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Modular Bicyclophane-Based Molecular Platforms
Chemistry. 2023 Sep 18:e202302662. doi: 10.1002/chem.202302662. Online ahead of print.ABSTRACTThe modular synthesis of a series of nanoscale phenylene bicyclophanes with an intraaanular orthogonal pillar is described. The compounds are obtained by a Suzuki cross-coupling condensation and are characterized by mass spectrometry and NMR spectroscopy as well as in situ scanning tunneling microscopy at the solid/liquid interface of highly ordered pyrolytic graphite. In addition, their structures and conformations are supported by quantum chemical calculations, also after adsorption to the substrate. A set of two alkyl chain sub...
Source: Chemistry - September 18, 2023 Category: Chemistry Authors: Daniel Kalle Joshua Bahr Tristan Johannes Keller Julius Kleine B üning Stefan Grimme Markus Bursch Stefan-Sven Jester Sigurd H öger Source Type: research
Diseases of the Coronary Microcirculation: Diagnosis and Treatment
CONCLUSION: Approximately 25% of patients with CMD have symptoms that do not respond to intensive treatment with the currently available modalities. New treatments, including interventional therapies, are being studied. Their long-term benefit remains to be assessed and compared to that of the existing methods.PMID:37721132 | DOI:10.3238/arztebl.m2023.0205
Source: Deutsches Arzteblatt International - September 18, 2023 Category: General Medicine Authors: Helen Ullrich-Daub Steffen Daub Maximilian Olschewski Thomas M ünzel Tommaso Gori Source Type: research
Synthesis of chitosan-based perylene dye material for photovoltaic solar-cell application
This study proposes a novel chitosan biopolymer-based perylene dye; the dye is modified by chitosan with perylene-3,4,9,10-tetracarboxylic anhydride using a one-pot acylation of nitrogen nucleophiles for DSSCs. The chitosan biopolymer-based perylene dyes were characterized using attenuated total reflection infrared spectroscopy, solid-state 13C CP-TOSS nuclear magnetic resonance spectroscopy, X-ray powder diffraction analysis, thermogravimetric analysis, X-ray photoelectron spectrometry, and high-resolution field-emission scanning electron microscopy. The ultraviolet-visible and fluorescence spectroscopy of chitosan biopol...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Santosh Kumar Ira Singh Nazrul Hsan Bhabani Sankar Swain Joonseok Koh Source Type: research
Bacterial cellulose/gum Arabic composite production by in-situ modification from lavender residue hydrolysate
In this study, bacterial cellulose/gum Arabic composite (BC/GA) was synthesized by in-situ modification from lavender residue hydrolysate for the first time. The in-situ modification with GA adding showed great beneficial effect for BC/GA synthesis. Both the product (BC or BC/GA) yield and the product (BC or BC/GA) production per sugars consumption increased greatly by the in-situ modification when compared with the fermentation without GA adding (2.90 g/L vs. 0.91 g/L, and 0.461 g/g vs. 0.138 g/g). It is hypothesized that the combination of BC and GA is the main mechanism for the beneficial effect of the in-situ modificat...
