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3D interconnected porous PMMA scaffold integrating with advanced nanostructured CaP-based biomaterials for rapid bone repair and regeneration
J Mech Behav Biomed Mater. 2023 Sep 7;147:106106. doi: 10.1016/j.jmbbm.2023.106106. Online ahead of print.ABSTRACTBioactive scaffolds with polymer and nanostructured bioactive glass-based composites are promising materials for regenerative applications in consequence of close mimics of natural bone composition. Poly methyl methacrylate (PMMA) is a highly preferred thermoplastic polymer for orthopedic applications as it has good biocompatibility. Different kinds of bioactive, biodegradable as well as biocompatible biomaterial composites such as Bioglass (BG), Hydroxyapatite (Hap), and Tricalcium phosphate (TCP) can be integ...
Source: Journal of the Mechanical Behavior of Biomedical Materials - September 14, 2023 Category: Materials Science Authors: K Elakkiya P Bargavi S Balakumar Source Type: research
A morphometric approach to morphology analysis of palatal rugae in sibling groups
This study aimed to determine whether there are significant differences in 3D palatal rugae shape between siblings. Digital casts representing 25 pairs of full siblings from each group, male-male (MM), female-female (FF), and female-male (FM), were digitized and transferred to a GM system. The palatal rugae were determined, quantified, and visualized using GMM computational tools with MorphoJ software (University of Manchester). Principal component analysis (PCA) and canonical variates analysis (CVA) were employed to analyze palatal rugae shape variability and distinguish between sibling groups based on shape. Additionally...
Source: Journal of Forensic Sciences - September 14, 2023 Category: Forensic Medicine Authors: Sock Nee Tey Alizae Marny Fadzlin Syed Mohamed Murshida Marizan Nor Source Type: research
Differences in whole-brain metabolism are associated with the expression of genes related to neurovascular unit integrity and synaptic plasticity in temporal lobe epilepsy
DISCUSSION: Our findings, combined with the analysis of neuroimaging and transcriptional data, suggest that genes related to NVU integrity and synaptic plasticity may drive alterations to brain metabolism that mediate the genetic risk of TLE.PMID:37707571 | DOI:10.1007/s00259-023-06433-8
Source: Molecular Medicine - September 14, 2023 Category: Molecular Biology Authors: Ling Xiao Yongxiang Tang Chijun Deng Jian Li Rong Li Haoyue Zhu Danni Guo Zhiquan Yang Hongyu Long Li Feng Shuo Hu Source Type: research
Insights into the formulation properties, biocompatibility, and permeability of poorly water-soluble methoxyflavones with PEG400 and propylene glycol
Acta Pharm. 2023 Sep 14;73(3):385-404. doi: 10.2478/acph-2023-0030. Print 2023 Sep 1.ABSTRACTHerein, thermal and non-thermal techniques were used to elucidate the putative physical and chemical interactions between poorly water-soluble Kaempferia methoxyflavones and PEG400/propylene glycol. Additionally, the biocompatibility of methoxyflavone-glycol solutions was evaluated using Caco-2 cells whereas the absorptive transport was investigated by measuring the apparent permeability coefficient (P app) of the methoxyflavones and transepithelial electrical resistance (TEER) of the Caco-2 cell monolayer. Data from differential s...
Source: Acta Pharmaceutica - September 14, 2023 Category: Drugs & Pharmacology Authors: Fredrick Nwude Eze Chaweewan Jansakul Teerapol Srichana Source Type: research
PLGA-based microspheres loaded with metformin hydrochloride: modified double emulsion method preparation, optimization, characterization, and in vitro evaluation
Ann Pharm Fr. 2023 Sep 12:S0003-4509(23)00105-0. doi: 10.1016/j.pharma.2023.09.002. Online ahead of print.ABSTRACTThe modified solvent removal method was used to encapsulate metformin hydrochloride (MH) within poly(lactic-co-glycolic acid) (PLGA) microspheres. The study investigated the effect of varying polymer concentrations on the loading and release of the drug from the microspheres. The encapsulation process involved using a double emulsion method, resulting in microspheres with particle diameters ranging from approximately 4.4 µm to 2.7 µm. The study achieved high encapsulation efficiencies, ranging from 81% to 90%...
