEDV infections of different genotypes. Avermectin derivatives can also inhibit PEDV infections. A time of addition assay showed that Ivermectin exhibited potent anti-PEDV activity when added simultaneously with or post virus infection. Furthermore, Ivermectin significantly inhibited the late stage of viral infection by affecting viral release. RNA sequencing indicates Ivermectin induces cell cycle arrest, which may be related to its ability to inhibit viral release. Interestingly, when combined with Niclosamide,...
Source: Virology - September 9, 2023 Category: Virology Authors: Yue Wang Panpan Qin Chenxu Zhao Yaqin Li Shuai Li Fangfang Fan Dongliang Li Huimin Huang Hong Duan Xia Yang Wenjuan Du Yongtao Li Source Type: research
Emerging threat of antimicrobial resistance in Neisseria gonorrhoeae: pathogenesis, treatment challenges, and potential for vaccine development
Arch Microbiol. 2023 Sep 9;205(10):330. doi: 10.1007/s00203-023-03663-0.ABSTRACTThe continuous rise of antimicrobial resistance (AMR) is a serious concern as it endangers the effectiveness of healthcare interventions that rely on antibiotics in the long run. The increasing resistance of Neisseria gonorrhoeae, the bacteria responsible for causing gonorrhea, to commonly used antimicrobial drugs, is a major concern. This has now become a critical global health crisis. In the coming years, there is a risk of a hidden epidemic caused by the emergence of gonococcal AMR. This will worsen the global situation. Infections caused by...
Source: Archives of Microbiology - September 9, 2023 Category: Microbiology Authors: Umairah Natasya Mohd Omeershffudin Suresh Kumar Source Type: research
A fully integrated duplex RT-LAMP device for the detection of viral infections
In this study, we showed and evaluated a prototype of a microfluidic system, and showed that duplex RT-LAMP can detect and distinguish between the two viruses, with LoDs of 2,000 copies/ml for bovine coronavirus and 200 copies/ml for influenza A/X-31 virus.PMID:37682413 | PMC:PMC10491696 | DOI:10.1007/s10544-023-00676-w
Source: Biomedical Microdevices - September 8, 2023 Category: Biomedical Engineering Authors: Nicolas Mytzka Skaiste Arbaciauskaite Natalia Sandetskaya Kai Mattern Dirk Kuhlmeier Source Type: research