Source: International Journal of Biological Macromolecules - September 18, 2023 Category: Biochemistry Authors: Huai-Peng Jia Xiao-Lin Wang Zhuo-Wei Liu Yi Wu Jing Gao Yong Hu Yun Chen Chao Huang Source Type: research
Radiation-dependent demyelination in normal appearing white matter in glioma patients, determined using quantitative magnetic resonance imaging
CONCLUSION: In the long-term follow-up for glioma patients, qMRI is a powerful tool for detecting small changes, such as a decrease of myelin concentration, in NAWM after CRT.PMID:37720464 | PMC:PMC10500023 | DOI:10.1016/j.phro.2023.100451
Source: Health Physics - September 18, 2023 Category: Physics Authors: Anna Ljusberg Ida Blystad Peter Lundberg Emelie Adolfsson Anders Tisell Source Type: research
Treatment with a tissue-selective oestrogen complex does not affect disease pathology but reduces pre-BI cells in lupus-prone mice
CONCLUSION: TSEC does not aggravate a mouse model of lupus, when given in doses that protect against postmenopausal lupus-associated bone loss. This indicates that further investigations into TSEC as a treatment for osteoporosis or vasomotor symptoms in postmenopausal women with SLE are warranted.PMID:37722827 | DOI:10.1080/03009742.2023.2251753
Source: Scandinavian Journal of Rheumatology - September 18, 2023 Category: Rheumatology Authors: C Drevinge J M Scheffler J Nordqvist C Engdahl H Carlsten U Islander Source Type: research
Molecular Complex of HSIM-loaded Polymeric Nanoparticles: Potential Carriers in Osteoporosis
CONCLUSION: Bone-targeting nanoparticles incorporating functionalized simvastatin can target bone. Thus, in order to distribute simvastatin subcutaneously for the treatment of osteoporosis, the developed nanoparticles may act as a promising approach.PMID:37718521 | DOI:10.2174/1389450124666230915092910
Source: Current Drug Targets - September 18, 2023 Category: Drugs & Pharmacology Authors: Malkiet Kaur Manju Nagpal Amarjot Kaur Grewal Samrat Chauhan Chander Parkash Dora Thakur Gurjeet Singh Source Type: research
Improved diagnostic accuracy for coronary artery disease detection with quantitative 3D < sup > 82 < /sup > Rb PET myocardial perfusion imaging
CONCLUSIONS: Normal databases tailored to 3D PET images provide significantly improved diagnostic accuracy for PET MPI evaluation with automated quantitative TPD. Clinical application of these techniques should be considered to support accurate image interpretation.PMID:37721579 | DOI:10.1007/s00259-023-06414-x
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Jennifer M Renaud Alexis Poitrasson-Rivi ère Jonathan B Moody Tomoe Hagio Edward P Ficaro Venkatesh L Murthy Source Type: research
The Value of < sup > 18 < /sup > F-FDG PET/MRI in Detecting Lumbar Radiculopathy for Selective Percutaneous Endoscopic Discectomy: a Case Report
Nucl Med Mol Imaging. 2023 Oct;57(5):247-250. doi: 10.1007/s13139-023-00797-3. Epub 2023 Mar 29.ABSTRACTMagnetic resonance imaging (MRI) is the most popular imaging modality for investigating intervertebral disc herniation. However, it has a high chance for identifying incidental findings that are morphologically or structurally abnormal but not responsible for patients' symptoms. Although a previous study suggested that 18F-fluorodeoxyglucose (18F-FDG) positron emission tomography/magnetic resonance imaging (PET/MRI) may help identify neuroinflammation in lumbar radiculopathy, there is currently no direct evidence obtaine...
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Chih-Ying Su Guo-Shu Huang Wei-Chou Chang Chih-Chien Wang Chun-Wen Chen Yi-Chih Hsu Source Type: research
< sup > 68 < /sup > Ga-DOTANOC PET/CT for Screening and Surveillance of Von Hippel-Lindau (VHL) disease
CONCLUSION: Our results show that 68 Ga-DOTANOC PET/CT may be a useful modality for screening and follow-up of associated tumors in patients with germline gene mutation for VHL. It can be used as a one-stop imaging modality for VHL patients and may substitute for separate radiological investigations, making it more convenient for patients in terms of time and cost.PMID:37720877 | PMC:PMC10504222 | DOI:10.1007/s13139-023-00810-9
Source: Molecular Medicine - September 18, 2023 Category: Molecular Biology Authors: Shamim Ahmed Shamim Geetanjali Arora Naresh Kumar Jhangir Hussain Shreya Datta Gupta Arun Raj St Kritin Shankar Alpesh Goyal Rajesh Khadgawat Sambit Sagar Chandrasekhar Bal Source Type: research
Artificial intelligence in breast imaging: potentials and challenges
Phys Med Biol. 2023 Sep 18. doi: 10.1088/1361-6560/acfade. Online ahead of print.ABSTRACTBreast cancer, which is the most common type of malignant tumor among humans, is a leading cause of death in females. Standard treatment strategies, including neoadjuvant chemotherapy, surgery, postoperative chemotherapy, targeted therapy, endocrine therapy, and radiotherapy, are tailored for individual patients. Such personalized therapies have tremendously reduced the threat of breast cancer in females. Furthermore, early imaging screening plays an important role in reducing the treatment cycle and improving breast cancer prognosis. ...