Source: Annales Pharmaceutiques Francaises - September 14, 2023 Category: Drugs & Pharmacology Authors: Priyanka Chauhan Himanshu Paliwal Chetan Singh Chauhan Ankit Paliwal Source Type: research
Use of primary health care services and mortality in older patients with type 2 diabetes with or without comorbidities
CONCLUSIONS: In older patients with T2D, the presence of comorbidities was associated with increased use of PHC services and increased mortality. Increase in the number of appointments was associated with reduced mortality in patients with T2D with or without comorbidities.Key PointsIn older patients with T2D, it has not been studied whether and to what extend multimorbidity affects use of PHC services and mortality.The presence of comorbidities according to the Charlson Comorbidity Index (CCI) was associated with increased use of PHC services.The number of appointments to GPs or nurses was associated with reduced mortalit...
Source: Primary Care - September 14, 2023 Category: Primary Care Authors: E Mellanen T Kauppila H Kautiainen M Lehto O Rahkonen K Pitk älä M K Laine Source Type: research
Three ways of organising general practitioner's medical services in sheltered housing. A qualitative study
CONCLUSION: Residents in round-the-clock staffed sheltered housing constitute a varied group that generally has substantial medical assistance needs. Given that many residents lack autonomy to manage their own care needs and make decisions, models with fewer GPs like models ii and iii seem to provide a better medical professional offer. Moving towards such an organising of the medical services for sheltered housing residents could have implications for GPs' workload and competence needs. Future studies are needed to test models and assess implications.PMID:37706637 | DOI:10.1080/02813432.2023.2256381
Source: Primary Care - September 14, 2023 Category: Primary Care Authors: Laila Tingvold Line Melby Source Type: research
Cerebellar volumes and the intrinsic cerebellar network in patients with obstructive sleep apnea
CONCLUSION: This study established that patients with OSA exhibited decreased total cerebellar volumes and particularly reduced volumes in subdivisions such as the left lobule VIIB compared to healthy controls. These findings suggest potential involvement of the cerebellum in the underlying mechanisms of OSA.PMID:37710027 | DOI:10.1007/s11325-023-02916-y
Source: Sleep and Breathing - September 14, 2023 Category: Sleep Medicine Authors: Jinseung Kim Ho-Joon Lee Dong Ah Lee Kang Min Park Source Type: research
An Exploratory Investigation into Optimal Indicators and Thresholds for Anemia Diagnosis Through Abdominal CT Plain Scans
CONCLUSIONS: Among the various parameters obtained from abdominal CT plain scans, the CT value of the abdominal aorta demonstrated the highest diagnostic efficacy in distinguishing between different degrees of anemia.PMID:37708544
Source: Alternative Therapies in Health and Medicine - September 14, 2023 Category: Complementary Medicine Authors: Xiang Feng Yuefeng Kong Hanhua Yu Source Type: research
White matter hyperintensity volume modifies the association between CSF vascular inflammatory biomarkers and regional FDG-PET along the Alzheimer's disease continuum
Neurobiol Aging. 2023 Aug 10;132:1-12. doi: 10.1016/j.neurobiolaging.2023.08.002. Online ahead of print.ABSTRACTIn older adults with abnormal levels of Alzheimer's disease neuropathology, lower cerebrospinal fluid (CSF) vascular endothelial growth factor (VEGF) levels are associated with lower [¹⁸F]-fluorodeoxyglucose positron emission tomography (FDG-PET) signal, but whether this association is (1) specific to VEGF or broadly driven by vascular inflammation, or (2) modified by vascular risk (e.g., white matter hyperintensities [WMHs]) remains unknown. To address this and build upon our past work, we evaluated whether 5...