Source: Physics in Medicine and Biology - September 18, 2023 Category: Physics Authors: Jiawei Li Danli Sheng Jiangang Chen Chao You Shuai Liu Huixiong Xu Cai Chang Source Type: research
PNIPAM-stabilized cubosomes as fusogenic delivery nanovectors for anticancer applications
Colloids Surf B Biointerfaces. 2023 Sep 9;231:113532. doi: 10.1016/j.colsurfb.2023.113532. Online ahead of print.ABSTRACTIn recent years, lipid cubic nanoparticles have emerged as promising nanocarriers for drug delivery, due to the several advantages they exhibit with respect to other lipid systems. Here, we report on lipid cubic nanoparticles stabilized by PNIPAM-based amphiphilic block copolymers, specifically, poly(N, N-dimethylacrylamide)-block-poly(N-isopropylacrylamide) (PDMA-b-PNIPAM), as a new class of drug delivery systems (DDS). In vitro studies on the internalization efficiency of the DDS towards two types of h...
Source: Colloids and Surfaces - September 18, 2023 Category: Biotechnology Authors: Arianna Balestri Laure Gibot Heinz Amenitisch Lorenzo Cervelli Costanza Montis Barbara Lonetti Debora Berti Source Type: research
Pursuit or discontinuation of anti-PD1 after 2 years of treatment in long-term responder patients with non-small cell lung cancer
CONCLUSION: The decision to continue ICI or not after 2 years of treatment depends mainly on the care center and does not seem to impact survival. Larger, randomized data sets are required to confirm this result.PMID:37720494 | PMC:PMC10501064 | DOI:10.1177/17588359231195600
Source: Adv Data - September 18, 2023 Category: Epidemiology Authors: Camille Ardin Sarah Humez Vincent Leroy Alexandre Ampere Soraya Bordier Fabienne Escande Am élie Turlotte Luc Stoven David Nunes Alexis Cortot Cl ément Gauvain Source Type: research
T-scans in implant procedures
Bioinformation. 2023 Jan 31;19(1):35-38. doi: 10.6026/97320630019035. eCollection 2023.ABSTRACTT scans are a breakthrough in technology which allows the user to accurately analyze the occlusion of a patient with minimal to zero errors. They are used during prosthodontic rehabilitation to map out the patient's occlusion to plan for replacements. Such a high advancement in technology has a backdraw. The cost of the equipment is a concern for simple dental practitioners. There are no large scale studies using T scans in determining the occlusion. Therefore, it is of interest to analyze the use of T scans in determining the pe...
Source: Bioinformation - September 18, 2023 Category: Bioinformatics Authors: Prabhav Kumar Iyer Suresh Venugopalan Thiyaneswaran N Sam Jebaraj Source Type: research
Comparing the effectiveness of novel high-end compression garment with common compression garment and kinesio tape in preventing edema and improving tissue perfusion in lower extremities
CONCLUSION: The novel bandage showed a statistically significant reduction in edema when compared intraindividually, but no statistically significant advantage was found when compared with the other compression garment B and kinesio tape.Despite the widespread use of kinesio tape, we did not find any improvement in the range of motion, edema prevention and circulation in the lower limb after application of kinesio tape.PMID:37718791 | DOI:10.3233/CH-238111
Source: Clinical Hemorheology and Microcirculation - September 18, 2023 Category: Hematology Authors: Sophia T Diesch Daniel Schiltz Julian Kammermeier Lukas Prantl Christian D Taeger Source Type: research