Source: Neurobiology of Aging - September 14, 2023 Category: Geriatrics Authors: Meral A Tubi Koral Wheeler Elizabeth Matsiyevskiy Matthew Hapenney Wendy J Mack Helena C Chui Kevin King Paul M Thompson Meredith N Braskie for Alzheimer ’s Disease Neuroimaging Initiative Source Type: research
The effect of postoperative hepatic fibrosis factors on morbidity in mitral valve replacement surgery: A single center ten years' experience
CONCLUSION: The AST/ALT ratio, which has been shown to be a predictor of cardiovascular mortality in various studies, was not useful in predicting mortality and morbidity in our study. However, a high FIB-4 index, another hepatic fibrosis index, was found to be associated with increased perioperative bleeding, duration of mechanical ventilation, and cardiac intensive care unit stay, which are important criteria in the prediction of morbidity in cardiovascular surgery.PMID:37706385 | PMC:PMC10284468 | DOI:10.4103/aca.aca_55_22
Source: Annals of Cardiac Anaesthesia - September 14, 2023 Category: Anesthesiology Authors: Mehmet Ali Yesiltas A K Hulya Yilmaz Yasemin Ozsahin Baris Sandal Ziya Salihoglu Kerem Erkalp Source Type: research
3D-printed polycaprolactone scaffolds coated with beta tricalcium phosphate for bone regeneration
CONCLUSION: We concluded that both meshes structured PCL and PCL/β-TCP scaffolds could promote the MG-63 cell growth, and PCL/β-TCP was better than the PCL scaffolds for the outcome of MG63 cell differentiation and mineralization.PMID:37709573 | DOI:10.1016/j.jfma.2023.08.009
Source: J Formos Med Assoc - September 14, 2023 Category: General Medicine Authors: Zolzaya Javkhlan Sheng-Hao Hsu Rung-Shu Chen Min-Huey Chen Source Type: research
Phasic and tonic muscle synergies are different in number, structure and sparseness
This study aims at testing whether phasic and tonic components are generated by distinct phasic and tonic synergies or by the same set of synergies with phasic and tonic activation coefficients. The study also aims at characterizing the differences between the phasic and the tonic synergies. Using a comprehensive mapping of upper-limb point-to-point movements, synergies were extracted from phasic and tonic EMG signal separately, estimating the tonic components with a linear ramp model. The goodness of reconstruction (R2) as a function of the number of synergies was compared, and sets of synergies extracted from each datase...
Source: Human Movement Science - September 14, 2023 Category: Neurology Authors: Cristina Brambilla Marta Russo Andrea d'Avella Alessandro Scano Source Type: research
Differences in diffusion tensor imaging parameters of brain white matter tracts between patients with myotonic dystrophy type 1 and type 2 - a retrospective single-centre study
CONCLUSIONS: Our results indicate diffuse disintegration of white matter pathways in DM patients, especially in the DM1 group. The damage to all types of fibres (association, commissural, and projection) may explain the diversity of clinical symptoms, which were more severe in the DM1 group of patients than in the DM2 group.CLINICAL IMPLICATIONS: DTI in patients with DM may help us to understand the neural mechanisms underlying brain involvement during the disease. In future, it may help to identify biomarkers for disease progression and treatment response.PMID:37706668 | DOI:10.5603/pjnns.95587
Source: Neurologia i Neurochirurgia Polska - September 14, 2023 Category: Neurology Authors: Edyta Maj Tomasz Wolak Joanna de Meulder Katarzyna Janiszewska Miko łaj Wojtaszek Anna Kostera-Pruszczyk Marek Go łębiowski Anna Łusakowska Source Type: research
Molecular characteristics and clinical features of Staphylococcus epidermidis healthcare-associated late-onset bacteremia among infants hospitalized in neonatal intensive care units
CONCLUSIONS: More than 90% of S. epidermidis bloodstream isolates from infants in NICU in Taiwan were resistant to oxacillin. Though diverse, more than 90% of the isolates (episodes) belonged to CC2. No statistically significant differences were found in terms of clinical characteristics among the infants infected with genetically different strains.PMID:37709633 | DOI:10.1016/j.jmii.2023.08.005
Source: Journal of Microbiology, Immunology, and Infection - September 14, 2023 Category: Microbiology Authors: Yi-Hsuan Huang Yu-Rou Yeh Rey-In Lien Ming-Chou Chiang Yhu-Chering Huang Source Type: research
